Mechanism by which proteins in heart cells regulate calcium identified

Researchers at University of Bristol have published new findings that reveal the mechanisms by which two proteins regulate the amount of calcium in the heart. In the heart cells of healthy people, calcium is released from stores within the cells and causes the heart to beat and pump blood. The protein FKBP12 increases calcium fluxes through gates called the ryanodine receptor (RyR) channels, while a similar protein with a very different function, FKBP12.6, blocks the effects of FKBP12. However, this dual regulation may be damaged in patients with heart failure, leading to irregular heartbeat and even death. Identifying the way the process works could help in treating the underlying risk. “These new findings are important because we can use this information to help develop new treatments for patients with heart disease to reduce the risks of sudden cardiac death,” explained Professor Rebecca Sitsapesan.