Method for producing B cell population and method for producing monoclonal antibody using same | Patent Number 11578132

US 11578132 B2
Application Number16478295
Publication NumberUS 20200071410 A1
Pendency5 years, 1 month, 1 day
Filled DateJan 15, 2018
Priority DateJan 15, 2018
Publication DateMar 5, 2020
Expiration DateJan 14, 2038
Inventor/ApplicantsHiroshi Kita
Tomoyuki Nakaishi
Daisuke Kitamura
Mitsuaki Kitano
Tatsuya Moutai
ExaminesQIAN, CELINE X
Art Unit1636
Technology Center1600
Law Firm
You must be logged in to view
Login
Attorneys
Module Locked
International
3
A61K
C12N
C07K
National
0
Field of Search
0

It is an object of the present invention to provide a method for efficiently producing a B cell population comprising B cells that recognize a specific antigen. According to the present invention, provided is a method for producing a B cell population, comprising: a step (c) of culturing a cell population comprising B cells together with a specific antigen in the absence of IL-21, in the absence of IL-4, and in the presence of a cytokine other than IL-21 and IL-4, while giving stimulation mediated by CD40 and a BAFF receptor to the cells; and a step (d) of culturing the cell population comprising B cells, while giving stimulation mediated by has to the cells, so as to obtain a B cell population comprising B cells that recognize the specific antigen.

You must be logged in to view
Login
Module Locked
Module Locked
Patent Prosecution report image

Empower your practice with Patexia Publication Prosecution IP Module.

Get access to our exclusive rankings and unlock powerful data.

Looking for a Publication Attorney?

Get in touch with our team or create your account to start exploring a network of over 120K attorneys.