CROSS-REFERENCE TO RELATED APPLICATIONS 0001 This application claims benefit of priority from United States Provisional Patent Application No. 60/396,922, filed Jul. 17, 2002.

FIELD OF THE INVENTION 0002 This invention provides a combination of an allosteric alkyne inhibitor of matrix metalloproteinase-13 with celecoxib or valdecoxib, a pharmaceutical composition comprising the combination, and methods of using the combination to treat diseases characterized by connective tissue breakdown, including cartilage damage, and inflammation or pain. Such diseases include arthritis, heart failure, multiple sclerosis, atherosclerosis, and osteoporosis.

BACKGROUND OF THE INVENTION 0003 More than 23 million Americans have some form of arthritis. Among the various forms of arthritis, osteoarthritis (OA) is the most prevalent, affecting 21 million Americans. Characterized by the degeneration of joint cartilage and adjacent bone, OA is a chronic disorder that can cause pain and stiffness. Rheumatoid arthritis (RA), which affects more than 2.1 million Americans, is an autoimmune disease that affects joint lining, cartilage and bones. 0004 Aspirin and conventional nonsteroidal anti-inflammatory drugs (NSAIDs) such as ibuprofen, diclofenac, and naproxen are the primary agents used to treat OA- and RA-related pain. These agents inhibit prostaglandin release by blocking cyclooxygenase-mediated conversion of cell membrane lipids from arachidonic acid. 0005 Two forms of COX are now known, a constitutive isoform usually named cyclooxygenase-1 (COX-1) and an inducible isoform usually named cyclooxygenase-2 (COX-2), the latter of which expression is upregulated at sites of inflammation. COX-1 appears to play a physiological role and to be responsible for gastrointestinal and renal protection. On the other hand, COX-2 appears to play a pathological role and is believed to be the predominant isoform present in inflammation conditions. The therapeutic use of conventional COX inhibitors, which are typically nonselective inhibitors of both COX-1 and COX-2, is limited due to drug associated side effects, including life threatening ulceration and renal toxicity. Compounds that selectively inhibit COX-2 would exert anti-inflammatory effects without the adverse side effects associated with COX-1 inhibition. 0006 Valdecoxib is a COX-2 specific inhibitor that was approved in 2001 by the United States Food and Drug Administration (FDA) for treating the signs and symptoms of osteoarthritis (OA) and adult rheumatoid arthritis (RA); and the treatment of pain associated with menstrual cramping. Valdecoxib tablets are marketed under the tradename BEXTRA. In a combined analysis of various clinical studies with valdecoxib, valdecoxib was well tolerated with an overall upper gastrointestinal safety profile (ulcers, perforations, obstructions and GI bleeds) significantly better than the conventional NSAIDs studied such as ibuprofen, diclofenac and naproxen. 0007 Matrix metalloproteinases (MMPs) are naturally occurring enzymes found in most mammals. Stromelysin-1 and gelatinase A are members of the matrix metalloproteinases (MMP) family. Other members include fibroblast collagenase (MMP-1), neutrophil collagenase (MMP-8), gelatinase B (92 kDa gelatinase) (MMP-9), stromelysin-2 (MMP-10), stromelysin-3 (MMP-11), matrilysin (MMP-7), collagenase 3 (MMP-13), and other newly discovered membrane-associated matrix metalloproteinases. 0008 Over-expression or activation of MMPs, or an imbalance between MMPs and their endogenous inhibitors, namely tissue inhibitors of metalloproteinases (TIMPs), have been suggested as factors in the pathogenesis of diseases characterized by the breakdown of extracellular matrix or connective tissues. These diseases include rheumatoid arthritis, osteoarthritis, osteoporosis, periodontitis, multiple sclerosis, gingivitis, corneal epidermal and gastric ulceration, atherosclerosis, neointimal proliferation which leads to restenosis and ischemic heart failure, and tumor metastasis. 0009 A major limitation on the use of currently known MMP inhibitors is their lack of specificity for any particular MMW enzyme. Recent data has established that specific MMP enzymes are associated with some diseases, with no effect on others. The MMPs are generally categorized based on their substrate specificity, and indeed the collagenase subfamily of MMP-1, MMP-8, and MMP-13 selectively cleave native interstitial collagens, and thus are associated only with diseases linked to such interstitial collagen tissue. This is evidenced by the recent discovery that MM-13 alone is over expressed in breast carcinoma, while MMP-1 alone is over expressed in papillary carcinoma (see Chen et al., J. Am. Chem. Soc., 2000;122:9648-9654). 0010 Another major limitation of currently known MMP inhibitors related to their lack of specificity for any particular MMP enzyme is their production of undesirable side effects related to inhibition of multiple MMP enzymes and/or tumor necrosis factor-alpha converting enzyme (TACE). One example of such a side effect is musculoskeletal syndrome (MSS). 0011 There appears to be few selective inhibitors of MMP-13 reported. A compound named WAY-170523 has been reported by Chen et al., supra., 2000, and a few other compounds are reported in PCT International Patent Application Publication Number WO 01/63244 Al, as allegedly selective inhibitors of MMP-13. Further, U.S. Pat. No. 6,008,243 discloses inhibitors of MMP-13. These inhibitors contain functional groups that ligate, coordinate, or bind the catalytic zinc cation on MM-13. However, selectivity in these cases can mean only a 5-fold or 10-fold greater inhibition of MMP-13 versus as few as one other MMP enzyme. Further, no selective or non-allosteric alkyne inhibitor of MMP-13 has been marketed for the treatment of any disease in any mammal. 0012 Applicant has previously discovered highly selective inhibitors of MMP-13 that show promising pharmacological and pharmacokinetic activity in vivo. These inhibitors have been the subject of previously filed patent applications. 0013 Applicant's inhibitors are more selective than prior art inhibitors for MMP-13 versus other MMP enzymes, both in terms of relative potencies and in terms of the numbers of the other MMP enzymes. For example, some of Applicant's inhibitors have shown 100-fold or greater selectivity with MMP-13 versus five or more other MMP enzymes, and further have shown efficacy in animal models of osteoarthritis. 0014 The observed selectivity of Applicant's inhibitors may be attributed to the inhibitors' binding to MMP-13 at an allosteric site and, further, to a binding mode which does not involve binding to the enzyme's catalytic zinc. Prior to Applicant's allosteric MMP-13 inhibitors, it is believed that all prior art MMP-13 inhibitors bound to an MMP enzyme's catalytic zinc and occupied the MMP enzyme's substrate binding site. This latter binding mode was erroneously believed by others to be necessary for MMP-13 inhibitor potency. 0015 Applicant's discovery that a combination of an allosteric alkyne inhibitor of MMP-13, or a pharmaceutically acceptable salt thereof, with celecoxib, or a pharmaceutically acceptable salt thereof, or valdecoxib, or a pharmaceutically acceptable salt thereof, is particularly useful for treating diseases characterized by damage to connective tissue such as cartilage damage. All that is required to treat diseases characterized by damage to connective tissue such as cartilage damage, including osteoarthritis, heart failure, multiple sclerosis, atherosclerosis, or osteoporosis in a mammal according to the invention is to administer to the mammal in need of treatment a therapeutically effective amount of the combination, wherein the combination comprises an allosteric alkyne inhibitor of MMP-13, or a pharmaceutically acceptable salt thereof, with celecoxib, or a pharmaceutically acceptable salt thereof, or valdecoxib, or a pharmaceutically acceptable salt thereof. As will be discussed below, the instant combination of an allosteric alkyne inhibitor of MMP-13, or a pharmaceutically acceptable salt thereof, with celecoxib, or a pharmaceutically acceptable salt thereof, or valdecoxib, or a pharmaceutically acceptable salt thereof, possesses many advantages over any combination of a prior art selective inhibitor of MMP-13 with a COX-2 inhibitor.

SUMMARY OF THE INVENTION 0016 This invention provides a combination, comprising an allosteric alkyne inhibitor of MMP-13, or a pharmaceutically acceptable salt thereof, with celecoxib, or a pharmaceutically acceptable salt thereof, or valdecoxib, or a pharmaceutically acceptable salt thereof. 0017 Another invention embodiment is a combination, comprising celecoxib, or a pharmaceutically acceptable salt thereof, and an allosteric alkyne inhibitor of MMP-13, or a pharmaceutically acceptable salt thereof. 0018 Other invention embodiments are: 0019 1. A combination, comprising valdecoxib, or a pharmaceutically acceptable salt thereof, and an allosteric alkyne inhibitor of MMP-13 of Formula (A) 1

0020 or a pharmaceutically acceptable salt thereof, or an N-oxide thereof, 0021 wherein: 0022 W1 is O, S, or NR3, wherein R3 is hydrogen, (C1-C6)alkyl, hydroxyl or cyano; 0023 W2 is selected from: 0024 hydrogen; 0025 trifluoromethyl; 0026 NH2; 0027 (C1-C10)alkylN(H); 0028 (C1-C10)alkyl2N, wherein each (C1-C10)alkyl moiety is the same or different; 0029 (C1-C6)alkyl; 0030 (C3-C6)alkenyl; 0031 (C3-C6)alkynyl; 0032 phenyl; 0033 naphthyl; 0034 phenyl-(C1-C10)alkyl; 0035 naphthyl-(C1-C10)alkyl; 0036 (C3-C10)cycloalkyl-(C1-C10)alkyl; 0037 an aromatic 5-membered or 6-membered monocyclic heterocycle comprising carbon atoms and from 1 to 4 heteroatoms selected from O, S, N(H), and N(C1-C10)alkyl; 0038 a nonaromatic 5-membered or 6-membered monocyclic heterocycle comprising carbon atoms and from 1 to 3 heteroatoms selected from O, S, N(H), and N(C1-C10)alkyl; 0039 wherein in W2 each (C1-C10)alkyl, (C1-C6)alkyl, (C3-C6)alkenyl, (C3-C6)alkynyl, phenyl, naphthyl, phenyl-(C1-C10)alkyl, naphthyl-(C1-C10)alkyl, (C3-C10)cycloalkyl-(C1-C10)alkyl, aromatic heterocycle, and nonaromatic heterocycle group is independently unsubstituted or substituted by from 1, to 3 groups, which may be identical or different, selected from halo, NH2, (C1-C10)alkylN(H), (C1-C10)alkyl2N, wherein each (C1-C10)alkyl moiety is the same or different, cyano, trihalo(C1-C6)alkyl, (C1-C6)acyl, C(O)OR4, OR4, and SR4; 0040 R4 is hydrogen or (C1-C6)alkyl; or 0041 W2 and W1 may be taken together to form a diradical group W2-W1 of formula

W3X4N;

0042 W3 is N or CR5 wherein R5 is selected from: 0043 hydrogen; 0044 OR6; 0045 SR6; 0046 (C1-C6)alkyl; 0047 (C3-C8)cycloalkyl; 0048 a saturated heterocycle comprising from 3 to 8 ring members which are carbon atoms and one heteroatom selected from O, S, N(H), and N(C1-C10)alkyl; 0049 phenyl; 0050 naphthyl; 0051 (C5-C10)heteroaryl comprising carbon atoms and from 1 to 4 heteroatoms selected from O, S, N(H), and N(C1-C10)alkyl; 0052 phenyl-(C1-C10)alkyl; and 0053 naphthyl-(C1-C10)alkyl; 0054 R6 is selected from hydrogen, (C1-C6)alkyl, phenyl-(C1-C10)alkyl, and naphthyl-(C1-C10)alkyl; 0055 wherein in W3 each (C1-C6)alkyl, (C3-C8)cycloalkyl, saturated heterocycle, phenyl, naphthyl, (C5-C10)heteroaryl, phenyl-(C1-C10)alkyl, and naphthyl-(C1-C10)alkyl group is independently unsubstituted or substituted by (CH2)pOH or (CH2)pNH2; 0056 p is an integer of from 0 to 4 inclusive; 0057 X4 is N or CR7, wherein R7 is selected from: 0058 hydrogen; 0059 NR8R9; 0060 OR8; 0061 SR8; 0062 (C1-C6)alkyl; 0063 (C3-C8)cycloalkyl; 0064 a saturated heterocycle comprising from 3 to 8 ring members which are carbon atoms and one heteroatom selected from O, S, N(H), and N(C1-C10)alkyl; 0065 phenyl; 0066 naphthyl; 0067 (C5-C10)heteroaryl comprising carbon atoms and from 1 to 4 heteroatoms selected from O, S, N(H), and N(C1-C10)alkyl; 0068 phenyl-(C1-C10)alkyl; and 0069 naphthyl-(C1-C10)alkyl; 0070 R8 and R9 are the same or different, and are selected from hydrogen; (C1-C6)alkyl; phenyl-(C1-C10)alkyl; and naphthyl-(C1-C10)alkyl; 0071 wherein in X4 each (C1-C6)alkyl, (C3-C8)cycloalkyl, saturated heterocycle, phenyl, naphthyl, (C5-C10)heteroaryl, phenyl-(C1-C10)alkyl, and naphthyl-(C1-C10)alkyl group is independently unsubstituted or substituted by (CH2)pOH or (CH2)pNH2, wherein p is an integer from 0 to 4 inclusive; 0072 X1, X2 and X3 independently of each other are N or C-R, wherein R is selected from: 0073 hydrogen; 0074 (C1-C6)alkyl; 0075 hydroxyl; 0076 (C1-C6)alkoxy; 0077 halo; 0078 trifluoromethyl; 0079 cyano; 0080 nitro; 0081 S(O)n1R4, wherein R4 is as defined above; NR10R11; 0082 n1 is an integer of from 0 to 2 inclusive; 0083 R10 and R11, are the same or different, and are independently selected from 0084 hydrogen; 0085 (C1-C6)alkyl; 0086 phenyl-(C1-C10)alkyl; and 0087 naphthyl-(C1-C10)alkyl; or 0088 R10 and R11, may be taken together with the nitrogen atom to which they are bonded to form a 5-membered or 6-membered ring containing carbon atoms, the nitrogen atom to which R10 and R11 are attached, and optionally a second heteroatom selected from O, S, N(H), and N(C1-C10)alkyl, 0089 wherein not more than two of the groups X1, X2, and X3 simultaneously are a nitrogen atom; 0090 n is an integer of from 0 to 8 inclusive; 0091 Z is C(R12)(R13); 0092 Each R12 and R13 independently of each other are selected from: 0093 hydrogen; 0094 (C1-C6)alkyl; 0095 trihalo(C1-C6)alkyl; 0096 halo; 0097 NH2; 0098 (C1-C6)alkylN(H); 0099 (C1-C6)alkyl2N, wherein each (C1-C6)alkyl moiety is the same or different; 0100 OR4; 0101 SR4; and 0102 C(O)OR4, wherein R4 is as defined above; or 0103 R12 and R13 on the same carbon atom may be taken together with the carbon atom to which they are attached to form a carbonyl group; and 0104 Z can contain 1 carbon-carbon double bond when two R12 groups are absent and n is an integer of from 2 to 8; and 0105 Z can contain 2 carbon-carbon double bonds when four R12 groups are absent or three R12 and one R13 groups are absent and n is an integer of from 3 to 8; and 0106 Z can contain 1 carbon-carbon triple bond when two each of R12 and R13 are absent and n is an integer of from 2 to 8; and 0107 Z can contain 2 carbon-carbon triple bonds when four each of R12 and R13 are absent and n is an integer of from 4 to 8; and 0108 One C(R12)(R13) group in Z can be replaced with O, N(H), N(C1-C6)alkyl, S, S(O), or S(O)2; 0109 A is selected from: 0110 phenyl; 0111 an aromatic 5-membered or 6-membered monocyclic heterocycle comprising carbon atoms and from 1 to 4 heteroatoms selected from O, S, N(H), and N(C1-C10)alkyl; 0112 a nonaromatic 5-membered or 6-membered monocycle comprising carbon atoms and from 0 to 4 heteroatoms selected from O, S, N(H), and N(C1-C10)alkyl; 0113 naphthyl; 0114 an aromatic 8-membered to 12-membered bicycle comprising two aromatic rings independently selected from 5-membered or 6-membered rings, wherein the rings may be the same or different and bonded or fused to each other, and wherein the bicycle comprises carbon atoms and from 1 to 6 hetero atoms selected from O, S, N(H), and N(C1-C10)alkyl; 0115 an aromatic 8-membered to 12-membered bicycle comprising one aromatic 5-membered or 6-membered ring and one non-aromatic 5-membered or 6-membered ring, wherein the rings may be bonded or fused to each other, and wherein the bicycle comprises carbon atoms and from 0 to 6 hetero atoms selected from O, S, N(H), and N(C1-C10)alkyl; and 0116 a non-aromatic 8-membered to 12-membered bicycle comprising two non-aromatic rings independently selected from 5-membered or 6-membered rings, wherein the rings may be the same or different and bonded or fused to each other, and wherein the bicycle comprises carbon atoms and from 0 to 4 hetero atoms selected from O, S, N(H), and N(C1-C10)alkyl; 0117 Each R2 may be the same or different, and is independently selected from: 0118 hydrogen; 0119 (C1-C6)alkyl; 0120 halo; 0121 cyano; 0122 nitro; 0123 trihalo(C1-C6)alkyl; 0124 NR10R11; 0125 OR14; 0126 SR14; 0127 S(O)R14; 0128 S(O)2R14; 0129 (C1-C6)acyl; 0130 (CH2)kNR10R11; 0131 X5(CH2)kNR10R11; 0132 (CH2)kSO2NR14R15; 0133 X5(CH2)kC(O)OR14; 0134 (CH2)kC(O)OR14; 0135 X5(CH2)kC(O)NR14R15; 0136 (CH2)kC(O)NR14R15; and 0137 X6R16; 0138 X5 is O, S, N(H), or N(C1-C6)alkyl; 0139 k is an integer of from 0 and 3 inclusive; 0140 R10 and R11 are as defined above; 0141 R14 and R15 may be the same or different, and independently are hydrogen or (C1-C6)alkyl; 0142 X6 is a single bond, CH2, Q, or S, S(O), or S(O)2; 0143 R16 is selected from: 0144 phenyl; 0145 an aromatic 5-membered or 6-membered monocyclic heterocycle comprising carbon atoms and from 1 to 4 heteroatoms selected from O, S, N(H), and N(C1-C10)alkyl; 0146 cyclopentyl; 0147 cyclohexyl; and 0148 a nonaromatic 5-membered or 6-membered monocyclic heterocycle comprising carbon atoms and from 1 to 3 heteroatoms selected from O, S, N(H), and N(C1-C10)alkyl; 0149 wherein in R16 each phenyl, aromatic 5-membered or 6-membered, heterocyclic ring, cyclopentyl, cyclohexyl, and non-aromatic 5-membered or 6-membered heterocyclic ring group independently is unsubstituted or substituted with from 1 to 3 groups independently selected from (C1-C6)alkyl, halo, trihalo(C1-C6)alkyl, hydroxyl, (C1-C6)alkoxy, SH, (C1-C6)alkylthio, NH2, (C1-C6)alkylN(H), (C1-C6)alkyl2N, wherein each (C1-C6)alkyl moiety may be the same or different; 0150 q is an integer of from 0 to 7 inclusive; 0151 R1 is a group selected from: 0152 hydrogen; 0153 (C1-C6)alkyl; 0154 (C3-C6)alkenyl; and 0155 (C3-C6)alkynyl, 0156 wherein in R1 each (C1-C6)alkyl, (C3-C6)alkenyl, and (C3-C6)alkynyl group is independently unsubstituted or substituted with from 1 to 3 groups independently selected from NH2, (C1-C6)alkylN(H), (C1-C6)alkyl2N, wherein each (C1-C6)alkyl moiety may be the same or different, (C1-C6)alkyl, cyano, trihalo(C1-C6)alkyl, C(O)OR4, OR4, SR4, wherein R4 is as defined above, and a group of formula (1) 2

0157 m is an integer of from 0 to 8 inclusive, 0158 Y is CR18R19; 0159 Each R18 and R19 independently of each other, is selected from: 0160 hydrogen; 0161 (C1-C6)alkyl; 0162 phenyl; 0163 trihalo(C1-C6)alkyl; 0164 halo; 0165 NH2; 0166 (C1-C6)alkylN(H); 0167 (C1-C6)alkyl2N, wherein each (C1-C6)alkyl moiety may be the same or different; 0168 OR4; 0169 SR4; and 0170 C(O)OR4; 0171 R4 is as defined above; 0172 Y can contain 1 carbon-carbon double bond when two R18 groups are absent and m is an integer of from 2 to 8; and 0173 Y can contain 2 carbon-carbon double bonds when four R18 groups are absent or three R18 and one R19 groups are absent and m is an integer of from 3 to 8; and 0174 Y can contain 1 carbon-carbon triple bond when two each of R18 and R19 are absent and m is an integer of from 2 to 8; and 0175 Y can contain 2 carbon-carbon triple bonds when four each of R18 and R19 are absent and m is an integer of from 4 to 8; and 0176 One C(R18)(R19) group in Y can be replaced with O, N(H), N(C1-C6)alkyl, S, S(O), or S(O)2; 0177 B is a group selected from: 0178 phenyl; 0179 an aromatic 5-membered or 6-membered monocyclic heterocycle comprising carbon atoms and from 1 to 4 heteroatoms selected from O, S, N(H), and N(C1-C10)alkyl; 0180 a nonaromatic 5-membered or 6-membered monocycle comprising carbon atoms and from 0 to 4 heteroatoms selected from O, S, N(H), and N(C1-C10)alkyl; 0181 naphthyl; 0182 an aromatic 8-membered to 12-membered bicycle comprising two aromatic rings independently selected from 5-membered or 6-membered rings, wherein the rings may be the same or different and bonded or fused to each other, and wherein the bicycle comprises carbon atoms and from 1 to 6 hetero atoms selected from O, S, N(H), and N(C1-C10)alkyl; 0183 an aromatic 8-membered to 12-membered bicycle comprising one aromatic 5-membered or 6-membered ring and one non-aromatic 5-membered or 6-membered ring, wherein the rings may be bonded or fused to each other, and wherein the bicycle comprises carbon atoms and from 0 to 6 hetero atoms selected from O, S, N(H), and N(C1-C10)alkyl; and 0184 a non-aromatic 8-membered to 12-membered bicycle comprising two non-aromatic rings independently selected from 5-membered or 6-membered rings, wherein the rings may be the same or different and bonded or fused to each other, and wherein the bicycle comprises carbon atoms and from 0 to 4 hetero atoms selected from O, S, N(H), and N(C1-C10)alkyl; 0185 r is an integer of from 0 to 7 inclusive, 0186 Each R17 may be the same or different and independently is selected from: 0187 hydrogen; 0188 (C1-C6)alkyl; 0189 halo; 0190 cyano; 0191 nitro; 0192 trihalo(C1-C6)alkyl; 0193 NR10OR11; 0194 OR14; 0195 SR14; 0196 S(O)R14; 0197 S(O)2R14; 0198 (C1-C6)acyl; 0199 (CH2)kNR10R11; 0200 X5(CH2)kNR10R11; 0201 (CH2)kSO2NR14R15; 0202 X5(CH2)kC(O)OR14; 0203 (CH2)kC(O)OR14; 0204 X5(CH2)kC(O)NR14R15; 0205 (CH2)kC(O)NR14R15; and 0206 X6-R16, wherein X5, k, R10, R11, R14, R15, X6, and R16 are as defined above. 0207 2. The combination according to Embodiment 1, wherein: 0208 W1 is O, S, or NR3, wherein R3 is hydrogen, (C1-C6)alkyl, hydroxyl or cyano; W2 is a group selected from: 0209 hydrogen; 0210 trifluoromethyl; 0211 NH2; 0212 (C1-C10)alkylN(H); 0213 (C1-C10)alkyl2N, wherein each (C1-C10)alkyl moiety may be the same or different; 0214 (C1-C6)alkyl; 0215 (C3-C6)alkenyl; 0216 (C3-C6)alkynyl; 0217 phenyl; 0218 naphthyl; 0219 phenyl-(C1-C10)alkyl; 0220 naphthyl-(C1-C10)alkyl; 0221 (C3-C10)cycloalkyl-(C1-C10)alkyl; and 0222 an aromatic heterocycle comprising 5 or 6 ring members which are carbon atoms and from 1 to 4 heteroatoms selected from O, S, N(H), and N(C1-C10)alkyl; 0223 a nonaromatic heterocycle comprising 5 or 6 ring members which are carbon atoms and from 1 to 3 heteroatoms selected from O, S, N(H), and N(C1-C10)alkyl; 0224 wherein in W2 the NH2, (C1-C10)alkylN(H), (C1-C10)alkyl2N, wherein each (C1-C10)alkyl moiety may be the same or different, (C1-C6)alkyl, (C3-C6)alkenyl, (C3-C6)alkynyl, phenyl, naphthyl, phenyl-(C1-C10)alkyl, naphthyl-(C1-C10)alkyl, (C3-C10)cycloalkyl-(C1-C10)alkyl, aromatic heterocycle, and nonaromatic heterocycle groups each independently may be unsubstituted or substituted by from 1 to 3 groups, which may be the same or different, and are selected from halo, NH2, (C1-C10)alkylN(H), (C1-C10)alkyl2N, wherein each (C1-C10)alkyl moiety may be the same or different, cyano, trihalo(C1-C6)alkyl, (C1-C6)acyl, C(O)OR4, OR4, and SR4, 0225 R4 is hydrogen or (C1-C6)alkyl; and X1, X2, X3, R11, R2, A, Z, n and q are as defined for Formula (A) in Embodiment 1. 0226 3. The combination according to Embodiment 1, wherein 0227 W1 is O or S; 0228 W2 is selected from hydrogen, (C1-C6)alkyl, phenyl-(C1-C6)alkyl, naphthyl-(C1-C6)alkyl, and (C3-C6)cycloalkyl-(C1-C6)alkyl; 0229 X1 is CH; 0230 X2 is CH or N; 0231 X3 is CH; and 0232 R1, R2, A, Z, n, and q are as defined for Formula (A) in Embodiment 1. 0233 4. The combination according to Embodiment 1, wherein 0234 W1 is O or S; 0235 W2 is selected from hydrogen, NH2, (C1-C10)alkylN(H), (C1-C10)alkyl2N, wherein each (C1-C10)alkyl moiety may be the same or different, (C1-C6)alkyl, (C3-C6)alkenyl, (C3-C6)alkynyl, phenyl, naphthyl, phenyl-(C1-C6)alkyl, naphthyl-(C1-C6)alkyl, and (C3-C6)cycloalkyl-(C1-C6)alkyl; 0236 X1 is N or CH; 0237 X2 is CH; 0238 X3 is CH; and 0239 R1, R2, A, Z, n, and q are as defined for Formula (A) in Embodiment 1. 0240 5. The combination according to Embodiment 1, wherein 0241 A is selected from phenyl, pyridyl, thienyl, imidazolyl, furyl, benzodioxolyl, benzodioxinyl, benzothienyl, benzofuryl, benzo1,2,5thiadiazolyl, benzo1,2,5oxadiazolyl, and indolyl; 0242 q is an integer of from 0 to 4 inclusive; 0243 Each R2 may be the same or different, and is selected from: 0244 hydrogen; 0245 (C1-C6)alkyl; 0246 halo; 0247 cyano; 0248 nitro; 0249 trihalo(C1-C6)alkyl; 0250 NR14R15; 0251 OR14; 0252 SO2R14; 0253 (CH2)kSO2NR14R15; 0254 X5(CH2)kC(O)OR14; 0255 (CH2)kC(O)OR14; 0256 X5(CH2)kC(O)NR14R15; 0257 (CH2)kC(O)NR14R15; and 0258 X6R16; 0259 X5 is O, S, or N(H); 0260 k is an integer of from 0 and 3 inclusive; 0261 R14 and R15 may be the same or different and are hydrogen or (C1-C6)alkyl; X6 is O; 0262 R16 is phenyl or phenyl substituted with from 1 to 5 groups independently selected from (C1-C6)alkyl, halo, and hydroxyl; and 0263 W1, W2, X1, X2, X3, R1, Z, and n are as defined for Formula (A) in Embodiment 1. 0264 6. The combination according to Embodiment 1, wherein 0265 A is selected from phenyl, pyridinyl, thienyl, imidazolyl, furyl, and benzodioxolyl; 0266 q is an integer of from 0 to 4 inclusive; 0267 Each R2 may be the same or different, and is independently selected from 0268 hydrogen; 0269 (C1-C6)alkyl; 0270 halo; 0271 cyano; 0272 nitro; 0273 trihalo(C1-C6)alkyl; 0274 NR14R15; 0275 OR14; 0276 SO2R14; 0277 (CH2)kSO2NR14R15; 0278 X5(CH2)kC(O)OR14; 0279 (CH2)kC(O)OR14; 0280 X5(CH2)kC(O)NR14R15; and 0281 (CH2)kC(O)NR14R15; 0282 X5 is O, S, or N(H); 0283 k is an integer of from 0 and 3 inclusive; 0284 R14 and R15 may be the same or different and are hydrogen or (C1-C6)alkyl; and W1, W2, X1, X2, X3, R1, Z, and n are as defined for Formula (A) in Embodiment 1. 0285 7. The combination according to Embodiment 1, wherein 0286 R1 is hydrogen, (C1-C6)alkyl, or the group of formula (1) 3

0287 m is an integer of from 0 to 3 inclusive; 0288 Y is CR18R19; 0289 R18 and R19 may be the same or different and independently are selected from hydrogen, (C1-C6)alkyl, and phenyl; and 0290 Y can contain 1 carbon-carbon double bond when two R18 groups are absent and m is an integer of from 2 to 8; and 0291 Y can contain 1 carbon-carbon triple bond when two each of R18 and R19 are absent and m is an integer of from 2 to 8; and 0292 One C(R18)(R19) group in Y can be replaced with O, N(H), S, S(O), or S(O)2; B is selected from phenyl, pyridinyl, thienyl, imidazolyl, furyl, benzodioxolyl, benzodioxinyl, benzothienyl, benzofuryl, benzo1,2,5,thiadiazolyl, benzo1,2,5oxadiazolyl, naphthyl, and indolyl; 0293 r is an integer of from 0 to 3 inclusive; 0294 Each R17 may be the same or different and is selected from: 0295 hydrogen; 0296 (C1-C6)alkyl, 0297 halo; 0298 cyano; 0299 nitro; 0300 trihalo(C1-C6)alkyl; 0301 NR14R15; 0302 OR14; 0303 SO2R14; 0304 (CH2)kSO2NR14R15; 0305 X5(CH2)kC(O)OR14; 0306 (CH2)kC(O)OR14; 0307 X5(CH2)kC(O)NR14R15; and 0308 (CH2)kC(O)NR14R15; 0309 k is an integer of from 0 to 3 inclusive; 0310 X5 is O, S, or N(H); 0311 R14 and R15 may be the same or different, and independently are hydrogen or (C1-C6)alkyl; and W1, W2, X1, X2, X3, R2, Z, n and q are as defined for Formula (A) in Embodiment 1. 0312 8. The combination of Embodiment 1, wherein 0313 R1 is a group of formula (1) 4

0314 wherein: 0315 m is an integer of from 0 to 3 inclusive; 0316 Y is CR18R19; 0317 R18 and R19 independently of each other are selected from hydrogen and methyl; and 0318 Y can contain 1 carbon-carbon double bond when two R18 groups are absent and m is an integer of from 2 to 8; and 0319 One C(R18)(R19) group in Y can be replaced with O, N(H), S, S(O), or S(O)2; 0320 B is selected from phenyl, pyridinyl, thienyl, imidazolyl, furyl, and benzodioxolyl; 0321 r is an integer of from 0 to 3 inclusive; 0322 Each R17 may be the same or different and is selected from: 0323 hydrogen; 0324 (C1-C6)alkyl; 0325 halo; 0326 cyano; 0327 nitro; 0328 trihalo(C1-C6)alkyl; 0329 NR14R15; 0330 OR14; 0331 SO2R14; 0332 (CH2)kSO2NR14R15; 0333 X5(CH2)kC(O)OR14; 0334 (CH2)kC(O)OR14; 0335 X5(CH2)kC(O)NR14R15; and 0336 (CH2)kC(O)NR14R15; 0337 k is an integer of from 0 to 3 inclusive; 0338 X5 is O, S, or N(H); 0339 R14 and R15, may be the same or different, and independently are hydrogen or (C1-C6)alkyl; 0340 and W1, W2, X1, X2, X3, R2, Z, n and q are as defined for Formula (A) in Embodiment 1. 0341 9. The combination of Embodiment 1, wherein: 0342 W1 is (C1-C6)alkyl; 0343 W2 is O; and 0344 R1 is a group of formula (1) 5

0345 wherein Y, B, R17, m, and r are as defined for Formula (A) in Embodiment 1. 0346 10. The combination of Embodiment 1, wherein: 0347 R1 is the group of formula (1) 6

0348 wherein 0349 m is 1; 0350 Y is CH2; 0351 B is phenyl, which is unsubstituted or substituted by (CH2)kC(O)OR14, wherein which k and R14 are as defined for Formula (A) in Embodiment 1. 0352 11. The combination of Embodiment 1, wherein the compound of Formula I is a compound of Formula (B) 7

0353 or a pharmaceutically acceptable salt thereof, or an N-oxide thereof, 0354 wherein: 0355 W3 is N or CR5; 0356 R5 is selected from: 0357 hydrogen; 0358 OR6; 0359 SR6; 0360 (C1-C6)alkyl; 0361 (C3-C8)cycloalkyl; 0362 a saturated heterocycle comprising from 3 to 8 ring members which are carbon atoms and one heteroatom selected from O, S, N(H), and N(C1-C10)alkyl; 0363 phenyl; 0364 naphthyl; 0365 (C5-C10)heteroaryl comprising carbon atoms and from 1 to 4 heteroatoms selected from O, S, N(H), and N(C1-C10)alkyl; 0366 phenyl-(C1-C10)alkyl; and 0367 naphthyl-(C1-C10)alkyl; 0368 R6 is selected from hydrogen, (C1-C6)alkyl, phenyl-(C1-C10)alkyl, and naphthyl-(C1-C10)alkyl; 0369 wherein in R5 each of the (C1-C6)alkyl, (C3-C8)cycloalkyl, saturated heterocycle, phenyl, naphthyl, (C5-C10)heteroaryl, phenyl-(C1-C10)alkyl, and naphthyl-(C1-C10)alkyl groups independently may be unsubstituted or substituted by (CH2)pOH or (CH2)pNH2; 0370 X4 is N or CR7; 0371 R7 is selected from: 0372 hydrogen; 0373 NR8R9; 0374 OR8; 0375 SR8; 0376 (C1-C6)alkyl; 0377 (C3-C8)cycloalkyl; 0378 a saturated heterocycle comprising from 3 to 8 ring members which are carbon atoms and one heteroatom selected from O, S, N(H), and N(C1-C10)alkyl; 0379 phenyl; 0380 naphthyl; 0381 (C5-C10)heteroaryl comprising carbon atoms and from 1 to 4 hetero atoms selected from O, S, N(H), and N(C1-C10)alkyl; 0382 phenyl-(C1-C10)alkyl; and 0383 naphthyl-(C1-C10)alkyl; 0384 R8 and R9 may be the same or different, and are selected from hydrogen, (C1-C6)alkyl, phenyl-(C1-C10)alkyl, and naphthyl-(C1-C10)alkyl; 0385 wherein in R7 the (C1-C6)alkyl, (C3-C8)cycloalkyl, saturated heterocycle, phenyl, naphthyl, (C5-C10)heteroaryl, phenyl-(C1-C10)alkyl, and naphthyl-(C1-C10)alkyl groups independently may be unsubstituted or independently substituted by (CH2)pOH or (CH2)pNH2; 0386 p is an integer of from 0 to 4 inclusive; and 0387 X1, X2, X3, R1, R2, A, Z, n and q are as defined for Formula (A) in Embodiment 1. 0388 12. The combination of Embodiment 11, wherein 0389 W3 is CR5; 0390 R5 is H or CH3; 0391 X4 is N or CR7; 0392 R7 is H or CH3; 0393 n is an integer of from 1 to 4 inclusive; and 0394 X1, X2, X3, R1, R2, A, Z and q are as defined for Formula (A) in Embodiment 1. 0395 13. The combination of Embodiment 11, wherein 0396 W3 is CR5; 0397 R5 is hydrogen; 0398 X4 is N; and 0399 R1 is a group of formula (1) 8

0400 wherein Y, B, R17, m, and r are as defined for Formula (B) in Embodiment 11. 0401 14. The combination of Embodiment 11, wherein: 0402 R1 is a group of formula (1) 9

0403 wherein 0404 m is 1; 0405 Y is CH2; 0406 B is phenyl which is unsubstituted or substituted by (CH2)kC(O)OR14; wherein 0407 k and R14 are as defined for Formula (B) in Embodiment 11. 0408 15. The combination of any one of Embodiments 1-14, wherein n is 1. 0409 16. The combination of any one of Embodiments 1-15, wherein Z is CR12R13 wherein R12 and R13 each are hydrogen. 0410 17. The combination of any one of Embodiments 1-16, wherein A is phenyl or an aromatic 5-membered or 6-membered monocycle comprising carbon atoms and from 1 to 4 heteroatoms selected from O, S, N(H), and N(C1-C10)alkyl, which phenyl or aromatic 5-membered or 6-membered monocycle may be unsubstituted or substituted by from 1 to 3 groups R2, wherein R2 is as defined for Formula I in Embodiment 1. 0411 18. The combination of any one of Embodiments 1-17, wherein the group A is phenyl or phenyl substituted by one group R2, wherein R2 is as defined for Formula (A) in Embodiment 1. 0412 19. The combination of any one of Embodiments 1-18, wherein the group A is phenyl substituted by one group R2, wherein R2 is methoxy. 0413 20. The combination of Embodiment 1, wherein the compound of Formula (A) is selected from: 0414 4-6-3-(4-methoxy-phenyl-)-prop-1-ynyl-1-methyl-2,4-dioxo-1,4-dihydro-2H-quinazolin-3-ylmethyl-benzoic acid methyl ester; 0415 4-1-methyl-2,4-dioxo-6-(3-phenyl-prop-1-ynyl)-1,4-dihydro-2H-quinazolin-3-ylmethyl-benzoic acid; 0416 4-6-3-(4-methoxy-phenyl-)-prop-1-ynyl-1-methyl-2,4-dioxo-1,4-dihydro-2H-quinazolin-3-ylmethyl-benzoic acid; 0417 4-6-3-(4-methoxy-phenyl-)-prop-1-ynyl-1-methyl-2,4-dioxo-1,4-dihydro-2H-pyrido3,4-dpyrimidin-3-ylmethyl-benzoic acid; 0418 4-1-methyl-2,4-dioxo-6-(3-phenyl-prop-1-ynyl)-1,4-dihydro-2H-pyrido3,4-dpyrimidin-3-ylmethyl-benzoic acid; 0419 4-benzyl-7-(3-phenyl-prop-1-ynyl)-4H-1,2,4triazolo4,3-aquinazolin-5-one; 0420 4-benzyl-7-3-(4-methoxy-phenyl)-prop-1-ynyl-4H-1,2,4triazolo4,3-aquinazolin-5-one; 0421 4-7-3-(4-methoxy-phenyl)-prop-1-ynyl-5-oxo-5H-1,2,4triazolo4,3-aquinazolin-4-ylmethyl -benzoic acid methyl ester; 0422 4-5-oxo-7-(3-phenyl-prop-1-ynyl)-5H-1,2,4triazolo4,3-aquinazolin-4-ylmethyl-benzoic acid; and 0423 4-(1-methyl-2,4-dioxo-6-(2-phenylethynyl)-1,4-dihydro-2H-quinazolin-3-ylmethyl)-benzoic acid; 0424 or a pharmaceutically acceptable salt thereof, or an N-oxide thereof. 0425 21. The combination of Embodiment 1, wherein the compound of Formula (A) is selected from: 0426 4-6-3-(4-methoxy-phenyl-)-prop-1-ynyl-1-methyl-2,4-dioxo-1,4-dihydro-2H-quinazolin-3-ylmethyl-benzoic acid methyl ester; 0427 4-1-methyl-2,4-dioxo-6-(3-phenyl-prop-1-ynyl)-1,4-dihydro-2H-quinazolin-3-ylmethyl-benzoic acid; 0428 4-6-3-(4-methoxy-phenyl-)-prop-1-ynyl-1-methyl-2,4-dioxo-1,4-dihydro-2H-quinazolin-3-ylmethyl-benzoic acid; 0429 4-6-3-(4-methoxy-phenyl-)-prop-1-ynyl-1-methyl-2,4-dioxo-1,4-dihydro-2H-pyrido3,4-dpyrimidin-3-ylmethyl-benzoic acid; 0430 4-1-methyl-2,4-dioxo-6-(3-phenyl-prop-1-ynyl)-1,4-dihydro-2H-pyrido3,4-dpyrimidin-3-ylmethyl-benzoic acid; 0431 4-benzyl-7-(3-phenyl-prop-1-ynyl)-4H-1,2,4triazolo4,3-aquinazolin-5-one; 0432 4-benzyl-7-3-(4-methoxy-phenyl)-prop-1-ynyl-4H-1,2,4triazolo4,3-aquinazolin-5-one; 0433 4-7-3-(4-methoxy-phenyl)-prop-1-ynyl-5-oxo-5H-1,2,4triazolo4,3-aquinazolin-4-ylmethyl-benzoic acid methyl ester; 0434 4-5-oxo-7-(3-phenyl-prop-1-ynyl)-5H-1,2,4triazolo4,3-aquinazolin-4-ylmethyl-benzoic acid; and 0435 4-(1-methyl-2,4-dioxo-6-(2-phenylethynyl)-1,4-dihydro-2H-quinazolin-3-ylmethyl)-benzoicacid. 0436 22. A combination, comprising valdecoxib, or a pharmaceutically acceptable salt thereof, and an allosteric alkyne inhibitor of MMP-13 of Formula I 10

0437 or a pharmaceutically acceptable salt thereof, or a tautomer thereof, wherein: 0438 G1 and G2 independently are 11

0439 wherein 0440 E is independently O or S; 0441 A is OR1 or NR1R2; 0442 R1 and R2 independently are hydrogen, C1-C6 alkyl, C2-C6 alkenyl, C2-C6 alkynyl, (CH2)naryl, (CH2)ncycloalkyl, or (CH2)nheteroaryl, or R1 and R2 are taken together with the nitrogen atom to which they are attached to complete a 3- to 8-membered ring having carbon atoms, the nitrogen atom bearing R1 and R2, and 0 or 1 heteroatom selected from N(H), N(CH3), O, and S, and which ring is optionally unsubstituted or substituted with O, halo, or methyl, wherein 0443 n is an integer of from 0 to 6; or 0444 G1 and G2 independently are hydrogen, halo, C1-C6 alkyl, C2-C6 alkenyl, C2-C6 alkynyl, (CH2)mOH, (CH2)mOR3, (CH2)mcycloalkyl, (CH2)maryl, (CH2)msubstituted aryl, (CH2)mheteroaryl, (CH2)msubstituted heteroaryl, CH(OH)(CH2)maryl, CHOH(CH2)msubstituted aryl, CH(OH)(CH2)m heteroaryl, CH(OH)(CH2)msubstituted heteroaryl, (CO2)q(CH2)maryl, (CO2)q(CH2)msubstituted aryl, (CO2)q(CH2)mheteroaryl, (CO2)q(CH2)msubstituted heteroaryl, (CO2)q(CH2)mcarbocycle, (CO2)q(CH2)mheterocycle, (CO2)q(CH2)mNR3R4, (CH2)mC(O)R3, (CH2)mC(O)OR3, (CH2)mC(O)NR3R4, (CH2)mC(S)NR3R4, or (CH2)mC(NH)NR3R4; 0445 m is an integer of from 0 to 6; 0446 q is an integer of 0 or 1; 0447 R3 and R4 independently are hydrogen, C1-C6 alkyl, (CH2)maryl, or (CH2)mheteroaryl, or R3 and R4 are taken together with the nitrogen atom to which they are attached to complete a 3- to 7-membered ring having carbon atoms, the nitrogen atom bearing R3 and R4, and 0 or 1 heteroatornis selected from N(H), N(CH3), O, and S; 0448 B is: 12

0449 wherein: 0450 each Y is independently 0 or S; 0451 R5, R6, and R7 independently are 0452 hydrogen, halo, hydroxy, C1-C6 alkyl, C1-C6 alkoxy, C2-C6 alkenyl, C2-C6 alkynyl, N02, NR9R10, CN, or CF3, wherein R9 and R10 independently are hydrogen, C1-C6 alkyl, C3-C7 cycloalkyl, phenyl, or benzyl, or R9 and R10 are taken together with the nitrogen atom to which they are attached to form a 3- to 7-membered ring having carbon atoms, the nitrogen atom bearing R9 and R1O, and 0 or 1 atoms selected from O, S, N(H), and N(CH3); 0453 R8 is hydrogen, C1-C6 alkyl, C2-C6 alkenyl, C2-C6 alkynyl, CH2CO2H, OH, NH2, or C1-C6 alkanoyl; 0454 X is S, S(O), S(O)2, O, N(R8), wherein R8 is as defined above, C(O), or CH2; and 0455 is a bond or is absent. 0456 23. The combination according to Embodiment 22, wherein 0457 G1 and G2 independently are 0458 (CH2)maryl, 0459 (CH2)msubstituted aryl, 0460 (CH2)mheteroaryl, or 0461 (CH2)msubstituted heteroaryl, wherein m is an integer of from 0 to 6 and aryl, substituted aryl, heteroaryl, and substituted heteroaryl are as defined for Formula I in Embodiment 22. 0462 24. The combination according to Embodiment 22, wherein the compound of Formula I is a compound of Formula II 14

0463 or a pharmaceutically acceptable salt thereof, or a tautomer thereof, wherein: 0464 G1 and G2 independently are 15

0465 wherein 0466 E is independently O or S; 0467 A is OR1 or NR1R2; 0468 R1 and R2 independently are hydrogen, C1-C6 alkyl, C2-C6 alkenyl, C2-C6 alkynyl, (CH2)naryl, (CH2)ncycloalkyl, or (CH2)nheteroaryl, or R1 and R2 are taken together with the nitrogen atom to which they are attached to complete a 3- to 8-membered ring having carbon atoms, the nitrogen atom bearing R1 and R2, and 0 or 1 heteroatom selected from N(H), N(CH3), O, and S, and which ring is optionally unsubstituted or substituted with O, halo, or methyl, wherein 0469 n is an integer of from 0 to 6; or 0470 G1 and G2 independently are hydrogen, halo, C1-C6 alkyl, C2-C6 alkenyl, C2-C6 alkynyl, (CH2)mOH, (CH2)mOR3, (CH2)mcycloalkyl, (CH2)maryl, (CH2)msubstituted aryl, (CH2)mheteroaryl, (CH2)msubstituted heteroaryl, CH(OH)(CH2)maryl, CHOH(CH2)msubstituted aryl, CH(OH)(CH2)mheteroaryl, CH(OH)(CH2)msubstituted heteroaryl, (CO2)q(CH2)maryl, (CO2)q(CH2)msubstituted aryl, (CO2)q(CH2)mheteroaryl, (C02)q(CH2)msubstituted heteroaryl, (CO2)q(CH2)mcarbocycle, (CO2)q(CH2)mheterocycle, (CO2)q(CH2)mNR3R4, (CH2)mC(O)R3, (CH2)mC(O)OR3, (CH2)mC(O)NR3R4, (CH2)mC(S)NR3R4, or (CH2)mC(NH)NR3R4; 0471 m is an integer of from 0 to 6; 0472 q is an integer of 0 or 1; 0473 R3 and R4 independently are hydrogen, C1-C6 alkyl, (CH2)maryl, or (CH2)mheteroaryl, or R3 and R4 are taken together with the nitrogen atom to which they are attached to complete a 3- to 7-membered ring having carbon atoms, the nitrogen atom bearing R3 and R4, and 0 or 1 heteroatoms selected from N(H), N(CH3), O, and S; and 0474 R5, R6, and R7 independently are hydrogen, halo, hydroxy, C1-C6 alkyl, C2-C6 alkenyl, C2-C6 alkynyl, C1-C6 alkoxy, NO2, CN, CF3, or NR9R10, wherein R9 and R10 independently are hydrogen, C1-C6 alkyl, C3-C7 cycloalkyl, phenyl, or benzyl, or R9 and R10 are taken together with the nitrogen atom to which they are attached to complete a 3- to 7-membered ring having carbon atoms, the nitrogen atom bearing R9 and R1O, and 0 or 1 heteroatoms selected from N(H), N(CH3), O, and S. 0475 25. The combination according to Embodiment 24, wherein: 0476 G1and G2 independently are 0477 (CH2)maryl, wherein m is 1 and aryl is phenyl, 0478 (CH2)msubstituted aryl, wherein m is 1 and substituted aryl is 4-methoxyphenyl, 3-methoxyphenyl, 4-fluorophenyl, 3-fluorophenyl, 4-chlorophenyl, 3-chlorophenyl, 4-bromophenyl, 3-bromophenyl, 4-nitrophenyl, 3-nitrophenyl, 4-methylsulfanylphenyl, 3-methylsulfanylphenyl, 4-methylphenyl, 3-methylphenyl, 4-cyanophenyl, 3-cyanophenyl, 4-carboxyphenyl, 3-carboxyphenyl, 4-methanesulfonylphenyl, or 3-methanesulfonylphenyl, 0479 (CH2)mheteroaryl, wherein m is 1 and heteroaryl is pyridin-4-yl, pyridin-3-yl, or pyridin-2-yl, or 0480 (CH2)msubstituted heteroaryl, wherein m is 1 and substituted heteroaryl is 2-methoxypyridin-4-yl; and 0481 R5, R6, and R8 are hydrogen. 0482 26. The combination according to Embodiment 24, wherein the compound of Formula II is selected from: 0483 3-(4-Methoxy-phenyl)-prop-1-ynyl)-N-(4-carboxybenzyl)-benzamide; 0484 N-(4-Methanesulfonyl-benzyl)-3-(4-methoxy-phenyl)-prop-1-ynyl)-benzamide; 0485 3-(3-Methoxy-phenyl)-prop-1-ynyl)-N-(4-carboxybenzyl)-benzamide; 0486 N-(4-Methanesulfonyl-benzyl)-3-(3-methoxy-phenyl)-prop-1-ynyl)-benzamide; 0487 3-(4-Cyano-phenyl)-prop-1-ynyl)-N-(4-carboxybenzyl)-benzamide; 0488 N-(4-Methanesulfonyl-benzyl)-3-(4-cyano-phenyl)-prop-1-ynyl)-benzamide; 0489 3-(3-Cyano-phenyl)-prop-1-ynyl)-N-(4-carboxybenzyl)-benzamide; 0490 N-(4-Methanesulfonyl-benzyl)-3(3-cyano-phenyl)-prop-1-ynyl)-benzamide; 0491 3-(4-Fluoro-phenyl)-prop-1-ynyl)-N-(4-carboxybenzyl)-benzamnide; 0492 N-(4-Methanesulfonyl-benzyl)-3-(4-fluoro-phenyl)-prop-1-ynyl)-benzamide; 0493 3-(3-Fluoro-phenyl)-prop-1-ynyl)-N-(4-carboxybenzyl)-benzamide; 0494 N-(4-Methanesulfonyl-benzyl)-3-(3-fluoro-phenyl)-prop-1-ynyl)-benzamide; 0495 3-(4-Chloro-phenyl)-prop-1-ynyl)-N-(4-carboxybenzyl)-benzamide; 0496 N-(4-Methanesulfonyl-benzyl)-3-(4-chloro-phenyl)-prop-1-ynyl)-benzamide; 0497 3-(3-Chloro-phenyl)-prop-1-ynyl)-N-(4-carboxybenzyl)-benzamide; 0498 N-(4-Methanesulfonyl-benzyl)-3-(3-chloro-phenyl)-prop-1-ynyl)-benzamide; 0499 3-(4-Bromo-phenyl)-prop-1-ynyl)-N-(4-carboxybenzyl)-benzamide; 0500 N-(4-Methanesulfonyl-benzyl)-3-(4-bromo-phenyl)-prop-1-ynyl)-benzamide; 0501 3-(3-Bromo-phenyl)-prop-1-ynyl)-N-(4-carboxybenzyl)-benzamide; 0502 N-(4-Methanesulfonyl-benzyl)-3-(3-bromo-phenyl)-prop-1-ynyl)-benzamide; 0503 3-(4-Methanesulfanyl-phenyl)-prop-1-ynyl)-N-(4-carboxybenzyl)-benzamide; 0504 N-(4-Methanesulfonyl-benzyl)-3-(4-methanesulfanyl-phenyl)-prop-1-ynyl)-benzamide; 0505 3-(3-Methanesulfanyl-phenyl)-prop-1-ynyl)-N-(4-carboxybenzyl)-benzamide; 0506 N-(4-Methanesulfonyl-benzyl)-3-(3-methanesulfanyl-phenyl)-prop-1-ynyl)-benzamide; 0507 3-(4-Methyl-phenyl)-prop-1-ynyl)-N-(4-carboxybenzyl)-benzamide; 0508 N-(4-Methanesulfonyl-benzyl)-3-(4-methyl-phenyl)-prop-1-ynyl)-benzamide; 0509 3-(3-Methyl-phenyl)-prop-1-ynyl)-N-(4-carboxybenzyl)-benzamnide; 0510 N-(4-Methanesulfonyl-benzyl)-3-(3-methyl-phenyl)-prop-1-ynyl)-benzamide; 0511 3-(3-Pyridin-4-yl-prop-1-ynyl)-N-(4-carboxybenzyl)-benzamide; 0512 N-(4-Methanesulfonyl-benzyl)-3-(3-pyridin-4-yl-prop-1-ynyl)-benzamiide; 0513 3-(3-Pyridin-3-yl-prop-1-ynyl)-N-(4-carboxybenzyl)-benzamide; 0514 N-(4-Methanesulfonyl-benzyl)-3-(3-pyridin-3-yl-prop-1-ynyl)-benzamide; 0515 3-3-(2-Methoxy-pyridin-4-yl)-prop-1-ynyl-N-(4-carboxybenzyl)-benzamide; and 0516 N-(4-Methanesulfonyl-benzyl)-3-3-(2-methoxy-pyridin-4-yl)-prop-1-ynyl-benzamide; 0517 or a pharmaceutically acceptable salt thereof, or a tautomer thereof. 0518 27. The combination according to Embodiment 24, wherein the compound of Formula II is selected from: 0519 3-(4-Methoxy-phenyl)-prop-1-ynyl)-N-(4-carboxybenzyl)-benzamide; 0520 N-(4-Methanesulfonyl-benzyl)-3-(4-methoxy-phenyl)-prop-1-ynyl)-benzamide; 0521 3-(3-Methoxy-phenyl)-prop-1-ynyl)-N-(4-carboxybenzyl)-benzamide; 0522 N-(4-Methanesulfonyl-benzyl)-3-(3-methoxy-phenyl)-prop-1-ynyl)-benzamide; 0523 3-(4-Cyano-phenyl)-prop-1-ynyl)-N-(4-carboxybenzyl)-benzamide; 0524 N-(4-Methanesulfonyl-benzyl)-3-(4-cyano-phenyl)-prop-1-ynyl)-benzamide; 0525 3-(3-Cyano-phenyl)-prop-1-ynyl)-N-(4-carboxybenzyl)-benzamide; 0526 N-(4-Methanesulfonyl-benzyl)-3-(3-cyano-phenyl)-prop-1-ynyl)-benzamide; 0527 3-(4-Fluoro-phenyl)-prop-1-ynyl)-N-(4-carboxybenzyl)-benzamide; 0528 N-(4-Methanesulfonyl-benzyl)-3-(4-fluoro-phenyl)-prop-1-ynyl)-benzamide; 0529 3-(3-Fluoro-phenyl)-prop-1-ynyl)-N-(4-carboxybenzyl)-benzamide; 0530 N-(4-Methanesulfonyl-benzyl)-3-(3-fluoro-phenyl)-prop-1-ynyl)-benzarnide; 0531 3-(4-Chloro-phenyl)-prop-1-ynyl)-N-(4-carboxybenzyl)-benzamide; 0532 N-(4-Methanesulfonyl-benzyl)-3-(4-chloro-phenyl)-prop-1-ynyl)-benzamide; 0533 3-(3-Chloro-phenyl)-prop-1-ynyl)-N-(4-carboxybenzyl)-benzamide; 0534 N-(4-Methanesulfonyl-benzyl)-3-(3-chloro-phenyl)-prop-1-ynyl)-benzamide; 0535 3-(4-Bromo-phenyl)-prop-1-ynyl)-N-(4-carboxybenzyl)-benzamide; 0536 N-(4-Methanesulfonyl-benzyl)-3-(4-bromo-phenyl)-prop-1-ynyl)-benzamide; 0537 3-(3-Bromo-phenyl)-prop-1-ynyl)-N-(4-carboxybenzyl)-benzamide; 0538 N-(4-Methanesulfonyl-benzyl)-3-(3-bromo-phenyl)-prop-1-ynyl)-benzamide; 0539 3-(4-Methanesulfanyl-phenyl)-prop-1-ynyl)-N-(4-carboxybenzyl)-benzamide; 0540 N-(4-Methanesulfonyl-benzyl)-3-(4-methanesulfanyl-phenyl)-prop-1-ynyl)-benzamide; 0541 3-(3-Methanesulfanyl-phenyl)-prop-1-ynyl)-N-(4-carboxybenzyl)-benzarmide; 0542 N-(4-Methanesulfonyl-benzyl)-3-(3-methanesulfanyl-phenyl)-prop-1-ynyl)-benzamide; 0543 3-(4-Methyl-phenyl)-prop-1-ynyl)-N-(4-carboxybenzyl)-benzamide; 0544 N-(4-Methanesulfonyl-benzyl)-3-(4-methyl-phenyl)-prop-1-ynyl)-benzamide; 0545 3-(3-Methyl-phenyl)-prop-1-ynyl)-N-(4-carboxybenzyl)-benzamide; 0546 N-(4-Methanesulfonyl-benzyl)-3-(3-methyl-phenyl)-prop-1-ynyl)-benzamide; 0547 3-(3-Pyridin-4-yl-prop-1-ynyl)-N-(4-carboxybenzyl)-benzamide; 0548 N-(4-Methanesulfonyl-benzyl)-3-(3-pyridin-4-yl-prop-1-ynyl)-benzamide; 0549 3-(3-Pyridin-3-yl-prop-1-ynyl)-N-(4-carboxybenzyl)-benzamide; 0550 N-(4-Methanesulfonyl-benzyl)-3-(3-pyridin-3-yl-prop-1-ynyl)-benzamide; 0551 3-3-(2-Methoxy-pyridin-4-yl)-prop-1-ynyl-N-(4-carboxybenzyl)-benzamide; and 0552 N-(4-Methanesulfonyl-benzyl)-3-3-(2-methoxy-pyridin-4-yl)-prop-1-ynyl-benzamide. 0553 28. The combination according to Embodiment 22, wherein the compound of Formula I is a compound of Formula III 16

0554 or a pharmaceutically acceptable salt thereof, or a tautomer thereof, wherein: 0555 G1 and G2 independently are 17

0556 wherein 0557 E is independently O or S; 0558 A is OR1 or NR1R2; 0559 R1 and R2 independently are hydrogen, C1-C6 alkyl, C2-C6 alkenyl, C2-C6 alkynyl, (CH2)naryl, (CH2)ncycloalkyl, or (CH2)nheteroaryl, or R1 and R2 are taken together with the nitrogen atom to which they are attached to complete a 3- to 8-membered ring having carbon atoms, the nitrogen atom bearing R1 and R2, and 0 or 1 heteroatom selected from N(H), N(CH3), O, and S, and which ring is optionally unsubstituted or substituted with O, halo, or methyl, wherein n is an integer of from 0 to 6; or 0560 G1 and G2 independently are hydrogen, halo, C1-C6 alkyl, C2-C6 alkenyl, C2-C6 alkynyl, (CH2)mOH, (CH2)mOR3, (CH2)mcycloalkyl, (CH2)maryl, (CH2)msubstituted aryl, (CH2)mheteroaryl, (CH2)msubstituted heteroaryl, CH(OH)(CH2)maryl, CHOH(CH2)msubstituted aryl, CH(OH)(CH2)m heteroaryl, CH(OH)(CH2)msubstituted heteroaryl, (CO2)q(CH2)maryl, (CO2)q(CH2)msubstituted aryl, (CO2)q(CH2)mheteroaryl, (CO2)q(CH2)msubstituted heteroaryl, (CO2)q(CH2)mcarbocycle, (CO2)q(CH2)mheterocycle, (CO2)q(CH2)mNR3R4, (CH2)mC(O)R3, (CH2)mC(O)OR3, (CH2)mC(O)NR3R4, (CH2)mC(S)NR3R4, or (CH2)mC(NH)NR3R4; 0561 m is an integer of from 0 to 6; 0562 q is an integer of 0 or 1; 0563 R3 and R4 independently are hydrogen, C1-C6 alkyl, (CH2)maryl, or (CH2)mheteroaryl, or R3 and R4 are taken together with the nitrogen atom to which they are attached to complete a 3- to 7-membered ring having carbon atoms, the nitrogen atom bearing R3 and R4, and 0 or 1 heteroatoms selected from N(H), N(CH3), O, and S; and 0564 R5 and R6 independently are hydrogen, halo, hydroxy, C1-C6 alkyl, C2-C6 alkenyl, C2-C6 alkynyl, C1-C6 alkoxy, NO2, CN, CF3, or NR9R10, wherein R9 and R10 independently are hydrogen, C1-C6 alkyl, C3-C7 cycloalkyl, phenyl, or benzyl, or R9 and R10 are taken together with the nitrogen atom to which they are attached to complete a 3- to 7-membered ring having carbon atoms, the nitrogen atom bearing R9 and R10, and 0 or 1 atoms selected from N(H), N(CH3), O, and S. 0565 29. The combination according to Embodiment 28, wherein: 0566 G1 and G2 independently are 0567 (CH2)maryl, wherein m is 1 and aryl is phenyl, 0568 (CH2)msubstituted aryl, wherein m is 1 and substituted aryl is 4-methoxyphenyl, 3-methoxy phenyl, 4-fluorophenyl, 3-fluorophenyl, 4-chlorophenyl, 3-chlorophenyl, 4-bromophenyl, 3-bromophenyl, 4-nitrophenyl, 3-nitrophenyl, 4-methylsulfanylphenyl, 3-methylsulfanylphenyl, 4-methylphenyl, 3-methylphenyl, 4-cyanophenyl, 3-cyanophenyl, 4-carboxyphenyl, 3-carboxyphenyl, 4-methanesulfonylphenyl, or 3-methanesulfonylphenyl, 0569 (CH2)mheteroaryl, wherein m is 1 and heteroaryl is pyridin-4-yl, pyridin-3-yl, or pyridin-2-yl, or 0570 (CH2)msubstituted heteroaryl, wherein m is 1 and substituted heteroaryl is 2-methoxypyridin-4-yl; and 0571 R5 and R6 are hydrogen. 0572 30. The combination according to Embodiment 28, wherein the compound of Formula III is selected from: 0573 3-(4-Methoxy-phenyl)-prop-1-ynyl)-N-(4-carboxybenzyl)-isonicotinamide; 0574 N-(4-Methanesulfonyl-benzyl)-3-(4-methoxy-phenyl)-prop-1-ynyl)-isonicotinamide; 0575 3-(3-Methoxy-phenyl)-prop-1-ynyl)-N-(4-carboxybenzyl)-isonicotinamide; 0576 N-(4-Methanesulfonyl-benzyl)-3-(3-methoxy-phenyl)-,prop-1-ynyl)-isonicotinamide; 0577 3-(4-Cyano-phenyl)-prop-1-ynyl)-N-(4-carboxybenzyl)-isonicotinamide; 0578 N-(4-Methanesulfonyl-benzyl)-3-(4-cyano-phenyl)-prop-1-ynyl)-isonicotinamide; 0579 3-(3-Cyano-phenyl)-prop-1-ynyl)-N-(4-carboxybenzyl)-isonicotinamide; 0580 N-(4-Methanesulfonyl-benzyl)-3-(3-cyano-phenyl)-prop-1-ynyl)-isonicotinamide; 0581 3-(4-Fluoro-phenyl)-prop-1-ynyl)-N-(4-carboxybenzyl)-isonicotinamide; 0582 N-(4-Methanesulfonyl-benzyl)-3-(4-fluoro-phenyl)-prop-1-ynyl)-isonicotinamide; 0583 3-(3-Fluoro-phenyl)-prop-1-ynyl)-N-(4-carboxybenzyl)-isonicotinamide; 0584 N-(4-Methanesulfonyl-benzyl)-3-(3-fluoro-phenyl)-prop-1-ynyl)-isonicotinamide; 0585 3-(4-Chloro-phenyl)-prop-1-ynyl)-N-(4-carboxybenzyl)-isonicotinamide; 0586 N-(4-Methanesulfonyl-benzyl)-3-(4-chloro-phenyl)-prop-1-ynyl)-isonicotinamide; 0587 3-(3-Chloro-phenyl)-prop-1-ynyl)-N-(4-carboxybenzyl)-isonicotinamide; 0588 N-(4-Methanesulfonyl-benzyl)-3-(3-chloro-phenyl)-prop-1-ynyl)-isonicotinamide; 0589 3-(4-Bromo-phenyl)-prop-1-ynyl)-N-(4-carboxybenzyl)-isonicotinamide; 0590 N-(4-Methanesulfonyl-benzyl)-3-(4-bromo-phenyl)-prop-1-ynyl)-isonicotinarmide; 0591 3-(3-Bromo-phenyl)-prop-1-ynyl)-N-(4-carboxybenzyl)-isonicotinamide; 0592 N-(4-Methanesulfonyl-benzyl)-3-(3-bromo-phenyl)-prop-1-ynyl)-isonicotinamide; 0593 3-(4-Methanesulfanyl-phenyl)-prop-1-ynyl)-N-(4 carboxybenzyl)-isonicotinarnide; 0594 N-(4-Methanesulfonyl-benzyl)3-(4-methanesulfanyl-phenyl)-prop-1-ynyl)-isonicotinamide; 0595 3-(3-Methanesulfanyl-phenyl)-prop-1-ynyl)-N-(4-carboxybenzyl)-isonicotinamide; 0596 N-(4-Methanesulfonyl-benzyl)-3-(3-methanesulfanyl-phenyl)-prop-1-ynyl)-isonicotinamide; 0597 3-(4-Methyl-phenyl)-prop-1-ynyl)-N-(4-carboxybenzyl)-isonicotinamide; 0598 N-(4-Methanesulfonyl-benzyl)-3-(4-methyl-phenyl)-prop-1-ynyl)-isonicotinamide; 0599 3-(3-Methyl-phenyl)-prop-1-ynyl)-N-(4-carboxybenzyl)-isonicotinamide; 0600 N-(4-Methanesulfonyl-benzyl)-3-(3-methyl-phenyl)-prop-1-ynyl)-isonicotinamide; 0601 3-(3-pyridin-4-yl-prop-1-ynyl)-N-(4-carboxybenzyl)-isonicotinamide; 0602 N-(4-Methanesulfonyl-benzyl)-3-(3-pyridin-4-yl-prop-1-ynyl)-isonicotinamide; 0603 3-(3-Pyridin-3-yl-prop-1-ynyl)-N-(4-carboxybenzyl)-isonicotinamide; 0604 N-(4-Methanesulfonyl-benzyl)-3-(3-pyridin-3-yl-prop-1-ynyl)-isonicotinamide; 0605 3-3-(2-Methoxy-pyridin-4-yl)-prop-1-ynyl-N-(4-carboxybenzyl)-isonicotinamide; and 0606 N-(4-Methanesulfonyl-benzyl)-3-3-(2-methoxy-pyridin-4-yl)-prop-1-ynyl-isonicotinamide; 0607 or a pharmaceutically acceptable salt thereof, or a tautomer thereof. 0608 31. The combination according to Embodiment 28, wherein the compound of Formula III is selected from: 0609 3-(4-Methoxy-phenyl)-prop-1-ynyl)-N-(4-carboxybenzyl)-isonicotinamide; 0610 N-(4-Methanesulfonyl-benzyl)-3-(4-methoxy-phenyl)-prop-1-ynyl)-isonicotinamide; 0611 3-(3-Methoxy-phenyl)-prop-1-ynyl)-N-(4-carboxybenzyl)-isonicotinamide; 0612 N-(4-Methanesulfonyl-benzyl)-3-(3-methoxy-phenyl)-prop-1-ynyl)-isonicotinamide; 0613 3-(4-Cyano-phenyl)-prop-1-ynyl)-N-(4-carboxybenzyl)-isonicotinamide; 0614 N-(4-Methanesulfonyl-benzyl)-3-(4-cyano-phenyl)-prop-1-ynyl)-isonicotinamide; 0615 3-(3-Cyano-phenyl)-prop-1-ynyl)-N-(4-carboxybenzyl)-isonicotinamide; 0616 N-(4-Methanesulfonyl-benzyl)-3-(3-cyano-phenyl)-prop-1-ynyl)-isonicotinamide; 0617 3-(4-Fluoro-phenyl)-prop-1-ynyl)-N-(4-carboxybenzyl)-isonicotinamide; 0618 N-(4-Methanesulfonyl-benzyl)-3-(4-fluoro-phenyl)-prop-1-ynyl)-isonicotinamide; 0619 3-(3-Fluoro-phenyl)-prop-1-ynyl)-N-(4-carboxybenzyl)-isonicotinamide; 0620 N-(4-Methanesulfonyl-benzyl)-3-(3-fluoro-phenyl)-prop-1-ynyl)-isonicotinamide; 0621 3-(4-Chloro-phenyl)-prop-1-ynyl)-N-(4-carboxybenzyl)-isonicotinarnide; 0622 N-(4-Methanesulfonyl-benzyl)-3-(4-chloro-phenyl)-prop-1-ynyl)-isonicotinamide; 0623 3-(3-Chloro-phenyl)-prop-1-ynyl)-N-(4-carboxybenzyl)-isonicotinamide; 0624 N-(4-Methanesulfonyl-benzyl)-3-(3-chloro-phenyl)-prop-1-ynyl)-isonicotinamide; 0625 3-(4-Bromo-phenyl)-prop-1-ynyl)-N-(4-carboxybenzyl)-isonicotinamide; 0626 N-(4-Methanesulfonyl-benzyl)-3-(4-bromo-phenyl)-prop-1-ynyl)-isonicotinamide; 0627 3-(3-Bromo-phenyl)-prop-1-ynyl)-N-(4-carboxybenzyl)-isonicotinamide; 0628 N-(4-Methanesulfonyl-benzyl)-3-(3-bromo-phenyl)-prop-1-ynyl)-isonicotinamide; 0629 3-(4-Methanesulfanyl-phenyl)-prop-1-ynyl)-N-(4-carboxybenzyl)-isonicotinamide; 0630 N-(4-Methanesulfonyl-benzyl)-3-(4-methanesulfanyl-phenyl)-prop-1-ynyl)-isonicotinamide; 0631 3-(3-Methanesulfanyl-phenyl)-prop-1-ynyl)-N-(4-carboxybenzyl)-isonicotinamide; 0632 N-(4-Methanesulfonyl-benzyl)-3-(3-methanesulfanyl-phenyl)-prop-1-ynyl)-isonicotinamide; 0633 3-(4-Methyl-phenyl)-prop-1-ynyl)-N-(4-carboxybenzyl)-isonicotinamide; 0634 N-(4-Methanesulfonyl-benzyl)-3-(4-methyl-phenyl)-prop-1-ynyl)-isonicotinamide; 0635 3-(3-Methyl-phenyl)-prop-1-ynyl)-N-(4-carboxybenzyl)-isonicotinamide; 0636 N-(4-Methanesulfonyl-benzyl)-3-(3-methyl-phenyl)-prop-1-ynyl)-isonicotinamide; 0637 3-(3-pyridin-4-yl-prop-1-ynyl)-N-(4-carboxybenzyl)-isonicotinamide; 0638 N-(4-Methanesulfonyl-benzyl)-3-(3-pyridin-4-yl-prop-1-ynyl)-isonicotinamide; 0639 3-(3-Pyridin-3-yl-prop-1-ynyl)-N-(4-carboxybenzyl)-isonicotinamide; 0640 N-(4-Methanesulfonyl-benzyl)-3-(3-pyridin-3-yl-prop-1-ynyl)-isonicotinamide; 0641 3-3-(2-Methoxy-pyridin-4-yl)-prop-1-ynyl-N-(4-carboxybenzyl)-isonicotinamide; and 0642 N-(4-Methanesulfonyl-benzyl)-3-3-(2-methoxy-pyridin-4-yl)-prop-1-ynyl-isonicotinamide. 0643 32. The combination according to Embodiment 22, wherein the compound of Formula I is a compound of Formula IV 18

0644 or a pharmaceutically acceptable salt thereof, or a tautomer thereof, wherein: 0645 G1 and G2 independently are 19

0646 wherein 0647 E is independently O or S; 0648 A is OR1 or NR1R2; 0649 R1 and R2 independently are hydrogen, C1-C6 alkyl, C2-C6 alkenyl, C2-C6 alkynyl, (CH2)naryl, (CH2)ncycloalkyl, or (CH2)nheteroaryl, or R1 and R2 are taken together with the nitrogen atom to which they are attached to complete a 3- to 8-membered ring having carbon atoms, the nitrogen atom bearing R1 and R2, and 0 or 1 heteroatom selected from N(H), N(CH3), O, and S, and which ring is optionally unsubstituted or substituted with O, halo, or methyl, wherein n is an integer of from 0 to 6; or 0650 G1 and G2 independently are hydrogen, halo, C1-C6 alkyl, C2-C6 alkenyl, C2-C6 alkynyl, (CH2)mOH, (CH2)mOR3, (CH2)mcycloalkyl, (CH2)maryl, (CH2)msubstituted aryl, (CH2)mheteroaryl, (CH2)msubstituted heteroaryl, CH(OH)(CH2)maryl, CHOH(CH2)msubstituted aryl, CH(OH)(CH2)m heteroaryl, CH(OH)(CH2)msubstituted heteroaryl, (CO2)q(CH2)maryl, (CO2)q(CH2)msubstituted aryl, (CO2)q(CH2)mheteroaryl, (CO2)q(CH2)msubstituted heteroaryl, (CO2)q(CH2)mcarbocycle, (CO2)q(CH2)mheterocycle, (CO2)q(CH2)mNR3R4, (CH2)mC(O)R3, (CH2)mC(O)OR3, (CH2)mC(O)NR3R4, (CH2)mC(S)NR3R4, or (CH2)mC(NH)NR3R4; 0651 m is an integer of from 0 to 6; 0652 q is an integer of 0 or 1; 0653 R3 and R4 independently are hydrogen, C1-C6 alkyl, (CH2)maryl, or (CH2)mheteroaryl, or R3 and R4 are taken together with the nitrogen atom to which they are attached to complete a 3- to 7-membered ring having carbon atoms, the nitrogen atom bearing R3 and R4, and 0 or 1 heteroatoms selected from N(H), N(CH3), O, and S; 0654 Y is independently O or S; 0655 R5, R6, and R7 independently are hydrogen, halo, hydroxy, C1-C6 alkyl, C2-C6 alkenyl, C2-C6 alkynyl, C1-C6 alkoxy, NO2, CN, CF3, or NR9R10, wherein R9 and R10 independently are hydrogen, C1-C6 alkyl, C3-C7 cycloalkyl, phenyl, or benzyl, or R9 and R10 are taken together with the nitrogen atom to which they are attached to complete a 3- to 7-membered ring having carbon atoms, the nitrogen atom bearing R9 and R10, and 0 or 1 heteroatoms selected from N(H), N(CH3), O, and S; and 0656 R8 is hydrogen, C1-C6 alkyl, C2-C6 alkenyl, C2-C6 alkynyl, C1-C6 alkoxy, C1-C6 alkanoyl, CH2CO2H, NH2, or OH. 0657 33. The combination according to Embodiment 32, wherein: 0658 Y is O; 0659 G1 and G2 independently are 0660 (CH2)maryl, wherein m is 1 and aryl is phenyl, 0661 (CH2)msubstituted aryl, wherein m is 1 and substituted aryl is 4-methoxyphenyl, 3-methoxyphenyl, 4-fluorophenyl, 3-fluorophenyl, 4-chlorophenyl, 3-chlorophenyl, 4-bromophenyl, 3-bromophenyl, 4-nitrophenyl, 3-nitrophenyl, 4-methylsulfanylphenyl, 3-methylsulfanylphenyl, 4-methylphenyl, 3-methylphenyl, 4-cyanophenyl, 3-cyanophenyl, 4-carboxyphenyl, 3-carboxyphenyl, 4-methanesulfonylphenyl, or 3-methanesulfonylphenyl, 0662 (CH2)mheteroaryl, wherein m is 1 and heteroaryl is piperidin-1-yl, piperazin-1-yl, tetrahydrofuran-2-yl, pyridin-4-yl, pyridin-3-yl, or pyridin-2-yl, 0663 (CH2)msubstituted heteroaryl, wherein m is 1 and substituted heteroaryl is 2-methoxypyridin-4-yl, or 0664 (CH2)mcycloalkyl, wherein m is 1 and cycloalkyl is cyclopropyl, cyclobutyl, cyclopentyl, cyclohexyl, or cycloheptyl; and 0665 R8 is hydrogen or methyl. 0666 34. The combination according to Embodiment 32, wherein the compound of Formula IV is selected from: 0667 2-Benzyl-4-methyl-1,1-dioxo-7-(3-phenyl-prop-1-ynyl)-1,4-dihydro-2H-116-benzo1,2,4thiadiazin-3-one; 0668 4-4-Methyl-1,1,3-trioxo-7-(3-phenyl-prop-1-ynyl)-3,4-dihydro-1H-116-benzo1,2,4thiadiazin-2-ylmethyl-benzoic acid; 0669 2-Benzyl-1,1-dioxo-7-(3-phenyl-prop-1-ynyl)-1,4-dihydro-2H-116-benzo1,2,4thiadiazin-3-one; 0670 4-1,1,3-Trioxo-7-(3-phenyl-prop-1-ynyl)-3,4-dihydro-1H-116-benzo1,2,4thiadiazin-2-ylmethyl-benzoic acid; 0671 2-Benzyl-4-methyl-1,1-dioxo-7-3-(4-methoxyphenyl)-prop-1-ynyl-1,4-dihydro-2H-116-benzo1,2,4thiadiazin-3-one; 0672 2-Benzyl-1,1-dioxo-7-3-(4-methoxyphenyl)-prop-1-ynyl-1,4-dihydro-2H-116-benzo1,2,4thiadiazin-3-one; 0673 4-1,1,3-Trioxo-7-3-(4-methoxyphenyl)-prop-1-ynyl-4-methyl-3,4-dihydro-116-benzo1,2,4thiadiazin-2-ylmethyl-benzoic acid; 0674 4-1,1,3-Trioxo-7-3-(4-methoxyphenyl)-prop-1-ynyl-3,4-dihydro-1H-116-benzo1,2,4thiadiazin-2-ylmethylbenzoic acid; 0675 2-Benzyl-4-methyl-1,1-dioxo-7-3-(3-methoxyphenyl)-prop-1-ynyl-1,4-dihydro-2H-116-benzo1,2,4thiadiazin-3-one; 0676 2-Benzyl-1,1-dioxo-7-3-(3-methoxyphenyl)-prop-1-ynyl-1,4-dihydro-2H-116-benzo1,2,4thiadiazin-3-one; 0677 4-1,1,3-Trioxo-7-3-(3-methoxyphenyl)-prop-1-ynyl-4-methyl-3,4-dihydro-1-116-benzo1,2,4thiadiazin-2-ylmethyl-benzoic acid; and 0678 4-1,1,3-Trioxo-7-3-(3-methoxyphenyl)-prop-1-ynyl-3,4-dihydro-116-benzo1,2,4thiadiazin-2-ylmethyl-benzoic acid; 0679 a pharmaceutically acceptable salt thereof, or a tautomer thereof. 0680 35. The combination according to Embodiment 32, wherein the compound of Formula IV is selected from: 0681 2-Benzyl-4-methyl-1,1-dioxo-7-(3-phenyl-prop-1-ynyl)-1,4-dihydro-2H-116-benzo1,2,4thiadiazin-3-one; 0682 4-4-Methyl-1,1,3-trioxo-7-(3-phenyl-prop-1-ynyl)-3,4-dihydro-1H-116-benzo1,2,4thiadiazin-2-ylmethyl-benzoic acid; 0683 2-Benzyl-1,1-dioxo-7-(3-phenyl-prop-1-ynyl)-1,4-dihydro-2H-116-benzo1,2,4thiadiazin-3-one; 0684 4-1,1,3-Trioxo-7-(3-phenyl-prop-1-ynyl)-3,4-dihydro-1H-116-benzo1,2,4thiadiazin-2-ylmethyl-benzoic acid; 0685 2-Benzyl-4-methyl-1,1-dioxo-7-3-(4-methoxyphenyl)-prop-1-ynyl-1,4-dihydro-2H-116-benzo1,2,4thiadiazin-3-one; 0686 2-Benzyl-1,1-dioxo-7-3-(4-methoxyphenyl)-prop-1-ynyl-1,4-dihydro-2H-116-benzo1,2,4thiadiazin-3-one; 0687 4-1,1,3-Trioxo-7-3-(4-methoxyphenyl)-prop-1-ynyl-4-methyl-3,4-dihydro-1H-116-benzo1,2,4thiadiazin-2-ylmethyl-benzoic acid; 0688 4-1,1,3-Trioxo-7-3-(4-methoxyphenyl)-prop-1-ynyl-3,4-dihydro-1H-116-benzo1,2,4thiadiazin-2-ylmethyl-benzoic acid; 0689 2-Benzyl-4-methyl-1,1-dioxo-7-3-(3-methoxyphenyl)-prop-1-ynyl-1,4-dihydro-2 H-116-benzo1,2,4thiadiazin-3-one; 0690 2-Benzyl-1,1-dioxo-7-3-(3-methoxyphenyl)-prop-1-ynyl-1,4-dihydro-2H-116-benzo1,2,4thiadiazin-3-one; 0691 4-1,1,3-Trioxo-7-3-(3-methoxyphenyl)-prop-1-ynyl-4-methyl-3,4-dihydro-1H-116-benzo1,2,4thiadiazin-2-ylmethyl-benzoic acid; and 0692 4-1,1,3-Trioxo-7-3-(3-methoxyphenyl)-prop-1-ynyl-3,4-dihydro-1H-116-benzo1,2,4thiadiazin-2-ylmethyl-benzoic acid. 0693 36. The combination according to Embodiment 22, wherein the compound of Formula I is a compound of Formula V 20

0694 or a pharmaceutically acceptable salt thereof, or a tautomer thereof, wherein: 0695 G1 and G2 independently are 21

0696 wherein 0697 E is independently O or S; 0698 A is OR1 or NR1R2; 0699 R1 and R2 independently are hydrogen, C1-C6 alkyl, C2-C6 alkenyl, C2-C6 alkynyl, (CH2)naryl, (CH2)ncycloalkyl, or (CH2)nheteroaryl, or R1 and R2 are taken together with the nitrogen atom to which they are attached to complete a 3- to 8-membered ring having carbon atoms, the nitrogen atom bearing R1 and R2, and 0 or 1 heteroatom selected from N(H), N(CH3), O, and S, and which ring is optionally unsubstituted or substituted with O, halo, or methyl, wherein n is an integer of from 0 to 6; or 0700 G1 and G2 independently are hydrogen, halo, C1-C6 alkyl, C2-C6 alkenyl, C2-C6 alkynyl, (CH2)mOH, (CH2)mOR3, (CH2)mcycloalkyl, (CH2)maryl, (CH2)msubstituted aryl, (CH2)mheteroaryl, (CH2)msubstituted heteroaryl, CH(OH)(CH2)maryl, CHOH(CH2)msubstituted aryl, CH(OH)(CH2)m heteroaryl, CH(OH)(CH2)msubstituted heteroaryl, (CO2)q(CH2)maryl, (CO2)q(CH2)msubstituted aryl, (CO2)q(CH2)mheteroaryl, (CO2)q(CH2)msubstituted heteroaryl, (CO2)q(CH2)mcarbocycle, (CO2)q(CH2)mheterocycle, (CO2)q(CH2)mNR3R4, (CH2)mC(O)R3, (CH2)mC(O)OR3, (CH2)mC(O)NR3R4, (CH2)mC(S)NR3R4, or (CH2)mC(NH)NR3R4; 0701 m is an integer of from 0 to 6; 0702 q is an integer of 0 or 1; 0703 R3 and R4 independently are hydrogen, C1-C6 alkyl, (CH2)maryl, or (CH2)mheteroaryl, or R3 and R4 are taken together with the nitrogen atom to which they are attached to complete a 3- to 7-membered ring having carbon atoms, the nitrogen atom bearing R3 and R4, and 0 or 1 heteroatoms selected from N(H), N(CH3), O, and S; 0704 Y is 0 or S; 0705 R5, R6, and R7 independently are hydrogen, halo, hydroxy, C1-C6 alkyl, C2-C6 alkenyl, C2-C6 alkynyl, C1-C6 alkoxy, NO2, CN, CF3, or NR9R10, wherein R9 and R10 independently are hydrogen, C1-C6 alkyl, C3-C7 cycloalkyl, phenyl, or benzyl, or R9 and R10 are taken together with the nitrogen atom to which they are attached to complete a 3- to 7-membered ring having carbon atoms, the nitrogen atom bearing R9 and R10, and 0 or 1 heteroatoms selected from N(H), N(CH3), O, and S; 0706 R8 is hydrogen, C1-C6 alkyl, C2-C6 alkenyl, C2-C6 alkynyl, C1-C6 alkoxy, C1-C6 alkanoyl, CH2CO2H, NH2, or OH; and 0707 is a bond or is absent. 0708 37. The combination according to Embodiment 36, wherein: 0709 Y is O; 0710 G1 and G2 independently are 0711 (CH2)maryl, wherein m is 1 and aryl is phenyl, 0712 (CH2)msubstituted aryl, wherein m is 1 and substituted aryl is 4-methoxyphenyl, 3-methoxyphenyl, 4-fluorophenyl, 3-fluorophenyl, 4-chlorophenyl, 3-chlorophenyl, 4-bromophenyl, 3-bromophenyl, 4-nitrophenyl, 3-nitrophenyl, 4-methylsulfanylphenyl, 3-methylsulfanylphenyl, 4-methylphenyl, 3-methylphenyl, 4-cyanophenyl, 3-cyanophenyl, 4-carboxyphenyl, 3-carboxyphenyl, 4-methanesulfonylphenyl, 3-methanesulfonylphenyl, 4-methoxycarbonyphenyl, or 3-methoxycarbonylphenyl, 0713 (CH2)mheteroaryl, wherein m is 1 and heteroaryl is pyridin-4-yl, pyridin-3-yl, or pyridin-2-yl, or 0714 (CH2)msubstituted heteroaryl, wherein m is 1 and substituted heteroaryl is 2-methoxypyridin-4-yl; 0715 R5, R6, and R7 are hydrogen; and 0716 R8 is methyl. 0717 38. The combination according to Embodiment 36, wherein the compound of Formula V is selected from: 0718 1-Methyl-6-(4-methoxy-phenyl)-prop-1-ynyl)-3-(4-carboxybenzyl)-1H-quinolin-4-one; 0719 3-(4-Methanesulfonyl-benzyl)-1-methyl-6-(4-methoxy-phenyl)-prop-1-ynyl)-1H-quinolin-4-one; 0720 1-Methyl-6-(3-methoxy-phenyl)-prop-1-ynyl)-3-(4-carboxybenzyl)-1H-quinolin-4-one; 0721 3-(4-Methanesulfonyl-benzyl)-1-methyl-6-(3-methoxy-phenyl)-prop-1-ynyl)-1H-quinolin-4-one; 0722 6-(4-Cyano-phenyl)-prop-1-ynyl)-1-methyl-3-(4-carboxybenzyl)-1H-quinolin-4-one; 0723 3-(4-Methanesulfonyl-benzyl)-6-(4-cyano-phenyl)-prop-1-ynyl)-1-methyl-1H-quinolin-4-one; 0724 6-(3-Cyano-phenyl)-prop-1-ynyl)-3-(4-carboxybenzyl)-1-methyl-1H-quinolin-4-one; 0725 4-(4-Methanesulfonyl-benzyl)-6-(3-cyano-phenyl)-prop-1-ynyl)-1-methyl-1H-quinolin-4-one; 0726 6-(4-Fluoro-phenyl)-prop-1-ynyl)-3-(4-carboxybenzyl)-1-methyl-1H-quinolin-4-one; 0727 3-(4-Methanesulfonyl-benzyl)-6-(4-fluoro-phenyl)-prop-1-ynyl)-1-methyl-1H-quinolin-4-one; 0728 6-(3-Fluoro-phenyl)-prop-1-ynyl)-3-(4-carboxybenzyl)-1-methyl-1H-quinolin-4-one; 0729 3-(4-Methanesulfonyl-benzyl)-6-(3-fluoro-phenyl)-prop-1-ynyl)-1-methyl-1H-quinolin-4-one; 0730 6-(4-Chloro-phenyl)-prop-1-ynyl)-3-(4-carboxybenzyl)-1-methyl-1H-quinolin-4-one; 0731 3-(4-Methanesulfonyl-benzyl)-6-(4-chloro-phenyl)-prop-1-ynyl)-1-methyl-1H-quinolin-4-one; 0732 6-(3-Chloro-phenyl)-prop-1-ynyl)-3-(4-carboxybenzyl)-1-methyl-1H-quinolin-4-one; 0733 3-(4-Methanesulfonyl-benzyl)-6-(3-chloro-phenyl)-prop-1-ynyl)-1-methyl-1H-quinolin-4-one; 0734 6-(4-Bromo-phenyl)-prop-1-ynyl)-3-(4-carboxybenzyl)-1-methyl-1H-quinolin-4-one; 0735 3-(4-Methanesulfonyl-benzyl)-6-(4-bromo-phenyl)-prop-1-ynyl)-1-methyl-1H-quinolin-4-one; 0736 6-(3-Bromo-phenyl)-prop-1-ynyl)-3-(4-carboxybenzyl)-1-methyl-1H-quinolin-4-one; 0737 3-(4-Methanesulfonyl-benzyl)-6-(3-bromo-phenyl)-prop-1-ynyl)-1-methyl-1H-quinolin-4-one; 0738 6-(4-Methanesulfanyl-phenyl)-prop-1-ynyl)-3-(4-carboxybenzyl)-1-methyl-1H-quinolin-4-one; 0739 3-(4-Methanesulfonyl-benzyl)-6-(4-methanesulfanyl-phenyl)-prop-1-ynyl)-1-methyl-1H-quinolin-4-one; 0740 6-(3-Methanesulfanyl-phenyl)-prop-1-ynyl)-3-(4-carboxybenzyl)-1-methyl-1H-quinolin-4-one; 0741 3-(4-Methanesulfonyl-benzyl)-6-(3-methanesulfanyl-phenyl)-prop-1-ynyl)-1-methyl-1H-quinolin-4-one; 0742 6-(4-Methyl-phenyl)-prop-1-ynyl)-3-(4-carboxybenzyl)-1-methyl-1H-quinolin-4-one; 0743 3-(4-Methanesulfonyl-benzyl)-6-(4-methyl-phenyl)-prop-1-ynyl)-1-methyl-1H-quinolin-4-one; 0744 6-(3-Methyl-phenyl)-prop-1-ynyl)-3-(4-carboxybenzyl)-1-methyl-1H-quinolin-4-one; 0745 3-(4-Methanesulfonyl-benzyl)-6-(3-methyl-phenyl)-prop-1-ynyl)-1-methyl-1H-quinolin-4-one; 0746 6-(3-Pyridin-4-yl-prop-1-ynyl)-3-(4-carboxybenzyl)-1-methyl-1H-quinolin-4-one; 0747 3-(4-Methanesulfonyl-benzyl)-6-(3-pyridin-4-yl-prop-1-ynyl)-1-methyl-1H-quinolin-4-one; 0748 6-(3-Pyridin-3-yl-prop-1-ynyl)-3-(4-carboxybenzyl)-1-methyl-1H-quinolin-4-one; 0749 3-(4-Methanesulfonyl-benzyl)-6-(3-pyridin-3-yl-prop-1-ynyl)-1-methyl-1H-quinolin-4-one; 0750 6-3-(2-Methoxy-pyridin-4-yl)-prop-1-ynyl-3-(4-carboxybenzyl)-1-methyl-1H-quinolin-4-one; 0751 3-(4-Methanesulfonyl-benzyl)-6-3-(2-methoxy-pyridin-4-yl)-prop-1-ynyl-1-methyl-1H-quinolin-4-one; 0752 1-Methyl-6-(4-methoxy-phenyl)-prop-1-ynyl)-3-(4-carboxybenzyl)-2,3-dihydro-1H-quinolin-4-one; 0753 3-(4-Methanesulfonyl-benzyl)-1-methyl-6-(4-methoxy-phenyl)-prop-1-ynyl)-2,3-dihydro-1H-quinolin-4-one; 0754 1-Methyl-6-(3-methoxy-phenyl)-prop-1-ynyl)-3-(4-carboxybenzyl)-2,3-dihydro-1H-quinolin-4-one; 0755 3-(4-Methanesulfonyl-benzyl)-1-methyl-6-(3-methoxy-phenyl)-prop-1-ynyl)-2,3-dihydro-1H-quinolin-4-one; 0756 6-(4-Cyano-phenyl)-prop-1-ynyl)-1-methyl-3-(4-carboxybenzyl)-2,3-dihydro-1H-quinolin-4-one; 0757 3-(4-Methanesulfonyl-benzyl)-6-(4-cyano-phenyl)-prop-1-ynyl)-1-methyl-2,3-dihydro-1H-quinolin-4-one; 0758 6-(3-Cyano-phenyl)-prop-1-ynyl)-3-(4-carboxybenzyl)-1-methyl-2,3-dihydro-1H-quinolin-4-one; 0759 4-(4-Methanesulfonyl-benzyl)-6-(3-cyano-phenyl)-prop-1-ynyl)-1-methyl-2,3-dihydro-1H-quinolin-4-one; 0760 6-(4-Fluoro-phenyl)-prop-1-ynyl)-3-(4-carboxybenzyl)-1-methyl-2,3-dihydro-1H-quinolin-4-one; 0761 3-(4-Methanesulfonyl-benzyl)-6-(4-fluoro-phenyl)-prop-1-ynyl)-1-methyl-2,3-dihydro-1H-quinolin-4-one; 0762 6-(3-Fluoro-phenyl)-prop-1-ynyl)-3-(4-carboxybenzyl)-1-methyl-2,3-dihydro-1H-quinolin-4-one; 0763 3-(4-Methanesulfonyl-benzyl)-6-(3-fluoro-phenyl)-prop-1-ynyl)-1-methyl-2,3-dihydro-1H-quinolin-4-one; 0764 6-(4-Chloro-phenyl)-prop-1-ynyl)-3-(4-carboxybenzyl)-1-methyl-2,3-dihydro-1H-quinolin-4-one; 0765 3-(4-Methanesulfonyl-benzyl)-6-(4-chloro-phenyl)-prop-1-ynyl)-1-methyl-2,3-dihydro-1H-quinolin-4-one; 0766 6-(3-Chloro-phenyl)-prop-1-ynyl)-3-(4-carboxybenzyl)-1-methyl-2,3-dihydro-1H-quinolin-4-one; 0767 3-(4-Methanesulfonyl-benzyl)-6-(3-chloro-phenyl)-prop-1-ynyl)-1-methyl-2,3-dihydro-1H-quinolin-4-one; 0768 6-(4-Bromo-phenyl)-prop-1-ynyl)-3-(4-carboxybenzyl)-1-methyl-2,3-dihydro-1H-quinolin-4-one; 0769 3-(4-Methanesulfonyl-benzyl)-6-(4-bromo-phenyl)-prop-1-ynyl)-1-methyl-2,3-dihydro-1H-quinolin-4-one; 0770 6-(3-Bromo-phenyl)-prop-1-ynyl)-3-(4-carboxybenzyl)-1-methyl-2,3-dihydro-1H-quinolin-4-one; 0771 3-(4-Methanesulfonyl-benzyl)-6-(3-bromo-phenyl)-prop-1-ynyl)-1-methyl-2,3-dihydro-1H-quinolin-4-one; 0772 6-(4-Methanesulfanyl-phenyl)-prop-1-ynyl)-3-(4-carboxybenzyl)-1-methyl-2,3-dihydro-1H-quinolin-4-one; 0773 3-(4-Methanesulfonyl-benzyl)-6-(4-methanesulfanyl-phenyl)-prop-1-ynyl)-1-methyl-2,3-dihydro-1H-quinolin-4-one; 0774 6-(3-Methanesulfanyl-phenyl)-prop-1-ynyl)-3-(4-carboxybenzyl)-1-methyl-2,3-dihydro-1H-quinolin-4-one; 0775 3-(4-Methanesulfonyl-benzyl)-6-(3-methanesulfanyl-phenyl)-prop-1-ynyl)-1-methyl-2,3-dihydro-1H-quinolin-4-one; 0776 6-(4-Methyl-phenyl)-prop-1-ynyl)-3-(4-carboxybenzyl)-1-methyl-2,3-dihydro-1H-quinolin-4-one; 0777 3-(4-Methanesulfonyl-benzyl)-6-(4-methyl-phenyl)-prop-1-ynyl)-1-methyl-2,3-dihydro-1H-quinolin-4-one; 0778 6-(3-Methyl-phenyl)-prop-1-ynyl)-3-(4-carboxybenzyl)-1-methyl-2,3-dihydro-1H-quinolin-4-one; 0779 3-(4-Methanesulfonyl-benzyl)-6-(3-methyl-phenyl)-prop-1-ynyl)-1-methyl-2,3-dihydro-1H-quinolin-4-one; 0780 6-(3-pyridin-4-yl-prop-1-ynyl)-3-(4-carboxybenzyl)-1-methyl-2,3-dihydro-1H-quinolin-4-one; 0781 3-(4-Methanesulfonyl-benzyl)-6-(3-pyridin-4-yl-prop-1-ynyl)-1-methyl-2,3-dihydro-1H-quinolin-4-one; 0782 6-(3-Pyridin-3-yl-prop-1-ynyl)-3-(4-carboxybenzyl)-1-methyl-2,3-dihydro-1H-quinolin-4-one; 0783 3-(4-Methanesulfonyl-benzyl)-6-(3-pyridin-3-yl-prop-1-ynyl)-1-methyl-2,3-dihydro-1H-quinolin-4-one; 0784 6-3-(2-Methoxy-pyridin-4-yl)-prop-1-ynyl-3-(4-carboxybenzyl)-1-methyl-2,3-dihydro-1H-quinolin-4-one; and 0785 3-(4-Methanesulfonyl-benzyl)-6-3-(2-methoxy-pyridin-4-yl)-prop-1-ynyl-1-methyl-2,3-dihydro-1H-quinolin-4-one; 0786 or a pharmaceutically acceptable salt thereof, or a tautomer thereof. 0787 39. The combination according to Embodiment 36, wherein the compound of Formula V is selected from: 0788 1-Methyl-6-(4-methoxy-phenyl)-prop-1-ynyl)-3-(4-carboxybenzyl)-1H-quinolin-4-one; 0789 3-(4-Methanesulfonyl-benzyl)-1-methyl-6-(4-methoxy-phenyl)-prop-1-ynyl)-1H-quinolin-4-one; 0790 1-Methyl-6-(3-methoxy-phenyl)-prop-1-ynyl)-3-(4-carboxybenzyl)-1H-quinolin-4-one; 0791 3-(4-Methanesulfonyl-benzyl)-1-methyl-6-(3-methoxy-phenyl)-prop-1-ynyl)-1H-quinolin-4-one; 0792 6-(4-Cyano-phenyl)-prop-1-ynyl)-1-methyl-3-(4-carboxybenzyl)-1H-quinolin-4-one; 0793 3-(4-Methanesulfonyl-benzyl)-6-(4-cyano-phenyl)-prop-1-ynyl)-1-methyl-1H-quinolin-4-one; 0794 6-(3-Cyano-phenyl)-prop-1-ynyl)-3-(4-carboxybenzyl)-1-methyl-1H-quinolin-4-one; 0795 4-(4-Methanesulfonyl-benzyl-6-(3-cyano-phenyl)-prop-1-ynyl)-1-methyl-1H-quinolin-4-one; 0796 6-(4-Fluoro-phenyl)-prop-1-ynyl)-3-(4-carboxybenzyl)-1-methyl-1H-quinolin-4-one; 0797 3-(4-Methanesulfonyl-benzyl)-6-(4-fluoro-phenyl)-prop-1-ynyl)-1-methyl-1H-quinolin-4-one; 0798 6-(3-Fluoro-phenyl)-prop-1-ynyl)-3-(4-carboxybenzyl)-1-methyl-1H-quinolin-4-one; 0799 3-(4-Methanesulfonyl-benzyl)-6-(3-fluoro-phenyl)-prop-1-ynyl)-1-methyl-1H-quinolin-4-one; 0800 6-(4-Chloro-phenyl)-prop-1-ynyl)-3-(4-carboxybenzyl)-1-methyl-1H-quinolin-4-one; 0801 3-(4-Methanesulfonyl-benzyl)-6-(4-chloro-phenyl)-prop-1-ynyl)-1-methyl-1H-quinolin-4-one; 0802 6-(3-Chloro-phenyl)-prop-1-ynyl)-3-(4-carboxybenzyl)-1-methyl-1H-quinolin-4-one; 0803 3-(4-Methanesulfonyl-benzyl)-6-(3-chloro-phenyl)-prop-1-ynyl)-1-methyl-1H-quinolin-4-one; 0804 6-(4-Bromo-phenyl)-prop-1-ynyl)-3-(4-carboxybenzyl)-1-methyl-1H-quinolin-4-one; 0805 3-(4-Methanesulfonyl-benzyl)-6-(4-bromo-phenyl)-prop-1-ynyl)-1-methyl-1H-quinolin-4-one; 0806 6-(3-Bromo-phenyl)-prop-1-ynyl)-3-(4-carboxybenzyl)-1-methyl-1H-quinolin-4-one; 0807 3-(4-Methanesulfonyl-benzyl)-6-(3-bromo-phenyl)-prop-1-ynyl)-1-methyl-1H-quinolin-4-one; 0808 6-(4-Methanesulfanyl-phenyl)-prop-1-ynyl)-3-(4-carboxybenzyl)-1-methyl-1H-quinolin-4-one; 0809 3-(4-Methanesulfonyl-benzyl)-6-(4-methanesulfanyl-phenyl)-prop-1-ynyl)-1-methyl-1H-quinolin-4-one; 0810 6-(3-Methanesulfanyl-phenyl)-prop-1-ynyl)-3-(4-carboxybenzyl)-1-methyl-1H-quinolin-4-one; 0811 3-(4-Methanesulfonyl-benzyl)-6-(3-methanesulfanyl-phenyl)-prop-1-ynyl)-1-methyl-1H-quinolin-4-one; 0812 6-(4-Methyl-phenyl)-prop-1-ynyl)-3-(4-carboxybenzyl)-1-methyl-1H-quinolin-4-one; 0813 3-(4-Methanesulfonyl-benzyl)-6-(4-methyl-phenyl)-prop-1-ynyl)-1-methyl-1H-quinolin-4-one; 0814 6-(3-Methyl-phenyl)-prop-1-ynyl)-3-(4-carboxybenzyl)-1-methyl-1H-quinolin-4-one; 0815 3-(4-Methanesulfonyl-benzyl)-6-(3-methyl-phenyl)-prop-1-ynyl)-1-methyl-1H-quinolin-4-one; 0816 6-(3-Pyridin-4-yl-prop-1-ynyl)-3-(4-carboxybenzyl)-1-methyl-1H-quinolin-4-one; 0817 3-(4-Methanesulfonyl-benzyl)-6-(3-pyridin-4-yl-prop-1-ynyl)-1-methyl-1H-quinolin-4-one; 0818 6-(3-Pyridin-3-yl-prop-1-ynyl)-3-(4-carboxybenzyl)-1-methyl-1H-quinolin-4-one; 0819 3-(4-Methanesulfonyl-benzyl)-6-(3-pyridin-3-yl-prop-1-ynyl)-1-methyl-1H-quinolin-4-one; 0820 6-3-(2-Methoxy-pyridin-4-yl)-prop-1-ynyl-3-(4-carboxybenzyl)-1-methyl-1H-quinolin-4-one; 0821 3-(4-Methanesulfonyl-benzyl)-6-3-(2-methoxy-pyridin-4-yl)-prop-1-ynyl-1-methyl-1H-quinolin-4-one; 0822 1-Methyl-6-(4-methoxy-phenyl)-prop-1-ynyl)-3-(4-carboxybenzyl)-2,3-dihydro-1H-quinolin-4-one; 0823 3-(4-Methanesulfonyl-benzyl)-1-methyl-6-(4-methoxy-phenyl)-prop-1-ynyl)-2,3-dihydro-1H-quinolin-4-one; 0824 1-Methyl-6-(3-methoxy-phenyl)-prop-1-ynyl)-3-(4-carboxybenzyl)-2,3-dihydro-1H-quinolin-4-one; 0825 3-(4-Methanesulfonyl-benzyl)-1-methyl-6-(3-methoxy-phenyl)-prop-1-ynyl)-2,3-dihydro-1H-quinolin-4-one; 0826 6-(4-Cyano-phenyl)-prop-1-ynyl)-1-methyl-3-(4-carboxybenzyl)-2,3-dihydro-1H-quinolin-4-one; 0827 3-(4-Methanesulfonyl-benzyl)-6-(4-cyano-phenyl)-prop-1-ynyl)-1-methyl-2,3-dihydro-1H-quinolin-4-one; 0828 6-(3-Cyano-phenyl)-prop-1-ynyl)-3-(4-carboxybenzyl)-1-methyl-2,3-dihydro-1H-quinolin-4-one; 0829 4-(4-Methanesulfonyl-benzyl)-6-(3-cyano-phenyl)-prop-1-ynyl)-1-methyl-2,3-dihydro-1H-quinolin-4-one; 0830 6-(4-Fluoro-phenyl)-prop-1-ynyl)-3-(4-carboxybenzyl)-1-methyl-2,3-dihydro-1H-quinolin-4-one; 0831 3-(4-Methanesulfonyl-benzyl)-6-(4-fluoro-phenyl)-prop-1-ynyl)-1-methyl-2,3-dihydro-1H-quinolin-4-one; 0832 6-(3-Fluoro-phenyl)-prop-1-ynyl)-3-(4-carboxybenzyl)-1-methyl-2,3-dihydro-1H-quinolin-4-one; 0833 3-(4-Methanesulfonyl-benzyl)-6-(3-fluoro-phenyl)-prop-1-ynyl)-1-methyl-2,3-dihydro-1H-quinolin-4-one; 0834 6-(4-Chloro-phenyl)-prop-1-ynyl)-3-(4-carboxybenzyl)-1-methyl-2,3-dihydro-1H-quinolin-4-one; 0835 3-(4-Methanesulfonyl-benzyl)-6-(4-chloro-phenyl)-prop-1-ynyl)-1-methyl-2,3-dihydro-1H-quinolin-4-one; 0836 6-(3-Chloro-phenyl)-prop-1-ynyl)-3-(4-carboxybenzyl)-1-methyl-2,3-dihydro-1H-quinolin-4-one; 0837 3-(4-Methanesulfonyl-benzyl)-6-(3-chloro-phenyl)-prop-1-ynyl)-1-methyl-2,3-dihydro-1H-quinolin-4-one; 0838 6-(4-Bromo-phenyl)-prop-1-ynyl)-3-(4-carboxybenzyl)-1-methyl-2,3-dihydro-1H-quinolin-4-one; 0839 3-(4-Methanesulfonyl-benzyl)-6-(4-bromo-phenyl)-prop-1-ynyl)-1-methyl-2,3-dihydro-1H-quinolin-4-one; 0840 6-(3-Bromo-phenyl)-prop-1-ynyl)-3-(4-carboxybenzyl)-1-methyl-2,3-dihydro-1H-quinolin-4-one; 0841 3-(4-Methanesulfonyl-benzyl)-6-(3-bromo-phenyl)-prop-1-ynyl)-1-methyl-2,3-dihydro-1H-quinolin-4-one; 0842 6-(4-Methanesulfanyl-phenyl)-prop-1-ynyl)-3-(4-carboxybenzyl)-1-methyl-2,3-dihydro-1H-quinolin-4-one; 0843 3-(4-Methanesulfonyl-benzyl)-6-(4-methanesulfanyl-phenyl)-prop-1-ynyl)-1-methyl-2,3-dihydro-1H-quinolin-4-one; 0844 6-(3-Methanesulfanyl-phenyl)-prop-1-ynyl)-3-(4-carboxybenzyl)-1-methyl-2,3-dihydro-1H-quinolin-4-one; 0845 3-(4-Methanesulfonyl-benzyl)-6-(3-methanesulfanyl-phenyl)-prop-1-ynyl)-1-methyl-2,3-dihydro-1H-quinolin-4-one; 0846 6-(4-Methyl-phenyl)-prop-1-ynyl)-3-(4-carboxybenzyl)-1-methyl-2,3-dihydro-1H-quinolin-4-one; 0847 3-(4-Methanesulfonyl-benzyl)-6-(4-methyl-phenyl)-prop-1-ynyl)-1-methyl-2,3-dihydro-1H-quinolin-4-one; 0848 6-(3-Methyl-phenyl)-prop-1-ynyl)-3-(4-carboxybenzyl)-1-methyl-2,3-dihydro-1H-quinolin-4-one; 0849 3-(4-Methanesulfonyl-benzyl)-6-(3-methyl-phenyl)-prop-1-ynyl)-1-methyl-2,3-dihydro-1H-quinolin-4-one; 0850 6-(3-pyridin-4-yl-prop-1-ynyl)-3-(4-carboxybenzyl)-1-methyl-2,3-dihydro-1H-quinolin-4-one; 0851 3-(4-Methanesulfonyl-benzyl)-6-(3-pyridin-4-yl-prop-1-ynyl)-1-methyl-2,3-dihydro-1H-quinolin-4-one; 0852 6-(3-Pyridin-3-yl-prop-1-ynyl)-3-(4-carboxybenzyl)-1-methyl-2,3-dihydro-1H-quinolin-4-one; 0853 3-(4-Methanesulfonyl-benzyl)-6-(3-pyridin-3-yl-prop-1-ynyl)-1-methyl-2,3-dihydro-1H-quinolin-4-one; 0854 6-3-(2-Methoxy-pyridin-4-yl)-prop-1-ynyl-3-(4-carboxybenzyl)-1-methyl-2,3-dihydro-1H-quinolin-4-one; and 0855 3-(4-Methanesulfonyl-benzyl)-6-3-(2-methoxy-pyridin-4-yl)-prop-1-ynyl-1-methyl-2,3-dihydro-1H-quinolin-4-one. 0856 40. The combination according to Embodiment 22, wherein the compound of Formula I is a compound of Formula VI 22

0857 or a pharmaceutically acceptable salt thereof, or a tautomer thereof, wherein: 0858 G1 and G2 independently are 23

0859 wherein 0860 E is independently O or S; 0861 A is OR1 or NR1R2; 0862 R1 and R2 independently are hydrogen, C1-C6 alkyl, C2-C6 alkenyl, C2-C6 alkynyl, (CH2)naryl, (CH2)ncycloalkyl, or (CH2)nheteroaryl, or R1 and R2 are taken together with the nitrogen atom to which they are attached to complete a 3- to 8-membered ring having carbon atoms, the nitrogen atom bearing R1 and R2, and 0 or 1 heteroatom selected from N(H), N(CH3), O, and S, and which ring is optionally unsubstituted or substituted with O, halo, or methyl, wherein n is an integer of from 0 to 6; or 0863 G1 and G2 independently are hydrogen, halo, C1-C6 alkyl, C2-C6 alkenyl, C2-C6 alkynyl, (CH2)mOH, (CH2)mOR3, (CH2)mcycloalkyl, (CH2)maryl, (CH2)msubstituted aryl, (CH2)mheteroaryl, (CH2)msubstituted heteroaryl, CH(OH)(CH2)maryl, CHOH(CH2)msubstituted aryl, CH(OH)(CH2)mheteroaryl, CH(OH)(CH2)msubstituted heteroaryl, (CO2)q(CH2)maryl, (CO2)q(CH2)msubstituted aryl, (CO2)q(CH2)mheteroaryl, (CO2)q(CH2)msubstituted heteroaryl, (CO2)q(CH2)mcarbocycle, (CO2)q(CH2)mheterocycle, (CO2)q(CH2)mNR3R4, (CH2)mC(O)R3, (CH2)mC(O)OR3, (CH2)mC(O)NR3R4, (CH2)mC(S)NR3R4, or (CH2)mC(NH)NR3R4; 0864 m is an integer of from 0 to 6; 0865 q is an integer of 0 or 1; 0866 R3 and R4 independently are hydrogen, C1-C6 alkyl, (CH2)maryl, or (CH2)mheteroaryl, or R3 and R4 are taken together with the nitrogen atom to which they are attached to complete a 3- to 7-membered ring having carbon atoms, the nitrogen atom bearing R3 and R4, and 0 or 1 heteroatoms selected from N(H), N(CH3), O, and S; 0867 Y is O or S: 0868 R5, R6, and R7 independently are hydrogen, halo, hydroxy, C1-C6 alkyl, C2-C6 alkenyl, C2-C6 alkynyl, C1-C6 alkoxy, NO2, CN, CF3, or NR9R10, wherein R9 and R10 independently are hydrogen, C1-C6 alkyl, C3-C7 cycloalkyl, phenyl, or benzyl, or R9 and R10 are taken together with the nitrogen atom to which they are attached to complete a 3- to 7-membered ring having carbon atoms, the nitrogen atom bearing R9 and R10, and 0 or 1 heteroatoms selected from N(H), N(CH3), O, and S; and 0869 X is S, (SO), S(O)2, O, N(R8), wherein R8 is as defined above, C(O), or CH2. 0870 41. The combination according to Embodiment 40, wherein: 0871 Y ix O; 0872 X is S; 0873 G1 and G2 independently are 0874 (CH2)maryl, wherein m is 1 and aryl is phenyl, 0875 (CH2)msubstituted aryl, wherein m is 1 and substituted aryl is 4-methoxyphenyl, 3-methoxyphenyl, 4-fluorophenyl, 3-fluorophenyl, 4-chlorophenyl, 3-chlorophenyl, 4-bromophenyl, 3-bromophenyl, 3,4-difluorophenyl, 3-fluoro-4-methoxyphenyl, 4-nitrophenyl, 3-nitrophenyl, 4-methylsulfanylphenyl, 3-methylsulfanylphenyl, 4-methylphenyl, 3-methylphenyl, 4-cyanophenyl, 3-cyanophenyl, 4-carboxyphenyl, 3-carboxyphenyl, 4-methanesulfonylphenyl, 3-methanesulfonylphenyl, 4-methoxycarbonyphenyl, or 3-methoxycarbonylphenyl, 0876 (CH2)mheteroaryl, wherein m is 1 and heteroaryl is pyridin-4-yl, pyridin-3-yl, or pyridin-2-yl, or 0877 (CH2)msubstituted heteroaryl, wherein m is 1 and substituted heteroaryl is 2-methoxypyridin-4-yl; and 0878 R5, R6, and R7 are hydrogen. 0879 42. The combination according to Embodiment 40, wherein the compound of Formula VI is selected from: 0880 2-(Phenyl)-prop-1-ynyl)-6-benzyl-4H-thiazolo3,2-apyridin-5-one; 0881 2-(4-Methoxy-phenyl)-prop-1-ynyl)-6-(4-carboxybenzyl)-4H-thiazolo3,2-apyridin-5-one; 0882 6-(4-Methanesulfonyl-benzyl)-2-(4-methoxy-phenyl)-prop-1-ynyl)-4H1-thiazolo3,2-apyridin-5-one; 0883 2-(3-Methoxy-phenyl)-prop-1-ynyl)-6-(4-carboxybenzyl)-4H-thiazolo3,2-apyridin-5-one; 0884 6-(4-Methanesulfonyl-benzyl)-2-(3-methoxy-phenyl)-prop-1-ynyl)-4H-thiazolo3,2-apyridin-5-one; 0885 2-(4-Cyano-phenyl)-prop-1-ynyl)-6-(4-carboxybenzyl)-4H-thiazolo3,2-apyridin-5-one; 0886 6-(4-Methanesulfonyl-benzyl)-2-(4-cyano-phenyl)-prop-1-ynyl)-4H-thiazolo3,2-apyridin-5-one; 0887 2-(3-Cyano-phenyl)-prop-1-ynyl)-6-(4-carboxybenzyl)-4H-thiazolo3,2-apyridin-5-one; 0888 6-(4-Methanesulfonyl-benzyl)-2-(3-cyano-phenyl)-prop-1-ynyl)-4H-thiazolo3,2-apyridin-5-one; 0889 2-(4-Fluoro-phenyl)-prop-1-ynyl)-6-(4-carboxybenzyl)-4H-thiazolo3,2-apyridin-5-one; 0890 6-(4-Methanesulfonyl-benzyl)-2-(4-fluoro-phenyl)-prop-1-ynyl)-4H-thiazolo3,2-apyridin-5-one; 0891 2-(3-Fluoro-phenyl)-prop-1-ynyl)-6-(4-carboxybenzyl)-4H-thiazolo3,2-apyridin-5-one; 0892 6-(4-Methanesulfonyl-benzyl)-2-(3-fluoro-phenyl)-prop-1-ynyl)-4H-thiazolo3,2-apyridin-5-one; 0893 2-(4-Chloro-phenyl)-prop-1-ynyl)-6-(4-carboxybenzyl)4H-thiazolo3,2-apyridin-5-one; 0894 6-(4-Methanesulfonyl-benzyl)-2-(4-chloro-phenyl)-prop-1-ynyl)-4H-thiazolo3,2-apyridin-5-one; 0895 2-(3-Chloro-phenyl)-prop-1-ynyl)-6-(4-carboxybenzyl)-4H-thiazolo3,2-apyridin-5-one; 0896 6-(4-Methanesulfonyl-benzyl)-2-(3-chloro-phenyl)-prop-1-ynyl)-4H-thiazolo3,2-apyridin-5-one; 0897 2-(4-Bromo-phenyl)-prop-1-ynyl)-6-(4-carboxybenzyl)-4H-thiazolo3,2-apyridin-5-one; 0898 6-(4-Methanesulfonyl-benzyl)-2-(4-bromo-phenyl)-prop-1-ynyl)-4H-thiazolo3,2-apyridin-5-one; 0899 2-(3-Bromo-phenyl)-prop-1-ynyl)-6-(4-carboxybenzyl)-4H-thiazolo3,2-apyridin-5-one; 0900 6-(4-Methanesulfonyl-benzyl)-2-(3-bromo-phenyl)-prop-1-ynyl)-4H-thiazolo3,2-apyridin-5-one; 0901 2-(4-Methanesulfanyl-phenyl)-prop-1-ynyl)-6-(4-carboxybenzyl)-4H-thiazolo3,2-apyridin-5-one; 0902 6-(4-Methanesulfonyl-benzyl)-2-(4-methanesulfanyl-phenyl)-prop-1-ynyl)-4H-thiazolo3,2-apyridin-5-one; 0903 2-(3-Methanesulfanyl-phenyl)-prop-1-ynyl)-6-(4-carboxybenzyl)-4H-thiazolo3,2-apyridin-5-one; 0904 6-(4-Methanesulfonyl-benzyl)-2-(3-methanesulfanyl-phenyl)-prop-1-ynyl)-4H-thiazolo3,2-apyridin-5-one; 0905 2-(4-Methyl-phenyl)-prop-1-ynyl)-6-(4-carboxybenzyl)-4H-thiazolo3,2-apyridin-5-one; 0906 6-(4-Methanesulfonyl-benzyl)-2-(4-methyl-phenyl)-prop-1-ynyl)-4H-thiazolo3,2-apyridin-5-one; 0907 2-(3-Methyl-phenyl)-prop-1-ynyl)-6-(4-carboxybenzyl)-4H-thiazolo3,2-apyridin-5-one; 0908 6-(4-Methanesulfonyl-benzyl)-2-(3-methyl-phenyl)-prop-1-ynyl)-4H-thiazolo3,2-apyridin-5-one; 0909 2-(3-Pyridin-4-yl-prop-1-ynyl)-6-(4-carboxybenzyl)-4H-thiazolo3,2-apyridin-5-one; 0910 6-(4-Methanesulfonyl-benzyl)-2-(3-pyridin-4-yl-prop-1-ynyl)-4H-thiazolo3,2-apyridin-5-one; 0911 2-(3-Pyridin-3-yl-prop-1-ynyl)-6-(4-carboxybenzyl)-4H-thiazolo3,2-apyridin-5-one; 0912 6-(4-Methanesulfonyl-benzyl)-2-(3-pyridin-3-yl-prop-1-ynyl)-4H-thiazolo3,2-apyridin-5-one; 0913 2-3-(2-Methoxy-pyridin-4-yl)-prop-1-ynyl-6-(4-carboxybenzyl)-4H-thiazolo3,2apyridin-5-one; and 0914 6-(4-Methanesulfonyl-benzyl)-2-3-(2-methoxy-pyridin-4-yl)-prop-1-ynyl-4H-thiazolo3,2-apyridin-5-one; 0915 or a pharmaceutically acceptable salt thereof, or a tautomer thereof. 0916 43. The combination according to Embodiment 40, wherein the compound of Formula VI is selected from: 0917 2-(Phenyl)-prop-1-ynyl)-6-benzyl-4H-thiazolo3,2-apyridin-5-one, 0918 2-(4-Methoxy-phenyl)-prop-1-ynyl)-6-(4-carboxybenzyl)-4H-thiazolo3,2-apyridin-5-one; 0919 6-(4-Methanesulfonyl-benzyl)-2-(4-methoxy-phenyl)-prop-1-ynyl)-4H-thiazolo3,2-apyridin-5-one; 0920 2-(3-Methoxy-phenyl)-prop-1-ynyl)-6-(4-carboxybenzyl)-4H-thiazolo3,2-apyridin-5-one; 0921 6-(4-Methanesulfonyl-benzyl)-2-(3-methoxy-phenyl)-prop-1-ynyl)-4H-thiazolo3,2-apyridin-5-one; 0922 2-(4-Cyano-phenyl)-prop-1-ynyl)-6-(4-carboxybenzyl)-4H-thiazolo3,2-apyridin-5-one; 0923 6-(4-Methanesulfonyl-benzyl)-2-(4-cyano-phenyl)-prop-1-ynyl)-4H-thiazolo3,2-apyridin-5-one; 0924 2-(3-Cyano-phenyl)-prop-1-ynyl)-6-(4-carboxybenzyl)-4H-thiazolo3,2-apyridin-5-one; 0925 6-(4-Methanesulfonyl-benzyl)-2-(3-cyano-phenyl)-prop-1-ynyl)-4H-thiazolo3,2-apyridin-5-one; 0926 2-(4-Fluoro-phenyl)-prop-1-ynyl)-6-(4-carboxybenzyl)-4H-thiazolo3,2-apyridin-5-one; 0927 6-(4-Methanesulfonyl-benzyl)-2-(4-fluoro-phenyl)-prop-1-ynyl)-4H-thiazolo3,2-apyridin-5-one; 0928 2-(3-Fluoro-phenyl)-prop-1-ynyl)-6-(4-carboxybenzyl)-4H-thiazolo3,2-apyridin-5-one; 0929 6-(4-Methanesulfonyl-benzyl)-2-(3-fluoro-phenyl)-prop-1-ynyl)-4H-thiazolo3,2-apyridin-5-one; 0930 2-(4-Chloro-phenyl)-prop-1-ynyl)-6-(4-carboxybenzyl)4H-thiazolo3,2-apyridin-5-one; 0931 6-(4-Methanesulfonyl-benzyl)-2-(4-chloro-phenyl)-prop-1-ynyl)-4H-thiazolo3,2-apyridin-5-one; 0932 2-(3-Chloro-phenyl)-prop-1-ynyl)-6-(4-carboxybenzyl)-4H-thiazolo3,2-apyridin-5-one; 0933 6-(4-Methanesulfonyl-benzyl)-2(3-chloro-phenyl)-prop-1-ynyl)-4H-thiazolo3,2-apyridin-5-one; 0934 2-(4-Bromo-phenyl)-prop-1-ynyl)-6-(4-carboxybenzyl)-4H-thiazolo3,2-apyridin-5-one; 0935 6-(4-Methanesulfonyl-benzyl)-2-(4-bromo-phenyl)-prop-1-ynyl)-4H-thiazolo3,2-apyridin-5-one; 0936 2-(3-Bromo-phenyl)-prop-1-ynyl)-6-(4-carboxybenzyl)-4H-thiazolo3,2-apyridin-5-one; 0937 6-(4-Methanesulfonyl-benzyl)-2-(3-bromo-phenyl)-prop-1-ynyl)-4H-thiazolo3,2-apyridin-5-one; 0938 2-(4-Methanesulfanyl-phenyl)-prop-1-ynyl)-6-(4-carboxybenzyl)-4H-thiazolo3,2-apyridin-5-one; 0939 6-(4-Methanesulfonyl-benzyl)-2-(4-methanesulfanyl-phenyl)-prop-1-ynyl)-4H-thiazolo3,2-apyridin-5-one; 0940 2-(3-Methanesulfanyl-phenyl)-prop-1-ynyl)-6-(4-carboxybenzyl)-4H-thiazolo3,2-apyridin-5-one; 0941 6-(4-Methanesulfonyl-benzyl)-2-(3-methanesulfanyl-phenyl)-prop-1-ynyl)-4H-thiazolo3,2-apyridin-5-one; 0942 2-(4-Methyl-phenyl)-prop-1-ynyl)-6-(4-carboxybenzyl)-4H-thiazolo3,2-apyridin-5-one; 0943 6-(4-Methanesulfonyl-benzyl)-2-(4-methyl-phenyl)-prop-1-ynyl)-4H-thiazolo3,2-apyridin-5-one; 0944 2-(3-Methyl-phenyl)-prop-1-ynyl)-6-(4-carboxybenzyl)-4H-thiazolo3,2-apyridin-5-one; 0945 6-(4-Methanesulfonyl-benzyl)-2-(3-methyl-phenyl)-prop-1-ynyl)-4H-thiazolo3,2-apyridin-5-one; 0946 2-(3-Pyridin-4-yl-prop-1-ynyl)-6-(4-carboxybenzyl)-4H-thiazolo3,2-apyridin-5-one; 0947 6-(4-Methanesulfonyl-benzyl)-2-(3-pyridin-4-yl-prop-1-ynyl)-4H-thiazolo3,2-apyridin-5-one; 0948 2-(3-Pyridin-3-yl-prop-1-ynyl)-6-(4-carboxybenzyl)-4H-thiazolo3,2-apyridin-5-one; 0949 6-(4-Methanesulfonyl-benzyl)-2-(3-pyridin-3-yl-prop-1-ynyl)-4H-thiazolo3,2-apyridin-5-one; 0950 2-3-(2-Methoxy-pyridin-4-yl)-prop-1-ynyl-6-(4-carboxybenzyl)-4H-thiazolo3,2-apyridin-5-one; and 0951 6-(4-Methanesulfonyl-benzyl)-2-3-(2-methoxy-pyridin-4-yl)-prop-1-ynyl-4H-thiazolo3,2-apyridin-5-one. 0952 44. The combination according to Embodiment 22, wherein the compound of Formula I is a compound of Formula VII 24

0953 or a pharmaceutically acceptable salt thereof, or a tautomer thereof, wherein: 0954 G1 and G2 independently are 25

0955 wherein 0956 E is independently O or S; 0957 A is OR1 or NR1R2; 0958 R1 and R2 independently are hydrogen, C1-C6 alkyl, C2-C6 alkenyl, C2-C6 alkynyl, (CH2)naryl, (CH2)ncycloalkyl, or (CH2)nheteroaryl, or R1 and R2 are taken together with the nitrogen atom to which they are attached to complete a 3- to 8-membered ring having carbon atoms, the nitrogen atom bearing R1 and R2, and 0 or 1 heteroatom selected from N(H), N(CH3), O, and S, and which ring is optionally unsubstituted or substituted with O, halo, or methyl, wherein n is an integer of from 0 to 6; or 0959 G1 and G2 independently are hydrogen, halo, C1-C6 alkyl, C2-C6 alkenyl, C2-C6 alkynyl, (CH2)mOH, (CH2)mOR3, (CH2)mcycloalkyl, (CH2)maryl, (CH2)msubstituted aryl, (CH2)mheteroaryl, (CH2)msubstituted heteroaryl, CH(OH)(CH2)maryl, CHOH(CH2)msubstituted aryl, CH(OH)(CH2)mheteroaryl, CH(OH)(CH2)msubstituted heteroaryl, (CO2)q(CH2)maryl, (CO2)q(CH2)msubstituted aryl, (CO2)q(CH2)mheteroaryl, (CO2)q(CH2)msubstituted heteroaryl, (CO2)q(CH2)mcarbocycle, (CO2)q(CH2)mheterocycle, (CO2)q(CH2)mNR3R4, (CH2)mC(O)R3, (CH2)mC(O)OR3, (CH2)mC(O)NR3R4, (CH2)mC(S)NR3R4, or (CH2)mC(NH)NR3R4; 0960 m is an integer of from 0 to 6; 0961 q is an integer of 0 or 1; 0962 R3 and R4 independently are hydrogen, C1-C6 alkyl, (CH2)maryl, or (CH2)mheteroaryl, or R3 and R4 are taken together with the nitrogen atom to which they are attached to complete a 3- to 7-membered ring having carbon atoms, the nitrogen atom bearing R3 and R4, and 0 or 1 heteroatoms selected from N(H), N(CH3), O, and S; 0963 Y is O or S: 0964 R5, R6, and R7 independently are hydrogen, halo, hydroxy, C1-C6 alkyl, C2-C6 alkenyl, C2-C6 alkynyl, C1-C6 alkoxy, NO2, CN, CF3, or NR9R10, wherein R9 and R10 independently are hydrogen, C1-C6 alkyl, C3-C7 cycloalkyl, phenyl, or benzyl, or R9 and R10 are taken together with the nitrogen atom to which they are attached to complete a 3- to 7-membered ring having carbon atoms, the nitrogen atom bearing R9 and R10, and 0 or 1 heteroatoms selected from N(H), N(CH3), O, and S; and 0965 X is S, (SO), S(O)2, O, N(R8), wherein R8 is as defined above, C(O), or CH2. 0966 45. The combination according to Embodiment 44, wherein: 0967 Y ix O; 0968 X is S; 0969 G1 and G2 independently are 0970 (CH2)maryl, wherein m is 1 and aryl is phenyl, 0971 (CH2)msubstituted aryl, wherein m is 1 and substituted aryl is 4-methoxyphenyl, 3-methoxyphenyl, 4-fluorophenyl, 3-fluorophenyl, 4-chlorophenyl, 3-chlorophenyl, 4-bromophenyl, 3-bromophenyl, 3,4-difluorophenyl, 3-fluoro-4-methoxyphenyl, 4-nitrophenyl, 3-nitrophenyl, 4-methylsulfanylphenyl, 3-methylsulfanylphenyl, 4-methylphenyl, 3-methylphenyl, 4-cyanophenyl, 3-cyanophenyl, 4-carboxyphenyl, 3-carboxyphenyl, 4-methanesulfonylphenyl, 3-methanesulfonylphenyl, 4-methoxycarbonyphenyl, or 3-methoxycarbonylphenyl, 0972 (CH2)mheteroaryl, wherein m is 1 and heteroaryl is pyridin-4-yl, pyridin-3-yl, or pyridin-2-yl, or 0973 (CH2)msubstituted heteroaryl, wherein m is 1 and substituted heteroaryl is 2-methoxypyridin-4-yl; and 0974 R5, R6, and R7 are hydrogen. 0975 46. The combination according to Embodiment 44, wherein the compound of Formula VII is selected from: 0976 2-(Phenyl-prop-1-ynyl)-5-(4-benzyl)-5H-thieno3,2-cpyridin-4-one; 0977 2-(4-Methoxy-phenyl)-prop-1-ynyl)-5-(4-carboxybenzyl)-5H-thieno3,2-cpyridin-4-one; 0978 5-(4-Methanesulfonyl-benzyl)-2-(4-methoxy-phenyl)-prop-1-ynyl)-5H-thieno3,2-cpyridin-4-one; 0979 2-(3-Methoxy-phenyl)-prop-1-ynyl)-5-(4-carboxybenzyl)-5H-thieno3,2-cpyridin-4-one; 0980 5-(4-Methanesulfonyl-benzyl)-2-(3-methoxy-phenyl)-prop-1-ynyl)-5H-thieno3,2-cpyridin-4-one; 0981 2-(4-Cyano-phenyl)-prop-1-ynyl)-5-(4-carboxybenzyl)-5H-thieno3,2-cpyridin-4-one; 0982 5-(4-Methanesulfonyl-benzyl)-2-(4-cyano-phenyl)-prop-1-ynyl)-5H-thieno3,2-cpyridin-4-one; 0983 2-(3-Cyano-phenyl)-prop-1-ynyl)-5-(4-carboxybenzyl)-5H-thieno3,2-cpyridin-4-one; 0984 5-(4-Methanesulfonyl-benzyl)-2-(3-cyano-phenyl)-prop-1-ynyl)-5H-thieno3,2-cpyridin-4-one; 0985 2-(4-Fluoro-phenyl)-prop-1-ynyl)-5-(4-carboxybenzyl)-5H-thieno3,2-cpyridin-4-one; 0986 5-(4-Methanesulfonyl-benzyl)-2-(4-fluoro-phenyl)-prop-1-ynyl)-5H-thieno3,2-cpyridin-4-one; 0987 2-(3-Fluoro-phenyl)-prop-1-ynyl)-5-(4-carboxybenzyl)-5H-thieno3,2-cpyridin-4-one; 0988 5-(4-Methanesulfonyl-benzyl)-2-(3-fluoro-phenyl)-prop-1-ynyl)-5H-thieno3,2-cpyridin-4-one; 0989 2-(4-Chloro-phenyl)-prop-1-ynyl)-5-(4-carboxybenzyl)5H-thieno3,2-cpyridin-4-one; 0990 5-(4-Methanesulfonyl-benzyl)-2-(4-chloro-phenyl)-prop-1-ynyl)-5H-thieno3,2-cpyridin-4-one; 0991 2-(3-Chloro-phenyl)-prop-1-ynyl)-5-(4-carboxybenzyl)-5H-thieno3,2-cpyridin-4-one; 0992 5-(4-Methanesulfonyl-benzyl)-2-(3-chloro-phenyl)-prop-1-ynyl)-5H-thieno3,2-cpyridin-4-one; 0993 2-(4-Bromo-phenyl)-prop-1-ynyl)-5-(4-carboxybenzyl)-5H-thieno3,2-cpyridin-4-one; 0994 5-(4-Methanesulfonyl-benzyl)-2-(4-bromo-phenyl)-prop-1-ynyl)-5H-thieno3,2-cpyridin-4-one; 0995 2-(3-Bromo-phenyl)-prop-1-ynyl)-5-(4-carboxybenzyl)-5H-thieno3,2-cpyridin-4-one; 0996 5-(4-Methanesulfonyl-benzyl)-2-(3-bromo-phenyl)-prop-1-ynyl)-5H-thieno3,2-cpyridin-4-one; 0997 2-(4-Methanesulfanyl-phenyl)-prop-1-ynyl)-5-(4-carboxybenzyl)-5H-thieno3,2-cpyridin-4-one; 0998 5-(4-Methanesulfonyl-benzyl)-2-(4-methanesulfanyl-phenyl)-prop-1-ynyl)-5H-thieno3,2-cpyridin-4-one; 0999 2-(3-Methanesulfanyl-phenyl)-prop-1-ynyl)-5-(4-carboxybenzyl)-5H-thieno3,2-cpyridin-4-one; 1000 5-(4-Methanesulfonyl-benzyl)-2-(3-methanesulfanyl-phenyl)-prop-1-ynyl)-5H-thieno3,2-cpyridin-4-one; 1001 2-(4-Methyl-phenyl)-prop-1-ynyl)-5-(4-carboxybenzyl)-5H-thieno3,2-cpyridin-4-one; 1002 5-(4-Methanesulfonyl-benzyl)-2-(4-methyl-phenyl)-prop-1-ynyl)-5H-thieno3,2-cpyridin-4-one; 1003 2-(3-Methyl-phenyl)-prop-1-ynyl)-5-(4-carboxybenzyl)-5H-thieno3,2-cpyridin-4-one; 1004 5-(4-Methanesulfonyl-benzyl)-2-(3-methyl-phenyl)-prop-1-ynyl)-5H-thieno3,2-cpyridin-4-one; 1005 2-(3-Pyridin-4-yl-prop-1-ynyl)-5-(4-carboxybenzyl)-5H-thieno3,2-cpyridin-4-one; 1006 5-(4-Methanesulfonyl-benzyl)-2-(3-pyridin-4-yl-prop-1-ynyl)-5H-thieno3,2-cpyridin-4-one; 1007 2-(3-Pyridin-3-yl-prop-1-ynyl)-5-(4-carboxybenzyl)-5H-thieno3,2-cpyridin-4-one; 1008 5-(4-Methanesulfonyl-benzyl)-2-(3-pyridin-3-yl-prop-1-ynyl)-5H-thieno3,2-cpyridin-4-one; 1009 2-3-(2-Methoxy-pyridin-4-yl)-prop-1-ynyl-5-(4-carboxybenzyl)-5H-thieno3,2-cpyridin-4-one; 1010 5-(4-Methanesulfonyl-benzyl)-2-3-(2-methoxy-pyridin-4-yl)-prop-1-ynyl-5H-thieno3,2-cpyridin-4-one; 1011 2-(Phenyl-prop-1-ynyl)-5-(4-benzyl)-7-methyl-5H-thieno3,2-cpyridin-4-one; 1012 2-(4-Methoxy-phenyl)-prop-1-ynyl)-5-(4-carboxybenzyl)-7-methyl-5H-thieno3,2-cpyridin-4-one; 1013 5-(4-Methanesulfonyl-benzyl)-2-(4-methoxy-phenyl)-prop-1-ynyl)-7-methyl-5H-thieno3,2-cpyridin-4-one; 1014 2-(3-Methoxy-phenyl)-prop-1-ynyl)-5-(4-carboxybenzyl)-7-methyl-5H-thieno3,2-cpyridin-4-one; 1015 5-(4-Methanesulfonyl-benzyl)-2-(3-methoxy-phenyl)-prop-1-ynyl)-7-methyl-5H-thieno3,2-cpyridin-4-one; 1016 2-(4-Cyano-phenyl)-prop-1-ynyl)-5-(4-carboxybenzyl)-7-methyl-5H-thieno3,2-cpyridin-4-one; 1017 5-(4-Methanesulfonyl-benzyl)-2-(4-cyano-phenyl)-prop-1-ynyl)-7-methyl-5H-thieno3,2-cpyridin-4-one; 1018 2-(3-Cyano-phenyl)-prop-1-ynyl)-5-(4-carboxybenzyl)-7-methyl-5H-thieno3,2-cpyridin-4-one; 1019 5-(4-Methanesulfonyl-benzyl)-2-(3-cyano-phenyl)-prop-1-ynyl)-7-methyl-5H-thieno3,2-cpyridin-4-one; 1020 2-(4-Fluoro-phenyl)-prop-1-ynyl)-5-(4-carboxybenzyl)-7-methyl-5H-thieno3,2-cpyridin-4-one; 1021 5-(4-Methanesulfonyl-benzyl)-2-(4-fluoro-phenyl)-prop-1-ynyl)-7-methyl-5H-thieno3,2-cpyridin-4-one; 1022 2-(3-Fluoro-phenyl)-prop-1-ynyl)-5-(4-carboxybenzyl)-7-methyl-5H-thieno3,2-cpyridin-4-one; 1023 5-(4-Methanesulfonyl-benzyl)-2-(3-fluoro-phenyl)-prop-1-ynyl)-7-methyl-5H-thieno3,2-cpyridin-4-one; 1024 2-(4-Chloro-phenyl)-prop-1-ynyl)-5-(4-carboxybenzyl)-7-methyl-5H-thieno3,2-cpyridin-4-one; 1025 5-(4-Methanesulfonyl-benzyl)-2-(4-chloro-phenyl)-prop-1-ynyl)-7-methyl-5H-thieno3,2-cpyridin-4-one; 1026 2-(3-Chloro-phenyl)-prop-1-ynyl)-5-(4-carboxybenzyl)-7-methyl-5H-thieno3,2-cpyridin-4-one; 1027 5-(4-Methanesulfonyl-benzyl)-2-(3-chloro-phenyl)-prop-1-ynyl)-7-methyl-5H-thieno3,2-cpyridin-4-one; 1028 2-(4-Bromo-phenyl)-prop-1-ynyl)-5-(4-carboxybenzyl)-7-methyl-5H-thieno3,2-cpyridin-4-one; 1029 5-(4-Methanesulfonyl-benzyl)-2-(4-bromo-phenyl)-prop-1-ynyl)-7-methyl-5H-thieno3,2-cpyridin-4-one; 1030 2-(3-Bromo-phenyl)-prop-1-ynyl)-5-(4-carboxybenzyl)-7-methyl-5H-thieno3,2-cpyridin-4-one; 1031 5-(4-Methanesulfonyl-benzyl)-2-(3-bromo-phenyl)-prop-1-ynyl)-7-methyl-5H-thieno3,2-cpyridin-4-one; 1032 2-(4-Methanesulfanyl-phenyl)-prop-1-ynyl)-7-methyl-5-(4-carboxybenzyl)-5H-thieno3,2-cpyridin-4-one; 1033 5-(4-Methanesulfonyl-benzyl)-2-(4-methanesulfanyl-phenyl)-prop-1-ynyl)-7-methyl-5H-thieno3,2-cpyridin-4-one; 1034 2-(3-Methanesulfanyl-phenyl)-prop-1-ynyl)-5-(4-carboxybenzyl)-7-methyl-5H-thieno3,2-cpyridin-4-one; 1035 5-(4-Methanesulfonyl-benzyl)-2-(3-methanesulfanyl-phenyl)-prop-1-ynyl)-7-methyl-5H-thieno3,2-cpyridin-4-one; 1036 2-(4-Methyl-phenyl)-prop-1-ynyl)-5-(4-carboxybenzyl)-7-methyl-5H-thieno3,2-cpyridin-4-one; 1037 5-(4-Methanesulfonyl-benzyl)-2-(4-methyl-phenyl)-prop-1-ynyl)-7-methyl-5H-thieno3,2-cpyridin-4-one; 1038 2-(3-Methyl-phenyl)-prop-1-ynyl)-5-(4-carboxybenzyl)-7-methyl-5H-thieno3,2-cpyridin-4-one; 1039 5-(4-Methanesulfonyl-benzyl)-2-(3-methyl-phenyl)-prop-1-ynyl)-7-methyl-5H-thieno3,2-cpyridin-4-one; 1040 2-(3-Pyridin-4-yl-prop-1-ynyl)-5-(4-carboxybenzyl)-7-methyl-5H-thieno3,2-cpyridin-4-one; 1041 5-(4-Methanesulfonyl-benzyl)-2-(3-pyridin-4-yl-prop-1-ynyl)-7-methyl-5H-thieno3,2-cpyridin-4-one; 1042 2-(3-Pyridin-3-yl-prop-1-ynyl)-5-(4-carboxybenzyl)-7-methyl-5H-thieno3,2-cpyridin-4-one; 1043 5-(4-Methanesulfonyl-benzyl)-2-(3-pyridin-3-yl-prop-1-ynyl)-7-methyl-5H-thieno3,2-cpyridin-4-one; 1044 2-3-(2-Methoxy-pyridin-4-yl)-prop-1-ynyl-5-(4-carboxybenzyl)-7-methyl-5H-thieno3,2-cpyridin-4-one; and 1045 5-(4-Methanesulfonyl-benzyl)-2-3-(2-methoxy-pyridin-4-yl)-prop-1-ynyl-7-methyl-5H-thieno3,2-cpyridin-4-one; 1046 or a pharmaceutically acceptable salt thereof, or a tautomer thereof. 1047 47. The combination according to Embodiment 44, wherein the compound of Formula VII is selected from: 1048 2-(Phenyl-prop-1-ynyl)-5-(4-benzyl)-5H-thieno3,2-cpyridin-4-one; 1049 2-(4-Methoxy-phenyl)-prop-1-ynyl)-5-(4-carboxybenzyl)-5H-thieno3,2-cpyridin-4-one; 1050 5-(4-Methanesulfonyl-benzyl)-2-(4-methoxy-phenyl)-prop-1-ynyl)-5H-thieno3,2-cpyridin-4-one; 1051 2-(3-Methoxy-phenyl)-prop-1-ynyl)-5-(4-carboxybenzyl)-5H-thieno3,2-cpyridin-4-one; 1052 5-(4-Methanesulfonyl-benzyl)-2-(3-methoxy-phenyl)-prop-1-ynyl)-5H-thieno3,2-cpyridin-4-one; 1053 2-(4-Cyano-phenyl)-prop-1-ynyl)-5-(4-carboxybenzyl)-5H-thieno3,2-cpyridin-4-one; 1054 5-(4-Methanesulfonyl-benzyl)-2-(4-cyano-phenyl)-prop-1-ynyl)-5H-thieno3,2-cpyridin-4-one; 1055 2-(3-Cyano-phenyl)-prop-1-ynyl)-5-(4-carboxybenzyl)-5H-thieno3,2-cpyridin-4-one; 1056 5-(4-Methanesulfonyl-benzyl)-2-(3-cyano-phenyl)-prop-1-ynyl)-5H-thieno3,2-cpyridin-4-one; 1057 2-(4-Fluoro-phenyl)-prop-1-ynyl)-5-(4-carboxybenzyl)-5H-thieno3,2-cpyridin-4-one; 1058 5-(4-Methanesulfonyl-benzyl)-2-(4-fluoro-phenyl)-prop-1-ynyl)-5H-thieno3,2-cpyridin-4-one; 1059 2-(3-Fluoro-phenyl)-prop-1-ynyl)-5-(4-carboxybenzyl)-5H-thieno3,2-cpyridin-4-one; 1060 5-(4-Methanesulfonyl-benzyl)-2-(3-fluoro-phenyl)-prop-1-ynyl)-5H-thieno3,2-cpyridin-4-one; 1061 2-(4-Chloro-phenyl)-prop-1-ynyl)-5-(4-carboxybenzyl)5H-thieno3,2-cpyridin-4-one; 1062 5-(4-Methanesulfonyl-benzyl)-2-(4-chloro-phenyl)-prop-1-ynyl)-5H-thieno3,2-cpyridin-4-one; 1063 2-(3-Chloro-phenyl)-prop-1-ynyl)-5-(4-carboxybenzyl)-5H-thieno3,2-cpyridin-4-one; 1064 5-(4-Methanesulfonyl-benzyl)-2-(3-chloro-phenyl)-prop-1-ynyl)-5H-thieno3,2-cpyridin-4-one; 1065 2-(4-Bromo-phenyl)-prop-1-ynyl)-5-(4-carboxybenzyl)-5H-thieno3,2-cpyridin-4-one; 1066 5-(4-Methanesulfonyl-benzyl)-2-(4-bromo-phenyl)-prop-1-ynyl)-5H-thieno3,2-cpyridin-4-one; 1067 2-(3-Bromo-phenyl)-prop-1-ynyl)-5-(4-carboxybenzyl)-5H-thieno3,2-cpyridin-4-one; 1068 5-(4-Methanesulfonyl-benzyl)-2-(3-bromo-phenyl)-prop-1-ynyl)-5H-thieno3,2-cpyridin-4-one; 1069 2-(4-Methanesulfanyl-phenyl)-prop-1-ynyl)-5-(4-carboxybenzyl)-5H-thieno3,2-cpyridin-4-one; 1070 5-(4-Methanesulfonyl-benzyl)-2-(4-methanesulfanyl-phenyl)-prop-1-ynyl)-5H-thieno3,2-cpyridin-4-one; 1071 2-(3-Methanesulfanyl-phenyl)-prop-1-ynyl)-5-(4-carboxybenzyl)-5H-thieno3,2-cpyridin-4-one; 1072 5-(4-Methanesulfonyl-benzyl)-2-(3-methanesulfanyl-phenyl)-prop-1-ynyl)-5H-thieno3,2-cpyridin-4-one; 1073 2-(4-Methyl-phenyl)-prop-1-ynyl)-5-(4-carboxybenzyl)-5H-thieno3,2-cpyridin-4-one; 1074 5-(4-Methanesulfonyl-benzyl)-2-(4-methyl-phenyl)-prop-1-ynyl)-5H-thieno3,2-cpyridin-4-one; 1075 2-(3-Methyl-phenyl)-prop-1-ynyl)-5-(4-carboxybenzyl)-5H-thieno3,2-cpyridin-4-one; 1076 5-(4-Methanesulfonyl-benzyl)-2-(3-methyl-phenyl)-prop-1-ynyl)-5H-thieno3,2-cpyridin-4-one; 1077 2-(3-Pyridin-4-yl-prop-1-ynyl)-5-(4-carboxybenzyl)-5H-thieno3,2-cpyridin-4-one; 1078 5-(4-Methanesulfonyl-benzyl)-2-(3-pyridin-4-yl-prop-1-ynyl)-5H-thieno3,2-cpyridin-4-one; 1079 2-(3-Pyridin-3-yl-prop-1-ynyl)-5-(4-carboxybenzyl)-5H-thieno3,2-cpyridin-4-one; 1080 5-(4-Methanesulfonyl-benzyl)-2-(3-pyridin-3-yl-prop-1-ynyl)-5H-thieno3,2-cpyridin-4-one; 1081 2-3-(2-Methoxy-pyridin-4-yl)-prop-1-ynyl-5-(4-carboxybenzyl)-5H-thieno3,2-cpyridin-4-one; 1082 5-(4-Methanesulfonyl-benzyl)-2-3-(2-methoxy-pyridin-4-yl)-prop-1-ynyl-5H-thieno3,2-cpyridin-4-one; 1083 2-(Phenyl-prop-1-ynyl)-5-(4-benzyl)-7-methyl-5H-thieno3,2-cpyridin-4-one; 1084 2-(4-Methoxy-phenyl)-prop-1-ynyl)-5-(4-carboxybenzyl)-7-methyl-5H-thieno3,2-cpyridin-4-one; 1085 5-(4-Methanesulfonyl-benzyl)-2-(4-methoxy-phenyl)-prop-1-ynyl)-7-methyl-5H-thieno3,2-cpyridin-4-one; 1086 2-(3-Methoxy-phenyl)-prop-1-ynyl)-5-(4-carboxybenzyl)-7-methyl-5H-thieno3,2-cpyridin-4-one; 1087 5-(4-Methanesulfonyl-benzyl)-2-(3-methoxy-phenyl)-prop-1-ynyl)-7-methyl-5H-thieno3,2-cpyridin-4-one; 1088 2-(4-Cyano-phenyl)-prop-1-ynyl)-5-(4-carboxybenzyl)-7-methyl-5H-thieno3,2-cpyridin-4-one; 1089 5-(4-Methanesulfonyl-benzyl)-2-(4-cyano-phenyl)-prop-1-ynyl)-7-methyl-5H-thieno3,2-cpyridin-4-one; 1090 2-(3-Cyano-phenyl)-prop-1-ynyl)-5-(4-carboxybenzyl)-7-methyl-5H-thieno3,2-cpyridin-4-one; 1091 5-(4-Methanesulfonyl-benzyl)-2-(3-cyano-phenyl)-prop-1-ynyl)-7-methyl-5H-thieno3,2-cpyridin-4-one; 1092 2-(4-Fluoro-phenyl)-prop-1-ynyl)-5-(4-carboxybenzyl)-7-methyl-5H-thieno3,2-cpyridin-4-one; 1093 5-(4-Methanesulfonyl-benzyl)-2-(4-fluoro-phenyl)-prop-1-ynyl)-7-methyl-5H-thieno3,2-cpyridin-4-one; 1094 2-(3-Fluoro-phenyl)-prop-1-ynyl)-5-(4-carboxybenzyl)-7-methyl-5H-thieno3,2-cpyridin-4-one; 1095 5-(4-Methanesulfonyl-benzyl)-2-(3-fluoro-phenyl)-prop-1-ynyl)-7-methyl-5H-thieno3,2-cpyridin-4-one; 1096 2-(4-Chloro-phenyl)-prop-1-ynyl)-5-(4-carboxybenzyl)-7-methyl-5H-thieno3,2-cpyridin-4-one; 1097 5-(4-Methanesulfonyl-benzyl)-2-(4-chloro-phenyl)-prop-1-ynyl)-7-methyl-5H-thieno3,2-cpyridin-4-one; 1098 2-(3-Chloro-phenyl)-prop-1-ynyl)-5-(4-carboxybenzyl)-7-methyl-5H-thieno3,2-cpyridin-4-one; 1099 5-(4-Methanesulfonyl-benzyl)-2-(3-chloro-phenyl)-prop-1-ynyl)-7-methyl-5H-thieno3,2-cpyridin-4-one; 1100 2-(4-Bromo-phenyl)-prop-1-ynyl)-5-(4-carboxybenzyl)-7-methyl-5H-thieno3,2-cpyridin-4-one; 1101 5-(4-Methanesulfonyl-benzyl)-2-(4-bromo-phenyl)-prop-1-ynyl)-7-methyl-5H-thieno3,2-cpyridin-4-one; 1102 2-(3-Bromo-phenyl)-prop-1-ynyl)-5-(4-carboxybenzyl)-7-methyl-5H-thieno3,2-cpyridin-4-one; 1103 5-(4-Methanesulfonyl-benzyl)-2-(3-bromo-phenyl)-prop-1-ynyl)-7-methyl-5H-thieno3,2-cpyridin-4-one; 1104 2-(4-Methanesulfanyl-phenyl)-prop-1-ynyl)-7-methyl-5-(4-carboxybenzyl)-5H-thieno3,2-cpyridin-4-one; 1105 5-(4-Methanesulfonyl-benzyl)-2-(4-methanesulfanyl-phenyl)-prop-1-ynyl)-7-methyl-5H-thieno3,2-cpyridin-4-one; 1106 2-(3-Methanesulfanyl-phenyl)-prop-1-ynyl)-5-(4-carboxybenzyl)-7-methyl-5H-thieno3,2-cpyridin-4-one; 1107 5-(4-Methanesulfonyl-benzyl)-2-(3-methanesulfanyl-phenyl)-prop-1-ynyl)-7-methyl-5H-thieno3,2-cpyridin-4-one; 1108 2-(4-Methyl-phenyl)-prop-1-ynyl)-5-(4-carboxybenzyl)-7-methyl-5H-thieno3,2-cpyridin-4-one; 1109 5-(4-Methanesulfonyl-benzyl)-2-(4-methyl-phenyl)-prop-1-ynyl)-7-methyl-5H-thieno3,2-cpyridin-4-one; 1110 2-(3-Methyl-phenyl)-prop-1-ynyl)-5-(4-carboxybenzyl)-7-methyl-5H-thieno3,2-cpyridin-4-one; 1111 5-(4-Methanesulfonyl-benzyl)-2-(3-methyl-phenyl)-prop-1-ynyl)-7-methyl-5H-thieno3,2-cpyridin-4-one; 1112 2-(3-Pyridin-4-yl-prop-1-ynyl)-5-(4-carboxybenzyl)-7-methyl-5H-thieno3,2-cpyridin-4-one; 1113 5-(4-Methanesulfonyl-benzyl)-2-(3-pyridin-4-yl-prop-1-ynyl)-7-methyl-5H-thieno3,2-cpyridin-4-one; 1114 2-(3-Pyridin-3-yl-prop-1-ynyl)-5-(4-carboxybenzyl)-7-methyl-5H-thieno3,2-cpyridin-4-one; 1115 5-(4-Methanesulfonyl-benzyl)-2-(3-pyridin-3-yl-prop-1-ynyl)-7-methyl-5H-thieno3,2-cpyridin-4-one; 1116 2-3-(2-Methoxy-pyridin-4-yl)-prop-1-ynyl-5-(4-carboxybenzyl)-7-methyl-5H-thieno3,2-cpyridin-4-one; and 1117 5-(4-Methanesulfonyl-benzyl)-2-3-(2-methoxy-pyridin-4-yl)-prop-1-ynyl-7-methyl-5H-thieno3,2-cpyridin-4-one. 1118 48. The combination according to Embodiment 22, wherein: 1119 B is 26

1120 wherein Y and R6 are as defined for Formula I in Embodiment 22. 1121 49. The combination according to Embodiment 48, wherein the compound of Formula I is selected from: 1122 4-2,4-dioxo-6-(3-phenyl-prop-1-ynyl)-1,4-dihydro-2H-214-benzod1,2thiazin-3-ylmethyl-benzoic acid; and 1123 4-2,2,4-trioxo-6-(3-phenyl-prop-1-ynyl)-1,4-dihydro-2H-216-benzod1,2thiazin-3-ylmethyl-benzoic acid; 1124 or a pharmaceutically acceptable salt thereof. 1125 50. The combination according to Embodiment 48, wherein the compound of Formula I is selected from: 1126 4-2,4-dioxo-6-(3-phenyl-prop-1-ynyl)-1,4-dihydro-2H-214-benzod1,2thiazin-3-ylmethyl-benzoic acid; and 1127 4-2,2,4-trioxo-6-(3-phenyl-prop-1-ynyl)-1,4-dihydro-2H-216-benzod1,2thiazin-3-ylmethyl-benzoic acid. 1128 51. The combination according to Embodiment 22, wherein: 1129 B is 27

1130 wherein Y and R6 are as defined for Formula I in Embodiment 22. 1131 52. The combination according to Embodiment 51, wherein the compound of Formula I is selected from: 1132 4-1,3-dioxo-7-(3-phenyl-prop-1-ynyl)-3,4-dihydro-1H-314-thia-2,6-diaza-naphthalen-2-ylmethyl-benzoic acid; and 1133 4-1,3,3-trioxo-7-(3-phenyl-prop-1-ynyl)-3,4-dihydro-1H-316-thia-2,6-diaza-naphthalen-2-ylmethyl-benzoic acid; 1134 or a pharmaceutically acceptable salt thereof. 1135 53. The combination according to Embodiment 51, wherein the compound of Formula I is selected from: 1136 4-1,3-dioxo-7-(3-phenyl-prop-1-ynyl)-3,4-dihydro-1H-314-thia-2,6-diaza-naphthalen-2-ylmethyl-benzoic acid; and 1137 4-1,3,3-trioxo-7-(3-phenyl-prop-1-ynyl)-3,4-dihydro-1H-316-thia-2,6-diaza-naphthalen-2-ylmethyl-benzoic acid. 1138 54. The combination according to Embodiment 22, wherein: 1139 B is 28

1140 wherein Y is as defined for Formula I in Embodiment 22. 1141 55. The combination according to Embodiment 54, wherein the compound of Formula I is selected from: 1142 4-2,4-dioxo-6-(3-phenyl-prop-1-ynyl)-4H-214-benzoe1,2,3oxathiazin-3-ylmethyl-benzoic acid; and 1143 4-2,2,4-trioxo-6-(3-phenyl-prop-1-ynyl)-4H-216-benzoe1,2,3oxathiazin-3-ylmethyl-benzoic acid; 1144 or a pharmaceutically acceptable salt thereof. 1145 56. The combination according to Embodiment 54, wherein the compound of Formula I is selected from: 1146 4-2,4-dioxo-6-(3-phenyl-prop-1-ynyl)-4H-214-benzo e1,2,3oxathiazin-3-ylmethyl-benzoic acid; and 1147 4-2,2,4-trioxo-6-(3-phenyl-prop-1-ynyl)-4H-216-benzoe1,2,3oxathiazin-3-ylmethyl-benzoic acid. 1148 57. The combination according to Embodiment 22, wherein: 1149 B is 29

1150 wherein Y is as defined for Formula I in Embodiment 22. 1151 58. The combination according to Embodiment 57, wherein the compound of Formula I is selected from: 1152 4-2,4-dioxo-6-(3-phenyl-prop-1-ynyl)-4H-1-oxa-214-thia-3,7-diaza-naphthalen-3-ylmethyl-benzoic acid; and 1153 4-2,2,4-trioxo-6-(3-phenyl-prop-1-ynyl)-4H-1-oxa-216-thia-3,7-diaza-naphthalen-3-ylmethyl-benzoic acid; 1154 or a pharmaceutically acceptable salt thereof. 1155 59. The combination according to Embodiment 57, wherein the compound of Formula I is selected from: 1156 4-2,4-dioxo-6-(3-phenyl-prop-1-ynyl)-4H-1-oxa-214-thia-3,7-diaza-naphthalen-3-ylmethyl-benzoic acid; and 1157 4-2,2,4-trioxo-6-(3-phenyl-prop-1-ynyl)-4H-1-oxa-216-thia-3,7-diaza-naphthalen-3-ylmethyl-benzoic acid. 1158 60. The combination according to Embodiment 22, wherein 1159 B is 30

1160 wherein Y and R8 are as defined for Formula I in Embodiment 22. 1161 61. The combination according to Embodiment 60, wherein the compound of Formula I is selected from: 1162 4-1-methyl-2,4-dioxo-6-(3-phenyl-prop-1-ynyl)-1,4-dihydro-2H-214-benzo1,2,6thiadiazin-3-ylmethyl-benzoic acid; 1163 4-2,4-dioxo-6-(3-phenyl-prop-1-ynyl)-1,4-dihydro-2H-214-benzo1,2,6thiadiazin-3-ylmethyl-benzoic acid; and 1164 4-1-methyl-2,2,4-trioxo-6-(3-phenyl-prop-1-ynyl)-1,4-dihydro-2H-216-benzo1,2,6thiadiazin-3-ylmethyl-benzoic acid; 1165 or a pharmaceutically acceptable salt thereof. 1166 62. The combination according to Embodiment 60, wherein the compound of Formula I is selected from: 1167 4-1-methyl-2,4-dioxo-6-(3-phenyl-prop-1-ynyl)-1,4-dihydro-2H-214-benzo1,2,6thiadiazin-3-ylmethyl-benzoic acid; 1168 4-2,4-dioxo-6-(3-phenyl-prop-1-ynyl)-1,4-dihydro-2H-214-benzo1,2,6thiadiazin-3-ylmethyl-benzoic acid; and 1169 4-1-methyl-2,2,4-trioxo-6-(3-phenyl-prop-1-ynyl)-1,4-dihydro-2H-216-benzo1,2,6thiadiazin-3-ylmethyl-benzoic acid. 1170 63. The combination according to Embodiment 22, wherein 1171 B is 31

1172 wherein Y and R8 are as defined for Formula I in Embodiment 22. 1173 64. The combination according to claim 63, wherein the compound of Formula I is selected from: 1174 3-1-methyl-2,4-dioxo-6-(3-phenyl-prop-1-ynyl)-1,4-dihydro-2H-214-pyrido3,4-c1,2,6thiadiazin-3-ylmethyl-benzoic acid; 1175 3-2,4-dioxo-6-(3-phenyl-prop-1-ynyl)-1,4-dihydro-2H-214-pyrido3,4-c1,2,6thiadiazin-3-ylmethyl-benzoic acid; and 1176 3-1-methyl-2,2,4-trioxo-6-(3-phenyl-prop-1-ynyl)-1,4-dihydro-2H-216-pyrido3,4-c1,2,6thiadiazin-3-ylmethyl-benzoic acid; 1177 or a pharmaceutically acceptable salt thereof. 1178 65. The combination according to claim 63, wherein the compound of Formula I is selected from: 1179 3-1-methyl-2,4-dioxo-6-(3-phenyl-prop-1-ynyl)-1,4-dihydro-2H-214-pyrido3,4-c1,2,6thiadiazin-3-ylmethyl-benzoic acid; 1180 3-2,4-dioxo-6-(3-phenyl-prop-1-ynyl)-1,4-dihydro-2H-214-pyrido3,4-c1,2,6thiadiazin-3-ylmethyl-benzoic acid; and 1181 3-1-methyl-2,2,4-trioxo-6-(3-phenyl-prop-1-ynyl)-1,4-dihydro-2H-216-pyrido3,4-c1,2,6thiadiazin-3-ylmethyl-benzoic acid. 1182 66. The combination according to claim 22, wherein 1183 B is 32

1184 wherein , R6 and R7 are as defined for Formula I in Embodiment 22. 1185 67. The combination according to Embodiment 66, wherein the compound of Formula I is selected from: 1186 4-1-oxo-7-(3-phenyl-prop-1-ynyl)-1H-114-benzoe1,2thiazin-2-ylmethyl-benzoic acid; and 1187 4-1,1-dioxo-7-(3-phenyl-prop-1-ynyl)-1H-116-benzoe1,2thiazin-2-ylmethyl-benzoic acid; 1188 or a pharmaceutically acceptable salt thereof. 1189 68. The combination according to Embodiment 66, wherein the compound of Formula I is selected from: 1190 4-1-oxo-7-(3-phenyl-prop-1-ynyl)-1H-114-benzoe1,2thiazin-2-ylmethyl-benzoic acid; and 1191 4-1,1-dioxo-7-(3-phenyl-prop-1-ynyl)-1H-116-benzoe1,2thiazin-2-ylmethyl-benzoic acid. 1192 69. The combination according to claim 22, wherein: 1193 B is 33

1194 wherein , R6 and R7 are as defined for Formula I in Embodiment 22. 1195 70. The combination according to Embodiment 69, wherein the compound of Formula I is selected from: 1196 4-1-oxo-7-(3-phenyl-prop-1-ynyl)-1H-114-thia-2,6-diaza-naphthalen-2-ylmethyl-benzoic acid; and 1197 4-1,1-dioxo-7-(3-phenyl-prop-1-ynyl)-1H-116-thia-2,6-diaza-naphthalen-2-ylmethyl-benzoic acid; or a pharmaceutically acceptable salt thereof. 1198 71. The combination according to Embodiment 69, wherein the compound of Formula I is selected from: 1199 4-1-oxo-7-(3-phenyl-prop-1-ynyl)-1H-114-thia-2,6-diaza-naphthalen-2-ylmethyl-benzoic acid; and 1200 4-1,1-dioxo-7-(3-phenyl-prop-1-ynyl)-1H-116-thia-2,6-diaza-naphthalen-2-ylmethyl-benzoic acid. 1201 72. The combination according to Embodiment 22, wherein 1202 B is 34

1203 wherein R8 is as defined for Formula I in Embodiment 22. 1204 73. The combination according to Embodiment 72, wherein the compound of Formula I is selected from: 1205 4-4-methyl-1,3-dioxo-7-(3-phenyl-prop-1-ynyl)-3,4-dihydro-1H-114-thia-2,4,6-triaza-naphthalen-2-ylmethyl-benzoic acid; 1206 4-1,3-dioxo-7-(3-phenyl-prop-1-ynyl)-3,4-dihydro-1H-114-thia-2,4,6-triaza-naphthalen-2-ylmethyl-benzoic acid; and 1207 4-4-methyl-1,1,3-trioxo-7-(3-phenyl-prop-1-ynyl)-3,4-dihydro-1H-116-thia-2,4,6-triaza-naphthalen-2-ylmethyl-benzoic acid; 1208 or a pharmaceutically acceptable salt thereof. 1209 74. The combination according to Embodiment 72, wherein the compound of Formula I is selected from: 1210 4-4-methyl-1,3-dioxo-7-(3-phenyl-prop-1-ynyl)-3,4-dihydro-1H-114-thia-2,4,6-triaza-naphthalen-2-ylmethyl-benzoic acid; 1211 4-1,3-dioxo-7-(3-phenyl-prop-1-ynyl)-3,4-dihydro-1H-114-thia-2,4,6-triaza-naphthalen-2-ylmethyl-benzoic acid; and 1212 4-4-methyl-1,1,3-trioxo-7-(3-phenyl-prop-1-ynyl)-3,4-dihydro-1H-116-thia-2,4,6-triaza-naphthalen-2-ylmethyl-benzoic acid. 1213 75. The combination according to Embodiment 22, wherein: 1214 B is 35

1215 wherein X and R8 are as defined for Formula I in Embodiment 22. 1216 76. The combination according to Embodiment 75, wherein the compound of Formula I is selected from: 1217 4-4-methyl-1,3-dioxo-6-(3-phenyl-prop-1-ynyl)3,4-dihydro-114-thieno2,3-e1,2,4thiadiazin-2-ylmethyl-benzoic acid; 1218 4-1,3-dioxo-6-(3-phenyl-prop-1-ynyl)3,4-dihydro-1H-114-thieno2,3-e1,2,4thiadiazin-2-ylmethyl-benzoic acid; 1219 4-4-methyl-1,1,3-trioxo-6-(3-phenyl-prop-1-ynyl)3,4-dihydro-1H-116-thieno2,3-e1,2,4thiadiazin-2-ylmethyl-benzoic acid; and 1220 4-1,1,3-trioxo-6-(3-phenyl-prop-1-ynyl)3,4-dihydro-1H-116-thieno2,3-e1,2,4thiadiazin-2-ylmethyl-benzoic acid; or a pharmaceutically acceptable salt thereof. 1221 77. The combination according to Embodiment 75, wherein the compound of Formula I is selected from: 1222 4-4-methyl-1,3-dioxo-6-(3-phenyl-prop-1-ynyl)3,4-dihydro-1H-114-thieno2,3-e1,2,4thiadiazin-2-ylmethyl-benzoic acid; 1223 4-1,3-dioxo-6-(3-phenyl-prop-1-ynyl)3,4-dihydro-1H-114-thieno2,3-e1,2,4thiadiazin-2-ylmethyl-benzoic acid; 1224 4-4-methyl-1,1,3-trioxo-6-(3-phenyl-prop-1-ynyl)3,4-dihydro-1H-116-thieno2,3-e1,2,4thiadiazin-2-ylmethyl-benzoic acid; and 1225 4-1,1,3-trioxo-6-(3-phenyl-prop-1-ynyl)3,4-dihydro-1H-116-thieno2,3-e1,2,4thiadiazin-2-ylmethyl-benzoic acid. 1226 78. The combination according to Embodiment 22, wherein 1227 B is 36

1228 wherein , X, R6, and R7 are as defined for Formula I in Embodiment 22. 1229 79. The combination according to Embodiment 78, wherein the compound of Formula I is selected from: 1230 4-1-oxo-6-(3-phenyl-prop-1-ynyl)-1H-114-thieno2,3-e1,2thiazin-2-ylmethyl-benzoic acid; and 1231 4-1,1-dioxo-6-(3-phenyl-prop-1-ynyl)-1H-116-thieno2,3-e1,2thiazin-2-ylmethyl-benzoic acid; 1232 or a pharmaceutically acceptable salt thereof. 1233 80. The combination according to Embodiment 78, wherein the compound of Formula I is selected from: 1234 4-1-oxo-6-(3-phenyl-prop-1-ynyl)-1H-114-thieno2,3-e1,2thiazin-2-ylmethyl-benzoic acid; and 1235 4-1,1-dioxo-6-(3-phenyl-prop-1-ynyl)-1H-116-thieno2,3-e1,2thiazin-2-ylmethyl-benzoic acid. 1236 81. The combination according to Embodiment 22, wherein 1237 B is 37

1238 wherein X and R7 are as defined for Formula I in Embodiment 22. 1239 82. The combination according to Embodiment 81, wherein the compound of Formula I is selected from: 1240 4-1,3-dioxo-6-(3-phenyl-prop-1-ynyl)-3,4-dihydro-1H-114-thieno2,3-e1,2thiazin-2-ylmethyl-benzoic acid; and 1241 4-1,1,3-trioxo-6-(3-phenyl-prop-1-ynyl)-3,4-dihydro-1H-116-thieno2,3-e1,2thiazin-2-ylmethyl-benzoic acid; or a pharmaceutically acceptable salt thereof. 1242 83. The combination according to Embodiment 81, wherein the compound of Formula I is selected from: 1243 4-1,3-dioxo-6-(3-phenyl-prop-1-ynyl)-3,4-dihydro-1H-114-thieno2,3-e1,2thiazin-2-ylmethyl-benzoic acid; and 1244 4-1,1,3-trioxo-6-(3-phenyl-prop-1-ynyl)-3,4-dihydro-1H-116-thieno2,3-e1,2thiazin-2-ylmethyl-benzoic acid. 1245 84. The combination according to Embodiment 22, wherein: 1246 B is 38

1247 wherein X, Y, and R7 are as defined for Formula I in Embodiment 22. 1248 85. The combination according to Embodiment 84, wherein the compound of Formula I is named 1249 4-4,6-dioxo-2-(3-phenyl-prop-1-ynyl)-6,7-dihydro-4H-thieno3,2-cpyridin-5-ylmethyl-benzoic acid; 1250 or a pharmaceutically acceptable salt thereof. 1251 86. The combination according to Embodiment 84, wherein the compound of Formula I is named 1252 4-4,6-dioxo-2-(3-phenyl-prop-1-ynyl)-6,7-dihydro-4H-thieno3,2-cpyridin-5-ylmethyl-benzoic acid. 1253 87. The combination according to Embodiment 22, wherein 1254 B is 39

1255 wherein , X, Y, R6, and R7 are as defined for Formula I in Embodiment 22. 1256 88. The combination according to Embodiment 87, wherein the compound of Formula I is named: 1257 4-4-oxo-2-(3-phenyl-prop-1-ynyl)-4H-thieno3,2-cpyridin-5-ylmethyl-benzoic acid; 1258 or a pharmaceutically acceptable salt thereof. 1259 89. The combination according to Embodiment 87, wherein the compound of Formula I is named: 1260 4-4-oxo-2-(3-phenyl-prop-1-ynyl)-4H-thieno3,2-cpyridin-5-ylmethyl-benzoic acid. 1261 90. The combination according to Embodiment 22, wherein 1262 B is 40

1263 wherein , X, R6, and R7 are as defined for Formula I in Embodiment 22. 1264 91. The combination according to Embodiment 90, wherein the compound of Formula I is selected from: 1265 4-4-oxo-2-(3-phenyl-prop-1-ynyl)-4H-1,414-dithia-3,5-diaza-inden-5-ylmethyl-benzoic acid; and 1266 4-4,4-dioxo-2-(3-phenyl-prop-1-ynyl)-4H-1,416-dithia-3,5-diaza-inden-5-ylmethyl-benzoic acid; 1267 or a pharmaceutically acceptable salt thereof. 1268 92. The combination according to Embodiment 90, wherein the compound of Formula I is selected from: 1269 4-4-oxo-2-(3-phenyl-prop-1-ynyl)-4H-1,414-dithia-3,5-diaza-inden-5-ylmethyl-benzoic acid; and 1270 4-4,4-dioxo-2-(3-phenyl-prop-1-ynyl)-4H-1,416-dithia-3,5-diaza-inden-5-ylmethyl-benzoic acid. 1271 93. The combination according to Embodiment 22, wherein 1272 B is 41

1273 wherein X and R7 are as defined for Formula I in Embodiment 22. 1274 94. The combination according to Embodiment 93, wherein the compound of Formula I is selected from: 1275 4-4,6-dioxo-2-(3-phenyl-prop-1-ynyl)-6,7-dihydro-4H-1,414-dithia-3,5-diaza-inden-5-ylmethyl-benzoic acid; and 1276 4-4,4,6-trioxo-2-(3-phenyl-prop-1-ynyl)-6,7-dihydro-4H-1,416-dithia-3,5-diaza-inden-5-ylmethyl-benzoic acid; 1277 or a pharmaceutically acceptable salt thereof. 1278 95. The combination according to Embodiment 93, wherein the compound of Formula I is selected from: 1279 4-4,6-dioxo-2-(3-phenyl-prop-1-ynyl)-6,7-dihydro-4H-1,414-dithia-3,5-diaza-inden-5-ylmethyl-benzoic acid; and 1280 4-4,4,6-trioxo-2-(3-phenyl-prop-1-ynyl)-6,7-dihydro-4H-1,416-dithia-3,5-diaza-inden-5-ylmethyl-benzoic acid. 1281 96. The combination according to Embodiment 22, wherein 1282 B is 42

1283 wherein X, Y, and R7 are as defined for Formula I in Embodiment 22. 1284 97. The combination according to Embodiment 96, wherein the compound of Formula I is named: 1285 4-4,6-dioxo-2-(3-phenyl-prop-1-ynyl)-6,7-dihydro-4H-thiazolo4,5-cpyridin-5-ylmethyl-benzoic acid; or a pharmaceutically acceptable salt thereof. 1286 98. The combination according to Embodiment 96, wherein the compound of Formula I is named: 1287 4-4,6-dioxo-2-(3-phenyl-prop-1-ynyl)-6,7-dihydro-4H-thiazolo4,5-cpyridin-5-ylmethyl-benzoic acid. 1288 99. The combination according to Embodiment 22, wherein 1289 B is 43

1290 wherein X and R8 are as defined for Formula I in Embodiment 22. 1291 100. The combination according to Embodiment 99, wherein the compound of Formula I is selected from: 1292 4-7-methyl-4,6-dioxo-2-(3-phenyl-prop-1-ynyl)-6,7-dihydro-4H-1,414-dithia-3,5,7-triaza-inden-5-ylmethyl-benzoic acid; 1293 4-4,6-dioxo-2-(3-phenyl-prop-1-ynyl)-6,7-dihydro-4H-1,414-dithia-3,5,7-triaza-inden-5-ylmethyl-benzoic acid; 1294 4-7-methyl-4,4,6-trioxo-2-(3-phenyl-prop-1-ynyl)-6,7-dihydro-4H-1,416-dithia-3,5,7-triaza-inden-5-ylmethyl-benzoic acid; and 1295 4-4,4,6-trioxo-2-(3-phenyl-prop-1-ynyl)-6,7-dihydro-4H-1,416-dithia-3,5,7-triaza-inden-5-ylmethyl-benzoic acid; 1296 or a pharmaceutically acceptable salt thereof. 1297 101. The combination according to Embodiment 99, wherein the compound of Formula I is selected from: 1298 4-7-methyl-4,6-dioxo-2-(3-phenyl-prop-1-ynyl)-6,7-dihydro-hH-1,414-dithia-3,5,7-triaza-inden-5-ylmethyl-benzoic acid; 1299 4-4,6-dioxo-2-(3-phenyl-prop-1-ynyl)-6,7-dihydro-hH-1,414-dithia-3,5,7-triaza-inden-5-ylmethyl-benzoic acid; 1300 4-7-methyl-4,4,6-trioxo-2-(3-phenyl-prop-1-ynyl)-6,7-dihydro-hH-1,416-dithia-3,5,7-triaza-inden-5-ylmethyl-benzoic acid; and 1301 4-4,4,6-trioxo-2-(3-phenyl-prop-1-ynyl)-6,7-dihydro-hH-1,416-dithia-3,5,7-triaza-inden-5-ylmethyl-benzoic acid. 1302 102. The combination according to Embodiment 22, wherein 1303 B is 44

1304 wherein , X, Y, R6, and R7 are as defined for Formula I in Embodiment 22. 1305 103. The combination according to Embodiment 102, wherein the compound of Formula I is named: 1306 4-4-oxo-2-(3-phenyl-prop-1-ynyl)-4H-thiazolo4,5-cpyridin-5-ylmethyl-benzoic acid; 1307 or a pharmaceutically acceptable salt thereof. 1308 104. The combination according to Embodiment 102, wherein the compound of Formula I is named: 1309 4-4-oxo-2-(3-phenyl-prop-1-ynyl)-4H-thiazolo4,5-cpyridin-5-ylmethyl-benzoic acid. 1310 105. A pharmaceutical composition, comprising a combination of valdecoxib, or a pharmaceutically acceptable salt thereof, and an allosteric alkyne inhibitor of MMP-13, or a pharmaceutically acceptable salt thereof, and a pharmaceutically acceptable carrier, diluent, or excipient. 1311 106. The pharmaceutical composition according to Embodiment 105, wherein the combination is the combination according to any one of Embodiments 1 to 104. 1312 107. The pharmaceutical composition according to Embodiment 105 or 106, wherein valdecoxib, or the pharmaceutically acceptable salt thereof, is in unit dosage form in an amount of from 1 milligram to 500 milligrams, and the allosteric alkyne inhibitor of MMP-13, or a pharmaceutically acceptable salt thereof, is in unit dosage form in an amount of from 10 milligrams to 600 milligrams. 1313 108. The pharmaceutical composition according to Embodiment 107, wherein valdecoxib, or the pharmaceutically acceptable salt thereof, is in unit dosage form in an amount of from 2 milligrams to 250 milligrams, and the allosteric alkyne inhibitor of MMP-13, or a pharmaceutically acceptable salt thereof, is in unit dosage form in an amount of from 10 milligrams to 300 milligrams. 1314 109. The pharmaceutical composition according to Embodiment 108, wherein valdecoxib, or the pharmaceutically acceptable salt thereof, is in unit dosage form in an amount of from 5 milligrams to 200 milligrams, and the allosteric alkyne inhibitor of MMP-13, or a pharmaceutically acceptable salt thereof, is in unit dosage form in an amount of from 25 milligrams to 300 milligrams. 1315 110. The pharmaceutical composition according to Embodiment 109, wherein valdecoxib, or the pharmaceutically acceptable salt thereof, is in unit dosage form in an amount of from 5 milligrams to 200 milligrams, and the allosteric alkyne inhibitor of MMP-13, or a pharmaceutically acceptable salt thereof, is in unit dosage form in an amount of from 25 milligrams to 200 milligrams. 1316 111. The pharmaceutical composition according to Embodiment 110, wherein valdecoxib, or the pharmaceutically acceptable salt thereof, is in unit dosage form in an amount of from 5 milligram to 100 milligrams, and the allosteric alkyne inhibitor of MMP-13, or a pharmaceutically acceptable salt thereof, is in unit dosage form in an amount of from 25 milligrams to 100 milligrams. 1317 112. A method of treating cartilage damage in a mammal in need thereof, comprising administering to the mammal a therapeutically effective amount of a combination comprising valdecoxib, or a pharmaceutically acceptable salt thereof, and an allosteric alkyne inhibitor of MMP-13, or a pharmaceutically acceptable salt thereof. 1318 113. The method according to Embodiment 112, wherein the combination is the combination according to any one of Embodiments 1 to 104. 1319 114. A method of treating cartilage damage in a mammal in need thereof, comprising administering to the mammal a therapeutically effective amount of a pharmaceutical composition, comprising a combination of valdecoxib, or a pharmaceutically acceptable salt thereof, and an allosteric alkyne inhibitor of MMP-13, or a pharmaceutically acceptable salt thereof, and a pharmaceutically acceptable carrier, diluent, or excipient. 1320 115. The method according to Embodiment 114, wherein the combination is the combination according to any one of Embodiments 1 to 104. 1321 116. The method according to Embodiment 114 or 115, wherein valdecoxib, or the pharmaceutically acceptable salt thereof, is in unit dosage form in an amount of from 1 milligram to 500 milligrams, and the allosteric alkyne inhibitor of MMP-13, or a pharmaceutically acceptable salt thereof, is in unit dosage form in an amount of from 10 milligrams to 600 milligrams. 1322 117. The method according to Embodiment 116, wherein valdecoxib, or the pharmaceutically acceptable salt thereof, is in unit dosage form in an amount of from 2 milligrams to 250 milligrams, and the allosteric alkyne inhibitor of MMP-13, or a pharmaceutically acceptable salt thereof, is in unit dosage form in an amount of from 10 milligrams to 300 milligrams. 1323 118. The method according to Embodiment 117, wherein valdecoxib, or the pharmaceutically acceptable salt thereof, is in unit dosage form in an amount of from 5 milligrams to 200 milligrams, and the allosteric alkyne inhibitor of MMP-13, or a pharmaceutically acceptable salt thereof, is in unit dosage form in an amount of from 25 milligrams to 300 milligrams. 1324 119. The method according to Embodiment 118, wherein valdecoxib, or the pharmaceutically acceptable salt thereof, is in unit dosage form in an amount of from 5 milligrams to 200 milligrams, and the allosteric alkyne inhibitor of MMP-13, or a pharmaceutically acceptable salt thereof, is in unit dosage form in an amount of from 25 milligrams to 200 milligrams. 1325 120. The method according to Embodiment 119, wherein valdecoxib, or the pharmaceutically acceptable salt thereof, is in unit dosage form in an amount of from 5 milligram to 100 milligrams, and the allosteric alkyne inhibitor of MMP-13, or a pharmaceutically acceptable salt thereof, is in unit dosage form in an amount of from 25 milligrams to 100 milligrams. 1326 121. A method of treating inflammation in a mammal in need thereof, comprising administering to the mammal a therapeutically effective amount of a combination comprising valdecoxib, or a pharmaceutically acceptable salt thereof, and an allosteric alkyne inhibitor of MMP-13, or a pharmaceutically acceptable salt thereof. 1327 122. The method according to Embodiment 121, wherein the combination is the combination according to any one of Embodiments 1 to 104. 1328 123. A method of treating inflammation in a mammal in need thereof, comprising administering to the mammal a therapeutically effective amount of a pharmaceutical composition, comprising a combination of valdecoxib, or a pharmaceutically acceptable salt thereof, and an allosteric alkyne inhibitor of MMP-13, or a pharmaceutically acceptable salt thereof, and a pharmaceutically acceptable carrier, diluent, or excipient. 1329 124. The method according to Embodiment 123, wherein the combination is the combination according to any one of Embodiments 1 to 104. 1330 125. The method according to Embodiment 123 or 124, wherein valdecoxib, or the pharmaceutically acceptable salt thereof, is in unit dosage form in an amount of from 1 milligram to 500 milligrams, and the allosteric alkyne inhibitor of MMP-13, or a pharmaceutically acceptable salt thereof, is in unit dosage form in an amount of from 10 milligrams to 600 milligrams. 1331 126. The method according to Embodiment 125, wherein valdecoxib, or the pharmaceutically acceptable salt thereof, is in unit dosage form in an amount of from 2 milligrams to 250 milligrams, and the allosteric alkyne inhibitor of MMP-13, or a pharmaceutically acceptable salt thereof, is in unit dosage form in an amount of from 10 milligrams to 300 milligrams. 1332 127. The method according to Embodiment 126, wherein valdecoxib, or the pharmaceutically acceptable salt thereof, is in unit dosage form in an amount of from 5 milligrams to 200 milligrams, and the allosteric alkyne inhibitor of MMP-13, or a pharmaceutically acceptable salt thereof, is in unit dosage form in an amount of from 25 milligrams to 300 milligrams. 1333 128. The method according to Embodiment 127, wherein valdecoxib, or the pharmaceutically acceptable salt thereof, is in unit dosage form in an amount of from 5 milligrams to 200 milligrams, and the allosteric alkyne inhibitor of MMP-13, or a pharmaceutically acceptable salt thereof, is in unit dosage form in an amount of from 25 milligrams to 200 milligrams. 1334 129. The method according to Embodiment 128, wherein valdecoxib, or the pharmaceutically acceptable salt thereof, is in unit dosage form in an amount of from 5 milligram to 100 milligrams, and the allosteric alkyne inhibitor of MMP-13, or a pharmaceutically acceptable salt thereof, is in unit dosage form in an amount of from 25 milligrams to 100 milligrams. 1335 130. A method of treating osteoarthritis in a mammal in need thereof, comprising administering to the mammal a therapeutically effective amount of a combination comprising valdecoxib, or a pharmaceutically acceptable salt thereof, and an allosteric alkyne inhibitor of MMP-13, or a pharmaceutically acceptable salt thereof. 1336 131. The method according to Embodiment 130, wherein the combination is the combination according to any one of Embodiments 1 to 104. 1337 132. A method of treating osteoarthritis in a mammal in need thereof, comprising administering to the mammal a therapeutically effective amount of a pharmaceutical composition, comprising a combination of valdecoxib, or a pharmaceutically acceptable salt thereof, and an allosteric alkyne inhibitor of MMP-13, or a pharmaceutically acceptable salt thereof, and a pharmaceutically acceptable carrier, diluent, or excipient. 1338 133. The method according to Embodiment 132, wherein the combination is the combination according to any one of Embodiments 1 to 104. 1339 134. The method according to Embodiment 132 or 133, wherein valdecoxib, or the pharmaceutically acceptable salt thereof, is in unit dosage form in an amount of from 1 milligram to 500 milligrams, and the allosteric alkyne inhibitor of MMP-13, or a pharmaceutically acceptable salt thereof, is in unit dosage form in an amount of from 10 milligrams to 600 milligrams. 1340 135. The method according to Embodiment 134, wherein valdecoxib, or the pharmaceutically acceptable salt thereof, is in unit dosage form in an amount of from 2 milligrams to 250 milligrams, and the allosteric alkyne inhibitor of MMP-13, or a pharmaceutically acceptable salt thereof, is in unit dosage form in an amount of from 10 milligrams to 300 milligrams. 1341 136. The method according to Embodiment 135, wherein valdecoxib, or the pharmaceutically acceptable salt thereof, is in unit dosage form in an amount of from 5 milligrams to 200 milligrams, and the allosteric alkyne inhibitor of MMP-13, or a pharmaceutically acceptable salt thereof, is in unit dosage form in an amount of from 25 milligrams to 300 milligrams. 1342 137. The method according to Embodiment 136, wherein valdecoxib, or the pharmaceutically acceptable salt thereof, is in unit dosage form in an amount of from 5 milligrams to 200 milligrams, and the allosteric alkyne inhibitor of MMP-13, or a pharmaceutically acceptable salt thereof, is in unit dosage form in an amount of from 25 milligrams to 200 milligrams. 1343 138. The method according to Embodiment 137, wherein valdecoxib, or the pharmaceutically acceptable salt thereof, is in unit dosage form in an amount of from 5 milligram to 100 milligrams, and the allosteric alkyne inhibitor of MMP-13, or a pharmaceutically acceptable salt thereof, is in unit dosage form in an amount of from 25 milligrams to 100 milligrams. 1344 139. A method of treating rheumatoid arthritis in a mammal in need thereof, comprising administering to the mammal a therapeutically effective amount of a combination comprising valdecoxib, or a pharmaceutically acceptable salt thereof, and an allosteric alkyne inhibitor of MMP-13, or a pharmaceutically acceptable salt thereof. 1345 140. The method according to Embodiment 139, wherein the combination is the combination according to any one of Embodiments 1 to 104. 1346 141. A method of treating rheumatoid arthritis in a mammal in need thereof, comprising administering to the mammal a therapeutically effective amount of a pharmaceutical composition, comprising a combination of valdecoxib, or a pharmaceutically acceptable salt thereof, and an allosteric alkyne inhibitor of MMP-13, or a pharmaceutically acceptable salt thereof, and a pharmaceutically acceptable carrier, diluent, or excipient. 1347 142. The method according to Embodiment 143, wherein the combination is the combination according to any one of Embodiments 1 to 104. 1348 143. The method according to Embodiment 141 or 142, wherein valdecoxib, or the pharmaceutically acceptable salt thereof, is in unit dosage form in an amount of from 1 milligram to 500 milligrams, and the allosteric alkyne inhibitor of MMP-13, or a pharmaceutically acceptable salt thereof, is in unit dosage form in an amount of from 10 milligrams to 600 milligrams. 1349 144. The method according to Embodiment 143, wherein valdecoxib, or the pharmaceutically acceptable salt thereof, is in unit dosage form in an amount of from 2 milligrams to 250 milligrams, and the allosteric alkyne inhibitor of MMP-13, or a pharmaceutically acceptable salt thereof, is in unit dosage form in an amount of from 10 milligrams to 300 milligrams. 1350 145. The method according to Embodiment 144, wherein valdecoxib, or the pharmaceutically acceptable salt thereof, is in unit dosage form in an amount of from 5 milligrams to 200 milligrams, and the allosteric alkyne inhibitor of MMP-13, or a pharmaceutically acceptable salt thereof, is in unit dosage form in an amount of from 25 milligrams to 300 milligrams. 1351 146. The method according to Embodiment 145, wherein valdecoxib, or the pharmaceutically acceptable salt thereof, is in unit dosage form in an amount of from 5 milligrams to 200 milligrams, and the allosteric alkyne inhibitor of MMP-13, or a pharmaceutically acceptable salt thereof, is in unit dosage form in an amount of from 25 milligrams to 200 milligrams. 1352 147. The method according to Embodiment 146, wherein valdecoxib, or the pharmaceutically acceptable salt thereof, is in unit dosage form in an amount of from 5 milligram to 100 milligrams, and the allosteric alkyne inhibitor of MMP-13, or a pharmaceutically acceptable salt thereof, is in unit dosage form in an amount of from 25 milligrams to 100 milligrams. 1353 148. A method of treating psoriatic arthritis in a mammal in need thereof, comprising administering to the mammal a therapeutically effective amount of a combination comprising valdecoxib, or a pharmaceutically acceptable salt thereof, and an allosteric alkyne inhibitor of MMP-13, or a pharmaceutically acceptable salt thereof. 1354 149. The method according to Embodiment 148, wherein the combination is the combination according to any one of Embodiments 1 to 104. 1355 150. A method of treating psoriatic arthritis in a mammal in need thereof, comprising administering to the mammal a therapeutically effective amount of a pharmaceutical composition, comprising a combination of valdecoxib, or a pharmaceutically acceptable salt thereof, and an allosteric alkyne inhibitor of MMP-13, or a pharmaceutically acceptable salt thereof, and a pharmaceutically acceptable carrier, diluent, or excipient. 1356 151. The method according to Embodiment 150, wherein the combination is the combination according to any one of Embodiments 1 to 104. 1357 152. The method according to Embodiment 150 or 151, wherein valdecoxib, or the pharmaceutically acceptable salt thereof, is in unit dosage form in an amount of from 1 milligram to 500 milligrams, and the allosteric alkyne inhibitor of MMP-13, or a pharmaceutically acceptable salt thereof, is in unit dosage form in an amount of from 10 milligrams to 600 milligrams. 1358 153. The method according to Embodiment 152, wherein valdecoxib, or the pharmaceutically acceptable salt thereof, is in unit dosage form in an amount of from 2 milligrams to 250 milligrams, and the allosteric alkyne inhibitor of MMP-13, or a pharmaceutically acceptable salt thereof, is in unit dosage form in an amount of from 10 milligrams to 300 milligrams. 1359 154. The method according to Embodiment 153, wherein valdecoxib, or the pharmaceutically acceptable salt thereof, is in unit dosage form in an amount of from 5 milligrams to 200 milligrams, and the allosteric alkyne inhibitor of MMP-13, or a pharmaceutically acceptable salt thereof, is in unit dosage form in an amount of from 25 milligrams to 300 milligrams. 1360 155. The method according to Embodiment 154, wherein valdecoxib, or the pharmaceutically acceptable salt thereof, is in unit dosage form in an amount of from 5 milligrams to 200 milligrams, and the allosteric alkyne inhibitor of MMP-13, or a pharmaceutically acceptable salt thereof, is in unit dosage form in an amount of from 25 milligrams to 200 milligrams. 1361 156. The method according to Embodiment 155, wherein valdecoxib, or the pharmaceutically acceptable salt thereof, is in unit dosage form in an amount of from 5 milligram to 100 milligrams, and the allosteric alkyne inhibitor of MMP-13, or a pharmaceutically acceptable salt thereof, is in unit dosage form in an amount of from 25 milligrams to 100 milligrams. 1362 157. A method of treating pain in a mammal in need thereof, comprising administering to the mammal a therapeutically effective amount of a combination comprising valdecoxib, or a pharmaceutically acceptable salt thereof, and an allosteric alkyne inhibitor of MMP-13, or a pharmaceutically acceptable salt thereof. 1363 158. The method according to Embodiment 157, wherein the combination is the combination according to any one of Embodiments 1 to 104. 1364 159. A method of treating pain in a mammal in need thereof, comprising administering to the mammal a therapeutically effective amount of a pharmaceutical composition, comprising a combination of valdecoxib, or a pharmaceutically acceptable salt thereof, and an allosteric alkyne inhibitor of MMP-13, or a pharmaceutically acceptable salt thereof, and a pharmaceutically acceptable carrier, diluent, or excipient. 1365 160. The method according to Embodiment 159, wherein the combination is the combination according to any one of Embodiments 1 to 104. 1366 161. The method according to Embodiment 159 or 160, wherein valdecoxib, or the pharmaceutically acceptable salt thereof, is in unit dosage form in an amount of from 1 milligram to 500 milligrams, and the allosteric alkyne inhibitor of MMP-13, or a pharmaceutically acceptable salt thereof, is in unit dosage form in an amount of from 10 milligrams to 600 milligrams. 1367 162. The method according to Embodiment 161, wherein valdecoxib, or the pharmaceutically acceptable salt thereof, is in unit dosage form in an amount of from 2 milligrams to 250 milligrams, and the allosteric alkyne inhibitor of MMP-13, or a pharmaceutically acceptable salt thereof, is in unit dosage form in an amount of from 10 milligrams to 300 milligrams. 1368 163. The method according to Embodiment 162, wherein valdecoxib, or the pharmaceutically acceptable salt thereof, is in unit dosage form in an amount of from 5 milligrams to 200 milligrams, and the allosteric alkyne inhibitor of MMP-13, or a pharmaceutically acceptable salt thereof, is in unit dosage form in an amount of from 25 milligrams to 300 milligrams. 1369 164. The method according to Embodiment 163, wherein valdecoxib, or the pharmaceutically acceptable salt thereof, is in unit dosage form in an amount of from 5 milligrams to 200 milligrams, and the allosteric alkyne inhibitor of MMP-13, or a pharmaceutically acceptable salt thereof, is in unit dosage form in an amount of from 25 milligrams to 200 milligrams. 1370 165. The method according to Embodiment 164, wherein valdecoxib, or the pharmaceutically acceptable salt thereof, is in unit dosage form in an amount of from 5 milligram to 100 milligrams, and the allosteric alkyne inhibitor of MMP-13, or a pharmaceutically acceptable salt thereof, is in unit dosage form in an amount of from 25 milligrams to 100 milligrams. 1371 Another invention embodiment is a combination according to any one of Embodiments 1 to 104, a pharmaceutical composition according to any one of Embodiments 105 to 111, or a method according to any one of Embodiments 112 to 165, except where valdecoxib, or the pharmaceutically acceptable salt thereof, is replaced by celecoxib, or a pharmaceutically acceptable salt thereof. 1372 Another invention embodiment is use of any one of the above combination Embodiments to treat a mammalian disease in a mammal in need of treatment, wherein the disease is selected from arthritis, rheumatoid arthritis, osteoarthritis, osteoporosis, periodontal diseases, inflammatory bowel disease, psoriasis, multiple sclerosis, cardiac insufficiency, atherosclerosis, asthma, chronic obstructive pulmonary disease, age-related macular degeneration, and cancers. 1373 Another invention embodiment is any of the above embodiments of a combination, comprising an allosteric alkyne inhibitor of MMP-13, or a pharmaceutically acceptable salt thereof, wherein the allosteric alkyne inhibitor of MMP-13 is any single compound named below in the Examples of allosteric alkyne inhibitors of MMP-13, with celecoxib, or a pharmaceutically acceptable salt thereof, or valdecoxib, or a pharmaceutically acceptable salt thereof. 1374 Another invention embodiment is any of the above embodiments of pharmaceutical compositions, comprising a combination containing an allosteric alkyne inhibitor of MMP-13, or a pharmaceutically acceptable salt thereof, wherein the allosteric alkyne inhibitor of MMP-13 is any single compound named below in the Examples of allosteric alkyne inhibitors of MMP-13, with celecoxib, or a pharmaceutically acceptable salt thereof, or valdecoxib, or a pharmaceutically acceptable salt thereof, together with a pharmaceutically acceptable carrier, diluent, or excipient. 1375 Another invention embodiment is any of the above embodiments of a methods of treating a disease in a mammal suffering therefrom, comprising administering to the mammal a therapeutically effective amount of a combination, comprising an allosteric alkyne inhibitor of MMP-13, or a pharmaceutically acceptable salt thereof, wherein the allosteric alkyne inhibitor of MMP-13 is any single compound named below in the Examples of allosteric alkyne inhibitors of MMP-13, with celecoxib, or a pharmaceutically acceptable salt thereof, or valdecoxib, or a pharmaceutically acceptable salt thereof. 1376 Another invention embodiment is a combination, comprising an allosteric alkyne inhibitor of MMP-13, or a pharmaceutically acceptable salt thereof, wherein the allosteric alkyne inhibitor of MMP-13 is any single compound named below in the Examples of allosteric alkyne inhibitors of MMP-13, with celecoxib, or a pharmaceutically acceptable salt thereof, or valdecoxib, or a pharmaceutically acceptable salt thereof. 1377 Another invention embodiment is a pharmaceutical composition, comprising a combination containing an allosteric alkyne inhibitor of MMP-13, or a pharmaceutically acceptable salt thereof, wherein the allosteric alkyne inhibitor of MMP-13 is any single compound named below in the Examples of allosteric alkyne inhibitors of MMP-13, with celecoxib, or a pharmaceutically acceptable salt thereof, or valdecoxib, or a pharmaceutically acceptable salt thereof, together with a pharmaceutically acceptable carrier, diluent, or excipient. 1378 Another invention embodiment is a method of treating a disease that is responsive to inhibition of MMP-13 and to selective inhibition of COX-2 in a mammal suffering therefrom, comprising administering to the mammal a therapeutically effective amount of the combination according to any one of Embodiments 1 to 104. 1379 Another invention embodiment is a method of treating a disease that is responsive to inhibition of MMP-13 and to selective inhibition of COX-2 in a mammal suffering therefrom, comprising administering to the mammal a therapeutically effective amount of a combination, comprising an allosteric alkyne inhibitor of MMP-13, or a pharmaceutically acceptable salt thereof, wherein the allosteric alkyne inhibitor of MMP-13 is any single compound named below in the Examples of allosteric alkyne inhibitors of MMP-13, with celecoxib, or a pharmaceutically acceptable salt thereof, or valdecoxib, or a pharmaceutically acceptable salt thereof. 1380 Another invention embodiment is a method of treating a first disease that is responsive to inhibition of MMP-13 and a second disease that is responsive to selective inhibition of COX-2 in a mammal suffering therefrom, comprising administering to the mammal a therapeutically effective amount of the combination according to any one of Embodiments 1 to 104. 1381 Another invention embodiment is a method of treating a first disease that is responsive to inhibition of MMP-13 and a second disease that is responsive to selective inhibition of COX-2 in a mammal suffering therefrom, comprising administering to the mammal a therapeutically effective amount of a combination, comprising an allosteric alkyne inhibitor of MMP-13, or a pharmaceutically acceptable salt thereof, wherein the allosteric alkyne inhibitor of MMP-13 is any single compound named below in the Examples of allosteric alkyne inhibitors of MMP-13, with celecoxib, or a pharmaceutically acceptable salt thereof, or valdecoxib, or a pharmaceutically acceptable salt thereof. 1382 Another invention embodiment is a method of treating an arthritic condition in a mammal, comprising administering to the mammal an amount of any one of the above described invention combinations, or any one of the above-described invention pharmaceutical compositions, sufficient to effectively treat the arthritic condition. 1383 Use of a combination comprising valdecoxib, or a pharmaceutically acceptable salt thereof, and an allosteric alkyne inhibitor of MMP-13, or a pharmaceutically acceptable salt thereof, for preparation of a medicament for treating cartilage damage in a mammal in need thereof. 1384 Use of a combination comprising valdecoxib, or a pharmaceutically acceptable salt thereof, and an allosteric alkyne inhibitor of MMP-13, or a pharmaceutically acceptable salt thereof, for preparation of a medicament for treating inflammation in a mammal in need thereof. 1385 Use of a combination comprising valdecoxib, or a pharmaceutically acceptable salt thereof, and an allosteric alkyne inhibitor of MMP-13, or a pharmaceutically acceptable salt thereof, for preparation of a medicament for treating osteoarthritis in a mammal in need thereof. 1386 Use of a combination comprising valdecoxib, or a pharmaceutically acceptable salt thereof, and an allosteric alkyne inhibitor of MMP-13, or a pharmaceutically acceptable salt thereof, for preparation of a medicament for treating rheumatoid arthritis in a mammal in need thereof. 1387 Use of a combination comprising valdecoxib, or a pharmaceutically acceptable salt thereof, and an allosteric alkyne inhibitor of MMP-13, or a pharmaceutically acceptable salt thereof, for preparation of a medicament for treating pain in a mammal in need thereof.

DETAILED DESCRIPTION OF THE INVENTION 1388 As noted above, the invention provides a combination, comprising an allosteric alkyne inhibitor of MMP-13, or a pharmaceutically acceptable salt thereof, with celecoxib, or a pharmaceutically acceptable salt thereof, or valdecoxib, or a pharmaceutically acceptable salt thereof. This invention also provides a method of treating a disease that is responsive to inhibition of MMP-13 and cyclooxygenase-2, comprising administering to a patient suffering from such a disease the invention combination comprising an allosteric alkyne inhibitor of MMP-13, or a pharmaceutically acceptable salt thereof, with celecoxib, or a pharmaceutically acceptable salt thereof, or valdecoxib, or a pharmaceutically acceptable salt thereof. This invention also provides a pharmaceutical composition, comprising the invention combination comprising an allosteric alkyne inhibitor of MMP-13, or a pharmaceutically acceptable salt thereof, with celecoxib, or a pharmaceutically acceptable salt thereof, or valdecoxib, or a pharmaceutically acceptable salt thereof, and a pharmaceutically acceptable carrier, diluent, or excipient. 1389 The invention combinations may also be further combined with other pharmaceutical agents depending on the disease being treated. 1390 The terms are as defined below or as they otherwise occur in the specification. 1391 More particularly, the terms used herein to describe the allosteric alkyne inhibitors of Formula (A) are defined immediately below. 1392 The terms (C1-C6)alkyl and (C1-C10)alkyl means a linear or branched group containing respectively from 1 to 6 or from 1 to 10 carbon atoms; example of such groups, without implying any limitation are methyl, ethyl, propyl, isopropyl, tert-butyl, neopentyl, hexyl, heptyl, and 3-methyl-hexyl. 1393 The term (C3-C6)alkenyl means a linear or branched group containing from 3 to 6 carbon atoms, and 1 or 2 double bonds; examples of such groups without impying any limitation are allyl, 3-buten-1-yl, 2-methyl-buten-1-yl, and hexenyl. It should be appreciated that allenes of from 3 to 6 carbon atoms are embraced by (C3-C6)alkenyl. 1394 The term (C3-C6)alkynyl means a linear or branched group containing from 3 to 6 carbon atoms, and one or two triple bonds; examples of such groups without implying any limitation are 3-butyn-1-yl, 2-methyl-butyn-1-yl, and hexynyl. 1395 The term (C1-C6)alkoxy means the (C1-C6)alkyl group as mentioned above bound through an oxygen atom; examples of such groups without implying any limitation are methoxy, ethoxy, n-propyloxy, and tert-butyloxy. 1396 The terms (C1-C6)alkylN(H) or (C1-C6)alkyl2N and (C1-C10)alkylN(H) or (C1-C10)alkyl2N mean the (C1-C6)alkyl or (C1-C10)alkyl groups, respectively, as defined above bound through a nitrogen atom which is N(H) or N, respectively; example of such groups, without implying any limitation are methyl amino, isobutyl amino, dimethylamino, ethylamino, and diethylamino. 1397 The term (C5-C10)heteroaryl means a 5-membered or 6-membered monocyclic heteroaromatic ring containing carbon atoms and from 1 to 4 heteroatoms selected from O, S, N(H), and N(C1-C6)alkyl, or an 8-membered to 10-membered bicyclic heteroaromatic ring containing carbon atoms and from 1 to 4 heteroatoms selected from O, S, N(H), and N(C1-C6)alkyl; examples of such groups without implying any limitation are furyl, thienyl, pyrrolyl, pyrazolyl, pyridyl, pyrimidyl, pyrazinyl, benzofuryl, benzothienyl, indolyl, quinolyl, isoquinolyl, benzodioxolyl, benzodioxinyl, benzo1,2,5thiadiazolyl, benzo1,2,5oxadiazolyl, and 1-propyl-indolyl. 1398 The term (C3-C10)cycloalkyl means a monocyclic carbocyclic ring containing from 3 to 10 carbon atoms, or a bicyclic carbocyclic ring containing from 5 to 10 carbon atoms; examples of such groups without implying any limitation are cyclopropyl, cyclobutyl, cyclopentyl, cyclohexyl, cyclooctyl, cycloheptyl, adamantyl, decalinyl, and norbornyl. 1399 The terms phenyl-(C1-C10)alkyl, naphthyl-(C1-C10)alkyl, and (C3-C10)cycloalkyl-(C1-C10)alkyl mean a phenyl group, naphthyl group, or (C3-C10)cycloalkyl, respectively, bound through a (C1-C10)alkyl group, wherein (C1-C10)alkyl and (C3-C10)cycloalkyl are as defined above. 1400 The phrase aromatic 5-membered or 6-membered monocyclic heterocycle means a 5-membered or 6-membered heterocyclic ring comprising carbon atoms and from 1 to 4 heteroatoms selected from O, S, N(H), and N(C1-C10)alkyl, wherein (C1-C10)alkyl is as defined above; Examples include, but are not limited to, furyl, thienyl, pyrrolyl, pyrazolyl, pyridyl, pyrimidyl, and pyrazinyl. 1401 The phase nonaromatic 5-membered or 6-membered monocyclic heterocycle means a 5-membered or 6-membered heterocyclic ring comprising carbon atoms and from 1 to 3 heteroatoms selected from O, S, N(H), and N(C1-C10)alkyl; Examples include, but are not limited to, dihydrofuryl, tetrahydrofuranyl, pyrrolidinyl, morpholinyl, piperidinyl, tetrahydropyridinyl, and piperazinyl. 1402 The phrase nonaromatic 5-membered or 6-membered monocycle means a 5-membered or 6-membered carbocyclic or heterocyclic ring, comprising carbon atoms and from 0 to 4 heteroatoms selected from O, S, N(H), and N(C1-C10)alkyl; Examples include, but are not limited to, cyclopentyl, cyclohexyl, dihydrofuryl, tetrahydrofuranyl, pyrrolidinyl, morpholinyl, piperidinyl, tetahydropyridinyl, and piperazinyl. 1403 The phrase aromatic 8-membered to 12-membered bicycle comprising two aromatic rings independently selected from 5-membered or 6-membered rings means an 8-membered to 12-membered bicyclic ring comprising carbon atoms and from 1 to 6 hetero atoms selected from O, S, N(H), and N(C1-C10)alkyl, wherein the bicyclic ring comprises two 5-membered aromatic rings, one 5-membered aromatic ring and one 6-membered aromatic ring, or two 6-membered aromatic rings. The aromatic rings may be carbocyclic or heterocyclic, the same or different, such as phenyl, furyl, thienyl, pyrrolyl, pyrazolyl, pyridyl, pyrimidyl, and pyrazinyl. Further, the two aromatic rings may be bonded to each other (e.g., biphenyl) or fused to each other (e.g., naphthyl). Examples of aromatic 8-membered to 12-membered bicycle comprising two aromatic rings independently selected from 5-membered or 6-membered rings include, but are not limited to, biphenyl, naphthyl, phenylpyridyl, benzofuranyl, benzimidazolyl, and fused dithienyl. 1404 The phrase aromatic 8-membered to 12-membered bicycle comprising one aromatic 5-membered or 6-membered ring and one non-aromatic 5-membered or 6-membered ring means an 8-membered to 12-membered bicyclic ring comprising carbon atoms and from 1 to 6 hetero atoms selected from O, S, N(H), and N(C1-C10)alkyl, wherein the bicyclic ring comprises a 5-membered aromatic ring and a 5-membered nonaromatic ring, a 5-membered aromatic ring and a 6-membered nonaromatic ring, a 6-membered aromatic ring and a 5-membered nonaromatic ring, or a 6-membered aromatic ring and a 6-membered nonaromatic ring. one 5-membered aromatic ring and one 6-membered aromatic ring, or two 6-membered aromatic rings. The aromatic rings may be carbocyclic or heterocyclic, the same or different, such as phenyl, furyl, thienyl, pyrrolyl, pyrazolyl, pyridyl, pyrimidyl, and pyrazinyl. The nonaromatic rings may be carbocyclic or heterocyclic, the same or different, such as cyclopentyl, dihydrofuranyl, pyrrolidinyl, piperidinyl, and morpholinyl. Further, the two rings may be bonded to each other (e.g., phenyl-pyrrolidinyl) or fused to each other (e.g., dihydroindolyl). Examples of aromatic 8-membered to 12-membered bicycle comprising one aromatic 5-membered or 6-membered ring and one non-aromatic 5-membered or 6-membered rings include, but are not limited to, phenyl-pyrrolidinyl, tetrahydronaphthyl, dihydroindolyl, and tetrahydrobenzofuranyl. 1405 The phrase non-aromatic 8-membered to 12-membered bicycle comprising two non-aromatic rings independently selected from 5-membered or 6-membered rings means an 8-membered to 12-membered bicyclic ring comprising carbon atoms and from 0 to 4 heteroatoms selected from O, S, N(H), and N(C1-C10)alkyl, wherein the bicyclic ring comprises two 5-membered nonaromatic rings, one 5-membered nonaromatic ring and one 6-membered nonaromatic ring, or two 6-membered nonaromatic rings. The nonaromatic rings may be carbocyclic or heterocyclic, the same or different, such as cyclohexyl, dihydrofuryl, pyrrolidinyl, dihydrofuranyl, piperidinyl, and morpholinyl. Further, the two nonaromatic rings may be bonded to each other (e.g., cyclopentyl-tetrahydrofuranyl) or fused to each other (e.g., decahydro-isoquinolinyl). Examples of nonaromatic 8-membered to 12-membered bicycle comprising two nonaromatic 5-membered or 6-membered rings include, but are not limited to, cyclopentyl-tetrahydrofuranyl and decahydro-isoquinolinyl. 1406 The term trihalo(C1-C6)alkyl means an (C1-C6)alkyl group as defined above which is substituted with three halo groups, wherein each halo is independently selected from fluoro, chloro, bromo, and iodo, and further each halo may be on the same carbon atom or different carbon atoms of the (C1-C6)alkyl moiety; examples of such groups without implying any limitation are trifluoromethyl, 2,2,2-trifluoroethyl, and 1-chloro-2,2-difluoroethyl. 1407 The term (C1-C6)acyl means an (C1-C6)alkyl group as defined above or a phenyl group bound through a carbonyl group; examples of such groups without implying any limitation are acetyl, ethylcarbonyl, and benzoyl. 1408 The term halo includes fluoro, chloro, bromo, and iodo. 1409 The terms used herein to describe the allosteric alkyne inhibitors of Formula I are defined immediately below. 1410 The term C1-C6 alkyl means straight and branched carbon chains having from 1 to 6 carbon atoms. Examples of such alkyl groups include methyl, ethyl, isopropyl, tert-butyl, neopentyl, and n-hexyl. The alkyl groups can be substituted if desired, with from 1 to 3 groups selected from hydroxy, amino, alkylamino, and dialkylamino, halo, trifluoromethyl, carboxy, nitro, and cyano. 1411 Examples of NR1R2 or NR3R4 groups include amino, methylamino, di-isopropylamino, acetyl amino, propionyl amino, 3-aminopropyl amino, 3-ethylaminobutyl amino, 3-di-n-propylamino-propyl amino, 4-diethylaminobutyl amino, and 3-carboxypropionyl amino. R1 and R2, or R3 and R4, can independently be taken together with the nitrogen to which they are attached to form a ring having 3 to 7 carbon atoms and 1, 2, or 3 heteroatoms selected from the group consisting of nitrogen, substituted nitrogen, wherein substituted nitrogen is as defined below, oxygen, and sulfur. Examples of such cyclic NR1R2 or NR3R4 groups include pyrrolidinyl, piperazinyl, 4-methylpiperazinyl, 4-benzylpiperazinyl, pyridinyl, piperidinyl, pyrazinyl, morpholinyl, and the like. 1412 Amino means NH2. 1413 Halo includes fluoro, chloro, bromo, and iodo. 1414 Alkenyl means straight and branched hydrocarbon radicals having from 2 to 6 carbon atoms and one double bond and includes ethenyl, 3-buten-1-yl, 2-ethenylbutyl, 3-hexen-1-yl, and the like. 1415 Alkynyl means straight and branched hydrocarbon radicals having from 2 to 6 carbon atoms and one triple bond and includes ethynyl, 3-butyn-1-yl, propynyl, 2-butyn-1-yl, 3-pentyn-1-yl, and the like. 1416 Carbocycle and Cycloalkyl mean a monocyclic or polycyclic hydrocarbyl group such as cyclopropyl, cycloheptyl, cyclooctyl, cyclodecyl, cyclobutyl, adamantyl, norpinanyl, decalinyl, norbornyl, cyclohexyl, and cyclopentyl. Such groups can be substituted with groups such as hydroxy, keto, and the like. Also included are rings in which 1 to 3 heteroatoms replace carbons. Such groups are termed heterocycle or heterocyclyl, which means a cycloalkyl group also bearing at least one heteroatom selected from O, S, or NR2, examples being oxiranyl, pyrrolidinyl, piperidyl, 4-methylpiperazinyl, tetrahydropyran, and morpholine. 1417 Alkoxy refers to the alkyl groups mentioned above bound through oxygen, examples of which include methoxy, ethoxy, isopropoxy, tert-butoxy, and the like. In addition, alkoxy refers to polyethers such as O(CH2)2OCH3, and the like. 1418 Alkanoyl groups are alkyl linked through a carbonyl, ie, C1-C5C(O). Such groups include formyl, acetyl, propionyl, butyryl, and isobutyryl. 1419 Acyl means an alkyl or aryl (Ar) group bonded through a carbonyl group, ie, RC(O). For example, acyl includes a C1-C6 alkanoyl, including substituted alkanoyl, wherein the alkyl portion can be substituted by NR1R2 or a carboxylic or heterocyclic group. Typical acyl groups include acetyl, benzoyl, and the like. 1420 The alkyl, alkenyl, alkoxy, and alkynyl groups described above are optionally substituted, preferably by 1 to 3 groups selected from NR1R2, phenyl, substituted phenyl, heterocycle, thio C1-C6 alkyl, C1-C6 alkoxy, hydroxy, carboxy, C1-C6 alkoxycarbonyl, halo, nitrile, cycloalkyl, and a 5- or 6-membered carbocyclic ring or heterocyclic ring having 1 or 2 heteroatoms selected from nitrogen, substituted nitrogen, oxygen, and sulfur. 1421 Substituted nitrogen means nitrogen bearing C1-C6 alkyl or (CH2)nPh where n is 1, 2, or 3. Perhalo and polyhalo substitution is also embraced. 1422 Examples of substituted alkyl groups include 2-aminoethyl, pentachloroethyl, trifluoromethyl, 2-diethylaminoethyl, 2-dimethylaminopropyl, ethoxycarbonylmethyl, 3-phenylbutyl, methanesulfanylmethyl, methoxymethyl, 3-hydroxypentyl, 2-carboxybutyl, 4-chlorobutyl, 3-cyclopropylpropyl, pentafluoroethyl, benzyl(Bn), 3-morpholinopropyl, piperazinylmethyl, pyridyl-4-methyl(Py-4-me), 3-(pyridyl-4-thio)propyl, and 2-(4-methylpiperazinyl)ethyl. 1423 Examples of substituted alkynyl groups include 2-methoxyethynyl, 2-ethylsulfanylethynyl, 4-(1-piperazinyl)-3-(butynyl), 3-phenyl-5-hexynyl, 3-diethylamino-3-butynyl, 4-chloro-3-butynyl, 4-cyclobutyl-4-hexenyl, and the like. 1424 Typical substituted alkoxy groups include aminomethoxy, trifluoromethoxy, 2-diethylaminoethoxy, 2-ethoxycarbonylethoxy, 3-hydroxypropoxy, 6-carboxhexyloxy, and the like. 1425 Further, examples of substituted alkyl, alkenyl, and alkynyl groups include dimethylaminomethyl, carboxymethyl, 4-dimethylamino-3-buten-1-yl, 5-ethylmethylamino-3-pentyn-1-yl, 4-morpholinobutyl, 4-tetrahydropyrinidylbutyl, 3-imidazolidin-1-ylpropyl, 4-tetrahydrothiazol-3-yl-butyl, phenylmethyl, 3-chlorophenylmethyl, and the like. 1426 The terms Ar and aryl refer to unsubstituted and substituted aromatic groups. Heteroaryl groups have from 4 to 10 ring atoms, which are carbon atoms and from 1 to 4 of which are independently selected from the group consisting of O, S, and N. Preferred heteroaryl groups have 1 or 2 heteroatoms in a 5- or 6-membered aromatic ring. Mono- and bicyclic aromatic ring systems are included in the definition of aryl and heteroaryl. Typical aryl groups include phenyl and naphthyl. Typical substituted aryl groups include 2,4,6-tribromophenyl, 4,7-dichloronaphthyl, 3-chlorophenyl, 3,4-methylenedioxyphenyl, and 2,6-dibromophenyl. Typical heteroaryl groups include pyridyl, benzothienyl, furanyl, indolyl, benzotriazolyl, indazolyl, pyrrolyl, pyrazolyl, imidazolyl, thiazolyl, and the like. 1427 Typical substituted heteroaryl groups include 3-methylpyridyl, 4-thiopyridyl, 4-ethylbenzothienyl, and 3,4-diethylfuranyl. 1428 Preferred Ar groups are phenyl and phenyl substituted by 1, 2, or 3 groups independently selected from alkyl, alkoxy, thio, thioalkyl, heteroaryl, heterocyclyl, halo, hydroxy, COOR9, trifluoromethyl, nitro, amino of the formula NR1R2, and T(CH2)mQR3 or T(CH2)mCO2R3, wherein m is 1 to 6; T is O, S, NR3, N(O)R3, NR1R2Y, or CR1R2, Q is O, S, NR3, N(O)R3, or NR1R2Y, wherein R1 and R2 are as described above, and R9 is alkyl or substituted alkyl, for example, methyl, trichloroethyl, diphenylmethyl, and the like. The alkyl and alkoxy groups can be substituted as defined above. For example, typical groups are carboxyalkyl, alkoxycarbonylalkyl, hydroxyalkyl, hydroxyalkoxy, and alkoxyalkyl. Examples of substituted phenyl are 3-methoxyphenyl, 4-(1H-tetrazol-5-yl)phenyl 2,6-dichlorophenyl, 3-nitrophenyl, 4-dimethylaminophenyl, and biphenyl. 1429 Unless moieties of a compound of the invention are defined as being unsubstituted, the moieties of the compound of the invention may be substituted. In the event where the substituents of the moieties which may be substituted are not defined above, the moieties of the compound of the invention may be optionally substituted from 1 to 3 times at any of from 1 to 3 carbon atoms, respectively, wherein each carbon atom is capable of substitution by replacement of a hydrogen atom with a group independently selected from: 1430 C1-C4 alkyl; 1431 C2-C4 alkenyl; 1432 C2-C4 alkynyl; 1433 CF3; 1434 halo; 1435 OH; 1436 O(C1-C4 alkyl); 1437 OCH2F; 1438 OCHF2; 1439 OCF3; 1440 OC(O)(C1-C4 alkyl); 1441 OC(O)O(C1-C4 alkyl); 1442 OC(O)NH(C1-C4 alkyl); 1443 OC(O)N(C1-C4 alkyl)2; 1444 OC(S)NH(C1-C4 alkyl); 1445 OC(S)N(C1-C4 alkyl)2; 1446 SH; 1447 S(C1-C4 alkyl); 1448 S(O)(C1-C4 alkyl); 1449 S(O)2-(C1-C4 alkyl); 1450 SC(O)(C1-C4 alkyl); 1451 SC(O)O(C1-C4 alkyl); 1452 NH2; 1453 N(H)(C1-C4 alkyl); 1454 N(C1-C4 alkyl)2; 1455 N(H)C(O)(C1-C4 alkyl); 1456 N(CH3)C(O)(C1-C4 alkyl); 1457 N(H)C(O)CF3; 1458 N(CH3)C(O)CF3; 1459 N(H)C(S)(C1-C4 alkyl); 1460 N(CH3)C(S)(C1-C4 alkyl); 1461 N(H)S(O)2(C1-C4 alkyl); 1462 N(H)C(O)NH2; 1463 N(H)C(O)NH(C1-C4 alkyl); 1464 N(CH3)C(O)NH(C1-C4 alkyl); 1465 N(H)C(O)N(C1-C4 alkyl)2; 1466 N(CH3)C(O)N(C1-C4 alkyl)2; 1467 N(H)S(O)2NH2; 1468 N(H)S(O)2NH(C1-C4 alkyl); 1469 N(CH3)S(O)2NH(C1-C4 alkyl); 1470 N(H)S(O)2N(C1-C4 alkyl)2; 1471 N(CH3)S(O)2N(C1-C4 alkyl)2; 1472 N(H)C(O)O(C1-C4 alkyl); 1473 N(CH3)C(O)O(C1-C4 alkyl); 1474 N(H)S(O)2O(C1-C4 alkyl); 1475 N(CH3)S(O)2O(C1-C4 alkyl); 1476 N(CH3)C(S)NH(C1-C4 alkyl); 1477 N(CH3)C(S)N(C1-C4 alkyl)2; 1478 N(CH3)C(S)O(C1-C4 alkyl); 1479 N(H)C(S)NH2; 1480 NO2; 1481 CO2H; 1482 CO2(C1-C4 alkyl); 1483 C(O)N(H)OH; 1484 C(O)N(CH3)OH; 1485 C(O)N(CH3)OH; 1486 C(O)N(CH3)O(C1-C4 alkyl); 1487 C(O)N(H)(C1-C4 alkyl); 1488 C(O)N(C1-C4 alkyl)2; 1489 C(S)N(H)(C1-C4 alkyl); 1490 C(S)N(C1-C4 alkyl)2; 1491 C(NH)N(H)(C1-C4 alkyl); 1492 C(NH)N(C1-C4 alkyl)2; 1493 C(NCH3)N(H)(C1-C4 alkyl); 1494 C(NCH3)N(C1-C4 alkyl)2; 1495 C(O)(C1-C4 alkyl); 1496 C(NH)(C1-C4 alkyl); 1497 C(NCH3)(C1-C4 alkyl); 1498 C(NOH)(C1-C4 alkyl); 1499 C(NOCH3)(C1-C4 alkyl); 1500 CN; 1501 CHO; 1502 CH2OH; 1503 CH2O(C1-C4 alkyl); 1504 CH2NH2; 1505 CH2N(H)(C1-C4 alkyl); and 1506 CH2N(C1-C4 alkyl)2; wherein 1507 C1-C4 alkyl means a straight or branched, unsubstituted alkyl chain of from 1 to 4 carbon atoms; 1508 C2-C4 alkenyl means a straight or branched, unsubstituted alkenyl chain of from 2 to 4 carbon atoms; and 1509 C2-C4 alkynyl means a straight or branched, unsubstituted alkynyl chain of from 2 to 4 carbon atoms. 1510 The phrase tertiary organic amine means a trisubstituted nitrogen group wherein the 3 substituents are independently selected from C1-C12 alkyl, C3-C12 cycloalkyl, benzyl, or wherein two of the substituents are taken together with the nitrogen atom to which they are attached to form a 5- or 6-membered, monocyclic heterocycle containing one nitrogen atom and carbon atoms, and the third substituent is selected from C1-C12 alkyl and benzyl, or wherein the three substituents are taken together with the nitrogen atom to which they are attached to form a 7- to 12-membered bicyclic heterocycle containing 1 or 2 nitrogen atoms and carbon atoms, and optionally a CN double bond when 2 nitrogen atoms are present. Illustrative examples of tertiary organic amine include triethylamine, diisopropylethylamine, benzyl diethylamino, dicyclohexylmethyl-amine, 1,8-diazabicycle5.4.0undec-7-ene (DBU), 1,4-diazabicyclo2.2.2octane (TED), and 1,5-diazabicycle4.3.0non-5-ene. 1511 It should be appreciated that the S1 site of MMP-13 was previously thought to be a grossly linear channel which contained an opening at the top that allowed an amino acid side chain from a substrate molecule to enter during binding, and was closed at the bottom. Applicant has discovered that the S1 site is actually composed of an S1 channel angularly connected to a newly discovered pocket which applicant calls the S1 site. The S1 site is open to solvent at the bottom, which can expose a functional group of Applicant's allosteric alkyne inhibitors to solvent. For illustrative purposes, the S1 site of the MMP-13 enzyme can now be thought of as being like a sock with a hole in the toes, wherein the S1 channel is the region from approximately the opening to the ankle, and the S1 site is the foot region below the ankle, which foot region is angularly connected to the ankle region. 1512 More particularly, the S1 channel is a specific part of the S1 site and is formed largely by Leu218, Val219, His222 and by residues from Leu239 to Tyr244. The S1 binding site which has been newly discovered is defined by residues from Tyr246 to Pro255. The S1 site contains at least two hydrogen bond donors and aromatic groups which interact with a compound which is an allosteric alkyne inhibitor of MMP-13. 1513 Without wishing to be bound by any particular theory, the inventor believes that the S1 site could be a recognition site for triple helix collagen, the natural substrate for MMP-13. It is possible that the conformation of the S1 site is modified only when an appropriate compound binds to MMP-13, thereby interfering with the collagen recognition process. This newly discovered pattern of binding offers the possibility of greater selectivity than what is achievable with the binding pattern of known selective inhibitors of MMP-13, wherein the known binding pattern requires ligation of the catalytic zinc atom at the active site and occupation the S1 channel, but not the S1 site. 1514 The invention provides combinations which comprise an allosteric alkyne inhibitor of MMP-13. An allosteric alkyne inhibitor of MMP-13 is any compound that contains a carbon-carbon triple bond, and that binds allosterically into the S1 site of the MMP-13 enzyme, including the S1 channel, and a newly discovered S1 site, without ligating, coordinating, or binding the catalytic zinc of the MMP-13. 1515 The instant allosteric alkyne inhibitors of MMP-13 are described in U.S. provisional application No. 60/329,216; and U.S. provisional application No. 60/329,181, which is related to co-pending PCT international application PCT/EP01/11824, all filed on Oct. 12,2001. These U.S. provisional applications and the PCT international application are hereby incorporated herein by reference. 1516 It should be appreciated that invention combinations may comprise celecoxib, or a pharmaceutically acceptable salt thereof, or valdecoxib, or a pharmaceutically acceptable salt thereof, and an allosteric alkyne inhibitor of MMP-13, or a pharmaceutically acceptable salt thereof, wherein the allosteric alkyne inhibitor of MMP-13, or a pharmaceutically acceptable salt thereof, may embrace any one of the compound embodiments described in U.S. provisional application No. 60/329,216, U.S. provisional application No. 60/329,181, and the related co-pending PCT international application PCT/EP01/11824, including variants thereof described in the respective specifications and claims. It should be further appreciated that the above described pharmaceutical compositions may comprise these invention combinations. It should be further appreciated that the above described methods of prevention, treatment, or inhibition may comprise administration of these invention combinations. 1517 A compound that is an allosteric alkyne inhibitor of MMP-13 may be readily identified by one of ordinary skill in the pharmaceutical or medical arts by assaying an alkyne test compound for inhibition of MMP-13 as described below in Biological Methods 1 or 2, and for allosteric inhibition of MMP-13 by assaying the alkyne test compound for inhibition of MMP-13 in the presence of an inhibitor to the catalytic zinc of MMP-13 as described below in Biological Methods 3 or 4. 1518 Further, an allosteric alkyne inhibitor of MMP-13 having an anti-inflammatory, an analgesic, anti-arthritic, or a cartilage damage inhibiting effect, or any combination of these effects, may be readily identified by one of ordinary skill in the pharmaceutical or medical arts by assaying the allosteric alkyne inhibitor of MMP-13 in any number of well known assays for measuring determining the allosteric alkyne inhibitor of MMP-13's effects on cartilage damage, arthritis, inflammation, or pain. These assays include in vitro assays that utilize cartilage samples and in vivo assays in whole animals that measure cartilage degradation, inhibition of inflammation, or pain alleviation. 1519 For example with regard to assaying cartilage damage in vitro, an amount of an allosteric alkyne inhibitor of MMP-13 or control vehicle may be administered with a cartilage damaging agent to cartilage, and the cartilage damage inhibiting effects in both tests studied by gross examination or histopathologic examination of the cartilage, or by measurement of biological markers of cartilage damage such as, for example, proteoglycan content or hydroxyproline content. Further, in vivo assays to assay cartilage damage may be performed as follows: an amount of an allosteric alkyne inhibitor of MMP-13 or control vehicle may be administered with a cartilage damaging agent to an animal, and the effects of the allosteric alkyne inhibitor of MMP-13 being assayed on cartilage in the animal may be evaluated by gross examination or histopathologic examination of the cartilage, by observation of the effects in an acute model on functional limitations of the affected joint that result from cartilage damage, or by measurement of biological markers of cartilage damage such as, for example, proteoglycan content or hydroxyproline content. 1520 Several methods of identifying an allosteric alkyne inhibitor of MMP-13 with cartilage damage inhibiting properties are described below. The amount to be administered in an assay to identify an allosteric alkyne inhibitor of MMP-13 is dependent upon the particular assay employed, but in any event is not higher than the well known maximum amount of a compound that the particular assay can effectively accommodate. 1521 Similarly, allosteric alkyne inhibitors of MMP-13 having pain-alleviating properties may be identified using any one of a number of in vivo animal models of pain. 1522 Still similarly, allosteric alkyne inhibitors of MMP-13 having anti-inflammatory properties may be identified using any one of a number of in vivo animal models of inflammation. For example, for an example of inflammation models, see U.S. Pat. No. 6,329,429, which is incorporated herein by reference. 1523 Still similarly, allosteric alkyne inhibitors of MMP-13 having anti-arthritic properties may be identified using any one of a number of in vivo animal models of arthritis. For example, for an example of arthritis models, see also U.S. Pat. No. 6,329,429. 1524 Any allosteric alkyne inhibitor of MMP-13 is readily available, either commercially, or by synthetic methodology, well known to those skilled in the art of organic chemistry. For specific syntheses, see the examples below and the preparations of allosteric alkyne inhibitors of MMP-13 described in the above-referenced patent applications. 1525 The term celecoxib means the compound named 4-(5-(4-methylphenyl)-3-(trifluoromethyl)-1H-pyrazol-1-yl)-benzenesulfonamide. Celecoxib is currently approved by the FDA for the treatment of osteoarthritis, rheumatoid arthritis, and Polyposis-familial adenomatus. Celecoxib is marketed under the tradename Celebrex. Celecoxib is currently in clinical trials for the treatment of bladder cancer, chemopreventative-lung cancer, and post-operative pain, and is registered for the treatment of dysmenorrhea. Celecoxib has the structure drawn below: 45

1526 It should be appreciated that the invention combination may include celecoxib, or a pharmaceutically acceptable salt thereof. Preferred invention combinations include celecoxib. 1527 The term valdecoxib means the compound named 4-(5-methyl-3-phenyl-4-isoxazolyl)-benzenesulfonamide. Valdecoxib has been approved by the FDA for treating osteoarthritis, rheumatoid arthritis, dysmenorrhea, and general pain, and is marketed under the tradename Bextra. Valdecoxib is in clinical trials for the treatment of migraine. Valdecoxib has the structure drawn below: 46

1528 It should be appreciated that the invention combination may include valdecoxib, or a pharmaceutically acceptable salt thereof. Preferred invention combinations include valdecoxib. 1529 It should be further appreciated that celecoxib and valdecoxib are each selective inhibitors of COX-2, which is also known as prostaglandin synthase-2 and prostaglandin PGH2 synthase. 1530 A selective inhibitor of COX-2 means compounds that inhibit COX-2 selectively versus COX-1 such that a ratio of IC50 for a compound with COX-1 divided by a ratio of IC50 for the compound with COX-2 is greater than, or equal to, 5, where the ratios are determined in one or more of the in vitro, in vivo, or ex vivo assays described below. All that is required to determine whether a compound is a selective COX-2 inhibitor is to assay a compound in one of the pairs of assays described in Biological Methods 5 to 8 below. Preferred selective COX-2 inhibitors have a selectivity greater than 5 fold versus COX-1 in the assay described in Biological Method 5 below. 1531 The term NSAID is an acronym for the phrase nonsteroidal anti-inflammatory drug, which means any compound which inhibits cyclooxygenase-1 (COX-1) and cyclooxygenase-2. Most NSAIDs fall within one of the following five structural classes: (1) propionic acid derivatives, such as ibuprofen, naproxen, naprosyn, diclofenac, and ketoprofen; (2) acetic acid derivatives, such as tolmetin and sulindac; (3) fenamic acid derivatives, such as mefenamic acid and meclofenamic acid; (4) biphenylcarboxylic acid derivatives, such as diflunisal and flufenisal; and (5) oxicams, such as piroxim, peroxicam, sudoxicam, and isoxicam. Other useful NSAIDs include aspirin, acetominophen, indomethacin, and phenylbutazone. Selective inhibitors of cyclooxygenase-2 as described above may be considered to be NSAIDs also. 1532 For the purposes of this invention, the term arthritis, which is synonymous with the phrase arthritic condition, includes osteoarthritis, rheumatoid arthritis, degenerative joint disease, spondyloarthropathies, gouty arthritis, systemic lupus erythematosus, juvenile arthritis, and psoriatic arthritis. An allosteric alkyne inhibitor of MMP-13 having an anti-arthritic effect is a compound as defined above that inhibits the progress, prevents further progress, or reverses progression, in part or in whole, of any one or more symptoms of any one of the arthritic diseases and disorders listed above. 1533 Other mammalian diseases and disorders which are treatable by administration of an invention combination alone, or contained in a pharmaceutical composition as defined below, include: fever (including rheumatic fever and fever associated with influenza and other viral infections), common cold, dysmenorrhea, menstrual cramps, inflammatory bowel disease, Crohn's disease, emphysema, acute respiratory distress syndrome, asthma, bronchitis, chronic obstructive pulmonary disease, Alzheimer's disease, organ transplant toxicity, cachexia, allergic reactions, allergic contact hypersensitivity, cancer (such as solid tumor cancer including colon cancer, breast cancer, lung cancer and prostrate cancer; hematopoietic malignancies including leukemias and lymphomas; Hodgkin's disease; aplastic anemia, skin cancer and familiar adenomatous polyposis), tissue ulceration, peptic ulcers, gastritis, regional enteritis, ulcerative colitis, diverticulitis, recurrent gastrointestinal lesion, gastrointestinal bleeding, coagulation, anemia, synovitis, gout, ankylosing spondylitis, restenosis, periodontal disease, epidermolysis bullosa, osteoporosis, loosening of artificial joint implants, atherosclerosis (including atherosclerotic plaque rupture), aortic aneurysm (including abdominal aortic aneurysm and brain aortic aneurysm), periarteritis nodosa, congestive heart failure, myocardial infarction, stroke, cerebral ischemia, head trauma, spinal cord injury, neuralgia, neuro-degenerative disorders (acute and chronic), autoimmune disorders, Huntington's disease, Parkinson's disease, migraine, depression, peripheral neuropathy, pain (including low back and neck pain, headache and toothache), gingivitis, cerebral amyloid angiopathy, nootropic or cognition enhancement, amyotrophic lateral sclerosis, multiple sclerosis, ocular angiogenesis, corneal injury, macular degeneration, conjunctivitis, abnormal wound healing, muscle or joint sprains or strains, tendonitis, skin disorders (such as psoriasis, eczema, scleroderma and dermatitis), myasthenia gravis, polymyositis, myositis, bursitis, burns, diabetes (including types I and II diabetes, diabetic retinopathy, neuropathy and nephropathy), tumor invasion, tumor growth, tumor metastasis, corneal scarring, scleritis, immunodeficiency diseases (such as AIDS in humans and FLV, FIV in cats), sepsis, premature labor, hypoprothrombinemia, hemophilia, thyroiditis, sarcoidosis, Behcet's syndrome, hypersensitivity, kidney disease, Rickettsial infections (such as Lyme disease, Erlichiosis), Protozoan diseases (such as malaria, giardia, coccidia), reproductive disorders (preferably in livestock), epilepsy, convulsions, and septic shock. 1534 The term Thr245 means threonine 245 of an MMP-13 enzyme. 1535 The term Thr247 means threonine 247 of an MMP-13 enzyme. 1536 The term Met253 means methionine 253 of an MMP-13 enzyme. 1537 The term His251 means histidine 251 of an MMP-13 enzyme. 1538 It should be appreciated that the matrix metalloproteinases include, but are not limited to, the following enzymes: 1539 MMP-1, also known as interstitial collagenase, collagenase-1, or fibroblast-type collagenase; 1540 MMP-2, also known as gelatinase A or 72 kDa Type IV collagenase; 1541 MMP-3, also known as stromelysin or stromelysin-1; 1542 MMP-7, also known as matrilysin or PUMP-1; 1543 MMP-8, also known as collagenase-2, neutrophil collagenase or polymorphonuclear-type (PMN-type) collagenase; 1544 MMP-9, also known as gelatinase B or 92 kDa Type IV collagenase; 1545 MMP-10, also known as stromelysin-2; 1546 MMP 11, also known as stromelysin-3; 1547 MMP-12, also known as metalloelastase; 1548 MMP-13, also known as collagenase-3; 1549 MMP-14, also known as membrane-type (MT) 1-MMP or MT1-MMP; 1550 MMP-15, also known as MT2-MMP; 1551 MMP-16, also known as MT3-MMP; 1552 MMP-17, also known as MT4-MMP; 1553 MMP-18; and 1554 MMP-19. 1555 Other known MMPs include MMP-26 (Matrilysin-2). 1556 The phrase allosteric alkyne inhibitor of MMP-13 means an inhibitor containing a carbon-carbon triple bond moiety that binds to, coordinates to, or ligates a site in an MMP-13 enzyme that is at a location other than the enzyme's catalytically active site, wherein the catalytically active site is the site where the catalytic zinc cation of the MMP-13 enzyme binds, ligates, or coordinates a natural substrate(s). Thus an allosteric alkyne inhibitor of MMP-13 is any alkyne-containing inhibitor of an MMP-13 that does not bind to, coordinate to, or ligate, either directly or indirectly via a bridging water molecule, the catalytic zinc cation of a MMP-13. 1557 Further, an allosteric alkyne inhibitor of MMP-13, as used in the present invention, is a compound that does not ligate, coordinate to, or bind to the catalytic zinc cation of MMP-13, or a truncated form thereof, and is 5 times more potent in vitro versus MMP-13, or a truncated form thereof, than versus at least 2 other matrix metalloproteinase enzymes, including MMP-1, MMP-2, MMP-3, MMP-7, MMP-8, MMP-9, MMP-10, MMP-11, MMP-12, MMP-14, MMP-17, MMP-18, MMP-19, MMP-21, and MMP-26, and tumor necrosis factor alpha convertase (TACE). A preferred aspect of the present invention is combinations comprising allosteric alkyne inhibitors of MMP-13 that are selective inhibitors of MMP-13 over MMP-1. 1558 Other aspects of the present invention are allosteric alkyne inhibitors of MMP-13, or a pharmaceutically acceptable salt thereof, that are 10, 20, 50, 100, or 1000 times more potent versus MMP-13 than versus at least two of any other MMP enzyme or TACE. 1559 Still other aspects of the present invention are allosteric alkyne inhibitors of MMP-13, or a pharmaceutically acceptable salt thereof, that are selective inhibitors of MMP-13 versus 2, 3, 4, 5, 6, or 7 other MMP enzymes, or versus TACE and 1, 2, 3, 4, 5, 6, or 7 other MMP enzymes. 1560 It should be appreciated that selectivity of an allosteric alkyne inhibitor of MMP-13, or a pharmaceutically acceptable salt thereof, is a multidimensional characteristic that includes the number of other MMP enzymes and TACE over which selectivity for MMP-13 inhibition is present and the degree of selectivity of inhibition of MMP-13 over another particular MMP or TACE, as measured by, for example, the IC50 in micromolar concentration of inhibitor for the inhibition of the other MMP enzyme or TACE divided by the IC50 in micromolar concentration of inhibitor for the inhibition of MMP-13. 1561 The term IC50 means the concentration of a compound, usually expressed as micromolar or nanomolar, required to inhibit an enzyme's catalytic activity by 50%. 1562 The term ED40 means the concentration of a compound, usually expressed as micromolar or nanomolar, required to treat a disease in about 40% of a patient group. 1563 The term ED30 means the concentration of a compound, usually expressed as micromolar or nanomolar, required to treat a disease in 30% of a patient group. 1564 The phrase pharmaceutical composition means a composition suitable for administration in medical or veterinary use. 1565 The term admixed and the phrase in admixture are synonymous and mean in a state of being in a homogeneous or heterogeneous mixture. Preferred is a homogeneous mixture. 1566 As used herein, the phrase cartilage damage means a disorder of hyaline cartilage and subchondral bone characterized by hypertrophy of tissues in and around the involved joints, which may or may not be accompanied by deterioration of hyaline cartilage surface. 1567 The phrase treating, which is related to the terms treat and treated, means administration of an invention combination as defined above that inhibits the progress, prevents further progress, or reverses progression, in part or in whole, of any one or more symptoms of any one of the diseases and disorders listed above. 1568 The term comprising, which is synonymous with the terms including, containing, or characterized by, is inclusive or open-ended, and does not exclude additional, unrecited elements or method steps from the scope of the invention that is described following the term. 1569 The phrase consisting of is closed-ended, and excludes any element, step, or ingredient not specified in the description of the invention that follows the phrase. 1570 The phrase consisting essentially of limits the scope of the invention that follows to the specified elements, steps, or ingredients, and those further elements, steps, or ingredients that do not materially affect the basic and novel characteristics of the invention. 1571 The invention combination also includes isotopically-labelled compounds, which are identical to those recited above, but for the fact that one or more atoms are replaced by an atom having an atomic mass or mass number different from the atomic mass or mass number usually found in nature. Examples of isotopes that can be incorporated into compounds of the invention include isotopes of hydrogen, carbon, nitrogen, oxygen, phosphorous, fluorine and chlorine, such as 2H, 3H, 13C, 14C, 15N, 18O, 17O, 31P, 32P, 35S, 18F and 36Cl, respectively. Compounds of the present invention and pharmaceutically acceptable salts of said compounds which contain the aforementioned isotopes and/or other isotopes of other atoms are within the scope of this invention. Certain isotopically labelled compounds of the present invention, for example those into which radioactive isotopes such as 3H and 14C are incorporated, are useful in drug and/or substrate tissue distribution assays. Tritiated, i.e., 3H and carbon-14, i.e., 14C, isotopes are particularly preferred for their ease of preparation and detectability. Further, substitution with heavier isotopes such as deuterium, i.e., 2H, can afford certain therapeutic advantages resulting from greater metabolic stability, for example increased in vivo half-life or reduced dosage requirements and, hence, may be preferred in some circumstances. Isotopically labelled compounds of those described above in this invention can generally be prepared by carrying out the procedures incorporated by reference above or disclosed in the Schemes and/or in the Examples and Preparations below, by substituting a readily available isotopically labelled reagent for a non-isotopically labelled reagent. 1572 One of ordinary skill in the art will appreciate that the combinations of the invention are useful in treating a diverse array of diseases. One of ordinary skill in the art will also appreciate that when using the combinations of the invention in the treatment of a specific disease that the combinations of the invention may be combined with various existing therapeutic agents used for that disease. 1573 For the treatment of rheumatoid arthritis, the combinations of the invention may be combined with agents such as TNF- inhibitors such as anti-TNF monoclonal antibodies and TNF receptor immunoglobulin molecules (such as Enbrel), low dose methotrexate, lefunimide, hydroxychloroquine, d-penicillamine, auranofin or parenteral or oral gold. 1574 The combinations of the invention can also be used in combination with existing therapeutic agents for the treatment of osteoarthritis. Suitable agents to be used in combination include standard non-steroidal anti-inflammatory agents (hereinafter NSAID's) such as piroxicam, diclofenac, propionic acids such as naproxen, flurbiprofen, fenoprofen, ketoprofen and ibuprofen, fenamates such as mefenamic acid, indomethacin, sulindac, apazone, pyrazolones such as phenylbutazone, salicylates such as aspirin, COX-2 inhibitors such as celecoxib and rofecoxib, analgesics and intraarticular therapies such as corticosteroids and hyaluronic acids such as hyalgan and synvisc. 1575 This invention also relates to a method of or a pharmaceutical composition for treating inflammatory processes and diseases comprising administering a combination of this invention to a mammal, including a human, cat, livestock or dog, wherein said inflammatory processes and diseases are defined as above and said inhibitory combination is used in combination with one or more other therapeutically active agents under the following conditions: 1576 A.) where a joint has become seriously inflamed as well as infected at the same time by bacteria, fungi, protozoa and/or virus, said inhibitory combination is administered in combination with one or more antibiotic, antifungal, antiprotozoal and/or antiviral therapeutic agents; 1577 B.) where a multi-fold treatment of pain and inflammation is desired, said inhibitory combination is administered in combination with inhibitors of other mediators of inflammation, comprising one or more members independently selected from the group consisting essentially of: 1578 (1) NSAIDs; 1579 (2) H1-receptor antagonists; 1580 (3) kinin-B1- and B2-receptor antagonists; 1581 (4) prostaglandin inhibitors selected from the group consisting of PGD-, PGF-PGI2- and PGE-receptor antagonists; 1582 (5) thromboxane A2 (TXA2-) inhibitors; 1583 (6) 5-, 12- and 15-lipoxygenase inhibitors; 1584 (7) leukotriene LTC4-, LTD4/LTE4- and LTB4-inhibitors; 1585 (8) PAF-receptor antagonists; 1586 (9) gold in the form of an aurothio group together with one or more hydrophilic groups; 1587 (10) immunosuppressive agents selected from the group consisting of cyclosporine, azathioprine and methotrexate; 1588 (11) anti-inflammatory glucocorticoids; 1589 (12) penicillamine; 1590 (13) hydroxychloroquine; 1591 (14) anti-gout agents including coichicine; xanthine oxidase inhibitors including allopurinol; and uricosuric agents selected from probenecid, sulfinpyrazone and benzbromarone; 1592 C. where older mammals are being treated for disease conditions, syndromes and symptoms found in geriatric mammals, said inhibitory combination is administered in combination with one or more members independently selected from the group consisting essentially of: 1593 (1) cognitive therapeutics to counteract memory loss and impairment; 1594 (2) anti-hypertensives and other cardiovascular drugs intended to offset the consequences of atherosclerosis, hypertension, myocardial ischemia, angina, congestive heart failure and myocardial infarction, selected from the group consisting of: 1595 a. diuretics; 1596 b. vasodilators; 1597 c. -adrenergic receptor antagonists; 1598 d. angiotensin-II converting enzyme inhibitors (ACE-inhibitors), alone or optionally together with neutral endopeptidase inhibitors; 1599 e. angiotensin II receptor antagonists; 1600 f. renin inhibitors; 1601 g. calcium channel blockers; 1602 h. sympatholytic agents; 1603 i. 2-adrenergic agonists; 1604 j. -adrenergic receptor antagonists; and 1605 k. HMG-CoA-reductase inhibitors (anti-hypercholesterolemics); 1606 (3) antineoplastic agents selected from: 1607 a. antimitotic drugs selected from: 1608 i. vinca alkaloids selected from: 1609 1 vinblastine and 1610 2 vincristine; 1611 (4) growth hormone secretagogues; 1612 (5) strong analgesics; 1613 (6) local and systemic anesthetics; and 1614 (7) H2-receptor antagonists, proton pump inhibitors and other gastroprotective agents. 1615 The active ingredient of the present invention may be administered in combination with inhibitors of other mediators of inflammation, comprising one or more members selected from the group consisting essentially of the classes of such inhibitors and examples thereof which include, matrix metalloproteinase inhibitors, aggrecanase inhibitors, TACE inhibitors, leucotriene receptor antagonists, IL-1 processing and release inhibitors, ILra, H1-receptor antagonists; kinin-B1- and B2-receptor antagonists; prostaglandin inhibitors such as PGD-, PGF-PGI2- and PGE-receptor antagonists; thromboxane A2 (TXA2-) inhibitors; 5- and 12-lipoxygenase inhibitors; leukotriene LTC4-, LTD4/LTE4- and LTB4-inhibitors; PAF-receptor antagonists; gold in the form of an aurothio group together with various hydrophilic groups; immunosuppressive agents, e.g., cyclosporine, azathioprine and methotrexate; anti-inflammatory glucocorticoids; penicillamine; hydroxychloroquine; anti-gout agents, e.g., colchicine, xanthine oxidase inhibitors, e.g., allopurinol and uricosuric agents, e.g., probenecid, sulfinpyrazone and benzbromarone. 1616 The combinations of the present invention may also be used in combination with anticancer agents such as endostatin and angiostatin or cytotoxic drugs such as adriamycin, daunomycin, cis-platinum, etoposide, taxol, taxotere and alkaloids, such as vincristine and antimetabolites such as methotrexate. 1617 The combinations of the present invention may also be used in combination with anti-hypertensives and other cardiovascular drugs intended to offset the consequences of atherosclerosis, including hypertension, myocardial ischemia including angina, congestive heart failure and myocardial infarction, selected from vasodilators such as hydralazine, -adrenergic receptor antagonists such as propranolol, calcium channel blockers such as nifedipine, 2-adrenergic agonists such as clonidine, -adrenergic receptor antagonists such as prazosin and HMG-CoA-reductase inhibitors (anti-hypercholesterolemics) such as lovastatin or atorvastatin. 1618 The combination of the present invention may also be administered in combination with one or more antibiotic, antifungal, antiprotozoal, antiviral or similar therapeutic agents. 1619 The combinations of the present invention may also be used in combination with CNS agents such as antidepressants (such as sertraline), anti-Parkinsonian drugs (such as L-dopa, requip, mirapex, MAOB inhibitors such as selegine and rasagiline, comP inhibitors such as Tasmar, A-2 inhibitors, dopamine reuptake inhibitors, NMDA antagonists, nicotine agonists, dopamine agonists and inhibitors of neuronal nitric oxide synthase) and anti-Alzheimer's drugs such as donepezil, tacrine, COX-2 inhibitors, propentofylline or metryfonate. 1620 The combinations of the present invention may also be used in combination with osteoporosis agents such as roloxifene, lasofoxifene, droloxifene or fosomax and immunosuppressant agents such as FK-506 and rapamycin. 1621 The present invention also relates to the formulation of the combination of the present invention alone or with one or more other therapeutic agents which are to form the intended combination, including wherein said different drugs have varying half-lives, by creating controlled-release forms of said drugs with different release times which achieves relatively uniform dosing; or, in the case of non-human patients, a medicated feed dosage form in which said drugs used in the combination are present together in admixture in the feed composition. There is further provided in accordance with the present invention co-administration in which the combination of drugs is achieved by the simultaneous administration of said drugs to be given in combination; including co-administration by means of different dosage forms and routes of administration; the use of combinations in accordance with different but regular and continuous dosing schedules whereby desired plasma levels of said drugs involved are maintained in the patient being treated, even though the individual drugs making up said combination are not being administered to said patient simultaneously. 1622 The term drugs, which is synonymous with the phrases active components, active compounds, and active ingredients, includes celecoxib, or a pharmaceutically acceptable salt thereof, valdecoxib, or a pharmaceutically acceptable salt thereof, and an allosteric alkyne inhibitor of MMP-13, and may further include one or two of the other therapeutic agents described above. 1623 The invention method is useful in human and veterinary medicines for treating mammals suffering from one or more of the above-listed diseases and disorders. 1624 The term mammal includes humans, companion animals such as cats and dogs, primates such as monkeys and chimpanzees, and livestock animals such as horses, cows, pigs, and sheep. 1625 The phrase livestock animals as used herein refers to domesticated quadrupeds, which includes those being raised for meat and various byproducts, e.g., a bovine animal including cattle and other members of the genus Bos, a porcine animal including domestic swine and other members of the genus Sus, an ovine animal including sheep and other members of the genus Ovis, domestic goats and other members of the genus Capra; domesticated quadrupeds being raised for specialized tasks such as use as a beast of burden, e.g., an equine animal including domestic horses and other members of the family Equidae, genus Equus, or for searching and sentinel duty, e.g., a canine animal including domestic dogs and other members of the genus Canis; and domesticated quadrupeds being raised primarily for recreational purposes, e.g., members of Equus and Canis, as well as a feline animal including domestic cats and other members of the family Felidae, genus Felis. 1626 All that is required to practice the method of this invention is to administer a combination of valdecoxib, or a pharmaceutically acceptable salt thereof, or celecoxib, or a pharmaceutically acceptable salt thereof, and an allosteric alkyne inhibitor of MMP-13, or a pharmaceutically acceptable salt thereof, in an amount that is therapeutically effective for preventing, inhibiting, or reversing the condition being treated. The invention combination can be administered directly or in a pharmaceutical composition as described below. 1627 A therapeutically effective amount, or, simply, effective amount, of an invention combination will generally be from about 1 to about 300 mg/kg of subject body weight of valdecoxib, or a pharmaceutically acceptable salt thereof, or celecoxib, or a pharmaceutically acceptable salt thereof, and from about 1 to about 300 mg/kg of subject body weight of an allosteric alkyne inhibitor of MMP-13, or a pharmaceutically acceptable salt thereof. Typical doses will be from about 10 to about 5000 mg/day for an adult subject of normal weight for each component of the combination. In a clinical setting, regulatory agencies such as, for example, the Food and Drug Administration (FDA) in the U.S. may require a particular therapeutically effective amount. 1628 In determining what constitutes an effective amount or a therapeutically effective amount of an invention combination for treating, preventing, or reversing one or more symptoms of any one of the diseases and disorders described above that are being treated according to the invention methods, a number of factors will generally be considered by the medical practitioner or veterinarian in view of the experience of the medical practitioner or veterinarian, including the Food and Drug Administration guidelines, or guidelines from an equivalent agency, published clinical studies, the subject's (e.g., mammal's) age, sex, weight and general condition, as well as the type and extent of the disease, disorder or condition being treated, and the use of other medications, if any, by the subject. As such, the administered dose may fall within the ranges or concentrations recited above, or may vary outside them, ie, either below or above those ranges, depending upon the requirements of the individual subject, the severity of the condition being treated, and the particular therapeutic formulation being employed. Determination of a proper dose for a particular situation is within the skill of the medical or veterinary arts. Generally, treatment may be initiated using smaller dosages of the invention combination that are less than optimum for a particular subject. Thereafter, the dosage can be increased by small increments until the optimum effect under the circumstance is reached. For convenience, the total daily dosage may be divided and administered in portions during the day, if desired. 1629 Pharmaceutical compositions, described briefly here and more fully below, of an invention combination may be produced by formulating the invention combination in dosage unit form with a pharmaceutical carrier. Some examples of dosage unit forms are tablets, capsules, pills, powders, aqueous and nonaqueous oral solutions and suspensions, and parenteral solutions packaged in containers containing either one or some larger number of dosage units and capable of being subdivided into individual doses. Alternatively, the active components of the invention combination may be formulated separately. 1630 Some examples of suitable pharmaceutical carriers, including pharmaceutical diluents, are gelatin capsules; sugars such as lactose and sucrose; starches such as corn starch and potato starch; cellulose derivatives such as sodium carboxymethyl cellulose, ethyl cellulose, methyl cellulose, and cellulose acetate phthalate; gelatin; talc; stearic acid; magnesium stearate; vegetable oils such as peanut oil, cottonseed oil, sesame oil, olive oil, corn oil, and oil of theobroma; propylene glycol, glycerin; sorbitol; polyethylene glycol; water; agar; alginic acid; isotonic saline, and phosphate buffer solutions; as well as other compatible substances normally used in pharmaceutical formulations. 1631 The compositions to be employed in the invention can also contain other components such as coloring agents, flavoring agents, and/or preservatives. These materials, if present, are usually used in relatively small amounts. The compositions can, if desired, also contain other therapeutic agents commonly employed to treat any of the above-listed diseases and disorders. 1632 The percentage of the active ingredients of valdecoxib, or a pharmaceutically acceptable salt thereof, or celecoxib, or a pharmaceutically acceptable salt thereof, and an allosteric alkyne inhibitor of MMP-13, or a pharmaceutically acceptable salt thereof, in the foregoing compositions can be varied within wide limits, but for practical purposes it is preferably present in a total concentration of at least 10% in a solid composition and at least 2% in a primary liquid composition. The most satisfactory compositions are those in which a much higher proportion of the active ingredients are present, for example, up to about 95%. 1633 Preferred routes of administration of an invention combination are oral or parenteral. However, another route of administration may be preferred depending upon the condition being treated. For exampled, topical administration or administration by injection may be preferred for treating conditions localized to the skin or a joint. Administration by transdermal patch may be preferred where, for example, it is desirable to effect sustained dosing. 1634 It should be appreciated that the different routes of administration may require different dosages. For example, a useful intravenous (IV) dose is between 5 and 50 mg, and a useful oral dosage is between 20 and 800 mg, both for each of valdecoxib, or a pharmaceutically acceptable salt thereof, or celecoxib, or a pharmaceutically acceptable salt thereof, and the allosteric alkyne inhibitor of MMP-13, or a pharmaceutically acceptable salt thereof. The dosage is within the dosing range used in treatment of the above-listed diseases, or as would be determined by the needs of the patient as described by the physician. 1635 The invention combination may be administered in any form. Preferably, administration is in unit dosage form. A unit dosage form of the invention combination to be used in this invention may also comprise other compounds useful in the therapy of diseases described above. A further description of pharmaceutical formulations useful for administering the invention combinations is provided below. 1636 The active components of the invention combination, including valdecoxib, or a pharmaceutically acceptable salt thereof, or celecoxib, or a pharmaceutically acceptable salt thereof, an allosteric alkyne inhibitor of MMP-13, or a pharmaceutically acceptable salt thereof, and other compounds as described above, if any, may be formulated together or separately and may be administered together or separately. The particular formulation and administration regimens used may be tailored to the particular patient and condition being treated by a practitioner of ordinary skill in the medical or pharmaceutical arts. 1637 The advantages of using an invention combination comprising valdecoxib, or a pharmaceutically acceptable salt thereof, or celecoxib, or a pharmaceutically acceptable salt thereof, and an allosteric alkyne inhibitor of MMP-13, or a pharmaceutically acceptable salt thereof, in a method of the instant invention include the nontoxic nature of the compounds which comprise the combination at and substantially above therapeutically effective doses, their ease of preparation, the fact that the compounds are well-tolerated, and the ease of topical, IV, or oral administration of the drugs. 1638 Another important advantage is that the present invention combinations more effectively target a particular disease that is responsive to inhibition of MMP-13 with fewer undesirable side effects than similar combinations that contain MMP-13 inhibitors that are not allosteric alkyne inhibitors of MMP-13. This is so because the instant allosteric alkyne inhibitors of MMP-13, or a pharmaceutically acceptable salt thereof, do not directly, or indirectly via a bridging water molecule, ligate, coordinate to, or bind to the catalytic zinc cation of MMP-13, but instead bind at a different location from where natural substrate binds to MMP-13. The binding requirements of an allosteric MMP-13 binding site are unique to MMP-13, and account for the specificity of the instant allosteric alkyne inhibitors of MMP-13 for inhibiting MMP-13 over any other MMP enzyme. This binding mode has not been reported in the art. Indeed, prior art inhibitors of MMP-13 bind to the catalytic zinc cations of other MMP enzymes as well as to the catalytic zinc cation of MMP-13 and, and are consequently significantly less selective inhibitors of MMP-13 enzyme. 1639 The instant allosteric alkyne inhibitors of MMP-13 are thus therapeutically superior to other inhibitors of MMP-13, or even tumor necrosis factor-alpha converting enzyme (TACE), because of fewer undesirable side effects from inhibition of the other MMP enzymes or TACE. For example, virtually all prior art MMP inhibitors tested clinically to date have exhibited an undesirable side effect known as muscoloskeletal syndrome (MSS). MSS is associated with administering an inhibitor of multiple MMP enzymes or an inhibitor of a particular MMP enzyme such as MMP-1. MSS will be significantly reduced in type and severity by administering the invention combination instead of any combination of a prior art MMP-13 inhibitor with celecoxib or valdecoxib, or a pharmaceutically acceptable salt thereof. The invention combinations are superior to similar combinations that include a COX-2 selective inhibitor with an MMP inhibitor that interacts with the catalytic zinc cation of the MMP-13 enzyme as discussed above, even if that inhibitor shows some selectivity for the MMP-13. 1640 This advantage of the instant combinations will also significantly increase the likelihood that agencies which regulate new drug approvals, such as the United States Food and Drug Administration, will approve the instant combination versus a competing similar combination as discussed above even in the unlikely event that the two combinations behaved similarly in clinical trials. These regulatory agencies are increasingly aware that clinical trials, which test drug in limited population groups, do not always uncover safety problems with a drug, and thus all other things being equal, the agencies will favor the drug with the lowest odds of producing undesirable side effects. 1641 Another important advantage is that the independent anti-inflammatory and pain reducing properties described above for valdecoxib and celecoxib and the disease modifying properties of allosteric alkyne inhibitors of MMP-13 provide patients suffering from cartilage damage, arthritis, preferably osteoarthritis, inflammation and/or pain with both relief of symptoms and prevention or inhibition of the underlying disease pathology such as cartilage degradation. 1642 A further advantage of the invention combination is administration of the invention combination to treat a disease or disorder in a mammal may allow lower doses of valdecoxib, or a pharmaceutically acceptable salt thereof, or celecoxib, or a pharmaceutically acceptable salt thereof, and/or an allosteric alkyne inhibitor of MMP-13 of the combination to be used than would be used if valdecoxib, or a pharmaceutically acceptable salt thereof, or celecoxib, or a pharmaceutically acceptable salt thereof, and the allosteric inhibitor of MMP-13 were each administered alone. Another expected advantage is that two therapeutically beneficial effects, for example, inhibiting cartilage damage and alleviating pain, are obtainable with the invention combination whereas just one of those effects is possible with a single active component of the combination. 1643 Some of the compounds utilized in an invention combination are capable of further forming pharmaceutically acceptable salts, including, but not limited to, acid addition and/or base salts. The acid addition salts are formed from basic compounds, whereas the base addition salts are formed from acidic compounds. All of these forms are within the scope of the compounds useful in the invention combination. 1644 Pharmaceutically acceptable acid addition salts of the basic compounds useful in the invention combination include nontoxic salts derived from inorganic acids such as hydrochloric, nitric, phosphoric, sulfuric, hydrobromic, hydroiodic, hydrofluoric, phosphorous, and the like, as well nontoxic salts derived from organic acids, such as aliphatic mono- and dicarboxylic acids, phenyl-substituted alkanoic acids, hydroxy alkanoic acids, alkanedioic acids, aromatic acids, aliphatic and aromatic sulfonic acids, etc. Such salts thus include sulfate, pyrosulfate, bisulfate, sulfite, bisulfite, nitrate, phosphate, monohydrogenphosphate, dihydrogenphosphate, metaphosphate, pyrophosphate, chloride, bromide, iodide, acetate, trifluoroacetate, propionate, caprylate, isobutyrate, oxalate, malonate, succinate, suberate, sebacate, fumarate, maleate, mandelate, benzoate, chlorobenzoate, methylbenzoate, dinitrobenzoate, phthalate, benzenesulfonate, toluenesulfonate, phenylacetate, citrate, lactate, malate, tartrate, methanesulfonate, and the like. Also contemplated are salts of amino acids such as arginate and the like and gluconate, galacturonate (see, for example, Berge S. M. et al., Pharmaceutical Salts, J. of Pharma. Sci., 1977;66:1). 1645 An acid addition salt of a basic compound useful in the invention combination is prepared by contacting the free base form of the compound with a sufficient amount of a desired acid to produce a nontoxic salt in the conventional manner. The free base form of the compound may be regenerated by contacting the acid addition salt so formed with a base, and isolating the free base form of the compound in the conventional manner. The free base forms of compounds prepared according to a process of the present invention differ from their respective acid addition salt forms somewhat in certain physical properties such as solubility, crystal structure, hygroscopicity, and the like, but otherwise free base forms of the compounds and their respective acid addition salt forms are equivalent for purposes of the present invention. 1646 A pharmaceutically acceptable base addition salt of an acidic compound useful in the invention combination may be prepared by contacting the free acid form of the compound with a nontoxic metal cation such as an alkali or alkaline earth metal cation, or an amine, especially an organic amine. Examples of suitable metal cations include sodium cation (Na), potassium cation (K), magnesium cation (Mg2), calcium cation (Ca2), and the like. Examples of suitable amines are N,N-dibenzylethylenediamine, chloroprocaine, choline, diethanolamine, dicyclohexylamine, ethylenediamine, N-methylglucamine, and procaine (see, for example, Berge, supra., 1977). 1647 A base addition salt of an acidic compound useful in the invention combination may be prepared by contacting the free acid form of the compound with a sufficient amount of a desired base to produce the salt in the conventional manner. The free acid form of the compound may be regenerated by contacting the salt form so formed with an acid, and isolating the free acid of the compound in the conventional manner. The free acid forms of the compounds useful in the invention combination differ from their respective salt forms somewhat in certain physical properties such as solubility, crystal structure, hygroscopicity, and the like, but otherwise the salts are equivalent to their respective free acid for purposes of the present invention. 1648 Certain of the compounds useful in the invention combination can exist in unsolvated forms as well as solvated forms, including hydrated forms. In general, the solvated forms, including hydrated forms, are equivalent to unsolvated forms and are encompassed within the scope of the present invention. 1649 Certain of the compounds useful in the invention combination possess one or more chiral centers, and each center may exist in the R or S configuration. An invention combination may utilize any diastereomeric, enantiomeric, or epimeric form of a compound useful in the invention combination, as well as mixtures thereof. 1650 Additionally, certain compounds useful in the invention combination may exist as geometric isomers such as the entgegen (E) and zusammen (Z) isomers of 1,2-disubstituted alkenyl groups or cis and trans isomers of disubstituted cyclic groups. An invention combination may utilize any cis, trans, syn, anti, entgegen (E), or zusammen (Z) isomer of a compound useful in the invention combination, as well as mixtures thereof. 1651 Certain compounds useful in the invention combination can exist as two or more tautomeric forms. Tautomeric forms of the compounds may interchange, for example, via enolization/de-enolization, 1,2-hydride, 1,3-hydride, or 1,4-hydride shifts, and the like. An invention combination may utilize any tautomeric form of a compound useful in the invention combination, as well as mixtures thereof. 1652 The syntheses of valdecoxib, or a pharmaceutically acceptable salt thereof, and celecoxib, or a pharmaceutically acceptable salt thereof, are well-known in the art, and have even been carried out to produce commercial-scale quantities of compound. The synthesis of allosteric inhibitors of MMP-13 are taught in the patent applications incorporated above by reference. 1653 Intermediates for the synthesis of valdecoxib, or a pharmaceutically acceptable salt thereof, celecoxib, or a pharmaceutically acceptable salt thereof, and an allosteric alkyne inhibitor of MMP-13, or a pharmaceutically acceptable salt thereof, useful in the invention combination may be prepared by one of ordinary skill in the art of organic chemistry by adapting various synthetic procedures incorporated by reference above or that are well-known in the art of organic chemistry. These synthetic procedures may be found in the literature in, for example, Reagents for Organic Synthesis, by Fieser and Fieser, John Wiley & Sons, Inc, New York, 2000; Comprehensive Organic Transformations, by Richard C. Larock, VCH Publishers, Inc, New York, 1989; the series Compendium of Organic Synthetic Methods, 1989, by Wiley-Interscience; the text Advanced Organic Chemistry, 4th edition, by Jerry March, Wiley-Interscience, New York, 1992; or the Handbook of Heterocyclic Chemistry by Alan R. Katritzky, Pergamon Press Ltd, London, 1985, to name a few. Alternatively, a skilled artisan may find methods useful for preparing the intermediates in the chemical literature by searching widely available databases such as, for example, those available from the Chemical Abstracts Service, Columbus, Ohio, or MDL Information Systems GmbH (formerly Beilstein Information Systems GmbH), Frankfurt, Germany. 1654 Preparations of the compounds useful in an invention combination may use starting materials, reagents, solvents, and catalysts that may be purchased from commercial sources or they may be readily prepared by adapting procedures in the references or resources cited above. Commercial sources of starting materials, reagents, solvents, and catalysts useful in preparing invention compounds include, for example, The Aldrich Chemical Company, and other subsidiaries of Sigma-Aldrich Corporation, St. Louis, Mo., BACHEM, BACHEM A. G., Switzerland, or Lancaster Synthesis Ltd, United Kingdom. 1655 Syntheses of some compounds useful in the invention combination may utilize starting materials, intermediates, or reaction products that contain a reactive functional group. During chemical reactions, a reactive functional group may be protected from reacting by a protecting group that renders the reactive functional group substantially inert to the reaction conditions employed. A protecting group is introduced onto a starting material prior to carrying out the reaction step for which a protecting group is needed. Once the protecting group is no longer needed, the protecting group can be removed. It is well within the ordinary skill in the art to introduce protecting groups during a synthesis of valdecoxib, or a pharmaceutically acceptable salt thereof, or celecoxib, or a pharmaceutically acceptable salt thereof, or an allosteric alkyne inhibitor of MMP-13, or a pharmaceutically acceptable salt thereof, and then later remove them. Procedures for introducing and removing protecting groups are known and referenced such as, for example, in Protective Groups in Organic Synthesis, 2nd ed., Greene T. W. and Wuts P. G., John Wiley & Sons, New York: New York, 1991, which is hereby incorporated by reference. 1656 Thus, for example, protecting groups such as the following may be utilized to protect amino, hydroxyl, and other groups: carboxylic acyl groups such as, for example, formyl, acetyl, and trifluoroacetyl; alkoxycarbonyl groups such as, for example, ethoxycarbonyl, tert-butoxycarbonyl (BOC), ,,-trichloroethoxycarbonyl (TCEC), and -iodoethoxycarbonyl; aralkyloxycarbonyl groups such as, for example, benzyloxycarbonyl (CBZ), para-methoxybenzyloxycarbonyl, and 9-fluorenylmethyloxycarbonyl (FMOC); trialkylsilyl groups such as, for example, trimethylsilyl (TMS) and tert-butyldimethylsilyl (TBDMS); and other groups such as, for example, triphenylmethyl (trityl), tetrahydropyranyl, vinyloxycarbonyl, ortho-nitrophenylsulfenyl, diphenylphosphinyl, para-toluenesulfonyl (Ts), mesyl, trifluoromethanesulfonyl, and benzyl. Examples of procedures for removal of protecting groups include hydrogenolysis of CBZ groups using, for example, hydrogen gas at 50 psi in the presence of a hydrogenation catalyst such as 10% palladium on carbon, acidolysis of BOC groups using, for example, hydrogen chloride in dichloromethane, trifluoroacetic acid (TFA) in dichloromethane, and the like, reaction of silyl groups with fluoride ions, and reductive cleavage of TCEC groups with zinc metal. 1657 Preparations of valdecoxib, or a pharmaceutically acceptable salt thereof, or an allosteric alkyne inhibitor of MMP-13, or a pharmaceutically acceptable salt thereof, useful in the invention combination are incorporated by reference to the patents, patent applications, and patent application publications described above. 1658 Preparations of allosteric alkyne inhibitors of MMP-13 are incorporated by reference as follows: 1659 1. Examples of Quinazoline Allosteric Alkyne Inhibitors of MMP-13: 1660 The syntheses of compounds of Formula (A), such as quinazoline-based allosteric alkyne inhibitors of MMP-13, are described in, and incorporated from, our co-pending U.S. provisional application No. 60/329,181, and the corresponding PCT International application number PCT/EP01/11824, both filed on Oct. 12, 2001. 1661 It should be appreciated that the allosteric alkyne inhibitors of MMP-13 in co-pending U.S. provisional application No. 60/329,181, and the corresponding PCT International application number PCT/EP011/11824 include a first scaffold ring, a second scaffold ring fused to the first scaffold ring, a first hydrophobic group, and a first hydrogen bond acceptor group. The alkyne carbon-carbon triple bond is located between the first scaffold ring and the first hydrophobic group, and forms part of the first hydrogen bond acceptor. 1662 2. Examples of Other Allosteric Alkyne Inhibitors of MMP-13: 1663 The syntheses of other allosteric alkyne inhibitors of MMP-13 are described in, and incorporated from, our co-pending U.S. provisional application No. 60/329,216, filed on Oct. 12, 2001. 1664 The allosteric alkyne inhibitors of MMP-13 have been evaluated in standard assays for their ability to inhibit the catalytic activity of various MMP enzymes. The assays used to evaluate the MMP biological activity of the invention compounds are well-known and routinely used by those skilled in the study of MMP inhibitors and their use to treat clinical conditions. For example, allosteric alkyne inhibitors of MMP-13 may be readily identified by assaying a test compound for inhibition of MMP-13 according to Biological Methods 1 or 2, and further assaying the test compound for allosteric inhibition of MMP-13 according to Biological Methods 3 or 4, as described below. 1665 The allosteric alkyne inhibitors of MMP-13 have been shown to be potent and selective inhibitors of MMP-13 catalytic domain versus full-length MMP-1 and MMP-3 catalytic domain. Potencies with MMP-13 catalytic domain for the allosteric inhibitors of MMP-13 typically range from about 0.001 M to about 1 M. Some compounds were further screened with full-length MMP-2, full-length MMP-7, full-length MMP-9, and MMP-14 catalytic domain, and were found to be selective inhibitors of MMP-13 versus these other MMP enzymes also. Selectivity of the allosteric inhibitors of MMP-13 for MMP-13 catalytic domain versus another MMP enzyme (full-length or catalytic domain), as determined by dividing the IC50 for the inhibitor with a comparator MMP enzyme by the IC50 of the inhibitor with MMP-13 catalytic domain, typically ranged from 5 to 50,000 fold. 1666 For illustration purposes, examples of allosteric alkyne inhibitors of MMP-13, and their inhibitory profiles with various MMP enzymes, are described below. To determine the inhibitory profiles, the allosteric alkyne inhibitors of MMP-13 have been evaluated in standard assays for their ability to inhibit the catalytic activity of various MMP enzymes. The assays used to evaluate the MMP biological activity of the invention compounds are well-known and routinely used by those skilled in the study of MMP inhibitors and their use to treat clinical conditions. 1667 The assays measure the amount by which a test compound reduces the hydrolysis of a thiopeptolide substrate catalyzed by a matrix metalloproteinase enzyme. Such assays are described in detail by Ye et al., in Biochemistry, 1992;31(45):11231-11235, which is incorporated herein by reference. One such assay is described below in Biological Method 1. 1668 Some of the particular methods described below use the catalytic domain of the MMP-13 enzyme, namely matrix metalloproteinase-13 catalytic domain (MMP-13CD), rather than the corresponding full-length enzyme, MMP-13. It has been shown previously by Ye Qi-Zhuang, Hupe D., and Johnson L. (Current Medicinal Chemistry, 1996;3:407-418) that inhibitor activity against a catalytic domain of an MMP is predictive of the inhibitor activity against the respective full-length MMP enzyme.

BIOLOGICAL METHOD 1 1669 Thiopeptolide substrates show virtually no decomposition or hydrolysis at or below neutral pH in the absence of a matrix metalloproteinase enzyme. A typical thiopeptolide substrate commonly utilized for assays is Ac-Pro-Leu-Gly-thioester-Leu-Leu-Gly-OEt. A 100 L assay mixture will contain 50 mM of N-2-hydroxyethylpiperazine-N-2-ethanesulfonic acid buffer (HEPES, pH 7.0), 10 mM CaCl2, 100 M thiopeptolide substrate, and 1 mM 5,5-dithio-bis-(2-nitro-benzoic acid) (DTNB). The thiopeptolide substrate concentration may be varied, for example from 10 to 800 M to obtain Km and Kcat values. The change in absorbance at 405 nm is monitored on a Thermo Max microplate reader (molecular Devices, Menlo Park, Calif.) at room temperature (22 C.). The calculation of the amount of hydrolysis of the thiopeptolide substrate is based on E41213600 M1 cm1 for the DTNB-derived product 3-carboxy-4-nitrothiophenoxide. Assays are carried out with and without matrix metalloproteinase inhibitor compounds, and the amount of hydrolysis is compared for a determination of inhibitory activity of the test compounds. 1670 Test compounds were evaluated at various concentrations in order to determine their respective IC50 values, the micromolar concentration of compound required to cause a 50% inhibition of catalytic activity of the respective enzyme. 1671 It should be appreciated that the assay buffer used with MMP-3CD was 50 mM N-morpholinoethane sulfonate (MES) at pH 6.0 rather than the HEPES buffer at pH 7.0 described above. 1672 The test described above for the inhibition of MMP-13 was also adapted and used to determine the ability of the compounds of formula (A) to inhibit the matrix metalloproteases MMP-1, MMP-2, MMP-3, MMP-7, MMP-9, MMP-12 and MMP-14. The results obtained show that the compounds of Formula (A) generally have IC50 values for MMP-13 which are about 100 times lower than the IC50 values for the same compounds with respect to the other matrix metalloproteases tested.

BIOLOGICAL METHOD 2 1673 Some representative allosteric alkyne inhibitors of MMP-13 have been evaluated for their ability to inhibit MMP-13. Inhibitor activity versus other MMPs with the compounds may be determined using, for example, MMP-1FL, which refers to full length interstitial collagenase; MMP-2FL, which refers to full length Gelatinase A; MMP-3CD, which refers to the catalytic domain of stromelysin; MMP-7FL, which refers to full length matrilysin; MMP-9FL, which refers to full length Gelatinase B; MMP-13CD, which refers to the catalytic domain of collagenase 3; and MMP-14CD, which refers to the catalytic domain of MMP-14. Test compounds can be evaluated at various concentrations in order to determine their respective IC50 values, the micromolar concentration of compound required to cause a 50% inhibition of the hydrolytic activity of the respective enzyme. 1674 The results of the above assays with other MMPs will establish that the allosteric alkyne inhibitors of MMP-13 are potent inhibitors of MMP enzymes, and are especially useful due to their selective inhibition of MMP-13. Because of this potent and selective inhibitory activity, the compounds are especially useful, in combination with a selective inhibitor of COX-2, to treat diseases mediated by the MMP enzymes and COX-2, and particularly those mediated by MMP-13 and COX-2. 1675 Allosteric alkyne inhibitors of MMP-13 may be readily identified by assaying a test compound for inhibition of MMP-13 according to the methods described below in Biological Methods 3 and 4.

BIOLOGICAL METHOD 3 1676 Fluorigenic peptide-1 substrate based assay for identifying allosteric alkyne inhibitors of MMP-13CD: 1677 Final Assay Conditions: 1678 50 mM HEPES buffer (pH 7.0) 1679 10 mM CaCl2 1680 10 M fluorigenic peptide-1 (FP1) substrate 1681 0 or 15 mM acetohydroxamic acid (AcNHOH)1 Kd 1682 2% DMSO (with or without inhibitor test compound) 1683 0.5 nM MMP-13CD enzyme 1684 Stock Solutions: 1685 1) 10 assay buffer: 500 mM HEPES buffer (pH 7.0) plus 100 mM CaCl21686 2) 10 mM FP1 substrate: (Mca)-Pro-Leu-Gly-Leu-(Dnp)-Dpa-Ala-Arg-NH2 (Bachem, M-1895; A novel coumarin-labeled peptide for sensitive continuous assays of the matrix metalloproteinases, Knight C. G., Willenbrock F., and Murphy, G., FEBS Lett., 1992;296:263-266). Prepared 10 mM stock by dissolving 5 mg FP1 in 0.457 mL DMSO. 1687 3) 3 M AcNHOH: Prepared by adding 4 mL H2O and 1 mL 10 assay buffer to 2.25 g AcNHOH (Aldrich 15,903-4). Adjusted pH to 7.0 with NaOH. Diluted volume to 10 mL with H2O. Final solution contained 3 M AcNHOH, 50 mM HEPES buffer (pH 7.0), and 10 mM CaCl2. 1688 4) AcNHOH dilution buffer: 50 mM HEPES buffer (pH 7.0) plus 10 mM CaCl21689 5) MMP-13CD enzyme: Stock concentration250 nM. 1690 6) Enzyme dilution buffer: 50 mM HEPES buffer (pH 7.0), 10 mM CaCl2, and 0.005% BRIJ 35 detergent (Calbiochem 203728; Protein Grade, 10%) 1691 Procedure (for One 96-Well Microplate): 1692 A. Prepared assay mixture: 1693 1100 L 10 assay buffer 1694 11 L 10 mM FP1 1695 55 L 3 M AcNHOH or 55 L AcNHOH dilution buffer 1696 8500 L H2O 1697 B. Diluted MMP-13CD to 5 nM Working Stock: 1698 22 L MMP-13CD (250 nM) 1699 1078 L enzyme dilution buffer 1700 C. Ran Kinetic Assay: 1701 1. Dispensed 2 L inhibitor test sample (in 100% DMSO) into well. 1702 2. Added 88 L assay mixture and mixed well, avoiding bubbles. 1703 3. Initiated reactions with 10 L of 5 nM MMP-13CD; mixed well, avoiding bubbles. 1704 4. Immediately measured the kinetics of,the reactions at room temperature. 1705 Fluorimeter: Fmax Fluorescence Microplate Reader & SOFTMAX PRO Version 1.1 software (Molecular Devices Corporation; Sunnyvale, Calif. 94089). 1706 Protocol menu: 1707 excitation: 320 nm emission: 405 nm 1708 run time: 15 min interval: 29 sec 1709 RFU min: 10 RFU max: 200 1710 Vmax points: 32/32 1711 D. Compared % of Control Activity and/or IC50 with Inhibitor Test Compound AcNHOH. 1712 Hydrolysis of the fluorigenic peptide-1 substrate, (Mca)Pro-Leu-Gly-Leu-Dpa-Ala-Arg-NH2; Bachem, catalog number M-1895, wherein Mca is (7-methoxy-coumarin-4-yl)acetyl and Dpa is (3-2,4-dinitrophenyl-L-2,3-diaminopropionyl), was used to screen for MMP-13 catalytic domain (CD) inhibitors. (Dpa may also be abbreviated as Dnp.) Reactions (100 L) contained 0.05 M Hepes buffer (pH 7), 0.01 M calcium chloride, 0.005% polyoxyethylene (23) lauryl ether (Brij 35), 0 or 15 mM acetohydroxamic acid, 10 M FP1, and 0.1 mM to 0.5 nM inhibitor in DMSO (2% final). 1713 After recombinant human MMP-13CD (0.5 nM final) was added to initiate the reaction, the initial velocity of FP1 hydrolysis was determined by monitoring the increase in fluorescence at 405 nm (upon excitation at 320 nm) continuously for up to 30 minutes on a microplate reader at room temperature. Alternatively, an endpoint read can also be used to determine reaction velocity provided the initial fluorescence of the solution, as recorded before addition of enzyme, is subtracted from the final fluorescence of the reaction mixture. The inhibitor was assayed at different concentration values, such as, for example, 100 M, 10 M, 1 M, 100 nM, 10 nM, and 1 nM. Then the inhibitor concentration was plotted on the X-axis against the percentage of control activity observed for inhibited experiments versus uninhibited experiments (i.e., (velocity with inhibitor) divided by (velocity without inhibitor)100) on the Y-axis to determine IC50 values. This determination was done for experiments done in the presence, and experiments done in the absence, of acetohydroxamic acid. Data were fit to the equation: percent control activity100/1((I/IC50)slope), where I is the inhibitor concentration, IC50 is the concentration of inhibitor where the reaction rate is 50% inhibited relative to the control, and slope is the slope of the IC50 curve at the curve's inflection point, using nonlinear least-squares curve-fitting equation regression. 1714 Results may be expressed as an IC50 Ratio (/) ratio, which means a ratio of the IC50 of the inhibitor with MMP-13 and a inhibitor to the catalytic zinc of MMP-13, divided by the IC50 of the inhibitor with MMP-13 without the inhibitor to the catalytic zinc of MMP-13. Allosteric alkyne inhibitors of MMP-13 have an IC50 Ratio (/) ratio of less than 1, and are synergistic with the inhibitor to the catalytic zinc of MMP-13 such as, for example, AcNHOH. Compounds which are not allosteric alkyne inhibitors of MMP-13 will be inactive in the assay or will have an IC50 Ratio (/) of greater than 1, unless otherwise indicated. Results can be confirmed by kinetics experiments which are well known in the biochemical art.

BIOLOGICAL METHOD 4 1715 Fluorigenic peptide-1 based assay for identifying allosteric alkyne inhibitors of matrix metalloproteinase-13 catalytic domain (MMP-13CD): 1716 In a manner similar to Biological Method 3, an assay is run wherein 1,10-phenanthroline is substituted for acetohydroxamic acid to identify allosteric alkyne inhibitors of MMP-13CD. 1717 Animal models may be used to establish that the instant allosteric alkyne inhibitors of MMP-13, or a pharmaceutically acceptable salt thereof, or an N-oxide thereof, would be useful for preventing, treating, and inhibiting cartilage damage, and thus for treating osteoarthritis, for example.

BIOLOGICAL METHOD 5 1718 Selective inhibitors of COX-2 may be identified by screening a test compound in the following assays. 1719 Human in Vitro Assays 1720 Human Cell-Based COX-1 Assay: 1721 Human peripheral blood obtained from healthy volunteers can be diluted to 1/10 volume with 3.8% sodium citrate solution. The platelet-rich plasma immediately obtained can be washed with 0.14 M sodium chloride containing 12 mM Tris-HCl (pH 7.4) and 1.2 mM EDTA. Platelets can then be washed with platelet buffer (Hanks buffer (Ca free) containing 0.2% BSA and 20 mM Hepes). Finally, the human washed platelets (HWP) can be suspended in platelet buffer at the concentration of 2.85108 cells/ml and stored at room temperature until use. The HWP suspension (70 l aliquots, final 2.0107 cells/ml) can be placed in a 96-well U bottom plate and 10 l aliquots of 12.6 mM calcium chloride added. Platelets can be incubated with A23187 (final 10 M, Sigma) with test compound (0.1-100 M) dissolved in DMSO (final concentration; less than 0.01%) at 37 C. for 15 minutes. The reaction can be stopped by addition of EDTA (final 7.7 mM) and TB2 in the supernatant quantitated by using a radioimmunoassay kit (Amersham) according to the manufacturer's procedure. 1722 Human Cell-Based COX-2 Assay: 1723 The human cell based COX-2 assay can be carried out as previously described (Moore et al., Inflamm. Res., 45, 54, 1996). Confluent human umbilical vein endothelial cells (HUVECs, Morinaga) in a 96-well flat bottom plate can be washed with 80 ml of RPMI1640 containing 2% FBS and incubated with hIL-1 (final concentration 300 U/ml, R & D Systems) at 37 C. for 24 hours. After washing, the activated HUVECs can be incubated with test compound (final concentration; 0.1 nM-1 M) dissolved in DMSO (final concentration; less than 0.01%) at 37 C. for 20 minutes and stimulated with A23187 (final concentration 30 mM) in Hanks buffer containing 0.2% BSA, 20 mM Hepes at 37 C. for 15 minutes. 6-Keto-PGF1, stable metabolite of PGI2, in the supernatant can be quantitated by using a radioimmunoassay method (antibody; Preseptive Diagnostics, SPA; Amersham). 1724 Canine in Vitro Assays: 1725 The following canine cell based COX 1 and COX-2 assays have been reported in Ricketts et al., Evaluation of Selective Inhibition of Canine Cyclooxygenase 1 and 2 by Carprofen and Other Nonsteroidal Anti-inflammatory Drugs, American Journal of Veterinary Research, 59 (11), 1441-1446. 1726 Protocol for Evaluation of Canine COX-1 Activity: 1727 Test compounds can be solubilized and diluted the day before the assay can be to be conducted with 0.1 mL of DMSO/9.9 mL of Hank's balanced salts solution (HBSS) and stored overnight at 4 C. On the day that the assay can be carried out, citrated blood can be drawn from a donor dog, centrifuged at 190g for 25 minutes at room temperature and the resulting platelet-rich plasma can then be transferred to a new tube for further procedures. The platelets can be washed by centrifuging at 1500g for 10 minutes at room temperature. The platelets can be washed with platelet buffer comprising Hank's buffer (Ca free) with 0.2% bovine serum albumin (BSA) and 20 mM HEPES. The platelet samples can then be adjusted to 1.5107/mL, after which 50 l of calcium ionophore (A23187) together with a calcium chloride solution can be added to 50 l of test compound dilution in plates to produce final concentrations of 1.7 M A23187 and 1.26 mM Ca. Then, 100 l of canine washed platelets can be added and the samples can be incubated at 37 C. for 15 minutes, after which the reaction can be stopped by adding 20 l of 77 mM EDTA. The plates can then be centrifuged at 2000g for 10 minutes at 4 C., after which 50 l of supernatant can be assayed for thromboxane B2 (TXB2) by enzyme-immunoassay (EIA). The pg/mL of TXB2 can be calculated from the standard line included on each plate, from which it can be possible to calculate the percent inhibition of COX-1 and the IC50 values for the test compounds. 1728 Protocol for Evaluation of Canine COX-2 Activity: 1729 A canine histocytoma (macrophage-like) cell line from the American Type Culture Collection designated as DH82, can be used in setting up the protocol for evaluating the COX-2 inhibition activity of various test compounds. There can be added to flasks of these cells 10 g/mL of LPS, after which the flask cultures can be incubated overnight. The same test compound dilutions as described above for the COX-1 protocol can be used for the COX-2 assay and can be prepared the day before the assay can be carried out. The cells can be harvested from the culture flasks by scraping and can then be washed with minimal Eagle's media (MEM) combined with 1% fetal bovine serum, centrifuged at 1500 rpm for 2 minutes and adjusted to a concentration of 3.2105 cells/mL. To 50 l of test compound dilution there can be added 50 l of arachidonic acid in MEM to give a 10 M final concentration and there can be added as well 100 l of cell suspension to give a final concentration of 1.6105 cells/mL. The test sample suspensions can be incubated for 1 hour and then centrifuged at 1000 rpm for 10 minutes at 4 C., after which 50 l aliquots of each test compound sample can be delivered to EIA plates. The EIA can be performed for prostaglandin E2 (PGE2) and the pg/mL concentration of PGE2 can be calculated from the standard line included on each plate. From this data it can be possible to calculate the percent inhibition of COX-2 and the IC50 values for the test compounds. Repeated investigations of COX-1 and COX-2 inhibition can be conducted over the course of several months. The results are averaged and a single COX-1:COX-2 ratio is calculated. 1730 Whole blood assays for COX-1 and COX-2 are known in the art such as the methods described in C. Brideau, et al., A Human Whole Blood Assay for Clinical Evaluation of Biochemical Efficacy of Cyclooxygenase Inhibitors, Inflammation Research, Vol. 45, pp. 68-74 (1996). These methods may be applied with feline, canine or human blood as needed.

BIOLOGICAL METHOD 6 1731 Carrageenan Induced Foot Edema in Rats 1732 Male Sprague-Dawley rats (5 weeks old, Charles River Japan) can be fasted overnight. A line can be drawn using a marker above the ankle on the right hind paw and the paw volume (V0) can be measured by water displacement using a plethysmometer (Muromachi). Animals can be given orally either vehicle (0.1% methyl cellulose or 5% Tween 80) or a test compound (2.5 ml per 100 g body weight). One hour later, the animals can then be injected intradermally with -carrageenan (0.1 ml of 1% w/v suspension in saline, Zushikagaku) into right hind paw (Winter et al., Proc. Soc. Exp. Biol. Med., 111, 544, 1962; Lombardino et al., Arzneim. Forsch., 25, 1629, 1975) and three hours later, the paw volume (V3) can be measured and the increase in volume (V3-V0) calculated. Since maximum inhibition attainable with classical NSAIDs is 60-70%, ED30 values can be calculated.

BIOLOGICAL METHOD 7 1733 Gastric Ulceration in Rats: 1734 The gastric ulcerogenicity of test compound can be assessed by a modification of the conventional method (Ezer et al., J. Pharm. Pharmacol., 28, 655, 1976; Cashin et al., J. Pharm. Pharmacol., 29, 330-336, 1977). Male Sprague-Dawley rats (5 weeks old, Charles River Japan), fasted overnight, can be given orally either vehicle (0.1% methyl cellulose or 5% Tween 80) or a test compound (1 ml per 100 g body weight). Six hours after, the animals can be sacrificed by cervical dislocation. The stomachs can be removed and inflated with 1% formalin solution (10 ml). Stomachs can be opened by cutting along the greater curvature. From the number of rats that showed at least one gastric ulcer or haemorrhaging erosion (including ecchymosis), the incidence of ulceration can be calculated. Animals did not have access to either food or water during the experiment.

BIOLOGICAL METHOD 8 1735 Canine Whole Blood ex Vivo Determinations of COX-1 and COX-2 Activity Inhibition 1736 The in vivo inhibitory potency of a test compound against COX-1 and COX-2 activity may be evaluated using an ex vivo procedure on canine whole blood. Three dogs can be dosed with 5 mg/kg of the test compound administered by oral gavage in 0.5% methylcellulose vehicle and three dogs can be untreated. A zero-hour blood sample can be collected from all dogs in the study prior to dosing, followed by 2- and 8-hour post-dose blood sample collections. Test tubes can be prepared containing 2 L of either (A) calcium ionophore A23187 giving a 50 M final concentration, which stimulates the production of thromboxane B2 (TXB2) for COX-1 activity determination; or of (B) lipopolysaccharide (LPS) to give a 10 g/mL final concentration, which stimulates the production of prostaglandin E2 (PGE2) for COX-2 activity determination. Test tubes with unstimulated vehicle can be used as controls. A 500 L sample of blood can be added to each of the above-described test tubes, after which they can be incubated at 37 C. for one hour in the case of the calcium ionophore-containing test tubes and overnight in the case of the LPS-containing test tubes. After incubation, 10 L of EDTA can be added to give a final concentration of 0.3%, in order to prevent coagulation of the plasma which sometimes occurs after thawing frozen plasma samples. The incubated samples can be centrifuged at 4 C. and the resulting plasma sample of 200 L can be collected and stored at 20 C. in polypropylene 96-well plates. In order to determine endpoints for this study, enzyme immunoassay (EIA) kits available from Cayman can be used to measure production of TXB2 and PGE2, utilizing the principle of competitive binding of tracer to antibody and endpoint determination by colorimetry. Plasma samples can be diluted to approximate the range of standard amounts which would be supplied in a diagnostic or research tools kit, i.e., 1/500 for TXB2 and 1/750 for PGE2. 1737 COX inhibition is observed when the measured percent inhibition is greater than that measured for untreated controls. The percent inhibition in the above table is calculated in a straightforward manner in accordance with the following equation: 1

% Inhibition (2 - hour) = \frac{({PGE}_{2} at t = 0) - ({PGE}_{2} at t = 2)}{({PGE}_{2} at t = 0)}

1738 Data Analysis: 1739 Statistical program packages, SYSTAT (SYSTAT, INC.) and StatView (Abacus Cencepts, Inc.) for Macintosh can be used. Differences between test compound treated group and control group can be tested for using ANOVA. The IC50 (ED30) values can be calculated from the equation for the log-linear regression line of concentration (dose) versus percent inhibition. 1740 The selective COX-2 inhibitors described above have been, or could have been, identified by at least one of the methods described above and show, or would show, IC50 values of 0.001 M to 3 M with respect to inhibition of COX-2 in either the canine or human assays. 1741 As mentioned above, COX-2 selectivity can be determined by ratio in terms of IC50 value of COX-1 inhibition to COX-2 inhibition. In general, it can be said that a compound showing a COX-1/COX-2 inhibition ratio of more than 5 has sufficient COX-2 selectivity. 1742 The newly discovered ability of an allosteric alkyne inhibitor of MMP-13, or a pharmaceutically acceptable salt thereof, to inhibit cartilage damage, alleviate pain, and treat osteoarthritis may be established in animal models as described below. The activity of an invention combination for treating cartilage damage and pain and/or inflammation may be determined by the procedures of Biological Methods 9 or 10 as described below.

BIOLOGICAL METHOD 9 1743 Monosodium Iodoacetate-Induced Osteoarthritis in Rat Model of Cartilage Damage (MIA Rat): 1744 One end result of the induction of osteoarthritis in this model, as determined by histologic analysis, is the development of an osteoarthritic condition within the affected joint, as characterized by the loss of Toluidine blue staining and formation of osteophytes. Associated with the histologic changes is a concentration-dependent degradation of joint cartilage, as evidenced by affects on hind-paw weight distribution of the limb containing the affected joint, the presence of increased amounts of proteoglycan or hydroxyproline in the joint upon biochemical analysis, or histopathological analysis of the osteoarthritic lesions. 1745 Generally, In the MIA Rat model on Day 0, the hind-paw weight differential between the right arthritic joint and the left healthy joint of male Wistar rats (150 g) are determined with an incapacitance tester, model 2KG (Linton Instrumentation, Norfolk, United Kingdom). The incapacitance tester has a chamber on top with an outwardly sloping front wall that supports a rat's front limbs, and two weight sensing pads, one for each hind paw, that facilitates this determination. Then the rats are anesthetized with isofluorine, and the right, hind leg knee joint is injected with 1.0 mg of mono-iodoacetate (MIA) through the infrapatellar ligament. Injection of MIA into the joint results in the inhibition of glycolysis and eventual death of surrounding chondrocytes. The rats are further administered either an invention combination such as a combination, comprising an allosteric alkyne inhibitor of MMP-13, or a pharmaceutically acceptable salt thereof, with celecoxib, or a pharmaceutically acceptable salt thereof, or valdecoxib, or a pharmaceutically acceptable salt thereof, or vehicle (in the instant case, water) daily for 14 days or 28 days. Both the allosteric alkyne inhibitor of MMP-13, or a pharmaceutically acceptable salt thereof, and celecoxib, or a pharmaceutically acceptable salt thereof, or valdecoxib, or a pharmaceutically acceptable salt thereof, are, each independently, typically administered at a dose of 30 mg per kilogram of rat per day (30 mg/kg/day), but each component of the combination may independently be administered at other doses such as, for example, 10 mg/kg/day, 60 mg/kg/day, 90-mg/kg/day, or 100 mg/kg/day according to the requirements of the combination being studied. It is well within the level of ordinary skill in the pharmaceutical arts to determine a proper dosage of an allosteric alkyne inhibitor of MMP-13, or a pharmaceutically acceptable salt thereof, and celecoxib, or a pharmaceutically acceptable salt thereof, or valdecoxib, or a pharmaceutically acceptable salt thereof, in this model. Administration of the allosteric alkyne inhibitor of MMP-13, or a pharmaceutically acceptable salt thereof, and celecoxib, or a pharmaceutically acceptable salt thereof, or valdecoxib, or a pharmaceutically acceptable salt thereof, in this model is optionally by oral administration or intravenous administration via an osmotic pump. Further, administration of the allosteric alkyne inhibitor of MMP-13, or a pharmaceutically acceptable salt thereof, and celecoxib, or a pharmaceutically acceptable salt thereof, or valdecoxib, or a pharmaceutically acceptable salt thereof, may be simultaneous as a co-formulation of both drugs, simultaneous by way of independent formulations of each drug of the invention combination alone according to optimal drug delivery profiles, or non-simultaneous such as, sequential administration of an independent formulation of one drug followed by, after some pre-determined period of time, administration of an independent formulation of the other drug of the invention combination. After 7 and 14 days for a two-week study, or 7, 14, and 28 days for a four-week study, the hind-paw weight distribution is again determined. Typically, the animals administered vehicle alone place greater weight on their unaffected left hind paw than on their right hind paw, while animals administered an invention combination show a more normal (i.e., more like a healthy animal) weight distribution between their hind paws. This change in weight distribution was proportional to the degree of joint cartilage damage. Percent inhibition of a change in hind paw joint function is calculated as the percent change in hind-paw weight distribution for treated animals versus control animals. For example, for a two week study, 1746 Percent inhibition of a change in hind paw joint function 2

Percent inhibition of a change in hind paw joint function = [1 - \frac{(W_{G})}{(W_{C})}] 100

1747 wherein: WC is the hind-paw weight differential between the healthy left limb and the arthritic limb of the control animal administered vehicle alone, as measured on Day 14; and 1748 WG is the hind-paw weight differential between the healthy left limb and the arthritic limb of the animal administered an invention combination, as measured on Day 14. 1749 In order to measure biochemical or histopathological end points in the MIA Rat model, some of the animals in the above study may be sacrificed, and the amounts of free proteoglycan in both the osteoarthritic right knee joint and the contralateral left knee joint may be determined by biochemical analysis. The amount of free proteoglycan in the contralateral left knee joint provides a baseline value for the amount of free proteoglycan in a healthy joint. The amount of proteoglycan in the osteoarthritic right knee joint in animals administered an invention combination, and the amount of proteoglycan in the osteoarthritic right knee joint in animals administered vehicle alone, are independently compared to the amount of proteoglycan in the contralateral left knee joint. The amounts of proteoglycan lost in the osteoarthritic right knee joints are expressed as percent loss of proteoglycan compared to the contralateral left knee joint control. The percent inhibition of proteoglycan loss, may be calculated as (proteoglycan loss from joint (%) with vehicle)(proteoglycan loss from joint with an invention combination)(proteoglycan loss from joint (%) with vehicle)100. 1750 The MIA Rat data that are expected from the analysis of proteoglycan loss would establish that an invention combination is effective for inhibiting cartilage damage and inflammation and/or alleviating pain in mammalian patients, including human. 1751 The results of these studies with oral dosing may be presented in tabular format in the columns labelled IJFL (%/SEM), wherein IJFL means Inhibition of Joint Function Limitation, SDCES, wherein SDCES means Significant Decrease In Cartilage Erosion Severity, and SIJWHLE, wherein SIJWHLE means Significant Increase in Joints Without Hind Limb Erosion. 1752 The proportion of subjects without hind limb erosions may be analyzed via an Exact Sequential Cochran-Annitage Trend test (SAS Institute, 1999). The Cochran-Armitage Trend test is employed when one wishes to determine whether the proportion of positive or Yes responders increases or decreases with increasing levels of treatment. For the particular study, it is expected that the number of animals without joint erosions increased with increasing dose. 1753 The ridit analysis may be used to determine differences in overall erosion severity. This parameter takes into account both the erosion grade (0no erosion, Ierosion extending into the superficial or middle layers, or IIdeep layer erosion), and area (small, medium and large, quantified by dividing the area of the largest erosion in each score into thirds) simultaneously. The analysis recognizes that each unit of severity is different, but does not assume a mathematical relationship between units. 1754 Another animal model for measuring effects of an invention combination on cartilage damage and inflammation and/or pain is described below in Biological Method 10.

BIOLOGICAL METHOD 10 1755 Induction of Experimental Osteoarthritis in Rabbit (EOA in Rabbit): 1756 Normal rabbits are anaesthetized and anteromedial incisions of the right knees performed. The anterior cruciate ligaments are visualized and sectioned. The wounds are closed and the animals are housed in individual cages, exercised, and fed ad libitum. Rabbits are given either vehicle (water) or an invention combination dosed three times per day with 30-mg/kg/dose or 10-mg/kg/dose. each independently determined for the allosteric alkyne inhibitor of MMP-13, or a pharmaceutically acceptable salt thereof, and celecoxib, or a pharmaceutically acceptable salt thereof, or valdecoxib, or a pharmaceutically acceptable salt thereof, but each drug of the combination may independently be administered at other doses such as, for example, 3 times 20 mg/kg/day or 3 times 60 mg/kg/day according to the requirements of the combination being studied. The rabbits are euthanized 8 weeks after surgery and the proximal end of the tibia and the distal end of the femur are removed from each animal. 1757 Macroscopic Grading 1758 The cartilage changes on the femoral condyles and tibial plateaus are graded separately under a dissecting microscope (Stereozoom, Bausch & Lomb, Rochester, N.Y.). The depth of erosion is graded on a scale of 0 to 4 as follows: grade 0normal surface; Grade 1minimal fibrillation or a slight yellowish discoloration of the surface; Grade 2erosion extending into superficial or middle layers only; Grade 3erosion extending into deep layers; Grade 4erosion extending to subchondral bone. The surface area changes are measured and expressed in mm2. Representative specimens may also be used for histologic grading (see below). 1759 Histologic Grading 1760 Histologic evaluation is performed on sagittal sections of cartilage from the lesional areas of the femoral condyle and tibial plateau. Serial sections (5 um) are prepared and stained with safranin-O. The severity of OA lesions is graded on a scale of 0-14 by two independent observers using the histologic-histochemical scale of Mankin et al. This scale evaluates the severity of OA lesions based on the loss of safranin-O staining (scale 0-4), cellular changes (scale 0-3), invasion of tidemark by blood vessels (scale 0-1) and structural changes (scale 0-6). On this latter scale, 0 indicates normal cartilage structure and 6 indicates erosion of the cartilage down to the subchondral bone. The scoring system is based on the most severe histologic changes in the multiple sections. 1761 Representative specimens of synovial membrane from the medial and lateral knee compartments are dissected from underlying tissues. The specimens are fixed, embedded, and sectioned (5 um) as above, and stained with hematoxylin-eosin. For each compartment, two synovial membrane specimens are examined for scoring purposes and the highest score from each compartment is retained. The average score is calculated and considered as a unit for the whole knee. The severity of synovitis is graded on a scale of 0 to 10 by two independent observers, adding the scores of 3 histologic criteria: synovial lining cell hyperplasia (scale 0-2); villous hyperplasia (scale 0-3); and degree of cellular infiltration by mononuclear and polymorphonuclear cells (scale 0-5): 0 indicates normal structure. 1762 Statistical Analysis 1763 Mean values and SEM is calculated and statistical analysis was done using the Mann-Whitney U-test. 1764 The results of these studies would be expected to show that an invention combination would reduce the size of the lesion on the tibial plateaus, and perhaps the damage in the tibia or on the femoral condyles, as well as show pain alleviating effects if measured. In conclusion, these results would show that an invention combination would have significant inhibition effects on the damage to cartilage and pain. 1765 The foregoing studies would establish that an invention combination is effective for the inhibition of cartilage damage and inflammation and/or alleviating pain, and thus useful for the treatment of osteoarthritis or rheumatoid arthritis in human, and other mammalian disorders. Such a treatment offers a distinct advantage over existing treatments that only modify pain or inflammation or and other secondary symptoms. The effectiveness of an invention combination in this model would indicate that the invention combination will have clinically useful effects in preventing and/or treating cartilage damage, pain and/or inflammation. 1766 Administration according to the invention method of celecoxib, or a pharmaceutically acceptable salt thereof, or valdecoxib, or a pharmaceutically acceptable salt thereof, and an allosteric alkyne inhibitor of MMP-13, or a pharmaceutically acceptable salt thereof, to a mammal to treat the diseases listed above is preferably, although not necessarily, accomplished by administering the compound, or a salt thereof, in a pharmaceutical dosage form. 1767 Celecoxib, or a pharmaceutically acceptable salt thereof, valdecoxib, or a pharmaceutically acceptable salt thereof, and the allosteric alkyne inhibitors of MMP-13, or a pharmaceutically acceptable salt thereof, can be prepared and administered according to the invention method in a wide variety of oral and parenteral pharmaceutical dosage forms. Thus, celecoxib, or a pharmaceutically acceptable salt thereof, or valdecoxib, or a pharmaceutically acceptable salt thereof, and the allosteric alkyne inhibitors of MMP-13, or a pharmaceutically acceptable salt thereof, can be administered,by injection, that is, intravenously, intramuscularly, intracutaneously, subcutaneously, intraduodenally, or intraperitoneally. Also, celecoxib, or a pharmaceutically acceptable salt thereof, or valdecoxib, or a pharmaceutically acceptable salt thereof, and the allosteric alkyne inhibitors of MMP-13, or a pharmaceutically acceptable salt thereof, can be administered by inhalation, for example, intranasally. Additionally, celecoxib, or a pharmaceutically acceptable salt thereof, or valdecoxib, or a pharmaceutically acceptable salt thereof, and the allosteric alkyne inhibitors of MMP-13, or a pharmaceutically acceptable salt thereof, can be administered transdermally. It will be obvious to those skilled in the art that the following dosage forms may comprise as the active components celecoxib, or a pharmaceutically acceptable salt thereof, or valdecoxib, or a pharmaceutically acceptable salt thereof, and an allosteric alkyne inhibitor of MMP-13, or a pharmaceutically acceptable salt thereof. The active compounds generally are present in a concentration of about 5% to about 95% by weight of the formulation. 1768 For preparing pharmaceutical compositions from celecoxib, or a pharmaceutically acceptable salt thereof, or valdecoxib, or a pharmaceutically acceptable salt thereof, and the allosteric alkyne inhibitors of MMP-13, or a pharmaceutically acceptable salt thereof, (i.e., the active components) pharmaceutically acceptable carriers can be either solid or liquid. Solid form preparations are preferred. Solid form preparations include powders, tablets, pills, capsules, cachets, suppositories, and dispersible granules. A solid carrier can be one or more substances which may also act as diluents, flavoring agents, solubilizers, lubricants, suspending agents, binders, preservatives, tablet disintegrating agents, or an encapsulating material. 1769 In powders, the carrier is a finely divided solid which is in a mixture with the finely divided active component. Powders suitable for intravenous administration or administration by injection may be lyophilized. 1770 In tablets, the active component is mixed with the carrier having the necessary binding properties in suitable proportions and compacted in the shape and size desired. 1771 The powders and tablets preferably contain from about 5% to about 70%, total, of the active component. Suitable carriers are magnesium carbonate, magnesium stearate, talc, sugar, lactose, pectin, dextrin, starch, gelatin, tragacanth, methylcellulose, sodium carboxymethylcellulose, a low melting wax, cocoa butter, and the like. The term preparation is intended to include the formulation of the active component with encapsulating material as a carrier providing a capsule in which the active component, with or without other carriers, is surrounded by a carrier, which is thus in association with it. Similarly, cachets and lozenges are included. Tablets, powders, capsules, pills, cachets, and lozenges can be used as solid dosage forms suitable for oral administration. 1772 For preparing suppositories, a low melting wax, such as a mixture of fatty acid glycerides or cocoa butter, is first melted and the active component is dispersed homogeneously therein, as by stirring. The molten homogenous mixture is then poured into convenient sized molds, allowed to cool, and thereby to solidify. 1773 Liquid form preparations include solutions, suspensions, and emulsions, for example, water or water propylene glycol solutions. For parenteral injection, liquid preparations can be formulated in solution in aqueous polyethylene glycol solution. 1774 Aqueous solutions suitable for oral use can be prepared by dissolving the active component in water and adding suitable colorants, flavors, stabilizing, and thickening agents as desired. 1775 Aqueous suspensions suitable for oral use can be made by dispersing the finely divided active component in water with viscous material, such as natural or synthetic gums, resins, methylcellulose, sodium carboxymethylcellulose, and other well-known suspending agents. 1776 Also included are solid form preparations which are intended to be converted, shortly before use, to liquid form preparations for oral administration. Such liquid forms include solutions, suspensions, and emulsions. These preparations may contain, in addition to the active component, colorants, flavors, stabilizers, buffers, artificial and natural sweeteners, dispersants, thickeners, solubilizing agents, and the like. 1777 The pharmaceutical preparation is preferably in unit dosage form. In such form, the preparation is subdivided into unit doses containing an appropriate quantity of the active component. The unit dosage form can be a packaged preparation, the package containing discrete quantities of preparation, such as packeted tablets, capsules, and powders in vials or ampoules. Also, the unit dosage form can be a capsule, tablet, cachet, or lozenge itself, or it can be the appropriate number of any of these in packaged form. 1778 The quantity of active component in a unit dose preparation may be varied or adjusted from 0.01 to 1000 mg, preferably 1 to 500 mg according to the particular application and the potency of the active components. The composition can, if desired, also contain other compatible therapeutic agents. 1779 In therapeutic use as agents to treat the above-listed diseases, the allosteric alkyne inhibitors of MMP-13, or a pharmaceutically acceptable salt thereof, or a combination of the same with valdecoxib, or a pharmaceutically acceptable salt thereof, or celecoxib, or a pharmaceutically acceptable salt thereof, are administered at a dose that is effective for treating at least one symptom of the disease or disorder being treated. The initial dosage of about 1 mg/kg to about 100 mg/kg daily of the active component will be effective. A daily dose range of about 25 mg/kg to about 75 mg/kg of the active component is preferred. The dosages, however, may be varied depending upon the requirements of the patient, the severity of the condition being treated, and the particular allosteric alkyne inhibitor of MMP-13, or a pharmaceutically acceptable salt thereof, and valdecoxib, or a pharmaceutically acceptable salt thereof, or celecoxib, or a pharmaceutically acceptable salt thereof, being employed in the invention combination. Determination of the proper dosage for a particular situation is within the skill of the art as described above. Typical dosages will be from about 0.1 mg/kg to about 500 mg/kg, and ideally about 25 mg/kg to about 250 mg/kg, such that it will be an amount that is effective to treat the particular disease or disorder being treated. 1780 A preferred composition for dogs comprises an ingestible liquid peroral dosage form selected from the group consisting of a solution, suspension, emulsion, inverse emulsion, elixir, extract, tincture and concentrate, optionally to be added to the drinking water of the dog being treated. Any of these liquid dosage forms, when formulated in accordance with methods well known in the art, can either be administered directly to the dog being treated, or may be added to the drinking water of the dog being treated. The concentrate liquid form, on the other hand, is formulated to be added first to a given amount of water, from which an aliquot amount may be withdrawn for administration directly to the dog or addition to the drinking water of the dog. 1781 A preferred composition provides delayed-, sustained- and/or controlled-release of valdecoxib, or a pharmaceutically acceptable salt thereof, or celecoxib, or a pharmaceutically acceptable salt thereof, and the allosteric alkyne inhibitor of MMP-13, or a pharmaceutically acceptable salt thereof. Such preferred compositions include all such dosage forms which produce 40% inhibition of cartilage degradation, and result in a plasma concentration of the active component of at least 3 fold the active component's ED40 for at least 2 hours; preferably for at least 4 hours; preferably for at least 8 hours; more preferably for at least 12 hours; more preferably still for at least 16 hours; even more preferably still for at least 20 hours; and most preferably for at least 24 hours. Preferably, there is included within the above-described dosage forms those which produce 40% inhibition of cartilage degradation, and result in a plasma concentration of the active component of at least 5 fold the active component's ED40 for at least 2 hours, preferably for at least 2 hours, preferably for at; least 8 hours, more preferably for at least 12 hours, still more preferably for at least 20 hours and most preferably for at least 24 hours. More preferably, there is included the above-described dosage forms which produce 50% inhibition of cartilage degradation, and result in a plasma concentration of the active component of at least 5 fold the active component's ED40 for at least 2 hours, preferably for at least 4 hours, preferably for at least 8 hours, more preferably for at least 12 hours, still more preferably for at least 20 hours and most preferably for at least 24 hours.

1782 The following Formulation Examples 1 to 8 illustrate the invention pharmaceutical compositions wherein the allosteric alkyne inhibitor of MMP-13, or a pharmaceutically acceptable salt thereof, and valdecoxib, or a pharmaceutically acceptable salt thereof, or celecoxib, or a pharmaceutically acceptable salt thereof, are formulated separately, each independently as described, When the formulations comprise the allosteric alkyne inhibitor of MMP-13, or a pharmaceutically acceptable salt thereof, and a pharmaceutically acceptable carrier, diluent, or excipient, they contain a cartilage damage treating effective amount or an anti-osteoarthritic effective amount of the allosteric alkyne inhibitor of MMP-13, or a pharmaceutically acceptable salt thereof. When the formulations comprise valdecoxib, or a pharmaceutically acceptable salt thereof, or celecoxib, or a pharmaceutically acceptable salt thereof, they contain a pain alleviating effective amount or an anti-inflammatory effective amount of valdecoxib or celecoxib. The examples are representative only, and are not to be construed as limiting the invention in any respect.

FORMULATION EXAMPLE 11783

1Tablet Formulation:IngredientAmount (mg)An allosteric alkyne inhibitor of MMP-13, celecoxib,25or valdecoxibLactose50Cornstarch (for mix)10Cornstarch (paste)10Magnesium stearate (1%)5Total100

1784 The allosteric alkyne inhibitor of MMP-13, celecoxib, or valdecoxib, lactose, and cornstarch (for mix) are blended to uniformity. The cornstarch (for paste) is suspended in 200 mL of water and heated with stirring to form a paste. The paste is used to granulate the mixed powders. The wet granules are passed through a No. 8 hand screen and dried at 80 C. The dry granules are lubricated with the 1% magnesium stearate and pressed into a tablet. Such tablets can be administered to a human from one to four times a day for inhibiting cartilage damage or treating osteoarthritis.

FORMULATION EXAMPLE 2 1785 Coated Tablets: 1786 The tablets of Formulation Example 1 are coated in a customary manner with a coating of sucrose, potato starch, talc, tragacanth, and colorant.

FORMULATION EXAMPLE 3 1787 Injection Vials: 1788 The pH of a solution of 500 g of an allosteric alkyne inhibitor of MMP-13, celecoxib, or valdecoxib and 5 g of disodium hydrogen phosphate is adjusted to pH 6.5 in 3 L of double-distilled water using 2 M hydrochloric acid. The solution is sterile filtered, and the filtrate is filled into injection vials, lyophilized under sterile conditions, and aseptically sealed. Each injection vial contains 25 mg of the allosteric alkyne inhibitor of MMP-13, celecoxib, or valdecoxib.

FORMULATION EXAMPLE 4 1789 Suppositories: 1790 A mixture of 25 g of an allosteric alkyne inhibitor of MMP-13, celecoxib, or valdecoxib, 100 g of soya lecithin, and 1400 g of cocoa butter is fused, poured into molds, and allowed to cool. Each suppository contains 25 mg of the allosteric alkyne inhibitor of MMP-13, celecoxib, or valdecoxib.

FORMULATION EXAMPLE 5 1791 Solution: 1792 A solution is prepared from 1 g of an allosteric alkyne inhibitor of MMP-13, celecoxib, or valdecoxib, 9.38 g of NaH2PO4.12H2O, 28.48 g of Na2HPO4.12H2O, and 0.1 g benzalkonium chloride in 940 mL of double-distilled water. The pH of the solution is adjusted to pH 6.8 using 2 M hydrochloric acid. The solution is diluted to 1.0 L with double-distilled water, and sterilized by irradiation. A 25 mL volume of the solution contains 25 mg of the allosteric alkyne inhibitor of MMP-13, celecoxib, or valdecoxib.

FORMULATION EXAMPLE 6 1793 Ointment: 1794 500 mg of an allosteric alkyne inhibitor of MMP-13, celecoxib, or valdecoxib is mixed with 99.5 g of petroleum jelly under aseptic conditions. A 5 g portion of the ointment contains 25 mg of the allosteric alkyne inhibitor of MMP-13, celecoxib, or valdecoxib.

FORMULATION EXAMPLE 7 1795 Capsules: 1796 2 kg of an allosteric alkyne inhibitor of MMP-13, celecoxib, or valdecoxib are filled into hard gelatin capsules in a customary manner such that each capsule contains 25 mg of the allosteric alkyne inhibitor of MMP-13, celecoxib, or valdecoxib.

FORMULATION EXAMPLE 8 1797 Ampoules: 1798 A solution of, 2.5 kg of an allosteric alkyne inhibitor of MMP-13, celecoxib, or valdecoxib is dissolved in 60 L of double-distilled water. The solution is sterile filtered, and the filtrate is filled into ampoules. The ampoules are lyophilized under sterile conditions and aseptically sealed. Each ampoule contains 25 mg of the allosteric alkyne inhibitor of MMP-13, celecoxib, or valdecoxib. 1799 The following Formulation Examples 9 to 16 illustrate the invention pharmaceutical compositions containing an invention combination in a single formulation with a pharmaceutically acceptable carrier, diluent, or excipient. The examples are representative only, and are not to be construed as limiting the invention in any respect.

FORMULATION EXAMPLE 91800

2Tablet Formulation:IngredientAmount (mg)An allosteric alkyne inhibitor of MMP-1325Valdecoxib or celecoxib20Lactose50Cornstarch (for mix)10Cornstarch (paste)10Magnesium stearate (1%)5Total120

1801 The allosteric alkyne inhibitor of MMP-13, valdecoxib or celecoxib, lactose, and cornstarch (for mix) are blended to uniformity. The cornstarch (for paste) is suspended in 200 mL of water and heated with stirring to form a paste. The paste is used to granulate the mixed powders. The wet granules are passed through a No. 8 hand screen and dried at 80 C. The dry granules are lubricated with the 1% magnesium stearate and pressed into a tablet. Such tablets can be administered to a human from one to four times a day for treatment of one of the above-listed diseases.

FORMULATION EXAMPLE 10 1802 Coated Tablets: 1803 The tablets of Formulation Example 9 are coated in a customary manner with a coating of sucrose, potato starch, talc, tragacanth, and colorant.

FORMULATION EXAMPLE 11 1804 Injection Vials: 1805 The pH of a solution of 250 g of valdecoxib or celecoxib, 500 g of an allosteric alkyne inhibitor of MMP-13, and 5 g of disodium hydrogen phosphate is adjusted to pH 6.5 in 3 L of double-distilled water using 2 M hydrochloric acid. The solution is sterile filtered, and the filtrate is filled into injection vials, lyophilized under sterile conditions, and aseptically sealed. Each injection vial contains 12.5 mg of valdecoxib or celecoxib and 25 mg of the allosteric alkyne inhibitor of MMP-13.

FORMULATION EXAMPLE 12 1806 Suppositories: 1807 A mixture of 50 g of valdecoxib or celecoxib, 25 g of an allosteric alkyne inhibitor of MMP-13, 100 g of soya lecithin, and 1400 g of cocoa butter is fused, poured into molds, and allowed to cool. Each suppository contains 50 mg of valdecoxib or celecoxib and 25 mg of the allosteric alkyne inhibitor of MMP-13.

FORMULATION EXAMPLE 13 1808 Solution: 1809 A solution is prepared from 0.5 g of valdecoxib or celecoxib, 1 g of an allosteric alkyne inhibitor of MMP-13, 9.38 g of NaH2PO4.12H2O, 28.48 g of Na2HPO4. 12H2O, and 0.1 g benzalkonium chloride in 940 L of double-distilled water. The pH of the solution is adjusted to pH 6.8 using 2 M hydrochloric acid. The solution is diluted to 1.0 L with double-distilled water, and sterilized by irradiation. A 25 mL volume of the solution contains 12.5 mg of valdecoxib or celecoxib and 25 mg of the allosteric alkyne inhibitor of MMP-13.

FORMULATION EXAMPLE 14 1810 Ointment: 1811 100 mg of valdecoxib or celecoxib, 500 mg of an allosteric alkyne inhibitor of MMP-13 is mixed with 99.4 g of petroleum jelly under aseptic conditions. A 5 g portion of the ointment contains 5 mg of valdecoxib or celecoxib and 25 mg of the allosteric alkyne inhibitor of MMP-13.

FORMULATION EXAMPLE 15 1812 Capsules: 1813 2 kg of valdecoxib or celecoxib and 20 kg of an allosteric alkyne inhibitor of MMP-13 are filled into hard gelatin capsules in a customary manner such that each capsule contains 25 mg of valdecoxib or celecoxib and 250 mg of the allosteric alkyne inhibitor of MMP-13.

FORMULATION EXAMPLE 16 1814 Ampoules: 1815 A solution of 2.5 kg of valdecoxib or celecoxib and 2.5 kg of an allosteric alkyne inhibitor of MMP-13 is dissolved in 60 L of double-distilled water. The solution is sterile filtered, and the filtrate is filled into ampoules. The ampoules are lyophilized under sterile conditions and aseptically sealed. Each ampoule contains 25 mg each of valdecoxib or celecoxib and the allosteric alkyne inhibitor of MMP-13. 1816 While it may be desirable to formulate valdecoxib or celecoxib and an allosteric alkyne inhibitor of MMP-13, or a pharmaceutically acceptable salt thereof, together in one capsule, tablet, ampoule, solution, and the like, for simultaneous administration, it is not necessary for the purposes of practicing the invention methods. Valdecoxib or celecoxib and an allosteric alkyne inhibitor of MMP-13, or a pharmaceutically acceptable salt thereof, of an invention combination alternatively can each be formulated independently in any form such as, for example, those of any one Formulation Examples 1 to 16, and administered to a patient either simultaneously or at different times. 1817 The following examples illustrate the invention pharmaceutical compositions containing discrete formulations of the active components of the invention combination and a pharmaceutically acceptable carrier, diluent, or excipient. The examples are representative only, and are not to be construed as limiting the invention in any respect.

FORMULATION EXAMPLE 171818

3Tablet Formulation of an allosteric alkyne inhibitor of MMP-13:IngredientAmount (mg)An allosteric alkyne inhibitor of MMP-1325Lactose50Cornstarch (for mix)10Cornstarch (paste)10Magnesium stearate (1%)5Total100

1819 An allosteric alkyne inhibitor of MMP-13, lactose, and cornstarch (for mix) are blended to uniformity. The cornstarch (for paste) is suspended in 200 mL of water and heated with stirring to form a paste. The paste is used to granulate the mixed powders. The wet granules are passed through a No. 8 hand screen and dried at 80 C. The dry granules are lubricated with the 1% magnesium stearate and pressed into a tablet. 1820 Injection Vial Formulation of Valdecoxib or Celecoxib: 1821 The pH of a solution of 500 g of valdecoxib or celecoxib and 5 g of disodium hydrogen phosphate is adjusted to pH 6.5 in 3 L of double-distilled water using 2 M hydrochloric acid. The solution is sterile filtered, and the filtrate is filled into injection vials, lyophilized under sterile conditions, and aseptically sealed. Each injection vial contains 25 mg of valdecoxib. 1822 Such tablets containing the allosteric alkyne inhibitor of MMP-13 can be administered to a human from one to four times a day for treatment of the above-listed diseases, and the injection solutions containing valdecoxib or celecoxib can be administered to a human 1 or 2 times per day, wherein the administration by injection is optionally simultaneous with administration of the tablets or at different times, for the treatment of one of the above-listed diseases.

FORMULATION EXAMPLE 18 1823 Coated Tablets Containing an Allosteric Alkyne Inhibitor of MMP-13: 1824 The tablets of Formulation Example 17 are coated in a customary manner with a coating of sucrose, potato starch, talc, tragacanth, and colorant. 1825 Capsules Containing Valdecoxib or Celecoxib: 1826 2 kg of valdecoxib or celecoxib are filled into hard gelatin capsules in a customary manner such that each capsule contains 25 mg of valdecoxib or celecoxib. 1827 Such coated tablets containing the allosteric alkyne inhibitor of MMP-13 can be administered to a human from one to four times a day for treatment of the above-listed diseases, and the capsules containing valdecoxib or celecoxib can be administered to a human 1 or 2 times per day, wherein the administration of the capsules is optionally simultaneous with administration of the tablets or at different times, for the treatment of one of the above-listed diseases. 1828 Still further, it should be appreciated that the invention methods comprising administering an invention combination to a mammal to treat diseases or disorders listed above may be used to treat different diseases simultaneously. For example, administration of valdecoxib or celecoxib in accordance with the invention combination may be carried out as described above to treat inflammation, arthritic pain, pain associated with menstrual cramping, and migraines, while an allosteric alkyne inhibitor of MMP-13, or a pharmaceutically acceptable salt thereof, may be administered to treat OA or inhibit cartilage damage. 1829 As shown above, the invention method offers a distinct advantage over existing treatments for diseases such as OA that comprise cartilage damage, wherein the existing treatments modify pain or secondary symptoms, but do not show a disease modifying effect. 1830 While the invention has been described and illustrated with reference to certain particular embodiments thereof, those skilled in the art will appreciate that various adaptations, changes; modifications, substitutions, deletions, or additions of procedures and protocols may be made without departing from the spirit and scope of the invention. It is intended, therefore, that the invention be defined by the scope of the claims that follow and that such claims be interpreted as broadly as is reasonable. 1831 Having described the invention method, various embodiments of the invention are hereupon claimed.