Method for isolating a self-renewing, multipotent, slow-cycling cell | Patent Application Number 10580511

10580511
Not Appealed
Patent NumberUS 07829336 B2
Publication NumberUS 20080047026 A1
Filled DateNov 12, 2004
Priority DateNov 24, 2003
Inventor/ApplicantsTudorita Tumbar
William E. Lowry
Cedrick Blanpain
Elaine Fuchs
ExaminesTON, THAIAN N
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The present invention relates to methods for isolating infrequently-dividing, slow-cycling cells, a feature which is typical of stem cells in their niche. The methods of the present invention are advantageously used as classical stem cells can be isolated. Further provided are methods for generating clonal populations and inhibiting the differentiation of these cells. In addition markers for distinguishing these cells from progenitor cells are also disclosed.

  • 1. A method for isolating a self-renewing, multipotent, slow-cycling cell comprising obtaining a population of cells from a sample and sorting the population of cells based on the presence of CD34 and the amount of a selected slow-cycling cell marker expressed by each cell, so that a self-renewing, multipotent, slow-cycling cell is isolated, wherein the selected slow-cycling cell marker is selected from the group of Transcription Factor 3, Transcription Factor 4, Alpha 6 Integrin, G-Protein-Coupled Receptor 49 and Bone Morphogenetic Protein Receptor 1A.
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