Mutation on a single stem cell spurs growth of fibroid uterine tumors

Scientists have finally pinpointed the molecular cause of a painful and often devastating condition that affects 60 percent of women by the age of 45. Researchers at Northwestern University discovered fibroid uterine tumors, which can cause irregular bleeding, anemia and infertility, are triggered by a single stem cell that develops a mutation starts to grow uncontrollably and activates other cells to do the same. The stem that initiates the tumor carries a mutation called MED12, which has been found in the majority of uterine fibroid tissues. Once initiated the tumors continue to grow in response to steroid tumors. “No one knew how these came about before,” Serdar Bulun, chair of obstetrics and gynecology at Northwestern University Feinberg School of Medicine and Northwestern Memorial Hospital, said. “The stem cells make up only 1.5 percent of the cells in the tumor, yet they are the essential drivers of its growth.” Understanding this process could lead scientists to develop new therapies, Bulun said.

Companies
1
Patents
1
0 Comments
Related Articles
How arsenic turns stem cells into cancer cells and spurs tumor growth
Researchers have discovered how arsenic exposure can turn normal stem cells into cancer stem cells and spur tumor growth. Michael... Read More
Ann Conkle
Apr 18, 2012
New findings in breast cancer contradict current views on cancer stem cells
Findings in breast cancer contradict the prevailing belief that only basal-like cells with stem cell qualities form invasive tumors. Most... Read More
Ann Conkle
Apr 25, 2012
Gene critical to development and spread of common lung cancer discovered
A gene that promotes initial development of the most common form of lung cancer and then drives its metastases has... Read More