26:["$","div",null,{"className":"flex flex-col gap-6","children":[["$","section",null,{"className":"flex flex-col gap-6","children":[["$","$L27",null,{}],["$","$L28",null,{"Icon":["$","svg",null,{"className":"remixicon-icon ","width":18,"height":18,"fill":"currentColor","viewBox":"0 0 24 24","children":["$","path",null,{"d":"M6 8V7a6 6 0 1 1 12 0v1h2a1 1 0 0 1 1 1v12a1 1 0 0 1-1 1H4a1 1 0 0 1-1-1V9a1 1 0 0 1 1-1h2zm13 2H5v10h14V10zm-8 5.732a2 2 0 1 1 2 0V18h-2v-2.268zM8 8h8V7a4 4 0 1 0-8 0v1z"}]}],"label":"You must be logged in to create a new article"}],"$L29"]}],["$","section",null,{"children":["$","$L2a",null,{"newsfeed":{"status":"success","items":[{"alias":"evolution-s-gift-may-also-be-at-the-root-of-a-form-of-autism","author":{"id":1035,"first_name":"Leyla","last_name":"Raiani","email":"l.kazvin@gmail.com","picture":"70bdbcda6e5a8c880bb71d4e149099ea.jpg","picture_size_prefixes":[35,50,75,200],"picture_path":"https://patexia-data.s3.amazonaws.com/users/user1035/"},"companies":[],"counts":{"comments":0,"favorites":0,"likes":0,"views":941},"created":"2012-05-14T17:45:45+00:00","modified":"2012-05-14T18:44:00+00:00","patents":["307502","7531568"],"people":[],"published":1,"tags":["autism"],"text":"$2b","title":"Evolution's gift may also be at the root of a form of autism","plain_text":"A recently evolved pattern of gene activity in the language and decision-making centers of the human brain is missing in a disorder associated with autism and learning disabilities, a new study by Yale University researchers shows. They identified the evolutionary changes that led the NOS1 gene to become active specifically in the parts of the developing human brain that form the adult centers for speech and language and decision-making. This pattern of NOS1 activity is controlled by a protein called FMRP and is missing in Fragile X syndrome, a disorder caused by a genetic defect on the X chromosome that disrupts FMRP production. Fragile X syndrome, the leading inherited form of intellectual disability, is also the most common single-gene cause of autism. The loss of NOS1 activity may contribute to some of the many cognitive deficits suffered by those with Fragile X syndrome, such as lower IQ, attention deficits, and speech and language delays. ","draft":0,"featured_data":{"featured":0},"lawfirms":[],"id":"4faced87c4b462955b000ecc","trademarks":[],"categories":[],"thumbnail":null,"thumbnail_path":null,"thumbnail_size_prefixes":[50]},{"alias":"compound-reduces-autism-like-behaviors-in-mice-4050","author":{"id":1035,"first_name":"Leyla","last_name":"Raiani","email":"l.kazvin@gmail.com","picture":"70bdbcda6e5a8c880bb71d4e149099ea.jpg","picture_size_prefixes":[35,50,75,200],"picture_path":"https://patexia-data.s3.amazonaws.com/users/user1035/"},"companies":[],"counts":{"comments":0,"favorites":1,"likes":0,"views":1024},"created":"2012-04-27T00:27:27+00:00","modified":"2012-04-27T00:27:27+00:00","patents":[],"people":[],"published":1,"tags":["experimental research","autism spectrum disorder"],"text":"

\r\n\tNational Institutes of Health researchers have reversed behaviors in mice resembling two of the three core symptoms of autism spectrum disorders. An experimental compound, called GRN-529, increased social interactions and lessened repetitive self-grooming behavior in a strain of mice that normally display such autism-like behaviors. GRN-529 is part of a class of agents that inhibit activity of some brain receptors for the chemical messenger glutamate. Similar compounds are already being tested in clinical trials for patients with an autism-related syndrome. Although mouse brain findings often don't translate to humans, the fact that compounds similar to GRN-529 are already in clinical trials for an overlapping condition strengthens the case for relevance, according to the researchers. The findings suggest a strategy for developing a single treatment that could target multiple diagnostic symptoms.

\r\n","title":"Compound reduces autism-like behaviors in mice","plain_text":"National Institutes of Health researchers have reversed behaviors in mice resembling two of the three core symptoms of autism spectrum disorders. An experimental compound, called GRN-529, increased social interactions and lessened repetitive self-grooming behavior in a strain of mice that normally display such autism-like behaviors. GRN-529 is part of a class of agents that inhibit activity of some brain receptors for the chemical messenger glutamate. Similar compounds are already being tested in clinical trials for patients with an autism-related syndrome. Although mouse brain findings often don't translate to humans, the fact that compounds similar to GRN-529 are already in clinical trials for an overlapping condition strengthens the case for relevance, according to the researchers. The findings suggest a strategy for developing a single treatment that could target multiple diagnostic symptoms. ","draft":0,"featured_data":{"featured":0},"lawfirms":[],"id":"4faceceac4b462955b000e22","trademarks":[],"categories":[],"thumbnail":null,"thumbnail_path":null,"thumbnail_size_prefixes":[50]},{"alias":"promising-autism-drug-progresses-to-clinical-study-4035","author":{"id":1092,"email":"elisabethm13@gmail.com","first_name":"Elisabeth","last_name":"Manville","picture":"08ad4b2028.jpg","picture_size_prefixes":[35,50,75,200],"picture_path":"https://patexia-data.s3.amazonaws.com/users/user1092/"},"companies":[{"id":null,"name":null,"alias":null}],"counts":{"comments":0,"favorites":0,"likes":0,"views":878},"created":"2012-04-26T17:49:49+00:00","modified":"2012-04-26T17:49:49+00:00","patents":[{"id":"27642","name":"07802253","title":"'System for session management of resources and tasks having records in the lookup table for the session'"}],"people":[],"published":1,"tags":["autism","drug","growth factors","autism spectrum disorder"],"text":"

\r\n\tA new clinical study will begin this month to evaluate the first drug shown to improve the symptoms of a subtype of autism. Researchers at Mount Sinai School of Medicine will look at the effect of insulin-like growth factor (IGF-1) in children who have SHANK3 deficiency (also called 22q13 Deletion Syndrome or Phelan-McDermid Syndrome), a known cause of autism spectrum disorder. The new study builds on previous research from 2010 which showed that after two weeks of IGF-1 treatment in a mouse model, deficits in nerve cell communication were reversed and deficiencies in adaptation of nerve cells to stimulation, a key part of learning and memory, were restored. IGF-1 is a US Food and Drug Administration-approved, commercially available compound that is known to promote neuronal cell survival as well as synaptic maturation and plasticity.

\r\n","title":"Promising autism drug progresses to clinical study","plain_text":"A new clinical study will begin this month to evaluate the first drug shown to improve the symptoms of a subtype of autism. Researchers at Mount Sinai School of Medicine will look at the effect of insulin-like growth factor (IGF-1) in children who have SHANK3 deficiency (also called 22q13 Deletion Syndrome or Phelan-McDermid Syndrome), a known cause of autism spectrum disorder. The new study builds on previous research from 2010 which showed that after two weeks of IGF-1 treatment in a mouse model, deficits in nerve cell communication were reversed and deficiencies in adaptation of nerve cells to stimulation, a key part of learning and memory, were restored. IGF-1 is a US Food and Drug Administration-approved, commercially available compound that is known to promote neuronal cell survival as well as synaptic maturation and plasticity. ","draft":0,"featured_data":{"featured":0},"lawfirms":[],"id":"4facece4c4b462955b000e13","trademarks":[],"categories":[],"thumbnail":null,"thumbnail_path":null,"thumbnail_size_prefixes":[50]},{"alias":"genetic-abnormalities-identified-as-possible-cause-of-autism-3973","author":{"id":1092,"email":"elisabethm13@gmail.com","first_name":"Elisabeth","last_name":"Manville","picture":"08ad4b2028.jpg","picture_size_prefixes":[35,50,75,200],"picture_path":"https://patexia-data.s3.amazonaws.com/users/user1092/"},"companies":[{"id":null,"name":null,"alias":null}],"counts":{"comments":0,"favorites":0,"likes":0,"views":793},"created":"2012-04-20T19:25:25+00:00","modified":"2012-04-20T19:25:25+00:00","patents":[{"id":"109388","name":"07717403","title":"'Accelerator device for a carburetor'"}],"people":[],"published":1,"tags":["gene","autism","genetics","autism spectrum disorder"],"text":"$2c","title":"Genetic abnormalities identified as possible cause of autism","plain_text":"A new study conducted by 15 institutions in three countries reveal that certain genetic abnormalities could lead to autism and other neurodevelopmental disorders. Balanced chromosomal abnormalities (BCAs) occur when genetic material within a chromosome, or between chromosomes are exchanged, and cause rearrangements in the genetic code. Due to these rearrangements, BCAs cause many disruptions that contribute to autism and other disorders. The researchers discovered that disruptions in various distinct sites in the genetic code and in several different groups of genes result in autism. This study is part of the ongoing Developmental Genome Anatomy Project (DGAP), which aims to identify genes critical in human development. “BCAs provide a unique opportunity to pinpoint a gene and validate it in a disorder,” Cynthia Morton, principal investigator of DGAP, said. “These discoveries can illuminate biological pathways that may be a window to a new therapy.”","draft":0,"featured_data":{"featured":0},"lawfirms":[],"id":"4faceca5c4b462955b000dd5","trademarks":[],"categories":[],"thumbnail":null,"thumbnail_path":null,"thumbnail_size_prefixes":[50]},{"alias":"study-of-half-siblings-provides-genetic-clues-to-autism-3921","author":{"id":1035,"first_name":"Leyla","last_name":"Raiani","email":"l.kazvin@gmail.com","picture":"70bdbcda6e5a8c880bb71d4e149099ea.jpg","picture_size_prefixes":[35,50,75,200],"picture_path":"https://patexia-data.s3.amazonaws.com/users/user1035/"},"companies":[{"id":"107999","name":"beton bolduc 1982","alias":"beton-bolduc-1982-inc-ax"}],"counts":{"comments":0,"favorites":0,"likes":0,"views":1014},"created":"2012-04-17T22:45:45+00:00","modified":"2012-04-17T22:45:45+00:00","patents":[{"id":"107999","name":"D0616168","title":"'Bucket'"}],"people":[],"published":1,"tags":["gene","autism","siblings"],"text":"

\r\n\tNew research from Washington University School of Medicine in St. Louis shows that the genetic reach of the disorder often extends to half siblings as well. On the surface, the finding may not be surprising — half siblings share about 25 percent of their genes. But the discovery is giving scientists new clues to how autism is inherited. According to principal investigator John N. Constantino, MD, the new research adds to recent evidence that even though autism is far more common in males, females still can inherit and pass along genetic risk for autism. The study found that autism risk for half siblings is about half of what it is for full siblings. Most of the half siblings studied had the same mothers. Given that half of the risk of transmission was lost and half was preserved among those maternal half siblings, mothers and fathers appear to be transmitting risk equally in families in which autism recurs.

\r\n","title":"Study of half siblings provides genetic clues to autism","plain_text":"New research from Washington University School of Medicine in St. Louis shows that the genetic reach of the disorder often extends to half siblings as well. On the surface, the finding may not be surprising — half siblings share about 25 percent of their genes. But the discovery is giving scientists new clues to how autism is inherited. According to principal investigator John N. Constantino, MD, the new research adds to recent evidence that even though autism is far more common in males, females still can inherit and pass along genetic risk for autism. The study found that autism risk for half siblings is about half of what it is for full siblings. Most of the half siblings studied had the same mothers. Given that half of the risk of transmission was lost and half was preserved among those maternal half siblings, mothers and fathers appear to be transmitting risk equally in families in which autism recurs.","draft":0,"featured_data":{"featured":0},"lawfirms":[],"id":"4facec6bc4b462955b000da2","trademarks":[],"categories":[],"thumbnail":null,"thumbnail_path":null,"thumbnail_size_prefixes":[50]},{"alias":"further-evidence-of-connection-between-autism-and-immune-system-differences-3886","author":{"id":1092,"email":"elisabethm13@gmail.com","first_name":"Elisabeth","last_name":"Manville","picture":"08ad4b2028.jpg","picture_size_prefixes":[35,50,75,200],"picture_path":"https://patexia-data.s3.amazonaws.com/users/user1092/"},"companies":[{"id":"144965","name":"bushman","alias":"bushman-ltd-th"}],"counts":{"comments":0,"favorites":0,"likes":0,"views":997},"created":"2012-04-16T19:53:53+00:00","modified":"2012-04-16T19:53:53+00:00","patents":[{"id":"144965","name":"07693217","title":"'Moving picture coding method and moving picture decoding method'"}],"people":[],"published":1,"tags":["autism","immune system","autism spectrum disorder","cytokines"],"text":"

\r\n\tResearchers at the University of Kansas Medical Center found significantly lower levels of several cytokines in children with autism disorder (AD) compared with unrelated healthy siblings who had members in their own families with autism spectrum disorders (ASD). Cytokines are cell-signaling protein molecules secreted by cells that perform as the immune system’s messengers and regulators. The study analyzed the plasma of 99 children with AD between the ages of 5 and 10 and that of 40 unrelated healthy siblings without AD who were age- and gender-matched. The research team used nanoparticle technology to examine cytokine patterns from peripheral blood. “Our study further supports a disturbed immune system in children with classic autism that may be related to genetic factors as cytokine proteins are coded by genes distributed among the human chromosomes,” Merlin G. Butler, a professor of psychiatry, said.

\r\n","title":"Further evidence of connection between autism and immune system differences","plain_text":"Researchers at the University of Kansas Medical Center found significantly lower levels of several cytokines in children with autism disorder (AD) compared with unrelated healthy siblings who had members in their own families with autism spectrum disorders (ASD). Cytokines are cell-signaling protein molecules secreted by cells that perform as the immune system’s messengers and regulators. The study analyzed the plasma of 99 children with AD between the ages of 5 and 10 and that of 40 unrelated healthy siblings without AD who were age- and gender-matched. The research team used nanoparticle technology to examine cytokine patterns from peripheral blood. “Our study further supports a disturbed immune system in children with classic autism that may be related to genetic factors as cytokine proteins are coded by genes distributed among the human chromosomes,” Merlin G. Butler, a professor of psychiatry, said.","draft":0,"featured_data":{"featured":0},"lawfirms":[],"id":"4facec3cc4b462955b000d81","trademarks":[],"categories":[],"thumbnail":null,"thumbnail_path":null,"thumbnail_size_prefixes":[50]}],"per_page":6,"page":1,"total":21,"total_pages":4,"access_rules":{"edit":false,"publish":false,"delete":false,"add_to_featured":false},"IP":"18.97.14.80","UA":"CCBot/2.0 (https://commoncrawl.org/faq/)"},"urlParams":{"tag":"autism"},"isLoggedIn":false,"isAdmin":"$undefined","session":{"isLoggedIn":false,"sessionHeaders":{"X-Client-User-Agent":"CCBot/2.0 (https://commoncrawl.org/faq/)","X-Client-Forwarded-For":"18.97.14.80, 216.239.34.21"}}}]}],["$","$25",null,{"children":"$L2d"}]]}]