Muscle endurance tests can detect abnormalities in the early stages of multiple sclerosis

While multiple sclerosis patients' walking abilities and muscle strength are examined regularly, doctors have yet to determine when the lower limb muscles begin to deteriorate. With earlier identification of mobility problems, doctors would be able to implement early intervention programs. Now, researchers from Tel Aviv University and Sheba Medical Center have discovered that specific laboratory tests for leg muscle endurance and gait -- the pattern of movement while walking or running -- are highly effective in identifying mobility deficits, which are difficult to discover during standard neurological testing, at the initial stage of MS. Patients in the early stages of MS had 40 percent less muscle endurance compared to their healthy counterparts. Additionally, distinct abnormalities were observed in their walking patterns. The study could help researchers understand the mechanisms underlying the evolution of MS, and improve the management of patients afflicted with the disease.