Pharmaceutical compositions comprising ((6bR,10aS)-1-(4-fluorophenyl)-4-(3-methyl-2,3,6b,9,10,10a-hexahydro-1H-pyrido[3,4:4,5]pyrrolo[1,2,3-de]quinoxalin-8(7H)-yl)butan-1-one or pharmaceutically acceptable salts thereof | Patent Number 10464938
US 10464938 B2Filled DateJun 12, 2019
Priority DateMar 12, 2007
Publication DateSep 26, 2019
Expiration DateMar 11, 2027
Inventor/ApplicantsPeng LI
Wei YAO
John Charles TOMESCH
James David Beard
Andrew S. THOMPSON
Hua CHENG
Lawrence P. Wennogle
Wei Yao
Andrew S. Thompson
James David BEARD
Peng Li
Lawrence P. WENNOGLE
Hua Cheng
Qiang ZHANG
Qiang Zhang
John Charles Tomesch
Wei YAO
John Charles TOMESCH
James David Beard
Andrew S. THOMPSON
Hua CHENG
Lawrence P. Wennogle
Wei Yao
Andrew S. Thompson
James David BEARD
Peng Li
Lawrence P. WENNOGLE
Hua Cheng
Qiang ZHANG
Qiang Zhang
John Charles Tomesch
ExaminesWILLIS, DOUGLAS M
Art Unit1624
Technology Center1600
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1. A pharmaceutical composition comprising toluenesulfonic acid and the compound of Formula 2J: or a pharmaceutically acceptable salt thereof, wherein: k is 1; m is 1; n is 1; R1 is 4-(4-fluorophenyl)-4-oxobutyl; R5 is H; R6a and R6b are independently H; R7, R8 and R9 are independently H; R10 is CH3; and X is —N—. 12. A pharmaceutical composition comprising a toluenesulfonic acid addition salt of the compound of Formula 2J: wherein: k is 1; m is 1; n is 1; R1 is 4-(4-fluorophenyl)-4-oxobutyl; R5 is H; R6a and R6b are independently H; R7, R8 and R9 are independently H; R10 is CH3; and X is —N—.
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