Antigen binding proteins to proprotein convertase subtilisin kexin type 9 (PCSK9) | Patent Number 08563698

1. An isolated monoclonal antibody, wherein, when bound to PCSK9, said monoclonal antibody binds to at least one residue within the sequence set forth by residues 123-132 of SEQ ID NO: 1, and wherein said monoclonal antibody reduces binding between PCSK9 and an EGFa domain of LDLR protein antagonizes PCSK9's inhibition of cellular LDL uptake.