0001 The invention relates to a process for the preparation of 5-aryinicotinaldehydes by reduction of the corresponding 5-aryinicotinic acids by catalytic hydrogenation in the presence of carboxylic anhydrides in which the catalyst used is a palladium/ligand complex, characterized in that the molar ratio between palladium and ligand is from 1:5 to 1:15 in the case of monodentate ligands and from 1:2.5 to 1:7.5 in the case of bidentate ligands. 0002 5-Arylnicotinaldehydes are important intermediates and end products in industrial organic chemistry. Appropriately substituted derivatives are, in particular, valuable intermediates in the synthesis of highly value-added end products or are themselves such end products, in particular for crop protection, such as, for example, fungicides, insecticides, herbicides or pesticides, or for the preparation of substances having high pharmaceutical activity. Production of the corresponding 5-arylnicotinaldehydes on an industrial scale makes highly economical and environmentally friendly preparation necessary. 0003 The 5-arylnicotinaldehydes are distinguished by an unexpected sensitivity to oxidation and disproportionation. Consequently, the methods described in the literature for the preparation of these compounds by chemoselective reduction of aromatic acids or their esters or by oxidation of aromatic alcohols cannot be applied to a satisfactory extent to the corresponding 5-arylnicotinic acid or the corresponding 5-arylnicotinyl alcohol. 0004 Methods for the reduction of nicotinic acid are known. Thus, for example, the reduction of nicotinic acid by palladium-catalysed hydrogenation is described in Chemistry Letters 1998, 1143-1144. The process disclosed therein is carried out in the presence of pivalic anhydride (trimethylacetic anhydride), giving, in the case of unsubstituted nicotinic acid, the corresponding aldehyde in good yields. 0005 However, if substituted nicotinic acids and in particular aromatic-substituted nicotinic acids are employed in this process, considerable losses of yield occur. In addition, the use of pivalic acid is associated with considerable costs, and consequently this process is not suitable for industrial application. 0006 The object on which the invention is based was to discover a process for the preparation of 5-arylnicotinaldehydes which makes inexpensive and environmentally friendly access even to this class of substances possible without the above-mentioned disadvantages. 0007 Surprisingly, it has now been found that 5-arylnicotinaldehydes can be obtained by reduction of the corresponding 5-aryinicotinic acids by catalytic hydrogenation in the presence of carboxylic anhydrides in which the catalyst used is a palladium/ligand complex if a molar ratio between palladium and ligand of from 1:5 to 1:15 is observed in the case of monodentate ligands and of from 1:2.5 to 1:7.5 in the case of bidentate ligands. 0008 The measure according to the invention also allows the use of other carboxylic anhydrides which are less expensive than pivalic anhydride and which, without an excess of ligand, give only a low yield of product. 0009 The invention thus relates to a process for the preparation of 5-arylnicotinaldehydes by reduction of the corresponding 5-arylnicotinic acids by catalytic hydrogenation in the presence of carboxylic anhydrides in which the catalyst used is a palladium/ligand complex, characterized in that the molar ratio between palladium and ligand is from 1:5 to 1:15 in the case of monodentate ligands and from 1:2.5 to 1:7.5 in the case of bidentate ligands. 0010 The invention preferably relates, in particular, to a process for the preparation of 5-arylnicotinaldehydes of the formula I 1

0011 in which 0012 A is a phenyl radical or naphthyl radical, each of which is unsubstituted or monosubstituted or polysubstituted by R, F, Cl, Br, I, CN, NO2, CF3, OCF3, OCHF2, OCF2CF3, OCHFCF3 or OH and in which, in addition, one or more CH groups may be replaced by N, and 0013 R is H, a straight-chain or branched alkyl radical having 1 to 15 carbon atoms which is monosubstituted by CF3 or at least monosubstituted by fluorine, where, in addition, one or more CH2 groups in these radicals may each, independently of one another, be replaced by S, O, OCO, COO or CHCH in such a way that heteroatoms are not directly adjacent, 0014 by reduction of the corresponding 5-arylnicotinic acids by catalytic hydrogenation in the presence of carboxylic anhydrides in which the catalyst used is a palladium/ligand complex, characterized in that the molar ratio between palladium and ligand is from 1:5 to 1:15 in the case of monodentate ligands and from 1:2.5 to 1:7.5 in the case of bidentate ligands. 0015 The invention furthermore relates to the use of the 5-arylnicotinaldehydes for the preparation of N-alkylated amines by reaction of the 5-aryinicotinaldehydes with primary amines to give the corresponding imines, followed by reduction. The reaction of the aldehydes with the amines and also the reduction of the imines can be carried out by methods known per se, as described in the literature (for example in standard works, such as Houben-Weyl, Methoden der organischen Chemie Methods of Organic Chemistry, Georg-Thieme-Verlag, Stuttgart, or Organikum Organic Chemistry, 17th Edition, VEB Deutscher Verlag der Wissenschaften, Berlin, 1988), to be precise under reaction conditions which are known and are suitable for the said reactions. 0016 The compounds of the formula I are, in particular, highly suitable for the preparation of N-alkylated amines of the formula X: 2

0017 In which 0018 R and R, independently of one another, are as defined for R or are F, Cl, Br, I, CN, NO2, CF3, OCF3, OCHF2, OCF2CF3, OCHFCF3 or OH, and A is as defined above, by reaction of the corresponding amines and reduction of the resultant imines by conventional reduction processes, in particular by catalytic hydrogenation or by using borohydrides, such as, for example, sodium borohydride. 0019 Similar compounds are already known from EP 0707007. 0020 Preference is given to the use of the aldehyde of the formula I in which A is 4-fluorophenyl for the preparation of (R)-2-5-(4-fluorophenyl)-3-pyridylmethylaminomethylchroman by reaction with R-chromanamine and reduction of the resultant imine. 0021 In the preferred compounds of the formulae above and below, R is H, an alkyl or alkoxy group having 1 to 10 carbon atoms or an alkenyl group having 2 to 7 carbon atoms. 0022 A is preferably a phenyl group, a phenyl group which is monosubstituted or disubstituted by F, a 4-fluorophenyl group, a pyrimidyl, a pyridyl, a pyrazyl or a pyridazyl group, in particular a 4-fluorophenyl group. 0023 Preference is given to compounds which contain at least one of the preferred radicals. 0024 If R is an alkyl group, in which, in addition, one CH2 group (alkoxy or oxaalkyl) may be replaced by an O atom, it may be straight-chain or branched. It preferably has 2, 3, 4, 5, 6, 7, 8, 9 or 12 carbon atoms and accordingly is preferably ethyl, propyl, butyl, pentyl, hexyl, heptyl, octyl, nonyl, decyl, ethoxy, propoxy, butoxy, pentoxy, hexyloxy, heptyloxy, octyloxy, nonyloxy or decyloxy, furthermore also undecyl, dodecyl, undecyloxy, dodecyloxy, 2-oxapropyl (2-methoxymethyl), 2-oxabutyl (methoxyethyl) or 3-oxabutyl (2-ethoxymethyl), 2-, 3- or 4-oxapentyl, 2-, 3-, 4- or 5-oxahexyl, or 2-, 3-, 4-, 5- or 6-oxaheptyl. Particular preference is given to hexyl, pentyl, butyl, n-butyl, propyl, i-propyl, methyl and ethyl, in particular propyl and pentyl; particularly preferred alkoxy groups are hexyloxy, pentoxy, n-butoxy, propoxy, i-propoxy, methoxy and ethoxy, in particular ethoxy and n-butoxy. Compounds of the formulae above and below which have branched wing groups R may be of importance. Branched groups of this type generally contain not more than two chain branches. R is preferably a straight-chain group or a branched group having not more than one chain branch. 0025 Preferred branched radicals are isopropyl, 2-butyl (1-methylpropyl), isobutyl (3-methylpropyl), tert-butyl, 2-methylbutyl, isopentyl (3-methylbutyl), 2-methylpentyl, 3-methylpentyl, 4-methylpentyl, 2-ethylhexyl, 5-methylhexyl, 2-propylpentyl, 6-methylheptyl, 7-methyloctyl, isopropoxy, 2-methylpropoxy, 2-methylbutoxy, 3-methylbutoxy, 2-methylpentoxy, 3-methylpentoxy, 2-ethylhexyloxy, 1-methylhexyloxy, 1-methylheptyloxy, 2-oxa-3-methylbutyl and 3-oxa-4-methylpentyl. 0026 The radical R may also be an optically active organic radical containing one or more asymmetrical carbon atoms. 0027 The process according to the invention is very particularly suitable for the preparation of the aldehydes of the formulae I1 to I10: 3

0028 In which R1 and R2 independently of one another, are as defined for R and are in particular F, CF3, OCF3, OCHF2 or H, and are very particularly preferably F. 0029 Very particularly preferred 5-arylnicotinaldehydes which can be prepared by the process according to the invention are the compounds of the formulae I1, I2, I9 and I10. 0030 The 5-arylnicotinic acids used as starting materials for the process according to the invention are either known or are prepared by methods known per se, as described in the literature (for example in standard works, such as Houben-Weyl, Methoden der organischen Chemie Methods of Organic Chemistry, Georg-Thieme-Verlag, Stuttgart), to be precise under reaction conditions which are known and suitable for said reactions. However, use can also be made of variants which are known per se, but are not mentioned here in greater detail. 0031 The 5-aryinicotinic acids are preferably prepared by Suzuki coupling (N. Miyaura, A. Suzuki, Chem. Rev. 95, 2457 (1995)) by reacting 5-bromonictonic acid, an alkyl 5-bromonicotinate, 5-bromonicotinyl alcohol or the alkylcarboxylic acid ester thereof with the corresponding arylboronic acids under known reaction conditions to give a compound of the formula II, III, IV or V: 4

0032 In which A is as defined above, and R3 is methyl, ethyl, n-propyl, isopropyl, n-butyl, sec-butyl or tert-butyl, 0033 subsequently hydrolysing the ester of the formulae III or V by conventional processes to give the free acid of the formula II or the alcohol of the formula IV, and oxidizing the alcohol of the formula IV by conventional methods to give the acid of the formula II. 0034 The acids of the formula II obtained in this way can be used directly for the process according to the invention. 0035 R3 is preferably methyl or ethyl, in particular methyl. 0036 Compounds of the formulae I, II, III and IV in which A is a 4-fluorophenyl radical are particularly preferred. 0037 The invention likewise relates to the novel compounds of the formulae I, II, III and IV. 0038 The reaction in the process according to the invention for the preparation of 5-arylnicotinaldehydes is simple to carry out, with the 5-aryinicotinic acids in question preferably being hydrogenated in organic solvents, at temperatures of from 10 to 180 C., preferably at from 20 to 150 C. and very particularly preferably from at 40 to 100 C., and at a pressure of from 1 to 150 bar, preferably at from 1.5 to 120 bar and in particular at from 2 to 100 bar, with addition of a carboxylic anhydride in the presence of a palladium/ligand complex. 0039 The solvents used for the process according to the invention are preferably ethers, such as, for example, diethyl ether or tetrahydrofuran, ketones, such as, for example, acetone, hydrocarbons, such as, for example, toluene, benzene, hexane or heptane, amides, such as, for example, dimethylformamide or N-methylpyrrolidone, or acid anhydrides, such as, for example, acetic anhydride. 0040 Particular preference is given to ethers, in particular tetrahydrofuran. 0041 Mixtures of the said solvents can likewise be used. 0042 The amount of solvent is not crucial; from 10 g to 500 g of solvent can preferably be added per g of the compound of the formula II to be reacted. 0043 The duration of the reaction depends on the selected reaction conditions. In general, the reaction duration is from 0.5 hour to 10 days, preferably from 1 to 24 hours. 0044 In a preferred embodiment of the invention, the end of the reduction to the aldehyde is determined by suitable analytical methods, for example HPLC, and the reduction is interrupted. 0045 The hydrogenation catalyst used is a palladium/ligand complex. 0046 Preferred ligands are the following: triphenylphosphine, diphenylphosphinoferrocene, tri-o-tolylphosphine, 1,2-bis(diphenylphosphino)ethane, 2,4-bis(diphenylphosphino)pentane, bis(diphenylphosphino)methane and tris(tert-butyl)phosphine. It is likewise possible to use mixtures of the ligands. 0047 Palladium is generally employed as a palladium compound, from which the corresponding catalyst is prepared by addition of ligands. It is likewise possible to employ palladium as a complex having the correct stoichiometric composition to which, in accordance with the invention, an amount of ligand is added so that the ligand excess defined in accordance with the invention is observed. 0048 Suitable palladium compounds employed in the presence of the excess of ligand are preferably the following: Tetrakis(triphenylphosphine)palladium(0), dibenzylidenepalladium(0) complexes, palladium on carbon (preferably 5%), PdCl2dppf, palladium acetate/tri-O-tolylphosphine complex, Pd(0)*dppe, Pd(0)*dppp, Pd(0)*dppm, Pd(COD)Cl2, PdCl2, Pd(OAc)2 and PdBr2. 0049 The molar ratio between palladium and the acid to be hydrogenated is preferably from 1:500 to 1:200, in particular from 1:50 to 1:100. 0050 The molar ratio between palladium and ligand is from 1:5 to 1:15, preferably from 1:5 to 1:10, in particular from 1:5 to 1:6, in the case of monodentate ligands and from 1:2.5 to 1:7.5, preferably from 1:2.5 to 1:5, in particular from 1:2.5 to 1:3, in the case of bidentate ligands. 0051 Non-solvent anhydrides used for the process are preferably pivalic anhydride, acetic anhydride, isobutyric anhydride, 5-norbornene-2,3-dicarboxylic anhydride, 1,2,3,6-tetrahydrophthalic anhydride and naphthalene-1,8-dicarboxylic anhydride. 0052 The molar ratio between the carboxylic anhydride and the 5-aryinicotinic acid is preferably from 10:1 to 8:1, preferably from 7:1 to 6:1 and in particular from 5:1 to 2:1. 0053 The compounds of the formula I can be obtained, after removal of the solvent, by conventional work-up steps, such as, for example, addition of water to the reaction mixture and extraction. It may be advantageous, for further purification of the product, subsequently to carry out a distillation or crystallization. 0054 The compounds of the formula I which can be prepared by the process according to the invention are important intermediates or end products in industrial organic chemistry. Appropriately substituted derivatives are, in particular, valuable intermediates in the synthesis of highly value-added end products or are such end products themselves, for crop protection, such as, for example, fungicides, insecticides, herbicides or pesticides, or for the preparation of substances having high pharmaceutical activity. 0055 Even without further embodiments, it is assumed that a person skilled in the art can utilize the above description in the broadest scope. The preferred embodiments should therefore merely be regarded as a descriptive disclosure which is not limiting in any way. 0056 The examples below are intended to illustrate the invention without representing a limitation. Unless otherwise stated, percentages are percent by weight. All temperatures are given in degrees Celsius.

EXAMPLE 1 0057 13.2 g of 4-fluorobenzeneboronic acid and 10.8 g of sodium hydrogen-carbonate are initially introduced, and a mixture of 16.1 g of 5-bromo-3-hydroxymethylpyridine, 30 ml of water and 60 ml of toluene is added with stirring and under a protective gas. A further 14 ml of water, 28 ml of toluene and 0.5 g of tetrakis(triphenylphosphine)palladium(0) are subsequently added. The reaction mixture is heated to reflux and held at this temperature for 2 hours. After cooling, the mixture is subjected to conventional work-up, giving 5-(4-fluorophenyl)nicotinyl alcohol. The alcohol is subsequently oxidized by conventional methods to give 5-(4-fluorophenyl)nicotinic acid.

EXAMPLE 2 0058 1.38 kg of 5-bromonicotinic acid, 1.10 kg of 4-fluorobenzeneboronic acid and 0.40 kg of Pd/activated carbon (5%) are introduced into 8.5 liters of water. The black suspension is rendered alkaline using 1.39 kg of 32% sodium hydroxide solution and warmed to 100 C. After 4 hours, the mixture is subjected to conventional work-up, giving 5-(4-fluorophenyl)nicotinic acid. 0059 Melting range: 198.5 C. to 203 C.

EXAMPLE 3 0060 15.3 g of methyl 5-(4-fluorophenyl)nicotinate (obtainable by Suzuki coupling of methyl 5-bromopyridine-3-carboxylate with 4-fluorobenzeneboronic acid analogously to Example 1 or 2) are saponified by conventional methods to give 5-(4-fluorophenyl)nicotinic acid.

EXAMPLE 4 0061 5-Bromo-3-acetoxymethylpyridine is reacted with 4-fluorobenzeneboronic acid as described in Example 1. The 5-(4-fluorophenyl)pyridin-3-ylmethyl acetate obtained is saponified by conventional methods and subsequently oxidized to give 5-(4-fluorophenyl)nicotinic acid.

EXAMPLE 5 0062 5-(4-Fluorophenyl)nicotinic acid is dissolved in tetrahydrofuran in an autoclave, three equivalents of the respective acid anhydride are added, and the mixture is rendered inert by repeatedly injecting a protective gas. A solution of Pd(OAc)2 and PPh3 in tetrahydrofuran is added in a counter-current of protective gas, and the reaction solution is subsequently hydrogenated at 80 C. under a hydrogen pressure of 8 bar with stirring. Conventional work-up gives the aldehyde in a yield of 98%.