⁷); a heteroaryl (the heteroaryl is optionally mono-substituted or poly-substituted with R⁷); a heteroaryl (C1-C3)alkyl (the heteroaryl moiety is optionally mono-substituted or poly-substituted with R⁷); a heteroaryl (C3-C6)cycloalkyl (the heteroaryl moiety is optionally mono-substituted or poly-substituted with R⁷); a heterocycloalkyl (the heterocycloalkyl is optionally substituted with R¹⁰); a heterocycloalkyl (C1-C6)alkyl (the heterocycloalkyl moiety is optionally substituted with R¹⁰); or a heterocycloalkyl (C3-C6)cycloalkyl (the heterocycloalkyl moiety is optionally substituted with R¹⁰),

R²represents a hydrogen atom; a (C1-C6)alkyl; a (C1-C6)haloalkyl; a (C3-C6)cycloalkyl; a (C3-C6)halocycloalkyl; a (C2-C6)alkenyl; a (C2-C6)haloalkenyl; a (C2-C6)alkynyl; a (C2-C6)haloalkynyl; a (C1-C6)alkoxy; a (C1-C6)haloalkoxy; a (C3-C6)cycloalkyl (C1-C6)alkyl; a (C3-C6)halocycloalkyl (C1-C6)alkyl; a phenyl (the phenyl is optionally mono-substituted or poly-substituted with R⁷); a phenyl (C1-C6)alkyl (the phenyl moiety is optionally mono-substituted or poly-substituted with R⁷); a heteroaryl (the heteroaryl is optionally mono-substituted or poly-substituted with R⁷); a heteroaryl (C1-C3)alkyl (the heteroaryl moiety is optionally mono-substituted or poly-substituted with R⁷); a cyano; a cyano (C1-C6)alkyl; a cyano (C3-C6)cycloalkyl; a hydroxy; a hydroxy (C1-C6)alkyl; a (C1-C6)alkoxy (C1-C6)alkyl; a formyl; an amino; a (C1-C6)alkylamino (the amino moiety is optionally substituted with R¹⁰); a (C1-C6)alkylcarbonyl; a (C1-C6)alkoxy (C1-C6)alkylcarbonyl; a (C3-C6)cycloalkylcarbonyl; a (C3-C6)cycloalkyl (C1-C6)alkylcarbonyl; a benzoyl (the benzoyl is optionally mono-substituted or poly-substituted with R⁷); a (C1-C6)alkoxycarbonyl; a (C1-C6)haloalkoxycarbonyl; a (C2-C6)alkenyloxycarbonyl; a carbamoyl; a (C1-C6)alkylaminocarbonyl (the amino moiety is optionally substituted with R¹⁰); a (C1-C6)alkoxycarbonyl (C1-C6)alkylamino (the amino moiety is optionally substituted with R¹⁰); a (C1-C6)alkoxycarbonylamino (the amino moiety is optionally substituted with R¹⁰); a ((C1-C6)alkylthio)carbonyl; a ((C1-C6)alkyl)thiocarbonyl; a ((C1-C6)alkoxy)thiocarbonyl; a thiocarbamoyl; a (C1-C6)alkylaminothiocarbonyl (the amino moiety is optionally substituted with R¹⁰); a (C1-C6)alkylsulfonyl; a (C1-C6)haloalkylsulfonyl; a sulfamoyl; a (C1-C6)alkylaminosulfonyl (the amino moiety is optionally substituted with R¹⁰); a (C1-C6)alkoxycarbonyl (C1-C6)alkyl; an aminocarbonyl (C1-C6)alkyl; a (C1-C6)alkylaminocarbonyl (C1-C6)alkyl (the amino moiety is optionally substituted with R¹⁰); a (C3-C6)cycloalkylaminocarbonyl (C1-C6)alkyl (the amino moiety is optionally substituted with R¹⁰); a (C1-C6)haloalkylaminocarbonyl (C1-C6)alkyl (the amino moiety is optionally substituted with R¹⁰); a (C1-C6)alkylcarbonyl (C1-C6)alkyl; a (C1-C6)haloalkylcarbonyl (C1-C6)alkyl; a (C1-C6)alkylcarbonyloxy (C1-C6)alkyl; a (C1-C6)alkoxycarbonyloxy (C1-C6)alkyl; a (C1-C6)alkoxycarbonylamino (C1-C6)alkyl (the amino moiety is optionally substituted with a (C1-C6)alkyl); a hydroxyimino; a hydroxyimino (C1-C6)alkyl; a (C1-C6)alkoxyimino; a (C1-C6)alkoxyimino (C1-C6)alkyl; or a (C1-C6)haloalkoxyimino (C1-C6)alkyl, or

R¹and R², together with the nitrogen atom to which R¹and R²are attached form a 3- to 8-membered heterocyclic ring or a 3- to 8-membered heterocyclic ring having 1 to 4 heteroatoms selected from an oxygen atom, a sulfur atom, and a nitrogen atom, and the heterocyclic ring is optionally substituted with a halogen atom, a cyano, a nitro, a (C1-C6)alkyl, a (C1-C6)alkoxy, a (C1-C6)haloalkyl, or an oxo,

R³represents a halogen atom; a cyano; a (C1-C6)alkyl; a (C1-C6)haloalkyl; a (C3-C6)cycloalkyl; a (C1-C6)alkoxy; or a (C1-C6)haloalkoxy,

R⁴represents a hydrogen atom; a halogen atom; a (C1-C6)alkyl; or a (C1-C6) haloalkyl,

R⁷represents a halogen atom; a (C1-C6)alkyl; a (C1-C6)haloalkyl; a (C3-C6)cycloalkyl; a (C3-C6)halocycloalkyl; a (C3-C6)cycloalkyl (C1-C6)alkyl; a (C3-C6)halocycloalkyl (C1-C6)alkyl; a (C1-C6)alkoxy; a (C1-C6)haloalkoxy; a (C1-C6)alkylthio; a (C1-C6)haloalkylthio; a (C1-C6)alkylsulfinyl; a (C1-C6)haloalkylsulfinyl; a (C1-C6)alkylsulfonyl; a (C1-C6)haloalkylsulfonyl; a (C1-C6)alkylthio (C1-C6)alkyl; a (C1-C6)haloalkylthio (C1-C6)alkyl; a (C1-C6)alkylsulfonyloxy; a (C1-C6)haloalkylsulfonyloxy; a phenyl (the phenyl is optionally mono-substituted or poly-substituted with a halogen atom, an alkyl, or a haloalkyl); a phenyl (C1-C6)alkyl; a phenyl (C1-C6)alkoxy; a cyano; or a nitro, and

R¹⁰represents a (C1-C6)alkyl; a (C1-C6) haloalkyl; a (C3-C6)cycloalkyl; a (C3-C6)halocycloalkyl; a (C1-C6)alkoxy; a (C1-C6)alkoxy (C1-C6)alkyl; a (C1-C6)haloalkoxy (C1-C6)alkyl; a (C1-C6)alkoxy (C1-C6)alkoxy (C1-C6)alkyl; a (C1-C6)alkylthio (C1-C6)alkyl; a (C1-C6)alkylsulfinyl (C1-C6)alkyl; a (C1-C6)alkylsulfonyl (C1-C6)alkyl; a (C1-C6)alkylthio (C1-C6)alkoxy (C1-C6)alkyl; a (C1-C6)alkylsulfinyl (C1-C6)alkoxy (C1-C6)alkyl; a (C1-C6)alkylsulfonyl (C1-C6)alkoxy (C1-C6)alkyl; a cyano (C1-C6)alkyl; a cyano (C1-C6)alkoxy (C1-C6)alkyl; a (C1-C6)alkylcarbonyl; a (C1-C6)haloalkylcarbonyl; a (C1-C6)alkoxycarbonyl; a (C1-C6)haloalkoxycarbonyl; a (C1-C6)alkylaminocarbonyl; a (C1-C6)haloalkylaminocarbonyl; a benzoyl (the benzoyl is optionally mono-substituted or poly-substituted with R⁷); a (C1-C6)alkylsulfonyl; a (C1-C6)haloalkylsulfonyl; a (C1-C6)alkylcarbonyl (C1-C6)alkyl; a (C1-C6)alkoxycarbonyl (C1-C6)alkyl; a (C1-C6)alkylaminocarbonyl (C1-C6)alkyl; a (C1-C6)alkylcarbonyloxy (C1-C6)alkyl; a (C1-C6)alkoxycarbonyloxy (C1-C6)alkyl; a (C1-C6)alkoxycarbonylamino (C1-C6)alkyl (the amino moiety is optionally substituted with a (C1-C6)alkyl); or a 5-methyl-1,3-dioxole-2-one-4-ylmethyl.

(14) An alkoxybenzoic acid derivative of formula [III] or a salt thereof,

[Image Omitted]

- wherein in the formula [III],
- G represents a hydrogen atom; a halogen atom; or a (C1-C6)alkyl,
- K represents a hydroxy; a (C1-C6)alkoxy; or a phenoxy (the phenoxy is optionally mono-substituted or poly-substituted with R⁷),
- R³represents a halogen atom; a cyano; a (C1-C6)alkyl; a (C1-C6)haloalkyl; a (C3-C6)cycloalkyl; a (C1-C6)alkoxy; or a (C1-C6)haloalkoxy,
- R⁴represents a hydrogen atom; a halogen atom; a (C1-C6)alkyl; or a (C1-C6)haloalkyl,
- R⁵represents a (C1-C12)alkyl (the (C1-C12)alkyl is optionally mono-substituted or poly-substituted with R⁶); a (C3-C6)cycloalkyl (the (C3-C6)cycloalkyl is optionally mono-substituted or poly-substituted with R⁶); a (C2-C6)alkenyl (the (C2-C6)alkenyl is optionally mono-substituted or poly-substituted with R⁶); or a (C2-C6)alkynyl (the (C2-C6)alkynyl is optionally mono-substituted or poly-substituted with R⁶),
- R⁶represents a halogen atom; a (C1-C6)alkyl; a (C1-C6)haloalkyl; a (C3-C6)cycloalkyl; a (C3-C6)halocycloalkyl; a hydroxy; a (C1-C6)alkoxy; a (C1-C6)haloalkoxy; a (C3-C6)cycloalkoxy; a (C3-C6)halocycloalkoxy; a (C1-C6)alkoxy (C1-C6)alkoxy; a (C1-C6)haloalkoxy (C1-C6)alkoxy; a (C1-C6)haloalkoxy (C1-C6)haloalkoxy; a thiol; a (C1-C6)alkylthio; a (C1-C6)haloalkylthio; a (C2-C6)alkenylthio; a (C2-C6)haloalkenylthio; a (C3-C6)cycloalkylthio; a (C3-C6)halocycloalkylthio; a (C3-C6)cycloalkyl (C1-C6)alkylthio; a (C3-C6)halocycloalkyl (C1-C6)alkylthio; a tri((C1-C6)alkyl)silyl (C1-C6)alkylthio; a (C1-C6)alkylthio (C1-C6)alkoxy; a (C1-C6)haloalkylthio (C1-C6)alkoxy; a (C1-C6)alkylsulfinyl; a (C1-C6)haloalkylsulfinyl; a (C3-C6)cycloalkylsulfinyl; a (C3-C6)halocycloalkylsulfinyl; a (C1-C6)alkylsulfonyl; a (C1-C6)haloalkylsulfonyl; a (C3-C6)cycloalkylsulfonyl; a (C3-C6)halocycloalkylsulfonyl; a formyl; a (C1-C6)alkylcarbonyl; a (C1-C6)haloalkylcarbonyl; a benzoyl (the benzoyl is optionally mono-substituted or poly-substituted with R⁷); a (C1-C6)alkoxycarbonyl; a (C1-C6)haloalkoxycarbonyl; a (C1-C6)alkylaminocarbonyl (the amino moiety is optionally substituted with R¹⁰); a (C1-C6)haloalkylaminocarbonyl (the amino moiety is optionally substituted with R¹⁰); a (C1-C6)alkylaminocarbonylthio (the amino moiety is optionally substituted with R¹⁰); a (C1-C6)haloalkylaminocarbonylthio (the amino moiety is optionally substituted with R¹⁰); a formyloxy; a (C1-C6)alkylcarbonyloxy; a (C1-C6)haloalkylcarbonyloxy; a benzoyloxy (the benzoyloxy is optionally mono-substituted or poly-substituted with R⁷); a (C1-C6)alkylsulfinyloxy; a (C1-C6)haloalkylsulfinyloxy; a (C3-C6)cycloalkylsulfinyloxy; a (C3-C6)halocycloalkylsulfinyloxy; a phenylsulfinyloxy (the phenylsulfinyloxy is optionally mono-substituted or poly-substituted with R⁷); a (C1-C6)alkylsulfonyloxy; a (C1-C6)haloalkylsulfonyloxy; a (C3-C6)cycloalkylsulfonyloxy; a (C3-C6)halocycloalkylsulfonyloxy; a phenylsulfonyloxy (the phenyl moiety is optionally mono-substituted or poly-substituted with R⁷); an amino; a (C1-C6)alkylamino (the amino moiety is optionally substituted with R¹⁰); a (C1-C6)haloalkylamino (the amino moiety is optionally substituted with R¹⁰); a (C1-C6)alkylcarbonylamino (the amino moiety is optionally substituted with R¹⁰); a (C1-C6)haloalkylcarbonylamino (the amino moiety is optionally substituted with R¹⁰); a phenylcarbonylamino (the phenyl moiety is optionally mono-substituted or poly-substituted with R⁷, and the amino moiety is optionally substituted with R¹⁰); a (C1-C6)alkoxycarbonylamino (the amino moiety is optionally substituted with R¹⁰); a (C1-C6)haloalkoxycarbonylamino (the amino moiety is optionally substituted with R¹⁰); a (C1-C6)alkylaminocarbonylamino (the amino moiety is optionally substituted with R¹⁰); a (C1-C6)haloalkylaminocarbonylamino (the amino moiety is optionally substituted with R¹⁰); a (C1-C6)alkylsulfinylamino (the amino moiety is optionally substituted with R¹⁰); a (C1-C6)haloalkylsulfinylamino (the amino moiety is optionally substituted with R¹⁰); a phenylsulfinylamino (the phenyl moiety is optionally mono-substituted or poly-substituted with R⁷, and the amino moiety is optionally substituted with R¹⁰); a (C1-C6)alkylsulfonylamino (the amino moiety is optionally substituted with R¹⁰); a (C1-C6)haloalkylsulfonylamino (the amino moiety is optionally substituted with R¹⁰); a phenylsulfonylamino (the phenyl moiety is optionally mono-substituted or poly-substituted with R⁷, and the amino moiety is optionally substituted with R¹⁰); a (C1-C6)alkoxyimino; a tri((C1-C6)alkyl)silyl; a phenyl (the phenyl is optionally mono-substituted or poly-substituted with R⁷); a phenoxy (the phenoxy is optionally mono-substituted or poly-substituted with R⁷); a phenyl (C1-C6)alkoxy (the phenyl moiety is optionally mono-substituted or poly-substituted with R⁷); a phenylthio (the phenylthio is optionally mono-substituted or poly-substituted with R⁷); a phenylsulfinyl (the phenylsulfinyl is optionally mono-substituted or poly-substituted with R⁷); a phenylsulfonyl (the phenylsulfonyl is optionally mono-substituted or poly-substituted with R⁷); a phenyl (C1-C6)alkylthio (the phenyl moiety is optionally mono-substituted or poly-substituted with R⁷); a phenyl (C1-C6)alkylsulfinyl (the phenyl moiety is optionally mono-substituted or poly-substituted with R⁷); a phenyl (C1-C6)alkylsulfonyl (the phenyl moiety is optionally mono-substituted or poly-substituted with R⁷); a —O—N═C(R⁸) (R⁹) group; an adamantyl; an azetidinyl (a nitrogen atom of the azetidinyl is optionally substituted with R¹⁰); a pyrrolidinyl (a nitrogen atom of the pyrrolidinyl is optionally substituted with R¹⁰); a piperidinyl (a nitrogen atom of the piperidinyl is optionally substituted with R¹⁰); a 1,3-dioxolanyl; a 1,3-dioxanyl; a pyrrolyl (the pyrrolyl is optionally mono-substituted or poly-substituted with R⁷); a pyrazolyl (the pyrazolyl is optionally mono-substituted or poly-substituted with R⁷); an imidazolyl (the imidazolyl is optionally mono-substituted or poly-substituted with R⁷); a triazolyl (the triazolyl is optionally mono-substituted or poly-substituted with R⁷); an oxazolyl (the oxazolyl is optionally mono-substituted or poly-substituted with R⁷); an isoxazolyl (the isoxazolyl is optionally mono-substituted or poly-substituted with R⁷); a thiazolyl (the thiazolyl is optionally mono-substituted or poly-substituted with R⁷); an isothiazolyl (the isothiazolyl is optionally mono-substituted or poly-substituted with R⁷); a pyridyl (the pyridyl is optionally mono-substituted or poly-substituted with R⁷, and further a nitrogen atom of the pyridyl is optionally oxidized to form a N-oxide); a pyrimidinyl (the pyrimidinyl is optionally mono-substituted or poly-substituted with R⁷); a pyridyloxy (the pyridyloxy is optionally mono-substituted or poly-substituted with R⁷); a tetrahydrofuranyl (the tetrahydrofuranyl is optionally mono-substituted or poly-substituted with R⁷); a 1,3-dioxoisoindolinyl (the 1,3-dioxoisoindolinyl is optionally mono-substituted or poly-substituted with R⁷); a cyano; a nitro; a carboxy; a thiocyanato; or an aminooxy,
- R⁷represents a halogen atom; a (C1-C6)alkyl; a (C1-C6)haloalkyl; a (C3-C6)cycloalkyl; a (C3-C6)halocycloalkyl; a (C3-C6)cycloalkyl (C1-C6)alkyl; a (C3-C6)halocycloalkyl (C1-C6)alkyl; a (C1-C6)alkoxy; a (C1-C6)haloalkoxy; a (C1-C6)alkylthio; a (C1-C6)haloalkylthio; a (C1-C6)alkylsulfinyl; a (C1-C6)haloalkylsulfinyl; a (C1-C6)alkylsulfonyl; a (C1-C6)haloalkylsulfonyl; a (C1-C6)alkylthio (C1-C6)alkyl; a (C1-C6)haloalkylthio (C1-C6)alkyl; a (C1-C6)alkylsulfonyloxy; a (C1-C6)haloalkylsulfonyloxy; a phenyl (the phenyl is optionally mono-substituted or poly-substituted with a halogen atom, an alkyl, or a haloalkyl); a phenyl (C1-C6)alkyl; a phenyl (C1-C6)alkoxy; a cyano; or a nitro,
- R⁸and R⁹are identical to or different from each other, and represent a hydrogen atom; a (C1-C6)alkyl; a (C1-C6)haloalkyl; a (C3-C6)cycloalkyl; a (C3-C6)halocycloalkyl; or a phenyl (the phenyl is optionally mono-substituted or poly-substituted with R⁷), or R⁸and R⁹, together with the carbon atom to which R⁸and R⁹are attached form a 3- to 6-membered ring, and
- R¹⁰represents a (C1-C6)alkyl; a (C1-C6)haloalkyl; a (C3-C6)cycloalkyl; a (C3-C6)halocycloalkyl; a (C1-C6)alkoxy; a (C1-C6)alkoxy (C1-C6)alkyl; a (C1-C6)haloalkoxy (C1-C6)alkyl; a (C1-C6)alkoxy (C1-C6)alkoxy (C1-C6)alkyl; a (C1-C6)alkylthio (C1-C6)alkyl; a (C1-C6)alkylsulfinyl (C1-C6)alkyl; a (C1-C6)alkylsulfonyl (C1-C6)alkyl; a (C1-C6)alkylthio (C1-C6)alkoxy (C1-C6)alkyl; a (C1-C6)alkylsulfinyl (C1-C6)alkoxy (C1-C6)alkyl; a (C1-C6)alkylsulfonyl (C1-C6)alkoxy (C1-C6)alkyl; a cyano (C1-C6)alkyl; a cyano (C1-C6)alkoxy (C1-C6)alkyl; a (C1-C6)alkylcarbonyl; a (C1-C6)haloalkylcarbonyl; a (C1-C6)alkoxycarbonyl; a (C1-C6)haloalkoxycarbonyl; a (C1-C6)alkylaminocarbonyl; a (C1-C6)haloalkylaminocarbonyl; a benzoyl (the benzoyl is optionally mono-substituted or poly-substituted with R⁷); a (C1-C6)alkylsulfonyl; a (C1-C6)haloalkylsulfonyl; a (C1-C6)alkylcarbonyl (C1-C6)alkyl; a (C1-C6)alkoxycarbonyl (C1-C6)alkyl; a (C1-C6)alkylaminocarbonyl (C1-C6)alkyl; a (C1-C6)alkylcarbonyloxy (C1-C6)alkyl; a (C1-C6)alkoxycarbonyloxy (C1-C6)alkyl; a (C1-C6)alkoxycarbonylamino (C1-C6)alkyl (the amino moiety is optionally substituted with a (C1-C6)alkyl); or a 5-methyl-1,3-dioxole-2-one-4-ylmethyl.

Effects of the Invention

The pest control agent comprising the compound of the present invention exhibits an excellent control effect on a wide range of pests such as Hemiptera pests, Lepidoptera pests, Coleoptera pests, Diptera pests, Hymenoptera pests, Orthoptera pests, Isoptera pests, Thysanoptera pests, Acari pests, and plant parasitic nematodes, and can also control pests having acquired chemical resistance.

DESCRIPTION OF EMBODIMENTS

Symbols and terms described in the present specification will be described.

In the present invention, the “pest control agent” means insecticides, acaricides, nematicides, and the like for agricultural or horticultural fields, animals such as domestic animals and pets, household use, or prevention of epidemics.

In the present invention, the “halogen atom” represents a fluorine atom; a chlorine atom; a bromine atom; or an iodine atom.

In the present invention, the description of “(C1-C6)” or the like indicates that the number of carbon atoms of the substituent following this description is 1 to 6 in this case.

In the present invention, unless otherwise specified, the “(C1-C6)alkyl” refers to a linear or branched alkyl group having 1 to 6 carbon atoms. Examples thereof include methyl, ethyl, n-propyl, isopropyl, n-butyl, sec-butyl, isobutyl, tert-butyl, n-pentyl, 1-methylbutyl, 2-methylbutyl, 3-methylbutyl, 1-ethylpropyl, 1,1-dimethylpropyl, 1,2-dimethylpropyl, neopentyl, n-hexyl, 1-methylpentyl, 2-methylpentyl, 3-methylpentyl, 4-methylpentyl, 1-ethylbutyl, 2-ethylbutyl, 1,1-dimethylbutyl, 1,2-dimethylbutyl, 1,3-dimethylbutyl, 2,2-dimethylbutyl, 2,3-dimethylbutyl, 3,3-dimethylbutyl, 1,1,2-trimethylpropyl, 1,2,2-trimethylpropyl, 1-ethyl-1-methylpropyl, and 1-ethyl-2-methylpropyl groups.

In the present invention, unless otherwise specified, the “(C1-C6)haloalkyl” refers to a linear or branched alkyl group having 1 to 6 carbon atoms and being substituted with 1 to 13 halogen atoms and which are identical or different. Examples thereof include fluoromethyl, difluoromethyl, trifluoromethyl, chloromethyl, dichloromethyl, trichloromethyl, bromomethyl, dibromomethyl, tribromomethyl, iodomethyl, chlorodifluoromethyl, dichlorofluoromethyl, 1-fluoroethyl, 2-fluoroethyl, 1,1-difluoroethyl, 2,2-difluoroethyl, 2,2,2-trifluoroethyl, 1,1,2,2-tetrafluoroethyl, pentafluoroethyl, 1-chloroethyl, 2-chloroethyl, 1,1-dichloroethyl, 2,2-dichloroethyl, 2,2,2-trichloroethyl, 1,1,2,2-tetrachloroethyl, pentachloroethyl, 1-bromoethyl, 2-bromoethyl, 2,2,2-tribromoethyl, 1-iodoethyl, 2-iodoethyl, 2-chloro-2,2-difluoroethyl, 2,2-dichloro-2-fluoroethyl, 1-fluoropropyl, 2-fluoropropyl, 3-fluoropropyl, 1,1-difluoropropyl, 2,2-difluoropropyl, 3,3-difluoropropyl, 3,3,3-trifluoropropyl, 2,2,3,3,3-pentafluoropropyl, 1,1,2,3,3,3-hexafluoropropyl, heptafluoropropyl, 1-fluoro-2-propyl, 2-fluoro-2-propyl, 1,1-difluoro-2-propyl, 1,2-difluoro-2-propyl, 1,3-difluoro-2-propyl, 1,2,3-trifluoro-2-propyl, 1,1,3,3-tetrafluoro-2-propyl, 1,1,1,3,3,3-hexafluoro-2-propyl, heptafluoro-2-propyl, 1-chloropropyl, 2-chloropropyl, 3-chloropropyl, 1,1-dichloropropyl, 2,2-dichloropropyl, 3,3-dichloropropyl, 3,3,3-trichloropropyl, 2,2,3,3,3-pentachloropropyl, heptachloropropyl, 1-chloro-2-propyl, 2-chloro-2-propyl, 1,1-dichloro-2-propyl, 1,2-dichloro-2-propyl, 1,3-dichloro-2-propyl, 1,2,3-trichloro-2-propyl, 1,1,3,3-tetrachloro propyl, 1,1,1,3,3,3-hexachloro-2-propyl, heptachloro propyl, 1-bromopropyl, 2-bromopropyl, 3-bromopropyl, 1-bromo-2-propyl, 2-bromo-2-propyl, 1-iodopropyl, 2-iodopropyl, 3-iodopropyl, 1-iodo-2-propyl, 2-iodo-2-propyl, 1-fluorobutyl, 2-fluorobutyl, 3-fluorobutyl, 4-fluorobutyl, 4,4-difluorobutyl, 4,4,4-trifluorobutyl, 4,4,4-trifluoro-3-methylbutyl, 3,3,4,4,4-pentafluorobutyl, 2,2,3,4,4,4-hexafluorobutyl, 2,2,3,3,4,4,4-heptafluorobutyl, nonafluorobutyl, 1,1,1-trifluoro-2-butyl, 4,4,4-trifluoro-2-butyl, 3,3,4,4,4-pentafluoro-2-butyl, nonafluoro-2-butyl, 1,1,1,3,3,3-hexafluoro-2-(trifluoromethyl)-2-propyl, 1-chlorobutyl, 2-chlorobutyl, 3-chlorobutyl, 4-chlorobutyl, 4,4-dichlorobutyl, 4,4,4-trichlorobutyl, nonachlorobutyl, 1,1,1-trichloro-2-butyl, 4,4,4-trichloro-2-butyl, nonachloro-2-butyl, 1-bromobutyl, 2-bromobutyl, 3-bromobutyl, 4-bromobutyl, 1-iodobutyl, 2-iodobutyl, 3-iodobutyl, 4-iodobutyl, 4-chloro-1,1,2,2,3,3,4,4-octafluorobutyl, 4-bromo-1,1,2,2,3,3,4,4-octafluorobutyl, 1-fluoropentyl, 2-fluoropentyl, 3-fluoropentyl, 4-fluoropentyl, 5-fluoropentyl, 5,5,5-trifluoropentyl, 4,4,5,5,5-pentafluoropentyl, 3,3,4,4,5,5,5-heptafluoropentyl, 2,2,3,3,4,4,5,5-octafluoropentyl, 2,2,3,3,4,4,5,5,5-nonafluoropentyl, undecafluoropentyl, 1-chloropentyl, 2-chloropentyl, 3-chloropentyl, 4-chloropentyl, 5-chloropentyl, 5,5,5-trichloropentyl, 4,4,5,5,5-pentachloropentyl, 3,3,4,4,5,5,5-heptachloropentyl, 2,2,3,3,4,4,5,5,5-nonachloropentyl, undecachloropentyl, 1-bromopentyl, 2-bromopentyl, 3-bromopentyl, 4-bromopentyl, 5-bromopentyl, 5-iodopentyl, 1-fluorohexyl, 2-fluorohexyl, 3-fluorohexyl, 4-fluorohexyl, 5-fluorohexyl, 6-fluorohexyl, 6,6,6-trifluorohexyl, 5,5,6,6,6-pentafluorohexyl, 4,4,5,5,6,6,6-heptafluorohexyl, 3,3,4,4,5,5,6,6,6-nonafluorohexyl, 2,2,3,3,4,4,5,5,6,6,6-undecafluorohexyl, 2,2,3,3,4,4,5,5,6,6-decafluorohexyl, tridecafluorohexyl, 1-chlorohexyl, 2-chlorohexyl, 3-chlorohexyl, 4-chlorohexyl, 5-chlorohexyl, 6-chlorohexyl, 5-bromohexyl, 6-bromohexyl, 5-iodohexyl, and 6-iodohexyl groups.

In the present invention, unless otherwise specified, the “(C3-C6)cycloalkyl” refers to a cycloalkyl group having 3 to 6 carbon atoms, and the ring may be arbitrarily substituted with alkyl groups in the range of the designated number of carbon atoms. Examples thereof include cyclopropyl, 1-methylcyclopropyl, 2-methylcyclopropyl, 2,2-dimethylcyclopropyl, cyclobutyl, 1-methylcyclobutyl, cyclopentyl, 1-methylcyclopentyl, and cyclohexyl groups.

In the present invention, unless otherwise specified, the “(C3-C6)halocycloalkyl” refers to a cycloalkyl group having 3 to 6 carbon atoms and being substituted with 1 to 11 halogen atoms and which are identical or different, and the ring may be arbitrarily substituted with alkyl groups or haloalkyl groups within the specified range of carbon atoms. Examples thereof include 1-fluorocyclopropyl, 2-fluorocyclopropyl, 2,2-difluorocyclopropyl, 2,2,3,3-tetrafluorocyclopropyl, 1-chlorocyclopropyl, 2-chlorocyclopropyl, 2,2-dichlorocyclopropyl, 2,2,3,3-tetrachlorocyclopropyl, 1-bromocyclopropyl, 2,2-dibromocyclopropyl, 1-iodocyclopropyl, 1-fluoromethylcyclopropyl, 1-difluoromethylcyclopropyl, 1-trifluoromethylcyclopropyl, 1-chloromethylcyclopropyl, 1-bromomethylcyclopropyl, 2,2-diiodocyclopropyl, 1-fluorocyclobutyl, 2-fluorocyclobutyl, 3-fluorocyclobutyl, 3,3-difluorocyclobutyl, heptafluorocyclobutyl, 1-difluoromethylcyclobutyl, 1-trifluoromethylcyclobutyl, 2-chlorocyclobutyl, 3-chlorocyclobutyl, 3,3-dichlorocyclobutyl, 3,3-dibromocyclobutyl, 3,3-diiodocyclobutyl, 1-fluorocyclopentyl, 2-fluorocyclopentyl, 3-fluorocyclopentyl, 2,2-difluorocyclopentyl, 3,3-difluorocyclopentyl, nonafluorocyclopentyl, 2,2-dichlorocyclopentyl, 3,3-dichlorocyclopentyl, 2,2-dibromocyclopentyl, 3,3-dibromocyclopentyl, 2,2-diiodocyclopentyl, 3,3-diiodocyclopentyl, 1-fluorocyclohexyl, 2-fluorocyclohexyl, 3-fluorocyclohexyl, 4-fluorocyclohexyl, 2,2-difluorocyclohexyl, 3,3-difluorocyclohexyl, 4,4-difluorocyclohexyl, 1-chlorocyclohexyl, 2-chlorocyclohexyl, 3-chlorocyclohexyl, 4-chlorocyclohexyl, 2,2-dichlorocyclohexyl, 3,3-dichlorocyclohexyl, 4,4-dichlorocyclohexyl, 3,3-dibromocyclohexyl, 4,4-dibromocyclohexyl, 3,3-diiodocyclohexyl, and 4,4-diiodocyclohexyl groups.

In the present invention, unless otherwise specified, the “(C2-C6)alkenyl” refers to a linear or branched alkenyl group having 2 to 6 carbon atoms. Examples thereof include vinyl, 1-propenyl, isopropenyl, 2-propenyl, 1-butenyl, 1-methyl-1-propenyl, 2-butenyl, 1-methyl-2-propenyl, 3-butenyl, 2-methyl-1-propenyl, 2-methyl-2-propenyl, 1,3-butadienyl, 1-pentenyl, 1-ethyl-2-propenyl, 2-pentenyl, 1-methyl-1-butenyl, 3-pentenyl, 1-methyl-2-butenyl, 4-pentenyl, 1-methyl-3-butenyl, 3-methyl-1-butenyl, 1,2-dimethyl-2-propenyl, 1,1-dimethyl-2-propenyl, 2-methyl-2-butenyl, 3-methyl-2-butenyl, 1,2-dimethyl-1-propenyl, 2-methyl-3-butenyl, 3-methyl-3-butenyl, 1,3-pentadienyl, 1-vinyl-2-propenyl, 1-hexenyl, 1-propyl-2-propenyl, 2-hexenyl, 1-methyl-1-pentenyl, 1-ethyl-2-butenyl, 3-hexenyl, 4-hexenyl, 5-hexenyl, 1-methyl-4-pentenyl, 1-ethyl butenyl, 1-(isobutyl)vinyl, 1-ethyl-1-methyl-2-propenyl, 1-ethyl-2-methyl-2-propenyl, 1-(isopropyl)-2-propenyl, 2-methyl-2-pentenyl, 3-methyl-3-pentenyl, 4-methyl-3-pentenyl, 1,3-dimethyl-2-butenyl, 1,1-dimethyl-3-butenyl, 3-methyl-4-pentenyl, 4-methyl-4-pentenyl, 1,2-dimethyl-3-butenyl, 1,3-dimethyl-3-butenyl, 1,1,2-trimethyl-2-propenyl, 1,5-hexadienyl, 1-vinyl-3-butenyl, and 2,4-hexadienyl groups.

In the present invention, unless otherwise specified, the “(C2-C6)haloalkenyl” refers to a linear or branched alkenyl group having 2 to 6 carbon atoms and being substituted with 1 to 11 halogen atoms and which are identical or different. Examples thereof include 1-fluorovinyl, 2-fluorovinyl, 1,2-difluorovinyl, 2,2-difluorovinyl, trifluorovinyl, 1-chlorovinyl, 2-chlorovinyl, 1,2-dichlorovinyl, 2,2-dichlorovinyl, trichlorovinyl, 1,2-dibromovinyl, 2,2-dibromovinyl, tribromovinyl, 1,2-diiodovinyl, 2,2-diiodovinyl, triiodovinyl, 1-fluoro-2-propenyl, 2-fluoro-2-propenyl, 3-fluoro-2-propenyl, 2,3-difluoro-2-propenyl, 3,3-difluoro-2-propenyl, 3,3-difluoro-1-propenyl, 2,3,3-trifluoro propenyl, 3,3,3-trifluoro-1-propenyl, 2-chloro-3,3,3-trifluoro-1-propenyl, 1,2,3,3,3-pentafluoro-1-propenyl, 1-chloro-2-propenyl, 2-chloro-2-propenyl, 3-chloro propenyl, 2,3-dichloro-2-propenyl, 3,3-dichloro-2-propenyl, 3,3-dichloro-1-propenyl, 2,3,3-trichloro-2-propenyl, 3,3,3-trichloro-1-propenyl, 3-bromo-2-propenyl, 3,3-dibromo-2-propenyl, 3,3-diiodo-2-propenyl, 2,2-difluoro-1-propene-2-yl, 3,3,3-trifluoro-1-propene-2-yl, 3,3,3-trichloro-1-propene-2-yl, 4-fluoro-3-butenyl, 4,4-difluoro-3-butenyl, 4,4-difluoro-3-butene-2-yl, 4,4,4-trifluoro-2-butenyl, 3,4,4-trifluoro-3-butenyl, 2-trifluoromethyl-2-propenyl, 2-trifluoromethyl-3,3-difluoro-2-propenyl, 4,4,4-trifluoro-3-chloro-2-butenyl, 4,4-dichloro-3-butenyl, 4,4,4-trichloro-2-butenyl, 2-trichloromethyl-2-propenyl, 5,5-difluoro-4-pentenyl, 4,5,5-trifluoro-4-pentenyl, 5,5,5-trifluoro-3-pentenyl, 4,4,4-trifluoro-3-methyl-2-butenyl, 4,4,4-trifluoro-3-trifluoromethyl-2-butenyl, 5,5-dichloro-4-pentenyl, 4,4,4-trichloro-3-methyl-2-butenyl, 6,6-difluoro-5-hexenyl, 5,6,6-trifluoro-5-pentenyl, 6,6,6-trifluoro-4-pentenyl, 5,5,5-trifluoro-4-methyl-3-pentenyl, 5,5,5-trifluoro-4-trifluoromethyl-3-pentenyl, 6,6-dichloro-5-hexenyl, and 5,5,5-trichloro-4-methyl-3-pentenyl groups.

In the present invention, unless otherwise specified, the “(C2-C6)alkynyl” refers to a linear or branched alkynyl group having 2 to 6 carbon atoms. Examples thereof include ethynyl, 1-propynyl, 2-propynyl, 1-butynyl, 1-methyl propynyl, 2-butynyl, 3-butynyl, 1-pentynyl, 1-ethyl propynyl, 2-pentynyl, 3-pentynyl, 1-methyl-2-butynyl, 4-pentynyl, 1-methyl-3-butynyl, 2-methyl-3-butynyl, 1-hexynyl, 1-(n-propyl)-2-propynyl, 2-hexynyl, 1-ethyl-2-butynyl, 3-hexynyl, 1-methyl-2-pentynyl, 1-methyl-3-pentynyl, 4-methyl-1-pentynyl, 3-methyl-1-pentynyl, 5-hexynyl, 1-ethyl-3-butynyl, 1-ethyl-1-methyl-2-propynyl, 1-(isopropyl)-2-propynyl, 1,1-dimethyl-2-butynyl, and 2,2-dimethyl-3-butynyl groups.

In the present invention, unless otherwise specified, the “(C2-C6)haloalkynyl” refers to a linear or branched alkynyl group having 2 to 6 carbon atoms and being substituted with 1 to 9 halogen atoms and which are identical or different. Examples thereof include fluoroethynyl, chloroethynyl, bromoethynyl, iodoethynyl, 3-fluoro-2-propynyl, 3-chloro-2-propynyl, 3-bromo-2-propynyl, 3-iodo-2-propynyl, 4-fluoro-3-butynyl, 4-chloro-3-butynyl, 4-bromo-3-butynyl, 4-iodo-3-butynyl, 4,4-difluoro-2-butynyl, 4,4-dichloro-2-butynyl, 4,4,4-trifluoro-2-butynyl, 4,4,4-trichloro-2-butynyl, 3-fluoro-1-methyl-2-propynyl, 3-chloro-1-methyl-2-propynyl, 5-fluoro-4-pentynyl, 5-chloro-4-pentynyl, 5,5,5-trifluoro-3-pentynyl, 5,5,5-trichloro pentynyl, 4-fluoro-2-methyl-3-butynyl, 4-chloro-2-methyl butynyl, 6-fluoro-5-hexynyl, 6-chloro-5-hexynyl, 6,6,6-trifluoro-4-hexynyl, 6,6,6-trichloro-4-hexynyl, 5-fluoro methyl-4-pentynyl, and 5-chloro-3-methyl-4-pentynyl groups.

In the present invention, unless otherwise specified, the “(C1-C6)alkoxy” refers to a ((C1-C6)alkyl)-O— group in which the alkyl moiety is as defined above. Examples thereof include methoxy, ethoxy, n-propoxy, isopropoxy, n-butoxy, isobutoxy, sec-butoxy, tert-butoxy, n-pentoxy, 1-methylbutoxy, 2-methylbutoxy, 3-methylbutoxy, 1-ethylpropoxy, 1,1-dimethylpropoxy, 1,2-dimethylpropoxy, and n-hexyloxy groups.

In the present invention, unless otherwise specified, the “(C1-C6)haloalkoxy” refers to a ((C1-C6)haloalkyl)-O—group in which the haloalkyl moiety is as defined above. Examples thereof include difluoromethoxy, dichloromethoxy, trifluoromethoxy, trichloromethoxy, tribromomethoxy, chlorodifluoromethoxy, bromodifluoromethoxy, 2-fluoroethoxy, 1-chloroethoxy, 2-chloroethoxy, 1-bromoethoxy, 2-bromoethoxy, 2,2-difluoroethoxy, 1,2-dichloroethoxy, 2,2-dichloroethoxy, 2,2,2-trifluoroethoxy, 2,2,2-trichloroethoxy, 1,1,2,2-tetrafluoroethoxy, pentafluoroethoxy, 2-bromo-2-chloroethoxy, 2-chloro-1,1,2,2-tetrafluoroethoxy, 1-chloro-1,2,2,2-tetrafluoroethoxy, 1-chloropropoxy, 2-chloropropoxy, 3-chloropropoxy, 2-bromopropoxy, 3-bromopropoxy, 2-bromo-1-methylethoxy, 3-iodopropoxy, 2,3-dichloropropoxy, 2,3-dibromopropoxy, 3,3,3-trifluoropropoxy, 3,3,3-trifluoro propoxy, 3,3,3-trichloropropoxy, 3-bromo-3,3-difluoropropoxy, 2,2-difluoropropoxy, 3,3-dichloro-3-fluoropropoxy, 2,2,3,3-tetrafluoropropoxy, 1-bromo-3,3,3-trifluoropropoxy, 2,2,3,3,3-pentafluoropropoxy, 2,2,2-trifluoro-1-trifluoromethylethoxy, heptafluoropropoxy, heptafluoro-2-propoxy, 1,2,2,2-tetrafluoro-1-trifluoromethylethoxy, 1,1,2,3,3,3-hexafluoropropoxy, 2-chlorobutoxy, 3-chlorobutoxy, 4-chlorobutoxy, 2-chloro-1,1-dimethylethoxy, 4-bromobutoxy, 3-bromo-2-methylpropoxy, 2-bromo-1,1-dimethylethoxy, 2,2-dichloro-1,1-dimethylethoxy, 2-chloro-1-chloromethyl-2-methylethoxy, 4,4,4-trifluorobutoxy, 3,3,3-trifluoro-1-methylpropoxy, 3,3,3-trifluoro-2-methylpropoxy, 2,3,4-trichlorobutoxy, 2,2,2-trichloro-1,1-dimethylethoxy, 4-chloro-4,4-difluorobutoxy, 4,4-dichloro-4-fluorobutoxy, 4-bromo-4,4-difluorobutoxy, 2,4-dibromo-4,4-difluorobutoxy, 3,4-dichloro-3,4,4-trifluorobutoxy, 3,3-dichloro-4,4,4-trifluorobutoxy, 4-bromo-3,3,4,4-tetrafluorobutoxy, 4-bromo-3-chloro-3,4,4-trifluorobutoxy, 2,2,3,3,4,4-hexafluorobutoxy, 2,2,3,4,4,4-hexafluorobutoxy, 2,2,2-trifluoro-1-methyl trifluoromethylethoxy, 3,3,3-trifluoro trifluoromethylpropoxy, 2,2,3,3,4,4,4-heptafluorobutoxy, 3,3,4,4,4-pentafluoro-2-butoxy, 2,3,3,3-tetrafluoro trifluoromethylpropoxy, 1,1,2,2,3,3,4,4-octafluorobutoxy, nonafluorobutoxy, perfluoro-tert-butoxy, 4-chloro-1,1,2,2,3,3,4,4-octafluorobutoxy, 5,5,5-trifluoropentoxy, 4,4,5,5,5-pentafluoropentoxy, 3,3,4,4,5,5,5-heptafluoropentoxy, 3,3,4,4,5,5,5-heptafluoro-2-pentoxy, 2,2,3,3,4,4,5,5,5-nonafluoropentoxy, 2,2,3,3,4,4,5,5-octafluoropentoxy, perfluoropentoxy, 4,4,5,5,5-pentafluoro-2-butoxy, 2,2-bis(trifluoromethyl)propoxy, 2,2,3,3,4,4,5,5,6,6,6-undecafluorohexyloxy, 3,3,4,4,5,5,6,6,6-nonafluorohexyloxy, 4,4,5,5,6,6,6-heptafluorohexyloxy, 2,2,3,3,4,4,5,5,6,6-decafluorohexyloxy, 4,4,4-trifluoro-3,3-bis(trifluoromethyl)butyloxy, and perfluorohexyloxy groups.

In the present invention, unless otherwise specified, the “(C3-C6)cycloalkyl C1-C6 alkyl” refers to a ((C3-C6)cycloalkyl)-((C1-C6)alkyl)- group in which the cycloalkyl moiety and the alkyl moiety are as defined above. Examples thereof include cyclopropylmethyl, cyclobutylmethyl, cyclopentylmethyl, cyclohexylmethyl, 1-(cyclopropyl)ethyl, 2-(cyclopropyl)ethyl, and 1-(cyclopropyl) propyl groups.

In the present invention, unless otherwise specified, the “(C3-C6)halocycloalkyl (C1-C6)alkyl” refers to a ((C3-C6)halocycloalkyl)-((C1-C6)alkyl)- group in which the halocycloalkyl moiety and the alkyl moiety are as defined above. Examples thereof include 2,2-difluorocyclopropylmethyl, 2,2-dichlorocyclopropylmethyl, 1-(2,2-difluorocyclopropyl)ethyl, 2-(2,2-difluorocyclopropyl)ethyl, 1-(2,2-dichlorocyclopropyl)ethyl, 2-(2,2-dichlorocyclopropyl)ethyl, 2-(2,2-difluorocyclopropyl)propyl, 3,3-difluorocyclobutylmethyl, 2,2,3,3-tetrafluorocyclobutylmethyl, 2-(2,2,3,3-tetrafluorocyclobutyl)ethyl, 2-(3,3-difluorocyclobutyl)ethyl, 2-(3,3-difluorocyclobutyl)propyl, 3,3-difluorocyclopentylmethyl, and 2-(3,3-difluorocyclopentyl)propyl groups.

In the present invention, unless otherwise specified, the “phenyl (C1-C6)alkyl” refers to a (phenyl)-((C1-C6)alkyl)-group. Examples thereof include benzyl, 1-phenylethyl, 2-phenylethyl, 2-phenylpropyl, 2-phenylbutyl, and 1-phenylpentyl groups.

In the present invention, unless otherwise specified, the “heteroaryl” refers to a 5- or 6-membered monocyclic heterocyclic ring having 1 to 6 heteroatoms selected from a nitrogen atom, an oxygen atom, and a sulfur atom, in addition to a carbon atom. Examples thereof include thiophene-2-yl, thiophene-3-yl, furan-2-yl, furan-3-yl, pyrrole-1-yl, pyrrole-2-yl, pyrrole-3-yl, oxazole-2-yl, oxazole-4-yl, oxazole-5-yl, isoxazole-3-yl, isoxazole-4-yl, isoxazole-5-yl, thiazole-2-yl, thiazole-4-yl, thiazole-5-yl, isothiazole-3-yl, isothiazole-4-yl, isothiazole-5-yl, imidazole-1-yl, imidazole-2-yl, imidazole-4-yl, pyrazole-1-yl, pyrazole-3-yl, pyrazole-4-yl, pyrazole-5-yl, 1,3,4-oxadiazole-2-yl, 1,2,3-oxadiazole-4-yl, 1,2,3-oxadiazole-5-yl, 1,2,4-oxadiazole-3-yl, 1,2,4-oxadiazole-5-yl, 1,2,5-oxadiazole-3-yl, 1,3,4-thiadiazole-2-yl, 1,2,3-thiadiazole-4-yl, 1,2,3-thiadiazole-5-yl, 1,2,4-thiadiazole-3-yl, 1,2,4-thiadiazole-5-yl, 1,2,5-thiadiazole-3-yl, 1,2,4-triazole-3-yl, 1,2,4-triazole-1-yl, 1,2,3-triazole-1-yl, 1,2,3-triazole-2-yl, 1,3,4-triazole-1-yl, tetrazole-1-yl, tetrazole-2-yl, tetrazole-5-yl, pyridine-2-yl, pyridine-3-yl, pyridine-4-yl, pyrimidine-2-yl, pyrimidine-4-yl, pyrimidine-5-yl, pyridazine-3-yl, pyridazine-4-yl, pyrazine-2-yl, and 1,3,5-triazine-2-yl groups.

In the present invention, unless otherwise specified, the “heteroaryl (C1-C3)alkyl” refers to a (heteroaryl)-((C1-C3)alkyl)- group in which the heteroaryl moiety is as defined above. Examples thereof include (pyridine yl)methyl, (pyridine-3-yl)methyl, (pyridine-4-yl)methyl, (pyrimidine-2-yl)methyl, (pyrimidine-4-yl)methyl, (thiazole-2-yl)methyl, (thiazole-4-yl)methyl, (thiazole yl)methyl, (pyrazole-1-yl)methyl, (pyrazole-3-yl)methyl, (pyrazole-4-yl)methyl, and (pyrazole-5-yl)methyl groups.

In the present invention, unless otherwise specified, the “heteroaryl (C3-C6)cycloalkyl” refers to a (heteroaryl)-((C3-C6)cycloalkyl)- group in which the heteroaryl moiety and the cycloalkyl moiety are as defined above. Examples thereof include 1-(pyridine-2-yl)cyclopropyl, 1-(pyridine-3-yl)cyclopropyl, 1-(pyridine-4-yl)cyclopropyl, 1-(pyrimidine-2-yl)cyclopropyl, 1-(pyrimidine-4-yl)cyclopropyl, 1-(thiazole-2-yl)cyclopropyl, 1-(thiazole-4-yl)cyclopropyl, 1-(thiazole-5-yl)cyclopropyl, 1-(pyrazole-1-yl)cyclopropyl, 1-(pyrazole-3-yl)cyclopropyl, 1-(pyrazole-4-yl)cyclopropyl, and 1-(pyrazole-5-yl)cyclopropyl groups.

In the present invention, unless otherwise specified, the “heterocycloalkyl” refers to a 3- to 6-membered saturated heterocyclic ring containing one or more atoms selected from an oxygen atom, a nitrogen atom, and a sulfur atom, in addition to a carbon atom. Examples thereof include oxetane-2-yl, oxetane-3-yl, thietane-3-yl, tetrahydrofuran-2-yl, tetrahydrofuran-3-yl, tetrahydrothiophene-3-yl, tetrahydropyran-2-yl, tetrahydropyran-3-yl, tetrahydropyran-4-yl, tetrahydrothiopyran-4-yl, morpholine-4-yl, azetidine-1-yl, azetidine-3-yl, pyrrolidine-3-yl, and piperidine-4-yl groups.

In the present invention, unless otherwise specified, the “cyano heterocycloalkyl” refers to a (cyano)-(heterocycloalkyl)-group in which the heterocycloalkyl moiety is as defined above. Examples thereof include 3-cyanooxetane-3-yl, 3-cyanothietane-3-yl, 3-cyanotetrahydrofuran-3-yl, 3-cyanotetrahydrothiophene-3-yl, 3-cyanotetrahydropyran-3-yl, 4-cyanotetrahydrothiopyran-4-yl, 3-cyanoazetidine-3-yl, 3-cyanopyrrolidine-3-yl, and 4-cyanopiperidine-4-yl groups.

In the present invention, unless otherwise specified, the “heterocycloalkyl (C1-C6)alkyl” refers to a (3- to 6-membered heterocycloalkyl)-((C1-C6)alkyl)- group in which the heterocycloalkyl moiety and the alkyl moiety are as defined above. Examples thereof include (oxetane-3-yl)methyl, (tetrahydrofuran-2-yl)methyl, (tetrahydrofuran-3-yl)methyl, (tetrahydropyran-2-yl)methyl, (tetrahydropyran-3-yl)methyl, and (tetrahydropyran yl)methyl groups.

In the present invention, unless otherwise specified, the “cyano (C1-C6)alkyl” refers to a (cyano)-((C1-C6)alkyl)- group in which the alkyl moiety is as defined above. Examples thereof include cyanomethyl, 1-cyanoethyl, 2-cyanoethyl, 1-cyanopropyl, 3-cyanopropyl, 2-cyano-2-propyl, 1-cyanobutyl, 4-cyanobutyl, 5-cyanopentyl, and 6-cyanohexyl groups.

In the present invention, unless otherwise specified, the “cyano (C3-C6)cycloalkyl” refers to a (cyano)-((C3-C6)cycloalkyl)- group in which the cycloalkyl moiety is as defined above. Examples thereof include 1-cyanocyclopropyl, 2-cyanocyclopropyl, 1-cyanomethylcyclopropyl, 1-cyanocyclobutyl, 3-cyanocyclobutyl, 1-cyanocyclopentyl, and 1-cyanocyclohexyl groups.

In the present invention, unless otherwise specified, the “hydroxy (C1-C6)alkyl” refers to a (hydroxy)-((C1-C6)alkyl)- group in which the alkyl moiety is as defined above. Examples thereof include hydroxymethyl, 1-hydroxyethyl, 2-hydroxyethyl, 1-hydroxypropyl, 2-hydroxypropyl, 3-hydroxypropyl, 1-hydroxybutyl, and 4-hydroxybutyl groups.

In the present invention, unless otherwise specified, the “(C1-C6)alkoxy (C1-C6)alkyl” refers to a ((C1-C6)alkoxy)-((C1-C6)alkyl)- group in which the alkoxy moiety and the alkyl moiety are as defined above. Examples thereof include methoxymethyl, 1-methoxyethyl, 2-methoxyethyl, 2-ethoxyethyl, 2-methoxypropyl, 3-methoxypropyl, 2-ethoxypropyl, 3-ethoxypropyl, 1-methyl-3-methoxybutyl, and 3-butoxybutyl groups.

In the present invention, unless otherwise specified, the “(C1-C6)alkylamino” refers to a ((C1-C6)alkyl)-NH— group in which the alkyl moiety is as defined above. Examples thereof include methylamino, ethylamino, n-propylamino, and isopropylamino groups.

In the present invention, unless otherwise specified, the “(C1-C6)alkylcarbonyl” refers to a ((C1-C6)alkyl)-C(═O)— group in which the alkyl moiety is as defined above. Examples thereof include acetyl, propionyl, 2-methylpropionyl, 2,2-dimethylpropionyl, butanoyl, pivaloyl, 2-methylbutanoyl, 3-methylbutanoyl, 2-ethylbutanoyl, 2,2-dimethylbutanoyl, 2,3-dimethylbutanoyl, 3,3-dimethylbutanoyl, pentanoyl, 2-methylpentanoyl, 3-methylpentanoyl, 4-methylpentanoyl, and hexanoyl groups.

In the present invention, unless otherwise specified, the “(C1-C6)alkoxy (C1-C6)alkylcarbonyl” refers to a ((C1-C6)alkyl)-O—((C1-C6)alkyl)-C(═O)— group in which the alkyl moiety is as defined above. Examples thereof include methoxyacetyl, ethoxyacetyl, propoxyacetyl, isopropoxyacetyl, butoxyacetyl, 2-methoxypropionyl, 3-methoxypropionyl, 2-ethoxypropionyl, 3-ethoxypropionyl, 2-methoxybutanoyl, 4-methoxybutanoyl, 2-methoxypentanoyl, and 5-methoxypentanoyl groups.

In the present invention, unless otherwise specified, the “(C3-C6)cycloalkylcarbonyl” refers to a ((C3-C6)cycloalkyl)-C(═O)— group in which the cycloalkyl moiety is as defined above. Examples thereof include cyclopropanecarbonyl, cyclobutanecarbonyl, cyclopentanecarbonyl, and cyclohexanecarbonyl groups.

In the present invention, unless otherwise specified, the “(C3-C6)cycloalkyl (C1-C6)alkylcarbonyl” refers to a ((C3-C6)cycloalkyl)-((C1-C6)alkyl)-C(═O)— group in which the cycloalkyl and alkyl moieties are as defined above. Examples thereof include 2-cyclopropylacetyl, 2-cyclobutylacetyl, 2-cyclopentylacetyl, 2-cyclohexylacetyl, 2-cyclopropylpropanol, and 2-cyclopropylbutanoyl groups.

In the present invention, unless otherwise specified, the “(C1-C6)alkoxycarbonyl” refers to a ((C1-C6)alkoxy)-C(═O)— group in which the alkoxy moiety is as defined above. Examples thereof include methoxycarbonyl, ethoxycarbonyl, n-propoxycarbonyl, isopropoxycarbonyl, n-butoxycarbonyl, isobutoxycarbonyl, sec-butoxycarbonyl, tert-butoxycarbonyl, n-pentoxycarbonyl, 1-methylbutoxycarbonyl, 2-methylbutoxycarbonyl, 3-methylbutoxycarbonyl, 1-ethylpropoxycarbonyl, 1,1-dimethylpropoxycarbonyl, 1,2-dimethylpropoxycarbonyl, and 2,2-dimethylpropoxycarbonyl groups.

In the present invention, unless otherwise specified, the “(C1-C6)alkylaminocarbonyl” refers to a ((C1-C6)alkyl)-NH—C(═O)— group in which the alkyl moiety is as defined above. Examples thereof include methylaminocarbonyl, ethylaminocarbonyl, n-propylaminocarbonyl, isopropylaminocarbonyl, n-butylaminocarbonyl, isobutylaminocarbonyl, sec-butylaminocarbonyl, tert-butylaminocarbonyl, n-pentylaminocarbonyl, 1-methylbutylaminocarbonyl, 2-methylbutylaminocarbonyl, 3-methylbutylaminocarbonyl, 1-ethylpropylaminocarbonyl, 1,1-dimethylpropylaminocarbonyl, 1,2-dimethylpropylaminocarbonyl, 2,2-dimethylpropylaminocarbonyl, and n-hexylaminocarbonyl groups.

In the present invention, unless otherwise specified, the “(C1-C6)alkoxycarbonyl (C1-C6)alkylamino” refers to a ((C1-C6)alkyl)-O—C(═O)—((C1-C6)alkyl)-NH— group in which the alkyl moiety is as defined above. Examples thereof include methoxycarbonylmethylamino, ethoxycarbonylmethylamino, tert-butoxycarbonylmethylamino, and 1-(tert-butoxycarbonyl)ethylamino groups.

In the present invention, unless otherwise specified, the “(C1-C6)alkoxycarbonylamino” refers to a ((C1-C6)alkyl)-O—C(═O)—NH— group in which the alkyl moiety is as defined above. Examples thereof include methoxycarbonylamino, ethoxycarbonylamino, isopropoxycarbonylamino, tert-butoxycarbonylamino, and isobutoxycarbonylamino groups.

In the present invention, unless otherwise specified, the “(C1-C6)alkylthio” refers to a ((C1-C6)alkyl)-S— group in which the alkyl moiety is as defined above. Examples thereof include methylthio, ethylthio, n-propylthio, isopropylthio, n-butylthio, isobutylthio, sec-butylthio, and tert-butylthio groups.

In the present invention, unless otherwise specified, the “((C1-C)alkylthio)carbonyl” refers to a ((C1-C)alkylthio)-C(═O)— group in which the alkylthio moiety is as defined above. Examples thereof include methylthiocarbonyl, ethylthiocarbonyl, and isopropylthiocarbonyl groups.

In the present invention, unless otherwise specified, the “((C1-C6)alkyl) thiocarbonyl” refers to a ((C1-C6)alkyl)-C(═S)— group in which the alkyl moiety is as defined above. Examples thereof include methyl(thiocarbonyl), ethyl(thiocarbonyl), n-propyl(thiocarbonyl), isopropyl(thiocarbonyl), n-butyl(thiocarbonyl), isobutyl(thiocarbonyl), sec-butyl(thiocarbonyl), tert-butyl(thiocarbonyl), and n-pentyl(thiocarbonyl) groups.

In the present invention, unless otherwise specified, the “((C1-C6)alkoxy) thiocarbonyl” refers to a ((C1-C6)alkyl)-O—C(═S)— group in which the alkyl moiety is as defined above. Examples thereof include methoxy(thiocarbonyl), ethoxy(thiocarbonyl), n-propoxy(thiocarbonyl), isopropoxy(thiocarbonyl), n-butoxy(thiocarbonyl), isobutoxy(thiocarbonyl), sec-butoxy(thiocarbonyl), tert-butoxy(thiocarbonyl), n-pentoxy(thiocarbonyl), 1-methylbutoxy(thiocarbonyl), 2-methylbutoxy(thiocarbonyl), 3-methylbutoxy(thiocarbonyl), 1-ethylpropoxy(thiocarbonyl), 1,1-dimethylpropoxy(thiocarbonyl), 1,2-dimethylpropoxy(thiocarbonyl), and 2,2-dimethylpropoxy(thiocarbonyl) groups.

In the present invention, unless otherwise specified, the “(C1-C6)alkylaminothiocarbonyl” refers to a ((C1-C6)alkyl)-NH—C(═S)— group in which the alkyl moiety is as defined above. Examples thereof include methylamino(thiocarbonyl), ethylamino(thiocarbonyl), n-propylamino(thiocarbonyl), isopropylamino(thiocarbonyl), n-butylamino(thiocarbonyl), isobutylamino(thiocarbonyl), sec-butylamino(thiocarbonyl), tert-butylamino(thiocarbonyl), n-pentylamino(thiocarbonyl), 1-methylbutylamino(thiocarbonyl), 2-methylbutylamino(thiocarbonyl), 3-methylbutylamino(thiocarbonyl), 1-ethylpropylamino(thiocarbonyl), 1,1-dimethylpropylamino(thiocarbonyl), 1,2-dimethylpropylamino(thiocarbonyl), 2,2-dimethylpropylamino(thiocarbonyl), and n-hexylamino(thiocarbonyl) groups.

In the present invention, unless otherwise specified, the “(C1-C6)alkylsulfonyl” refers to a ((C1-C6)alkyl)-S(═O)₂— group in which the alkyl moiety is as defined above. Examples thereof include methylsulfonyl, ethylsulfonyl, n-propylsulfonyl, isopropylsulfonyl, n-butylsulfonyl, isobutylsulfonyl, sec-butylsulfonyl, and tert-butylsulfonyl groups.

In the present invention, unless otherwise specified, the “(C1-C6)haloalkylsulfonyl” refers to a ((C1-C6)haloalkyl)-S(═O)₂— group in which the haloalkyl moiety is as defined above. Examples thereof include difluoromethylsulfonyl, trifluoromethylsulfonyl, trichloromethylsulfonyl, 2,2,2-trifluoroethylsulfonyl, pentafluoroethylsulfonyl, 3,3,3-trifluoropropylsulfonyl, heptafluoropropylsulfonyl, heptafluoro-2-propylsulfonyl, and nonafluorobutylsulfonyl groups.

In the present invention, unless otherwise specified, the “(C1-C6)alkylaminosulfonyl” refers to a ((C1-C6)alkyl)-NH—S(═O)₂— group in which the alkyl moiety is as defined above. Examples thereof include methylaminosulfonyl, ethylaminosulfonyl, n-propylaminosulfonyl, isopropylaminosulfonyl, n-butylaminosulfonyl, isobutylaminosulfonyl, sec-butylaminosulfonyl, tert-butylaminosulfonyl, n-pentylaminosulfonyl, 1-methylbutylaminosulfonyl, 2-methylbutylaminosulfonyl, 3-methylbutylaminosulfonyl, 1-ethylpropylaminosulfonyl, 1,1-dimethylpropylaminosulfonyl, 1,2-dimethylpropylaminosulfonyl, 2,2-dimethylpropylaminosulfonyl, and n-hexylaminosulfonyl groups.

In the present invention, unless otherwise specified, the “(C1-C6)alkoxycarbonyl (C1-C6)alkyl” refers to a ((C1-C6)alkoxy)-C(═O)—((C1-C6)alkyl)- group in which the alkoxy moiety and the alkyl moiety are as defined above. Examples thereof include methoxycarbonylmethyl, ethoxycarbonylmethyl, n-propoxycarbonylmethyl, isopropoxycarbonylmethyl, tert-butoxycarbonylmethyl, 1-(methoxycarbonyl)ethyl, 2-(methoxycarbonyl)ethyl, 1-(ethoxycarbonyl)ethyl, 2-(ethoxycarbonyl)ethyl, 1-(methoxycarbonyl)-1-methylethyl, 1-(ethoxycarbonyl)-1-methylethyl, and 2-(tert-butoxycarbonyl)ethyl groups.

In the present invention, unless otherwise specified, the “aminocarbonyl (C1-C6)alkyl” refers to a H₂N—C(═O)—((C1-C6)alkyl)- group in which the alkyl moiety is as defined above. Examples thereof include carbamoylmethyl, 1-carbamoylethyl, and 2-carbamoylethyl groups.

In the present invention, unless otherwise specified, the “(C1-C6)alkylaminocarbonyl (C1-C6)alkyl” refers to a ((C1-C6)alkyl)-NH—C(═O)—((C1-C6)alkyl)- group in which the alkyl moiety is as defined above. Examples thereof include N-methylcarbamoylmethyl, N-ethylcarbamoylmethyl, and N-(tert-butyl)carbamoylmethyl groups.

In the present invention, unless otherwise specified, the “(C3-C6)cycloalkylaminocarbonyl (C1-C6)alkyl” refers to a ((C3-C6)cycloalkyl)-NH—C(═O)—((C1-C6)alkyl)- group in which the cycloalkyl moiety and the alkyl moiety are as defined above. Examples thereof include N-cyclopropylcarbamoylmethyl, N-cyclobutylcarbamoylmethyl, N-cyclopentylcarbamoylmethyl, and N-cyclohexylcarbamoylmethyl groups.

In the present invention, unless otherwise specified, the “(C1-C6)haloalkylaminocarbonyl (C1-C6)alkyl” refers to a ((C1-C6)haloalkyl)-NH—C(═O)—((C1-C6)alkyl)- group in which the haloalkyl moiety and the alkyl moiety are as defined above. Examples thereof include N-(2,2-difluoroethyl)carbamoylmethyl, N-(2,2,2-trifluoroethyl)carbamoylmethyl, 1-[N-(2,2-difluoroethyl)carbamoyl]ethyl, 1-[N-(2,2,2-trifluoroethyl)carbamoyl]ethyl, 1-[N-(2,2-difluoroethyl)carbamoyl]-1-methylethyl, and 1-[N-(2,2,2-trifluoroethyl)carbamoyl]-1-methylethyl groups.

In the present invention, unless otherwise specified, the “(C1-C6)alkylcarbonyl (C1-C6)alkyl” refers to a ((C1-C6)alkyl)-C(═O)—((C1-C6)alkyl)- group in which the alkyl moiety is as defined above. Examples thereof include acetonyl, propionylmethyl, 2-methylpropionylmethyl, pivaloylmethyl, 2-acetylethyl, 2-propionylethyl, 2-(2-methylpropionyl)ethyl, 2-pivaloylethyl, 3-acetylpropyl, 3-propionylpropyl, 3-(2-methylpropionyl)propyl, and 3-pivaloylpropyl groups.

In the present invention, unless otherwise specified, the “(C1-C6)haloalkylcarbonyl (C1-C6)alkyl group” refers to a ((C1-C6)haloalkyl)-C(═O)—(C1-C6)alkyl)- group in which the haloalkyl moiety and the alkyl moiety are as defined above. Examples thereof include 2-oxo-3,3-difluoropropyl, 3-chloro-2-oxo-3,3-difluoropropyl, 2-oxo-3,3,3-trifluoropropyl, 3-oxo-4,4-difluorobutyl, 4-chloro-3-oxo-4,4-difluorobutyl, 3-oxo-4,4,4-trifluorobutyl, 3-oxo-4,4,5,5,5-pentafluoropentyl, 4-oxo-5,5,5-trifluoropentyl, and 4-oxo-5,5,6,6,6-pentafluorohexyl groups.

In the present invention, unless otherwise specified, the “hydroxyimino (C1-C6)alkyl” refers to a HO—N═((C1-C6)alkyl)- group in which the alkyl moiety is as defined above. Examples thereof include 1-(hydroxyimino)ethyl, 2-(hydroxyimino)ethyl, 1-(hydroxyimino)propyl, 2-(hydroxyimino)propyl, and 3-(hydroxyimino)propyl groups.

In the present invention, unless otherwise specified, the “(C1-C6)alkoxyimino” refers to a ((C1-C6)alkyl)-O—N═C— group in which the alkyl moiety is as defined above. Examples thereof include methoxyimino, ethoxyimino, and isopropoxyimino groups.

In the present invention, unless otherwise specified, the “(C1-C6)alkoxyimino (C1-C6)alkyl” refers to a ((C1-C6)alkyl)-O—N═C—((C1-C6)alkyl)- group in which the alkyl moiety is as defined above. Examples thereof include 1-(methoxyimino)ethyl, 2-(methoxyimino)ethyl, 1-(methoxyimino)propyl, 2-(methoxyimino)propyl, 3-(methoxyimino)propyl, 1-(ethoxyimino)ethyl, 2-(ethoxyimino)ethyl, 1-(ethoxyimino)propyl, 2-(ethoxyimino)propyl, 3-(ethoxyimino)propyl, 1-(isopropoxyimino)ethyl, and 2-(isopropoxyimino)ethyl groups.

In the present invention, unless otherwise specified, the “(C1-C6)haloalkoxyimino (C1-C6)alkyl” refers to a ((C1-C6)haloalkyl)-O—N═((C1-C6)alkyl)- group in which the haloalkyl moiety and the alkyl moiety are as defined above. Examples thereof include (2,2,2-trifluoroethoxyimino)methyl, 2-(2,2-difluoroethoxyimino)ethyl, 2-(2,2,2-trifluoroethoxyimino)ethyl, 2-(2,2,2-trifluoroethoxyimino)propyl, and 3-(2,2,2-trifluoroethoxyimino) propyl groups.

In the present invention, unless otherwise specified, the “(C1-C12)alkyl” refers to a linear or branched alkyl group having 1 to 12 carbon atoms. Examples thereof include, in addition to the examples of the (C1-C6)alkyl group, n-heptyl, n-octyl, n-nonyl, n-decyl, n-undecyl, n-dodecyl, 4,4-dimethylpentyl, 5-methylhexyl, 5,5-dimethylhexyl, 3,5,5-trimethylhexyl, 6-methylheptyl, 6,6-dimethylheptyl, 3,6,6-trimethylheptyl, 7-methyloctyl, 7,7-dimethyloctyl, 8-methylnonyl, 8,8-dimethylnonyl, 9-methyldecyl, 9,9-dimethyldecyl, and 10-methylundecyl groups.

In the present invention, unless otherwise specified, the “(C3-C6)cycloalkoxy” refers to a ((C3-C6)cycloalkyl) group in which the cycloalkyl moiety is as defined above. Examples thereof include cyclopropoxy, cyclobutoxy, cyclopentyloxy, and cyclohexyloxy groups.

In the present invention, unless otherwise specified, the “(C3-C6)halocycloalkoxy” refers to a ((C3-C6)halocycloalkyl)-O— group in which the halocycloalkyl moiety is as defined above. Examples thereof include 2,2-difluorocyclopropoxy, 2,2-dichlorocyclopropoxy, 3,3-difluorocyclobutoxy, 3,3-dichlorocyclobutoxy, 3-fluorocyclopentyloxy, 3,3-difluorocyclopentyloxy, nonafluorocyclopentyloxy, 3,3-dichlorocyclopentyloxy, 4,4-difluorocyclohexyloxy, and 4,4-dichlorocyclohexyloxy groups.

In the present invention, unless otherwise specified, the “(C1-C6)alkoxy (C1-C6)alkoxy” refers to a ((C1-C6)alkoxy)-((C1-C6)alkoxy)- group in which the alkoxy moiety is as defined above. Examples thereof include 2-methoxyethoxy, 3-methoxypropoxy, 2-ethoxyisopropoxy, 2-isopropoxybutoxy, 5-ethoxypentyloxy, 6-ethoxyhexyloxy, 2-(tert-butoxy)ethoxy, 2-methoxyisopentyloxy, and 2-isopropoxyisobutoxy groups.

In the present invention, unless otherwise specified, the “(C1-C6)haloalkoxy (C1-C6)alkoxy” refers to a ((C1-C6)haloalkoxy)-((C1-C6)alkoxy)- group in which the haloalkoxy and alkoxy moieties are as defined above. Examples thereof include 2-difluoromethoxyethoxy, 2-trifluoromethoxyethoxy, 3-trifluoromethoxypropoxy, and 2-(2,2,2-trifluoroethoxy)ethoxy groups.

In the present invention, unless otherwise specified, the “(C1-C6)haloalkoxy (C1-C6)haloalkoxy” refers to a ((C1-C6)haloalkoxy)-((C1-C6)haloalkoxy)- group in which the haloalkoxy moiety is as defined above. Examples thereof include 2-(difluoromethoxy)-1,1,2,2-tetrafluoroethoxy, 2-(trifluoromethoxy)-1,1,2,2-tetrafluoroethoxy, 1,1,2,3,3,3-hexafluoro-2-(heptafluoropropoxy)propoxy, and 2-(2,2,2-trifluoroethoxy)-1,1,2,2-tetrafluoroethoxy groups.

In the present invention, unless otherwise specified, the “(C1-C6)haloalkylthio” refers to a ((C1-C6)haloalkyl)-S— group in which the haloalkyl moiety is as defined above. Examples thereof include fluoromethylthio, difluoromethylthio, trifluoromethylthio, trichloromethylthio, 2,2,2-trifluoroethylthio, pentafluoroethylthio, 2,2,2-trichloroethylthio, 3,3,3-trifluoropropylthio, heptafluoropropylthio, 1,1,1,3,3,3-hexafluoropropan-2-ylthio, heptafluoropropan-2-ylthio, and 4,4,4-trifluorobutylthio groups.

In the present invention, unless otherwise specified, the “(C2-C6)alkenylthio” refers to a ((C2-C6)alkenyl)-S— group in which the alkenyl moiety is as defined above. Examples thereof include vinylthio, 1-propenylthio, isopropenylthio, 2-propenylthio, 2-butenylthio, 3-butenylthio, 2-pentenylthio, 3-pentenylthio, 4-pentenylthio, 2-methyl-2-butenylthio, 2,4-pentadienylthio, 2-hexenylthio, 3-hexenylthio, 4-hexenylthio, 5-hexenylthio, and 2,4-hexadienylthio groups.

In the present invention, unless otherwise specified, the “(C2-C6)haloalkenylthio” refers to a ((C2-C6)haloalkenyl)-S— group in which the haloalkenyl moiety is as defined above. Examples of thereof include 2,2-difluorovinylthio, 2,2-dichlorovinylthio, 3,3-difluoro-2-propenylthio, 2,3,3-trifluoro-2-propenylthio, 3-chloro-2-propenylthio, 3,3-dichloro-2-propenylthio, 3-bromo-2-propenylthio, 4,4-difluoro-3-butenylthio, 4,4-difluoro-3-butene-2-ylthio, 3,4,4-trifluoro-3-butenylthio, 4,4,4-trifluoro-3-chloro-2-butenylthio, 4,4-dichloro butenylthio, 4,5,5-trifluoro-4-pentenylthio, 5,5,5-trifluoro-3-pentenylthio, 4,4,4-trifluoro trifluoromethyl-2-butenylthio, 6,6-difluoro-5-hexenylthio, 5,6,6-trifluoro-5-hexenylthio, and 6,6-dichloro hexenylthio groups.

In the present invention, unless otherwise specified, the “(C3-C6)cycloalkylthio” refers to a ((C3-C6)cycloalkyl)-S— group in which the cycloalkyl moiety is as defined above. Examples thereof include cyclopropylthio, cyclobutylthio, cyclopentylthio, and cyclohexylthio groups.

In the present invention, unless otherwise specified, the “(C3-C6)halocycloalkylthio” refers to a ((C3-C6)halocycloalkyl)-S— group in which the halocycloalkyl moiety is as defined above. Examples thereof include 2,2-difluorocyclopropylthio, 2,2-dichlorocyclopropylthio, 3,3-difluorocyclobutylthio, 3,3-difluorocyclopentylthio, and 4,4-difluorocyclohexylthio groups.

In the present invention, unless otherwise specified, the “(C3-C6)cycloalkyl (C1-C6)alkylthio” refers to a ((C3-C6)cycloalkyl)-((C1-C6)alkyl)-S— group in which the cycloalkyl and alkyl moieties are as defined above. Examples thereof include cyclopropylmethylthio, 2-cyclopropylethylthio, 3-cyclopropylpropylthio, 4-cyclopropylbutylthio, 5-cyclopropylpentylthio, cyclobutylmethylthio, cyclopentylmethylthio, and cyclohexylmethylthio groups.

In the present invention, unless otherwise specified, the “(C3-C6)halocycloalkyl (C1-C6)alkylthio” refers to a ((C3-C6)halocycloalkyl)-((C1-C6)alkyl)-S— group in which the halocycloalkyl and alkyl moieties are as defined above. Examples thereof include 2,2-difluorocyclopropylmethylthio, 2,2-dichlorocyclopropylmethylthio, 2-(2,2-difluorocyclopropyl)ethylthio, 2-(2,2-dichlorocyclopropyl)ethylthio, 2,2-difluorocyclobutylmethylthio, and 4,4-difluorocyclohexylmethylthio groups.

In the present invention, unless otherwise specified, the “tri((C1-C6)alkyl)silyl (C1-C6)alkylthio” refers to a ((C1-C6)alkyl)₃Si—((C1-C6)alkyl)-S— group in which the alkyl moiety is as defined above, and the three alkyl groups of the ((C1-C6)alkyl)₃moiety are identical to or different from each other. Examples thereof include trimethylsilylmethylthio, triethylsilylmethylthio, trimethylsilylethylthio, tert-butyldimethylsilylmethylthio, and trimethylsilylpropylthio groups.

In the present invention, unless otherwise specified, the “(C1-C6)alkylthio (C1-C6)alkoxy” refers to a ((C1-C6)alkyl)-S—((C1-C6)alkyl)-O— group in which the alkyl moiety is as defined above. Examples thereof include methylthiomethoxy, 2-methylthioethoxy, ethylthiomethoxy, 2-ethylthioethoxy, tert-butylthiomethoxy, and 2-(tert-butylthio)ethoxy groups.

In the present invention, unless otherwise specified, the “(C1-C6)haloalkylthio (C1-C6)alkoxy” refers to a ((C1-C6)haloalkyl)-S—((C1-C6)alkyl)-O— group in which the haloalkyl and alkyl moieties are as defined above. Examples thereof include fluoromethylthiomethoxy, difluoromethylthiomethoxy, trifluoromethylthiomethoxy, 1-(fluoromethylthio)ethoxy, 1-(difluoromethylthio)ethoxy, 1-(trifluoromethylthio)ethoxy, 2-(fluoromethylthio)ethoxy, 2-(difluoromethylthio) ethoxy, and 2-(trifluoromethylthio) ethoxy groups.

In the present invention, unless otherwise specified, the “(C1-C6)alkylsulfinyl” refers to a ((C1-C6)alkyl)-S(═O)— group in which the alkyl moiety is as defined above. Examples thereof include methylsulfinyl, ethylsulfinyl, n-propylsulfinyl, isopropylsulfinyl, n-butylsulfinyl, isobutylsulfinyl, sec-butylsulfinyl, and tert-butylsulfinyl groups.

In the present invention, unless otherwise specified, the “(C1-C6)haloalkylsulfinyl” refers to a ((C1-C6)haloalkyl)-S(═O)— group in which the haloalkyl moiety is as defined above. Examples thereof include difluoromethylsulfinyl, trifluoromethylsulfinyl, 2,2,2-trifluoroethylsulfinyl, 2,2,2-trichloroethylsulfinyl, pentafluoroethylsulfinyl, heptafluoropropylsulfinyl, trichloromethylsulfinyl, and heptafluoro-2-propylsulfinyl groups.

In the present invention, unless otherwise specified, the “(C3-C6)cycloalkylsulfinyl” refers to a ((C3-C6)cycloalkyl)-S(═O)— group in which the cycloalkyl moiety is as defined above. Examples thereof include cyclopropylsulfinyl, cyclobutylsulfinyl, cyclopentylsulfinyl, and cyclohexylsulfinyl groups.

In the present invention, unless otherwise specified, the “(C3-C6)halocycloalkylsulfinyl” refers to a ((C3-C6)halocycloalkyl)-S(═O)— group in which the halocycloalkyl moiety is as defined above. Examples thereof include 2,2-difluorocyclopropylsulfinyl, 2,2-dichlorocyclopropylsulfinyl, 3,3-difluorocyclobutylsulfinyl, 3,3-difluorocyclopentylsulfinyl, and 4,4-difluorocyclohexylsulfinyl groups.

In the present invention, unless otherwise specified, the “(C3-C6)cycloalkylsulfonyl” refers to a ((C3-C6)cycloalkyl)-S(═O)₂— group in which the cycloalkyl moiety is as defined above. Examples thereof include cyclopropylsulfonyl, cyclobutylsulfonyl, cyclopentylsulfonyl, and cyclohexylsulfonyl groups.

In the present invention, unless otherwise specified, the “(C3-C6)halocycloalkylsulfonyl” refers to a ((C3-C6)halocycloalkyl)-S(═O)₂— group in which the halocycloalkyl moiety is as defined above. Examples thereof include 2,2-difluorocyclopropylsulfonyl, 2,2-dichlorocyclopropylsulfonyl, 3,3-difluorocyclobutylsulfonyl, 3,3-difluorocyclopentylsulfonyl, and 4,4-difluorocyclohexylsulfonyl groups.

In the present invention, unless otherwise specified, the “(C1-C6)haloalkylcarbonyl” refers to a ((C1-C6)haloalkyl)-C(═O)— group in which the haloalkyl moiety is as defined above. Examples thereof include fluoroacetyl, difluoroacetyl, trifluoroacetyl, chloroacetyl, trichloroacetyl, tribromoacetyl, 3,3,3-trifluoropropionyl, 3,3-difluoropropionyl, and 4,4,4-trifluorobutyryl groups.

In the present invention, unless otherwise specified, the “(C1-C6)haloalkoxycarbonyl” refers to a ((C1-C6)haloalkyl)-O—C(═O)— group in which the haloalkyl moiety is as defined above. Examples thereof include 2-fluoroethoxycarbonyl, 2,2,2-trifluoroethoxycarbonyl, 2,2,2-trichloroethoxycarbonyl, pentafluoroethoxycarbonyl, 3,3,3-trifluoropropoxycarbonyl, and heptafluoro-2-propoxycarbonyl groups.

In the present invention, unless otherwise specified, the “(C1-C6)haloalkylaminocarbonyl” refers to a ((C1-C6)haloalkyl)-NH—C(═O)— group in which the haloalkyl moiety is as defined above. Examples thereof include 2-fluoroethylaminocarbonyl, 2,2,2-trifluoroethylaminocarbonyl, 2,2,2-trichloroethylaminocarbonyl, pentafluoroethylaminocarbonyl, and 1,1,1,3,3,3-hexafluoro-2-propylaminocarbonyl groups.

In the present invention, unless otherwise specified, the “(C1-C6)alkylaminocarbonylthio” refers to a ((C1-C6)alkyl)-NH—C(═O)—S— group in which the alkyl moiety is as defined above. Examples thereof include methylaminocarbonylthio, ethylaminocarbonylthio, propylaminocarbonylthio, and isopropylaminocarbonylthio groups.

In the present invention, unless otherwise specified, the “(C1-C6)haloalkylaminocarbonylthio” refers to a ((C1-C6)haloalkyl)-NH—C(═O)—S— group in which the haloalkyl moiety is as defined above. Examples thereof include 2-fluoroethylaminocarbonylthio, 2,2,2-trifluoroethylaminocarbonylthio, 2,2,2-trichloroethylaminocarbonylthio, pentafluoroethylaminocarbonylthio, and 1,1,1,3,3,3-hexafluoro-2-propylaminocarbonylthio groups.

In the present invention, unless otherwise specified, the “(C1-C6)alkylcarbonyloxy” refers to a ((C1-C6)alkyl)-C(═O)O— group in which the alkyl moiety is as defined above. Examples thereof include acetoxy and propionyloxy groups.

In the present invention, unless otherwise specified, the “(C1-C6)haloalkylcarbonyloxy” refers to a ((C1-C6)haloalkyl)-C(═O)O— group in which the haloalkyl moiety is as defined above. Examples thereof include fluoroacetoxy, difluoroacetoxy, trifluoroacetoxy, chloroacetoxy, trichloroacetoxy, tribromoacetoxy, 3,3,3-trifluoropropionyloxy, 3,3-difluoropropionyloxy, and 4,4,4-trifluorobutyryloxy groups.

In the present invention, unless otherwise specified, the “(C1-C6)alkylsulfinyloxy” refers to a ((C1-C6)alkyl)-S(═O)—O— group in which the alkyl moiety is as defined above. Examples thereof include methylsulfinyloxy, ethylsulfinyloxy, n-propylsulfinyloxy, and isopropylsulfinyloxy groups.

In the present invention, unless otherwise specified, the “(C1-C6)haloalkylsulfinyloxy” refers to a ((C1-C6)haloalkyl)-S(═O)—O— group in which the haloalkyl moiety is as defined above. Examples thereof include difluoromethylsulfinyloxy, trifluoromethylsulfinyloxy, 2,2,2-trifluoroethylsulfinyloxy, pentafluoroethylsulfinyloxy, heptafluoropropylsulfinyloxy, trichloromethylsulfinyloxy, and heptafluoro-2-propylsulfinyloxy groups.

In the present invention, unless otherwise specified, the “(C3-C6)cycloalkylsulfinyloxy” refers to a ((C3-C6)cycloalkyl)-S(═O)—O— group in which the cycloalkyl moiety is as defined above. Examples thereof include cyclopropylfinyloxy, cyclobutylsulfinyloxy, cyclopentylsulfinyloxy, and cyclohexylsulfinyloxy groups.

In the present invention, unless otherwise specified, the “(C3-C6)halocycloalkylsulfinyloxy” refers to a ((C3-C6)halocycloalkyl)-S(═O)—O— group in which the halocycloalkyl moiety is as defined above. Examples thereof include 2,2-difluorocyclopropylsulfinyloxy, 2,2-dichlorocyclopropylsulfinyloxy, 3,3-difluorocyclobutylsulfinyloxy, 3,3-difluorocyclopentylsulfinyloxy, and 4,4-difluorocyclohexylsulfinyloxy groups.

In the present invention, unless otherwise specified, the “(C1-C6)alkylsulfonyloxy” refers to a ((C1-C6)alkyl)-S(═O)₂—O— group in which the alkyl moiety is as defined above. Examples thereof include methylsulfonyloxy, ethylsulfonyloxy, n-propylsulfonyloxy, and isopropylsulfonyloxy groups.

In the present invention, unless otherwise specified, the “(C1-C6)haloalkylsulfonyloxy” refers to a ((C1-C6)haloalkyl)-S(═O)₂—O— group in which the haloalkyl moiety is as defined above. Examples thereof include difluoromethylsulfonyloxy, trifluoromethylsulfonyloxy, trichloromethylsulfonyloxy, 2,2,2-trifluoroethylsulfonyloxy, 2,2,2-trichloroethylsulfonyloxy, 3,3,3-trifluoropropylsulfonyloxy, and heptafluoro-2-propylsulfonyloxy groups.

In the present invention, unless otherwise specified, the “(C3-C6)cycloalkylsulfonyloxy” refers to a ((C3-C6)cycloalkyl)-S(═O)₂—O— group in which the cycloalkyl moiety is as defined above. Examples thereof include cyclopropylsulfonyloxy, cyclobutylsulfonyloxy, cyclopentylsulfonyloxy, and cyclohexylsulfonyloxy groups.

In the present invention, unless otherwise specified, the “(C3-C6)halocycloalkylsulfonyloxy” refers to a ((C3-C6)halocycloalkyl)-S(═O)₂—O— group in which the halocycloalkyl moiety is as defined above. Examples thereof include 2,2-difluorocyclopropylsulfonyloxy, 2,2-dichlorocyclopropylsulfonyloxy, 3,3-difluorocyclobutylsulfonyloxy, 3,3-difluorocyclopentylsulfonyloxy, and 4,4-difluorocyclohexylsulfonyloxy groups.

In the present invention, unless otherwise specified, the “(C1-C6)haloalkylamino” refers to a ((C1-C6)haloalkyl)-NH— group in which the haloalkyl moiety is as defined above. Examples thereof include 2-fluoroethylamino, 2,2-difluoroethylamino, 2,2,2-trifluoroethylamino, 2,2,2-trichloroethylamino, pentafluoroethylamino, 3,3,3-trifluoropropylamino, and 1,1,1,3,3,3-hexafluoro-2-propylamino groups.

In the present invention, unless otherwise specified, the “(C1-C6)alkylcarbonylamino” refers to a ((C1-C6)alkyl)-C(═O)—NH— group in which the alkyl moiety is as defined above. Examples thereof include acetylamino, propionylamino, butyrylamino, and isobutyrylamino groups.

In the present invention, unless otherwise specified, the “(C1-C6)haloalkylcarbonylamino” refers to a ((C1-C6)haloalkyl)-C(═O)—NH— group in which the haloalkyl moiety is as defined above. Examples thereof include fluoroacetylamino, difluoroacetylamino, trifluoroacetylamino, chloroacetylamino, trichloroacetylamino, tribromoacetylamino, 3,3,3-trifluoropropionylamino, pentafluoropropionylamino, and 3,3-difluoropropionylamino group.

In the present invention, unless otherwise specified, the “(C1-C6)haloalkoxycarbonylamino” refers to a ((C1-C6)haloalkoxy)-C(═O)—NH— group in which the haloalkoxy moiety is as defined above. Examples thereof include 2-fluoroethoxycarbonylamino, 2,2,2-trifluoroethoxycarbonylamino, 2,2,2-trichloroethoxycarbonylamino, pentafluoroethoxycarbonylamino, 3,3,3-trifluoropropoxycarbonylamino, and heptafluoro-2-propoxycarbonylamino groups.

In the present invention, unless otherwise specified, the “(C1-C6)alkylaminocarbonylamino” refers to a ((C1-C6)alkyl)-NH—C(═O)—NH— group in which the alkyl moiety is as defined above. Examples thereof include methylaminocarbonylamino, ethylaminocarbonylamino, n-propylaminocarbonylamino, isopropylaminocarbonylamino, and tert-butylaminocarbonylamino groups.

In the present invention, unless otherwise specified, the “(C1-C6)haloalkylaminocarbonylamino” refers to a ((C1-C6)haloalkyl)-NH—C(═O)—NH— group in which the haloalkyl moiety is as defined above. Examples thereof include 2-fluoroethylaminocarbonylamino, 2,2,2-trifluoroethylaminocarbonylamino, 2,2,2-trichloroethylaminocarbonylamino, pentafluoroethylaminocarbonylamino, and 1,1,1,3,3,3-hexafluoro-2-propylaminocarbonylamino groups.

In the present invention, unless otherwise specified, the “(C1-C6)alkylsulfinylamino” refers to a ((C1-C6)alkyl)-SO—NH— group in which the alkyl moiety is as defined above. Examples thereof include methylsulfinylamino, ethylsulfinylamino, n-propylsulfinylamino, isopropylsulfinylamino, and tert-butylsulfinylamino groups.

In the present invention, unless otherwise specified, the “(C1-C6)haloalkylsulfinylamino” refers to a ((C1-C6)haloalkyl)-S(═O)—NH— group in which the haloalkyl moiety is as defined above. Examples thereof include fluoromethylsulfinylamino, difluoromethylsulfinylamino, trifluoromethylsulfinylamino, chloromethylsulfinylamino, trichloromethylsulfinylamino, 2,2,2-trifluoroethylsulfinylamino, 2,2-difluoroethylsulfinylamino, and 3,3,3-trifluoropropylsulfinylamino groups.

In the present invention, unless otherwise specified, the “(C1-C6)alkylsulfonylamino” refers to a ((C1-C6)alkyl)-S(═O)₂—NH— group in which the alkyl moiety is as defined above. Examples thereof include methylsulfonylamino, ethylsulfonylamino, n-propylsulfonylamino, isopropylsulfonylamino, and tert-butylsulfonylamino groups.

In the present invention, unless otherwise specified, the “(C1-C6)haloalkylsulfonylamino” refers to a ((C1-C6)haloalkyl)-S(═O)₂—NH— group in which the haloalkyl moiety is as defined above. Examples thereof include fluoromethylsulfonylamino, difluoromethylsulfonylamino, trifluoromethylsulfonylamino, chloromethylsulfonylamino, trichloromethylsulfonylamino, 2,2,2-trifluoroethylsulfonylamino, 2,2-difluoroethylsulfonylamino, and 3,3,3-trifluoropropylsulfonylamino groups.

In the present invention, unless otherwise specified, the “tri((C1-C6)alkyl)silyl” refers to a ((C1-C6)alkyl)₃-Si- group in which the alkyl moiety is as defined above, and the three alkyl groups are optionally identical or different from each other. Examples thereof include trimethylsilyl, triethylsilyl, triisopropylsilyl, dimethylisopropylsilyl, and tert-butyldimethylsilyl groups.

In the present invention, unless otherwise specified, the “phenyl (C1-C6)alkoxy” refers to a phenyl-((C1-C6)alkyl)-O— group in which the alkyl moiety is as defined above. Examples thereof include phenylmethoxy, 1-phenylethoxy, 2-phenylethoxy, 1-phenylpropoxy, 2-phenylbutoxy, and 1-phenylpentoxy groups.

In the present invention, unless otherwise specified, the “phenyl (C1-C6)alkylthio” refers to a phenyl-((C1-C6)alkyl)-S— group in which the alkyl moiety is as defined above. Examples thereof include phenylmethylthio, 1-phenylethylthio, 2-phenylethylthio, 1-phenylpropylthio, 2-phenylbutylthio, and 1-phenylpentylthio groups.

In the present invention, unless otherwise specified, the “phenyl (C1-C6)alkylsulfinyl” refers to a phenyl-((C1-C6)alkyl)-S(═O)— group in which the alkyl moiety is as defined above. Examples thereof include phenylmethylsulfinyl, 1-phenylethylsulfinyl, 2-phenylethylsulfinyl, 1-phenylpropylsulfinyl, 2-phenylbutylsulfinyl, and 1-phenylpentylsulfinyl groups.

In the present invention, unless otherwise specified, the “phenyl (C1-C6)alkylsulfonyl” refers to a phenyl-((C1-C6)alkyl)-S(═O)₂— group in which the alkyl moiety is as defined above. Examples thereof include phenylmethylsulfonyl, 1-phenylethylsulfonyl, 2-phenylethylsulfonyl, 1-phenylpropylsulfonyl, 2-phenylbutylsulfonyl, and 1-phenylpentylsulfonyl groups.

In the present invention, unless otherwise specified, the “(C1-C6)alkylthio (C1-C6)alkyl” refers to a ((C1-C6)alkyl)-S—((C1-C6)alkyl)- group in which the alkyl moiety is as defined above. Examples thereof include methylthiomethyl, ethylthiomethyl, n-propylthiomethyl, isopropylthiomethyl, 1-(methylthio)ethyl, 2-(methylthio)ethyl, 2-(ethylthio)ethyl, 1-(n-propylthio)ethyl, 2-(n-propylthio)ethyl, 1-(isopropylthio)ethyl, 2-(isopropylthio)ethyl, 1-(methylthio)propyl, 2-(methylthio)propyl, 3-(methylthio)propyl, 1-(ethylthio)propyl, 2-(ethylthio)propyl, 3-(ethylthio)propyl, 1-(n-propylthio) propyl, 2-(n-propylthio)propyl, 3-(n-propylthio)propyl, 1-(methylthio)butyl, 2-(methylthio)butyl, 3-(methylthio)butyl, 4-(methylthio)butyl, 1-(methylthio)pentyl, 2-(methylthio)pentyl, 3-(methylthio)pentyl, 4-(methylthio)pentyl, 5-(methylthio)pentyl, 2-(n-butylthio)ethyl, 2-(isobutylthio)ethyl, 2-(sec-butylthio)ethyl, 2-(tert-butylthio)ethyl, pentylthiomethyl, and hexylthiomethyl groups.

In the present invention, unless otherwise specified, the “(C1-C6)haloalkylthio (C1-C6)alkyl” refers to a ((C1-C6) haloalkyl)-S—((C1-C6)alkyl)- group in which the haloalkyl moiety and the alkyl moiety are as defined above. Examples thereof include 2-(difluoromethylthio)ethyl, 2-(trifluoromethylthio)ethyl, 2-(2,2-difluoroethylthio)ethyl, 2-(2,2,2-trifluoroethylthio)ethyl, 2-(3,3-difluoropropylthio)ethyl, 2-(3,3,3-trifluoropropylthio)ethyl, 3-(difluoromethylthio)propyl, 3-(trifluoromethylthio)propyl, 3-(2,2-difluoroethylthio)propyl, 3-(2,2,2-trifluoroethylthio)propyl, 3-(3,3-difluoropropylthio)propyl, 3-(3,3,3-trifluoropropylthio)propyl, 4-(trifluoromethylthio)butyl, and 5-(trifluoromethylthio)pentyl groups.

In the present invention, unless otherwise specified, the “(C1-C6)haloalkoxy (C1-C6)alkyl” refers to a ((C1-C6)haloalkyl)-O—((C1-C6)alkyl)- group in which the haloalkoxy moiety and the alkyl moiety are as defined above. Examples thereof include 2-(difluoromethoxy)ethyl, 2-(trifluoromethoxy)ethyl, 2-(2,2-difluoroethoxy)ethyl, 2-(2,2,2-trifluoroethoxy)ethyl, 2-(3,3-difluoropropioxy)ethyl, 2-(3,3,3-trifluoropropioxy)ethyl, 3-(difluoromethoxy)propyl, 3-(trifluoromethoxy)propyl, 3-(2,2-difluoroethoxy)propyl, 3-(2,2,2-trifluoroethoxy)propyl, 3-(3,3-difluoropropioxy)propyl, 3-(3,3,3-trifluoropropioxy)propyl, 4-(trifluoromethoxy)butyl, and 5-(trifluoromethoxy)pentyl groups.

In the present invention, unless otherwise specified, the “cyano (C3-C6)cycloalkyl (C1-C6)alkyl” refers to a (cyano)-((C3-C6)cycloalkyl)-((C1-C6)alkyl group)- group in which the cycloalkyl moiety and the alkyl moiety are as defined above. Examples thereof include (1-cyanocyclopropane-1-yl)methyl, 2-(1-cyanocyclopropane-1-yl)ethyl, (1-cyanocyclobutane-1-yl)methyl, 2-(1-cyanocyclobutane-1-yl)ethyl, (1-cyanocyclopentane-1-yl)methyl, 2-(1-cyanocyclopentane-1-yl)ethyl, (1-cyanocyclohexane-1-yl)methyl, and 2-(1-cyanocyclohexane-1-yl)ethyl groups.

In the present invention, unless otherwise specified, the “hydroxy (C3-C6)cycloalkyl” refers to a (hydroxy)-(C3-C6)cycloalkyl)- group in which the cycloalkyl moiety is as defined above. Examples thereof include 2-(hydroxy)cyclopropyl, 1-(hydroxymethyl)cyclopropyl, 3-(hydroxy)cyclobutyl, 3-(hydroxy)cyclopentyl, 4-(hydroxy)cyclohexyl, 2-(hydroxy)cyclopropyl, 1-(hydroxymethyl)cyclopropyl, 3-(hydroxy)cyclobutyl, 3-(hydroxy)cyclopentyl, and 4-(hydroxy)cyclohexyl groups.

In the present invention, unless otherwise specified, the “(C1-C6)alkylcarbonyloxy (C3-C6)cycloalkyl” refers to a ((C1-C6)alkyl)-C(═O)O—((C3-C6)cycloalkyl)- group in which the alkyl moiety and the cycloalkyl moiety are as defined above. Examples thereof include 2-(acetoxy)cyclopropyl, 1-(acetoxymethyl)cyclopropyl, 3-(acetoxy)cyclobutyl, 3-(acetoxy)cyclopentyl, 4-(acetoxy)cyclohexyl, 2-(propionyloxy)cyclopropyl, 1-(propionyloxymethyl)cyclopropyl, 3-(propionyloxy)cyclobutyl, 3-(propionyloxy)cyclopentyl, and 4-(propionyloxy)cyclohexyl groups.

In the present invention, unless otherwise specified, the “(C1-C6)alkylsulfonyloxy (C3-C6)cycloalkyl” refers to a ((C1-C6)alkyl)-S(═O)₂—O—((C3-C6)cycloalkyl)- group in which the alkyl moiety is as defined above. Examples thereof include 2-(methylsulfonyloxy)cyclopropyl, 1-(methylsulfonyloxymethyl)cyclopropyl, 3-(methylsulfonyloxy)cyclobutyl, 3-(methylsulfonyloxy)cyclopentyl, 4-(methylsulfonyloxy)cyclohexyl, 2-(ethylsulfonyloxy)cyclopropyl, 1-(ethylsulfonyloxymethyl)cyclopropyl, 3-(ethylsulfonyloxy)cyclobutyl, 3-(ethylsulfonyloxy)cyclopentyl, and 4-(ethylsulfonyloxy)cyclohexyl groups.

In the present invention, unless otherwise specified, the “(C1-C6)alkoxy (C3-C6)cycloalkyl” refers to a ((C1-C6)alkoxy)-((C3-C6)cycloalkyl)- group in which the alkoxy moiety and the cycloalkyl moiety are as defined above. Examples thereof include 1-(methoxy)cyclopropyl, 1-(ethoxy)cyclopropyl, 1-(methoxymethyl)cyclopropyl, 1-(ethoxymethyl)cyclopropyl, 1-(n-propoxy)cyclopropyl, 1-(isopropoxy)cyclopropyl, 1-(methoxy)cyclobutyl, 1-(ethoxy)cyclobutyl, 1-(n-propoxy)cyclobutyl, 1-(isopropoxy)cyclobutyl, 1-(methoxy)cyclopentyl, 1-(ethoxy)cyclopentyl, 1-(methoxy)cyclohexyl, and 1-(ethoxy)cyclohexyl groups.

In the present invention, unless otherwise specified, the “(C1-C6)haloalkoxy (C3-C6)cycloalkyl” refers to a ((C1-C6)haloalkoxy)-((C3-C6)cycloalkyl)- group in which the haloalkoxy moiety and the cycloalkyl moiety are as defined above. Examples thereof include 1-(difluoromethoxy)cyclopropyl, 1-(trifluoromethoxy)cyclopropyl, 1-(2,2-difluoroethoxy)cyclopropyl, 1-(2,2,2-trifluoroethoxy)cyclopropyl, 1-(difluoromethoxymethyl)cyclopropyl, 1-(trifluoromethoxymethyl)cyclopropyl, 1-(2,2-difluoroethoxymethyl)cyclopropyl, 1-(2,2,2-trifluoroethoxymethyl)cyclopropyl, 1-(difluoromethoxy)cyclobutyl, 1-(trifluoromethoxy)cyclobutyl, 1-(2,2-difluoroethoxy)cyclobutyl, 1-(2,2,2-trifluoroethoxy)cyclobutyl, 1-(difluoromethoxy)cyclopentyl, 1-(trifluoromethoxy)cyclopentyl, 1-(2,2-difluoroethoxy)cyclopentyl, 1-(2,2,2-trifluoroethoxy)cyclopentyl, 1-(difluoromethoxy)cyclohexyl, 1-(trifluoromethoxy)cyclohexyl, 1-(2,2-difluoroethoxy)cyclohexyl, and 1-(2,2,2-trifluoroethoxy)cyclohexyl groups.

In the present invention, unless otherwise specified, the “(C1-C6)alkylthio (C3-C6)cycloalkyl” refers to a ((C1-C6)alkyl)-S—((C3-C6)cycloalkyl group)- group in which the alkyl moiety and the cycloalkyl moiety are as defined above. Examples thereof include 1-(methylthio)cyclopropyl, 1-(ethylthio)cyclopropyl, 1-(methylthiomethyl)cyclopropyl, 1-(ethylthiomethyl)cyclopropyl, 1-(n-propylthio)cyclopropyl, 1-(isopropylthio)cyclopropyl, 1-(pentylthio)cyclopropyl, 1-(hexylthio)cyclopropyl, 1-(methylthio)cyclobutyl, 1-(ethylthio)cyclobutyl, 1-(n-propylthio)cyclobutyl, 1-(isopropylthio)cyclobutyl, 1-(pentylthio)cyclobutyl, 1-(hexylthio)cyclobutyl, 1-(methylthio)cyclopentyl, 1-(ethylthio)cyclopentyl, 1-(methylthio)cyclohexyl, and 1-(ethylthio)cyclohexyl groups.

In the present invention, unless otherwise specified, the “(C1-C6)haloalkylthio (C3-C6)cycloalkyl” refers to a ((C1-C6)haloalkyl)-S—((C3-C6)cycloalkyl group)- group in which the haloalkyl moiety and the cycloalkyl moiety are as defined above. Examples thereof include 1-(difluoromethylthio)cyclopropyl, 1-(trifluoromethylthio)cyclopropyl, 1-(2,2-difluoroethylthio)cyclopropyl, 1-(2,2,2-trifluoroethylthio)cyclopropyl, 1-(difluoromethylthiomethyl)cyclopropyl, 1-(trifluoromethylthiomethyl)cyclopropyl, 1-(2,2-difluoroethylthiomethyl)cyclopropyl, 1-(2,2,2-trifluoroethylthiomethyl)cyclopropyl, 1-(difluoromethylthio)cyclobutyl, 1-(trifluoromethylthio)cyclobutyl, 1-(2,2-difluoroethylthio)cyclobutyl, 1-(2,2,2-trifluoroethylthio)cyclobutyl, 1-(difluoromethylthio)cyclopentyl, 1-(trifluoromethylthio)cyclopentyl, 1-(2,2-difluoroethylthio)cyclopentyl, 1-(2,2,2-trifluoroethylthio)cyclopentyl, 1-(difluoromethylthio)cyclohexyl, 1-(trifluoromethylthio)cyclohexyl, 1-(2,2-difluoroethylthio)cyclohexyl, and 1-(2,2,2-trifluoroethylthio)cyclohexyl groups.

In the present invention, unless otherwise specified, the “(C1-C6)alkylsulfinyl (C3-C6)cycloalkyl” refers to a ((C1-C6)alkyl)-S(═O)—((C3-C6)cycloalkyl group)- group in which the alkyl moiety and the cycloalkyl moiety are as defined above. Examples thereof include 1-(methylsulfinyl)cyclopropyl, 1-(ethylsulfinyl)cyclopropyl, 1-(methylsulfinylmethyl)cyclopropyl, 1-(ethylsulfinylmethyl)cyclopropyl, 1-(n-propylsulfinyl)cyclopropyl, 1-(isopropylsulfinyl)cyclopropyl, 1-(pentylsulfinyl)cyclopropyl, 1-(hexylsulfinyl)cyclopropyl, 1-(methylsulfinyl)cyclobutyl, 1-(ethylsulfinyl)cyclobutyl, 1-(n-propylsulfinyl)cyclobutyl, 1-(isopropylsulfinyl)cyclobutyl, 1-(pentylsulfinyl)cyclobutyl, 1-(hexylsulfinyl)cyclobutyl, 1-(methylsulfinyl)cyclopentyl, 1-(ethylsulfinyl)cyclopentyl, 1-(methylsulfinyl)cyclohexyl, and 1-(ethylsulfinyl)cyclohexyl groups.

In the present invention, unless otherwise specified, the “(C1-C6)haloalkylsulfinyl (C3-C6)cycloalkyl” refers to a ((C1-C6)haloalkyl)-S(═O)—((C3-C6)cycloalkyl group)- group in which the haloalkyl moiety and the cycloalkyl moiety are as defined above. Examples thereof include 1-(difluoromethylsulfinyl)cyclopropyl, 1-(trifluoromethylsulfinyl)cyclopropyl, 1-(2,2-difluoroethylsulfinyl)cyclopropyl, 1-(2,2,2-trifluoroethylsulfinyl)cyclopropyl, 1-(difluoromethylsulfinylmethyl)cyclopropyl, 1-(trifluoromethylsulfinylmethyl)cyclopropyl, 1-(2,2-difluoroethylsulfinylmethyl)cyclopropyl, 1-(2,2,2-trifluoroethylsulfinylmethyl)cyclopropyl, 1-(difluoromethylsulfinyl)cyclobutyl, 1-(trifluoromethylsulfinyl)cyclobutyl, 1-(2,2-difluoroethylsulfinyl)cyclobutyl, 1-(2,2,2-trifluoroethylsulfinyl)cyclobutyl, 1-(difluoromethylsulfinyl)cyclopentyl, 1-(trifluoromethylsulfinyl)cyclopentyl, 1-(2,2-difluoroethylsulfinyl)cyclopentyl, 1-(2,2,2-trifluoroethylsulfinyl)cyclopentyl, 1-(difluoromethylsulfinyl)cyclohexyl, 1-(trifluoromethylsulfinyl)cyclohexyl, 1-(2,2-difluoroethylsulfinyl)cyclohexyl, and 1-(2,2,2-trifluoroethylsulfinyl)cyclohexyl groups.

In the present invention, unless otherwise specified, the “(C1-C6)alkylsulfonyl (C3-C6)cycloalkyl” refers to a ((C1-C6)alkyl)-S(═O)₂—((C3-C6)cycloalkyl group)- group in which the alkyl moiety and the cycloalkyl moiety are as defined above. Examples thereof include 1-(methylsulfonyl)cyclopropyl, 1-(ethylsulfonyl)cyclopropyl, 1-(methylsulfonylmethyl)cyclopropyl, 1-(ethylsulfonylmethyl)cyclopropyl, 1-(n-propylsulfonyl)cyclopropyl, 1-(isopropylsulfonyl)cyclopropyl, 1-(pentylsulfonyl)cyclopropyl, 1-(hexylsulfonyl)cyclopropyl, 1-(methylsulfonyl)cyclobutyl, 1-(ethylsulfonyl)cyclobutyl, 1-(n-propylsulfonyl)cyclobutyl, 1-(isopropylsulfonyl)cyclobutyl, 1-(pentylsulfonyl)cyclobutyl, 1-(hexylsulfonyl)cyclobutyl, 1-(methylsulfonyl)cyclopentyl, 1-(ethylsulfonyl)cyclopentyl, 1-(methylsulfonyl)cyclohexyl, and 1-(ethylsulfonyl)cyclohexyl groups.

In the present invention, unless otherwise specified, the “(C1-C6)haloalkylsulfonyl (C3-C6)cycloalkyl” refers to a ((C1-C6)haloalkyl)-S(═O)₂—((C3-C6)cycloalkyl group)- group in which the haloalkyl moiety and the cycloalkyl moiety are as defined above. Examples thereof include 1-(difluoromethylsulfonyl)cyclopropyl, 1-(trifluoromethylsulfonyl)cyclopropyl, 1-(2,2-difluoroethylsulfonyl)cyclopropyl, 1-(2,2,2-trifluoroethylsulfonyl)cyclopropyl, 1-(difluoromethylsulfonylmethyl)cyclopropyl, 1-(trifluoromethylsulfonylmethyl)cyclopropyl, 1-(2,2-difluoroethylsulfonylmethyl)cyclopropyl, 1-(2,2,2-trifluoroethylsulfonylmethyl)cyclopropyl, 1-(difluoromethylsulfonyl)cyclobutyl, 1-(trifluoromethylsulfonyl)cyclobutyl, 1-(2,2-difluoroethylsulfonyl)cyclobutyl, 1-(2,2,2-trifluoroethylsulfonyl)cyclobutyl, 1-(difluoromethylsulfonyl)cyclopentyl, 1-(trifluoromethylsulfonyl)cyclopentyl, 1-(2,2-difluoroethylsulfonyl)cyclopentyl, 1-(2,2,2-trifluoroethylsulfonyl)cyclopentyl, 1-(difluoromethylsulfonyl)cyclohexyl, 1-(trifluoromethylsulfonyl)cyclohexyl, 1-(2,2-difluoroethylsulfonyl)cyclohexyl, and 1-(2,2,2-trifluoroethylsulfonyl)cyclohexyl groups.

In the present invention, unless otherwise specified, the “(C1-C6)alkoxycarbonyl (C3-C6)cycloalkyl” refers to a ((C1-C6)alkyl)-O—C(═O)—((C3-C6)cycloalkyl)- group in which the alkyl moiety and the cycloalkyl moiety are as defined above. Examples thereof include 1-(methoxycarbonyl)cyclopropyl, 1-(ethoxycarbonyl)cyclopropyl, 2-(methoxycarbonyl)cyclopropyl, 2-(ethoxycarbonyl)cyclopropyl, 1-(methoxycarbonyl)cyclobutyl, 1-(ethoxycarbonyl)cyclobutyl, 1-(methoxycarbonyl)cyclopentyl, 1-(ethoxycarbonyl)cyclopentyl, 1-(methoxycarbonyl)cyclohexyl, 1-(ethoxycarbonyl)cyclohexyl, 1-(isopropoxycarbonyl)cyclohexyl, and 1-(tert-butoxycarbonyl)cyclohexyl groups.

In the present invention, unless otherwise specified, the “carboxy (C3-C6)cycloalkyl” refers to a (carboxy)-((C3-C6)cycloalkyl group)- group in which the cycloalkyl moiety is as defined above. Examples thereof include 1-(carboxy)cyclopropyl, 2-(carboxy)cyclopropyl, 1-(carboxy)cyclobutyl, 1-(carboxy)cyclopentyl, and 1-(carboxy)cyclohexyl groups.

In the present invention, unless otherwise specified, the “carbamoyl (C3-C6)cycloalkyl” refers to a (carbamoyl)-((C3-C6)cycloalkyl group)- group in which the cycloalkyl moiety is as defined above. Examples thereof include 1-(carbamoyl)cyclopropyl, 2-(carbamoyl)cyclopropyl, 1-(carbamoyl)cyclobutyl, 1-(carbamoyl)cyclopentyl, and 1-(carbamoyl)cyclohexyl groups.

In the present invention, unless otherwise specified, the “(C1-C6)alkylaminocarbonyl (C3-C6)cycloalkyl” refers to a ((C1-C6)alkyl)-NH—C(═O)—((C3-C6)cycloalkyl)- group in which the alkyl moiety and the cycloalkyl moiety are as defined above. Examples thereof include 1-(methylaminocarbonyl)cyclopropyl, 1-(ethylaminocarbonyl)cyclopropyl, 1-(n-propylaminocarbonyl)cyclopropyl, 1-(isopropylaminocarbonyl)cyclopropyl, 1-(tert-butylaminocarbonyl)cyclopropyl, 1-(methylaminocarbonyl)cyclobutyl, 1-(methylaminocarbonyl)cyclopentyl, and 1-(methylaminocarbonyl)cyclohexyl groups.

In the present invention, unless otherwise specified, the “heterocycloalkyl (C3-C6)cycloalkyl” refers to a (3- to 6-membered heterocycloalkyl)-((C3-C6)cycloalkyl group)-group in which the heterocycloalkyl moiety and the cycloalkyl moiety are as defined above. Examples thereof include 1-(oxetane-2-yl)cyclopropyl, 1-(oxetane yl)cyclopropyl, 1-(tetrahydrofuran-2-yl)cyclopropyl, 1-(tetrahydrofuran-3-yl)cyclopropyl, 1-(tetrahydrothiophene-3-yl)cyclopropyl, 1-(tetrahydropyran-2-yl)cyclopropyl, 1-(tetrahydropyran-3-yl)cyclopropyl, 1-(tetrahydropyran yl)cyclopropyl, 1-(tetrahydrothiopyran-4-yl)cyclopropyl, 1-(morpholine-4-yl)cyclopropyl, 1-(azetidine-3-yl)cyclopropyl, 1-(pyrrolidine-3-yl)cyclopropyl, and 1-(piperidine-4-yl)cyclopropyl groups.

In the present invention, unless otherwise specified, the “(C4-C8)bicycloalkyl” refers to a bicyclic cyclic alkyl group having 4 to 8 carbon atoms. Examples thereof include bicyclo[1.1.0]butane-2-yl, bicyclo[1.1.1]pentane-1-yl, bicyclo[2.1.0]pentane-2-yl, and bicyclo[2.1.0]pentane-5-yl groups.

In the present invention, unless otherwise specified, the “(C1-C6)alkylsulfinyl (C1-C6)alkyl” refers to a ((C1-C6)alkylsulfinyl)-((C1-C6)alkyl)- group in which the alkylsulfinyl moiety and the alkyl moiety are as defined above. Examples thereof include methylsulfinylmethyl, ethylsulfinylmethyl, n-propylsulfinylmethyl, isopropylsulfinylmethyl, 1-(methylsulfinyl)ethyl, 2-(methylsulfinyl)ethyl, 2-(ethylsulfinyl)ethyl, 1-(n-propylsulfinyl)ethyl, 2-(n-propylsulfinyl)ethyl, 1-(isopropylsulfinyl)ethyl, 2-(isopropylsulfinyl)ethyl, 1-(methylsulfinyl)propyl, 2-(methylsulfinyl)propyl, 3-(methylsulfinyl)propyl, 1-(ethylsulfinyl)propyl, 2-(ethylsulfinyl)propyl, 3-(ethylsulfinyl)propyl, 1-(n-propylsulfinyl) propyl, 2-(n-propylsulfinyl)propyl, 3-(n-propylsulfinyl)propyl, 1-(methylsulfinyl)butyl, 2-(methylsulfinyl)butyl, 3-(methylsulfinyl)butyl, 4-(methylsulfinyl)butyl, 1-(methylsulfinyl)pentyl, 2-(methylsulfinyl)pentyl, 3-(methylsulfinyl)pentyl, 4-(methylsulfinyl)pentyl, 5-(methylsulfinyl)pentyl, 2-(n-butylsulfinyl)ethyl, 2-(isobutylsulfinyl)ethyl, 2-(sec-butylsulfinyl)ethyl, 2-(tert-butylsulfinyl)ethyl, pentylsulfinylmethyl, and hexylsulfinylmethyl groups.

In the present invention, unless otherwise specified, the “(C1-C6)alkylsulfonyl (C1-C6)alkyl” refers to a ((C1-C6)alkylsulfonyl)-((C1-C6)alkyl)- group in which the alkylsulfonyl moiety and the alkyl moiety are as defined above. Examples thereof include methylsulfonylmethyl, ethylsulfonylmethyl, n-propylsulfonylmethyl, isopropylsulfonylmethyl, 1-(methylsulfonyl)ethyl, 2-(methylsulfonyl)ethyl, 2-(ethylsulfonyl)ethyl, 1-(n-propylsulfonyl)ethyl, 2-(n-propylsulfonyl)ethyl, 1-(isopropylsulfonyl)ethyl, 2-(isopropylsulfonyl)ethyl, 1-(methylsulfonyl)propyl, 2-(methylsulfonyl)propyl, 3-(methylsulfonyl)propyl, 1-(ethylsulfonyl)propyl, 2-(ethylsulfonyl)propyl, 3-(ethylsulfonyl)propyl, 1-(n-propylsulfonyl) propyl, 2-(n-propylsulfonyl)propyl, 3-(n-propylsulfonyl)propyl, 1-(methylsulfonyl)butyl, 2-(methylsulfonyl)butyl, 3-(methylsulfonyl)butyl, 4-(methylsulfonyl)butyl, 1-(methylsulfonyl)pentyl, 2-(methylsulfonyl)pentyl, 3-(methylsulfonyl)pentyl, 4-(methylsulfonyl)pentyl, 5-(methylsulfonyl)pentyl, 2-(n-butylsulfonyl)ethyl, 2-(isobutylsulfonyl)ethyl, 2-(sec-butylsulfonyl)ethyl, 2-(tert-butylsulfonyl)ethyl, pentylsulfonylmethyl, and hexylsulfonylmethyl groups.

In the present invention, unless otherwise specified, the “(C1-C6)alkoxy (C1-C6)alkoxy (C1-C6)alkyl” refers to a ((C1-C6)alkoxy)-((C1-C6)alkoxy)-((C1-C6)alkyl)- group in which the alkoxy moiety and the alkyl moiety are as defined above. Examples thereof include (2-methoxyethoxy)methyl and (2-ethoxyethoxy)methyl groups.

In the present invention, unless otherwise specified, the “cyano (C1-C6)alkoxy (C1-C6)alkyl” refers to a (cyano)-((C1-C6)alkoxy)-((C1-C6)alkyl)- group in which the alkoxy moiety and the alkyl moiety are as defined above. Examples thereof include a (2-cyanoethoxy)methyl group.

In the present invention, unless otherwise specified, the “(C1-C6)alkylthio (C1-C6)alkoxy (C1-C6)alkyl” refers to a ((C1-C6)alkylthio)-((C1-C6)alkoxy)-((C1-C6)alkyl)- group in which the alkylthio moiety, the alkoxy moiety, and the alkyl moiety are as defined above. Examples thereof include (2-methylthioethoxy)methyl and (2-ethylthioethoxy)methyl groups.

In the present invention, unless otherwise specified, the “(C1-C6)alkylsulfinyl (C1-C6)alkoxy (C1-C6)alkyl” refers to a ((C1-C6)alkylsulfinyl)-((C1-C6)alkoxy)-((C1-C6)alkyl)- group in which the alkylsulfinyl moiety, the alkoxy moiety, and the alkyl moiety are as defined above. Examples thereof include (2-methylsulfinylethoxy)methyl and (2-ethylsulfinylethoxy)methyl groups.

In the present invention, unless otherwise specified, the “(C1-C6)alkylsulfonyl (C1-C6)alkoxy (C1-C6)alkyl” refers to a ((C1-C6)alkylsulfonyl)-((C1-C6)alkoxy)-((C1-C6)alkyl)- group in which the alkylsulfonyl moiety, the alkoxy moiety, and the alkyl moiety are as defined above. Examples thereof include (2-methylsulfonylethoxy)methyl and (2-ethylsulfonylethoxy)methyl groups.

In the present invention, unless otherwise specified, the “(C1-C6)alkylcarbonyloxy (C1-C6)alkyl” refers to a ((C1-C6)alkyl)-C(═O)O—((C1-C6)alkyl)- group in which the alkyl moiety is as defined above. Examples thereof include acetoxymethyl, propionyloxymethyl, isobutyryloxymethyl, and pivaloyloxymethyl groups.

In the present invention, unless otherwise specified, the “(C1-C6)alkoxycarbonyloxy (C1-C6)alkyl” refers to a ((C1-C6)alkyl)-O—C(═O)—O—((C1-C6)alkyl)- group in which the alkyl moiety is as defined above. Examples thereof include methoxycarbonyloxymethyl, ethoxycarbonyloxymethyl, isopropoxycarbonyloxymethyl, tert-butoxycarbonyloxymethyl, and isobutoxycarbonyloxymethyl groups.

In the present invention, unless otherwise specified, the “(C1-C6)alkoxycarbonylamino (C1-C6)alkyl” refers to a ((C1-C6)alkyl)-O—C(═O)—NH—((C1-C6)alkyl)- group in which the alkyl moiety is as defined above. Examples thereof include methoxycarbonylaminomethyl, ethoxycarbonylaminomethyl, isopropoxycarbonylaminomethyl, tert-butoxycarbonylaminomethyl, and isobutoxycarbonylaminomethyl groups.

In the present invention, unless otherwise specified, the “(C2-C6)alkynyl (C3-C6)cycloalkyl” refers to a ((C2-C6)alkynyl)-((C1-C6)cycloalkyl)- group in which the alkynyl moiety and the cycloalkyl moiety are as defined above. Examples thereof include 1-(ethynyl)cyclopropyl, 1-(1-propynyl)cyclopropyl, 1-(2-propynyl)cyclopropyl, 1-(1-butynyl)cyclopropyl, 1-(2-butynyl)cyclopropyl, 1-(3-butynyl)cyclopropyl, and 1-(1-pentynyl)cyclopropyl groups.

In the present invention, unless otherwise specified, the “(C2-C6)alkenyloxycarbonyl” refers to a ((C1-C6)alkenyl)-O—C(═O)— group in which the alkenyl moiety is as defined above. Examples thereof include 1-propenyloxycarbonyl, isopropenyloxycarbonyl, 2-propenyloxycarbonyl, 2-butenyloxycarbonyl, 3-butenyloxycarbonyl, 2-pentenyloxycarbonyl, 3-pentenyloxycarbonyl, 4-pentenyloxycarbonyl, 2-methyl-2-butenyloxycarbonyl, 2,4-pentadienyloxycarbonyl, 2-hexenyloxycarbonyl, 3-hexenyloxycarbonyl, 4-hexenyloxycarbonyl, 5-hexenyloxycarbonyl, and 2,4-hexadienyloxycarbonyl groups.

In the present invention, unless otherwise specified, the “tri((C1-C6)alkyl)silyl (C1-C6)alkyl” refers to a ((C1-C6)alkyl)₃-Si—((C1-C6)alkyl)- group in which the tri (C1-C6 alkyl)silyl moiety and the alkyl moiety are as defined above, and three alkyl groups of the ((C1-C6)alkyl)₃moiety are optionally identical or different from each other.

Examples thereof include trimethylsilylmethyl, 1-trimethylsilylethyl, 1-trimethylsilylpropyl, 1-trimethylsilylbutyl, 1-trimethylsilylpentyl, 1-trimethylsilylhexyl, triethylsilylmethyl, 1-triethylsilylethyl, triisopropylsilylmethyl, 1-triisopropylsilylethyl, dimethylisilylmethyl, and tert-butyldimethylsilylmethyl groups.

In the present invention, unless otherwise specified, the “(C1-C6)alkoxymethyl” refers to a ((C1-C6)alkoxy)-methyl group in which the alkoxy moiety is as defined above. Examples thereof include methoxymethyl, ethoxymethyl, n-propoxymethyl, isopropoxymethyl, n-butoxymethyl, isobutoxymethyl, sec-butoxymethyl, tert-butoxymethyl, n-pentoxymethyl, 1-methylbutoxymethyl, 2-methylbutoxymethyl, 3-methylbutoxymethyl, 1-ethylpropoxymethyl, 1,1-dimethylpropoxymethyl, 1,2-dimethylpropoxymethyl, and 2,2-dimethylpropoxymethyl groups.

In the present invention, unless otherwise specified, the “(C1-C12)alkylene” refers to alkylene having 1 to 12 carbon atoms. Examples thereof include methylene, ethylene, n-propylene, n-butylene, n-hexylene, n-heptylene, n-octylene, and n-dodecylene.

In the present invention, unless otherwise specified, the “(C3-C6)cycloalkylene” refers to cycloalkylene having 3 to 6 carbon atoms. Examples thereof include cyclopropylene, cyclobutylene, cyclopentylene, and cyclohexylene.

In the present invention, unless otherwise specified, the “(C1-C6)alkyleneoxy (C1-C12)alkylene” refers to ((C1-C6)alkylene)-O—(C1-C12 alkylene) in which the alkylene moiety is as defined above. Examples thereof include methyleneoxymethylene (—CH₂—O—CH₂—), methyleneoxyethylene (—CH₂—O—CH₂CH₂—), and ethyleneoxyethylene (—CH₂CH₂—O—CH₂CH₂—).

In the present invention, unless otherwise specified, the “(C2-C6)alkenylene” refers to alkenylene having 2 to 6 carbon atoms. Examples thereof include vinylene, propenylene, and butenylene.

In the present invention, unless otherwise specified, the “(C2-C6)alkynylene” refers to alkynylene having 2 to 6 carbon atoms. Examples thereof include ethynylene, propynylene, butynylene, and pentynylene.

In the present invention, “optionally mono-substituted or poly-substituted with R⁶” means “optionally substituted with one or two or more R⁶”. When the group is substituted with two or more R⁶, the two or more R⁶are identical to or different from each other, and each represent a halogen atom; a (C1-C6)alkyl; a (C1-C6)haloalkyl; a (C3-C6)cycloalkyl; a (C3-C6)halocycloalkyl; a hydroxy; a (C1-C6)alkoxy; a (C1-C6)haloalkoxy; a (C3-C6)cycloalkoxy; a (C3-C6)halocycloalkoxy; a (C1-C6)alkoxy (C1-C6)alkoxy; a (C1-C6)haloalkoxy (C1-C6)alkoxy; a (C1-C6)haloalkoxy (C1-C6)haloalkoxy; a thiol; a (C1-C6)alkylthio; a (C1-C6)haloalkylthio; a (C2-C6)alkenylthio; a (C2-C6)haloalkenylthio; a (C3-C6)cycloalkylthio; a (C3-C6)halocycloalkylthio; a (C3-C6)cycloalkyl (C1-C6)alkylthio; a (C3-C6)halocycloalkyl (C1-C6)alkylthio; a tri((C1-C6)alkyl)silyl (C1-C6)alkylthio; a (C1-C6)alkylthio (C1-C6)alkoxy; a (C1-C6)haloalkylthio (C1-C6)alkoxy; a (C1-C6)alkylsulfinyl; a (C1-C6)haloalkylsulfinyl; a (C3-C6)cycloalkylsulfinyl; a (C3-C6)halocycloalkylsulfinyl; a (C1-C6)alkylsulfonyl; a (C1-C6)haloalkylsulfonyl; a (C3-C6)cycloalkylsulfonyl; a (C3-C6)halocycloalkylsulfonyl; a formyl; a (C1-C6)alkylcarbonyl; a (C1-C6)haloalkylcarbonyl; a benzoyl (the benzoyl is optionally mono-substituted or poly-substituted with R⁷); a (C1-C6)alkoxycarbonyl; a (C1-C6)haloalkoxycarbonyl; a (C1-C6)alkylaminocarbonyl (the amino moiety is optionally substituted with R¹⁰); a (C1-C6)haloalkylaminocarbonyl (the amino moiety is optionally substituted with R¹⁰); a (C1-C6)alkylaminocarbonylthio (the amino moiety is optionally substituted with R¹⁰); a (C1-C6)haloalkylaminocarbonylthio (the amino moiety is optionally substituted with R¹⁰); a formyloxy; a (C1-C6)alkylcarbonyloxy; a (C1-C6)haloalkylcarbonyloxy; a benzoyloxy (the benzoyloxy is optionally mono-substituted or poly-substituted with R⁷); a (C1-C6)alkylsulfinyloxy; a (C1-C6)haloalkylsulfinyloxy; a (C3-C6)cycloalkylsulfinyloxy; a (C3-C6)halocycloalkylsulfinyloxy; a phenylsulfinyloxy (the phenylsulfinyloxy is optionally mono-substituted or poly-substituted with R⁷); a (C1-C6)alkylsulfonyloxy; a (C1-C6)haloalkylsulfonyloxy; a (C3-C6)cycloalkylsulfonyloxy; a (C3-C6)halocycloalkylsulfonyloxy; a phenylsulfonyloxy (the phenyl moiety is optionally mono-substituted or poly-substituted with R⁷); an amino; a (C1-C6)alkylamino (the amino moiety is optionally substituted with R¹⁰); a (C1-C6)haloalkylamino (the amino moiety is optionally substituted with R¹⁰); a (C1-C6)alkylcarbonylamino (the amino moiety is optionally substituted with R¹⁰); a (C1-C6)haloalkylcarbonylamino (the amino moiety is optionally substituted with R¹⁰); a phenylcarbonylamino (the phenyl moiety is optionally mono-substituted or poly-substituted with R⁷, and the amino moiety is optionally substituted with R¹⁰); a (C1-C6)alkoxycarbonylamino (the amino moiety is optionally substituted with R¹⁰); a (C1-C6)haloalkoxycarbonylamino (the amino moiety is optionally substituted with R¹⁰); a (C1-C6)alkylaminocarbonylamino (the amino moiety is optionally substituted with R¹⁰); a (C1-C6)haloalkylaminocarbonylamino (the amino moiety is optionally substituted with R¹⁰); a (C1-C6)alkylsulfinylamino (the amino moiety is optionally substituted with R¹⁰); a (C1-C6)haloalkylsulfinylamino (the amino moiety is optionally substituted with R¹⁰); a phenylsulfinylamino (the phenyl moiety is optionally mono-substituted or poly-substituted with R⁷, and the amino moiety is optionally substituted with R¹⁰); a (C1-C6)alkylsulfonylamino (the amino moiety is optionally substituted with R¹⁰); a (C1-C6)haloalkylsulfonylamino (the amino moiety is optionally substituted with R¹⁰); a phenylsulfonylamino (the phenyl moiety is optionally mono-substituted or poly-substituted with R⁷, and the amino moiety is optionally substituted with R¹⁰); a (C1-C6)alkoxyimino; a tri((C1-C6)alkyl)silyl; a phenyl (the phenyl is optionally mono-substituted or poly-substituted with R⁷); a phenoxy (the phenoxy is optionally mono-substituted or poly-substituted with R⁷); a phenyl (C1-C6)alkoxy (the phenyl moiety is optionally mono-substituted or poly-substituted with R⁷); a phenylthio (the phenylthio is optionally mono-substituted or poly-substituted with R⁷); a phenylsulfinyl (the phenylsulfinyl is optionally mono-substituted or poly-substituted with R⁷); a phenylsulfonyl (the phenylsulfonyl is optionally mono-substituted or poly-substituted with R⁷); a phenyl (C1-C6)alkylthio (the phenyl moiety is optionally mono-substituted or poly-substituted with R⁷); a phenyl (C1-C6)alkylsulfinyl (the phenyl moiety is optionally mono-substituted or poly-substituted with R⁷); a phenyl (C1-C6)alkylsulfonyl (the phenyl moiety is optionally mono-substituted or poly-substituted with R⁷); a —O—N═C(R⁸) (R⁹) group; an adamantyl; an azetidinyl (a nitrogen atom of the azetidinyl is optionally substituted with R¹⁰); a pyrrolidinyl (a nitrogen atom of the pyrrolidinyl is optionally substituted with R¹⁰); a piperidinyl (a nitrogen atom of the piperidinyl is optionally substituted with R¹⁰); a 1,3-dioxolanyl; a 1,3-dioxanyl; a pyrrolyl (the pyrrolyl is optionally mono-substituted or poly-substituted with R⁷); a pyrazolyl (the pyrazolyl is optionally mono-substituted or poly-substituted with R⁷); an imidazolyl (the imidazolyl is optionally mono-substituted or poly-substituted with R⁷); a triazolyl (the triazolyl is optionally mono-substituted or poly-substituted with R⁷); an oxazolyl (the oxazolyl is optionally mono-substituted or poly-substituted with R⁷); an isoxazolyl (the isoxazolyl is optionally mono-substituted or poly-substituted with R⁷); a thiazolyl (the thiazolyl is optionally mono-substituted or poly-substituted with R⁷); an isothiazolyl (the isothiazolyl is optionally mono-substituted or poly-substituted with R⁷); a pyridyl (the pyridyl is optionally mono-substituted or poly-substituted with R⁷, and further a nitrogen atom of the pyridyl is optionally oxidized to form an N-oxide); a pyrimidinyl (the pyrimidinyl is optionally mono-substituted or poly-substituted with R⁷); a pyridyloxy (the pyridyloxy is optionally mono-substituted or poly-substituted with R⁷); a tetrahydrofuranyl (the tetrahydrofuranyl is optionally mono-substituted or poly-substituted with R⁷); a 1,3-dioxoisoindolinyl group (the dioxoisoindolinyl group is optionally mono-substituted or poly-substituted with R⁷); a cyano; a nitro; a carboxy; a thiocyanato; or an aminooxy.

In the present invention, “optionally mono-substituted or poly-substituted with R⁷” means “optionally substituted with one or two or more R⁷”. When the group is substituted with two or more R⁷, the two or more R⁷are identical to or different from each other, and each represent a halogen atom; a (C1-C6)alkyl; a (C1-C6)haloalkyl; a (C3-C6)cycloalkyl; a (C3-C6)halocycloalkyl; a (C3-C6)cycloalkyl (C1-C6)alkyl; a (C3-C6)halocycloalkyl (C1-C6)alkyl; a (C1-C6)alkoxy; a (C1-C6)haloalkoxy; a (C1-C6)alkylthio; a (C1-C6)haloalkylthio; a (C1-C6)alkylsulfinyl; a (C1-C6)haloalkylsulfinyl; a (C1-C6)alkylsulfonyl; a (C1-C6)haloalkylsulfonyl; a (C1-C6)alkylthio (C1-C6)alkyl; a (C1-C6)haloalkylthio (C1-C6)alkyl; a (C1-C6)alkylsulfonyloxy; a (C1-C6)haloalkylsulfonyloxy; a phenyl (the phenyl is optionally mono-substituted or poly-substituted with a halogen atom, an alkyl, or a haloalkyl); a phenyl (C1-C6)alkyl; a phenyl (C1-C6)alkoxy; a cyano; or a nitro group.

In the present invention, the agriculturally acceptable salt or salt means a salt of any compound of the present invention of formula [I], [II], or [III], which contains a hydroxyl group, a carboxyl group, an amino group, or the like, or a nitrogen atom of a pyridine ring in the structure thereof, with a metal or an organic base, or with a mineral acid or an organic acid. Examples of the metal include an alkali metal such as sodium or potassium, or an alkaline earth metal such as magnesium or calcium. Examples of the organic base include triethylamine or diisopropylamine. Examples of the mineral acid include phosphoric acid, hydrochloric acid, hydrobromic acid, hydroiodic acid, boric acid, or sulfuric acid. Examples of the organic acid include formic acid, acetic acid, lactic acid, ascorbic acid, succinic acid, fumaric acid, maleic acid, oxalic acid, citric acid, benzoic acid, salicylic acid, tartaric acid, methanesulfonic acid, 4-toluenesulfonic acid, and trifluoromethanesulfonic acid.

Next, representative compounds of the compounds included in the 3-alkoxybenzamide derivative of the present invention of formula [I] are shown in Tables 1 to 1062, representative compounds of the compounds included in the hydroxybenzamide derivative of the present invention of formula [II] are shown in Tables 1063 to 1064, and representative compounds of the compounds included in the alkoxybenzoic acid derivative of the present invention of formula [III] are shown in Tables 1065 to 1233. However, the compounds included in the derivatives of the present invention are not limited thereto. In addition, the compound numbers in the tables are referred to in the following description.

The compounds included in the 3-alkoxybenzamide derivative, alkoxybenzoic acid derivative, or hydroxybenzderivative of the present invention may have E- and Z-form geometric isomers depending on the type of the substituent, but the present invention includes a mixture containing these E-, Z-, or E- and Z-forms in an arbitrary ratio. In addition, the compounds included in the present invention may have optical isomers resulting from the presence of one or two or more asymmetric carbon atoms and asymmetric sulfur atoms, but the present invention includes all optically active forms, racemates, or diastereomers.

The following notations in the tables in the present specification represent, for example, corresponding groups as follows.

Me: Methyl;

Et: Ethyl;

n-Pr: n-Propyl;

i-Pr: Isopropyl;

n-Bu: n-Butyl;

t-Bu: tert-Butyl;

n-Pen: n-Pentyl;

t-Pen: tert-Pentyl;

n-Hex: n-Hexyl;

n-Heptyl: n-Heptyl;

n-Octyl: n-Octyl;

n-Nonyl: n-Nonyl;

n-Decyl: n-Decyl;

c-Pr: Cyclopropyl;

c-Pen: Cyclopentyl;

c-Hex: Cyclohexyl;

CHF₂: Difluoromethyl;

CF₃: Trifluoromethyl;

Ph(4-CF₃): 4-Trifluoromethylphenyl;

Ph(2-F-4-CF₃): 2-Fluoro-4-trifluoromethylphenyl;

Ph(3,4,5-Cl₃): 3,4,5-Trichlorophenyl;

c-Pr(2,2-F₂): 2,2-Difluorocyclopropyl;

N(Phth): Phthalimide;

THF: Tetrahydrofuran;

TABLE 1

Compound

Number
R¹
R²
R³
R⁴
R⁵
A

A-0001
CH₂CF₃
H
Cl
F
Me
O

A-0002
CH₂CF₃
H
Cl
F
Et
O

A-0003
CH₂CF₃
H
Cl
F
n-Pr
O

A-0004
CH₂CF₃
H
Cl
F
i-Pr
O

A-0005
CH₂CF₃
H
Cl
F
n-Bu
O

A-0006
CH₂CF₃
H
Cl
F
n-Pen
O

A-0007
CH₂CF₃
H
Cl
F
n-Hex
O

A-0008
CH₂CF₃
H
Cl
F
n-Heptyl
O

A-0009
CH₂CF₃
H
Cl
F
n-Octyl
O

A-0010
CH₂CF₃
H
Cl
F
n-Nonyl
O

A-0011
CH₂CF₃
H
Cl
F
n-Decyl
O

A-0012
CH₂CF₃
H
Cl
F
c-Pr
O

A-0013
CH₂CF₃
H
Cl
F
c-Pen
O

A-0014
CH₂CF₃
H
Cl
F
c-Hex
O

A-0015
CH₂CF₃
H
Cl
F
CH₂C(Me)═CH₂
O

A-0016
CH₂CF₃
H
Cl
F
CH₂CH₂CH═CH₂
O

A-0017
CH₂CF₃
H
Cl
F
CH₂CH₂CH═C(CH₃)₂
O

A-0018
CH₂CF₃
H
Cl
F
CH₂CH₂CH₂CH═CH₂
O

A-0019
CH₂CF₃
H
Cl
F
CH₂CH₂CH₂CH═C(CH₃)₂
O

A-0020
CH₂CF₃
H
Cl
F
CH₂CH₂CH₂CH₂CH═CH₂
O

A-0021
CH₂CF₃
H
Cl
F
CH₂CH₂CH₂CH₂CH═C(CH₃)₂
O

A-0022
CH₂CF₃
H
Cl
F
CH₂CH₂CH [Image Omitted]

CH
O

A-0023
CH₂CF₃
H
Cl
F
CH₂CH₂CH₂CH [Image Omitted]

CH
O

A-0024
CH₂CF₃
H
Cl
F
CH₂CH₂CH₂CH₂CH [Image Omitted]

CH
O

A-0025
CH₂CF₃
H
Cl
F
CH₂CH₂CH₂Cl
O

A-0026
CH₂CF₃
H
Cl
F
CH₂CH₂CH₂Br
O

A-0027
CH₂CF₃
H
Cl
F
CH₂CH₂CH₂CH₂Cl
O

A-0028
CH₂CF₃
H
Cl
F
CH₂CH₂CH₂CH₂Br
O

A-0029
CH₂CF₃
H
Cl
F
CH₂CH₂CH₂CH₂CH₂Cl
O

A-0030
CH₂CF₃
H
Cl
F
CH₂CH₂CH₂CH₂CH₂Br
O

A-0031
CH₂CF₃
H
Cl
Cl
CH₂CH₂CH₂CH₂CH₂Br
O

A-0032
CH₂CF₃
H
Cl
F
CH₂CH₂CH₂CH₂CH₂CH₂Cl
O

A-0033
CH₂CF₃
H
Cl
F
CH₂CH₂CH₂CH₂CH₂CH₂Br
O

A-0034
CH₂CF₃
H
Cl
F
CH₂CH₂CH₂CH₂CH₂CH₂CH₂Cl
O

A-0035
CH₂CF₃
H
Cl
F
CH₂CH₂CH₂CH₂CH₂CH₂CH₂Br
O

A-0036
CH₂CF₃
H
Cl
F
CH₂CH₂CH₂CH₂CH₂CH₂CH₂CH₂Br
O

A-0037
CH₂CF₃
H
Cl
F
CH₂CH(Me)CH₂Cl
O

A-0038
CH₂CF₃
H
Cl
F
CH₂CH(Me)CH₂Br
O

TABLE 2

Compound

Number
R¹
R²
R³
R⁴
R⁵
A

A-0039
CH₂CF₃
H
Cl
F
CH₂CH₂CH(Me)CH₂CH₂Cl
O

A-0040
CH₂CF₃
H
Cl
F
CH₂CH₂CH(Me)CH₂CH₂Br
O

A-0041
CH₂CF₃
H
Cl
F
CH₂CH₂CF═CF₂
O

A-0042
CH₂CF₃
H
Cl
F
CH₂CH═C(Cl)CF₃
O

A-0043
CH₂CF₃
H
Cl
F
CH₂CH₂CH₂CF═CF₂
O

A-0044
CH₂CF₃
H
Cl
F
CH₂CH₂CH₂CH₂CF═CF₂
O

A-0045
CH₂CF₃
H
Cl
F
CH₂CH₂CH₂CH₂CH₂CF═CF₂
O

A-0046
CH₂CF₃
H
Cl
F
CH₂(t-Bu)
O

A-0047
CH₂CF₃
H
Cl
F
CH₂CH₂(t-Bu)
O

A-0048
CH₂CF₃
H
Cl
F
CH₂CH₂CH₂(t-Bu)
O

A-0049
CH₂CF₃
H
Cl
F
CH₂CH₂CH₂CH₂(t-Bu)
O

A-0050
CH₂CF₃
H
Cl
F
CH₂CH₂CH₂CH₂CH₂(t-Bu)
O

A-0051
CH₂CF₃
H
Cl
F
CH₂CH₂CH₂CH₂CH₂CH₂(t-Bu)
O

A-0052
CH₂CF₃
H
Cl
F
CH₂CF₃
O

A-0053
CH₂CF₃
H
Cl
F
CH₂CH₂CF₃
O

A-0054
CH₂CF₃
H
Cl
F
CH₂CH₂CH₂CF₃
O

A-0055
CH₂CF₃
H
Cl
F
CH₂CH₂CH₂CH₂CF₃
O

A-0056
CH₂CF₃
H
Cl
F
CH₂CH₂CH₂CH₂CH₂CF₃
O

A-0057
CH₂CF₃
H
Cl
F
CH₂CH₂CH₂CH₂CH₂CH₂CF₃
O

A-0058
CH₂CF₃
H
Cl
F
CH₂CH₂CH₂CH₂CH₂CH₂CH₂CF₃
O

A-0059
CH₂CF₃
H
Cl
F
CH₂CF₂CF₃
O

A-0060
CH₂CF₃
H
Cl
F
CF₂CHFCF₃
O

A-0061
CH₂CF₃
H
Cl
F
CF₂CF₂CF₃
O

A-0062
CH₂CF₃
H
Cl
F
CH₂CF₂CF₂CF₃
O

A-0063
CH₂CF₃
H
Cl
F
CH₂CF₂CF₂CF₂CF₃
O

A-0064
CH₂CF₃
H
Cl
F
CH₂CF₂CF₂CF₂CHF2
O

A-0065
CH₂CF₃
H
Cl
F
CH(CF₃)CF₃
O

A-0066
CH₂CF₃
H
Cl
F
CH₂CF(CF₃)CF₃
O

A-0067
CH₂CF₃
H
Cl
F
CH₂CF₂CF(CF₃)CF₃
O

A-0068
CH₂CF₃
H
Cl
F
CH₂CF(CF₃)CF₂CF₃
O

A-0069
CH₂CF₃
H
Cl
F
CH₂CF₂CF₂CF(CF₃)CF₃
O

A-0070
CH₂CF₃
H
Cl
F
CH₂CF₂CF(CF₃)CF₂CF₃
O

A-0071
CH₂CF₃
H
Cl
F
CH₂CF(CF₃)CF₂CF₂CF₃
O

A-0072
CH₂CF₃
H
Cl
F
CH₂(c-Pr)
O

A-0073
CH₂CF₃
H
Cl
F
CH₂[c-Pr(1-Me)]
O

A-0074
CH₂CF₃
H
Cl
F
CH₂[c-Pr(1-Ph)]
O

A-0075
CH₂CF₃
H
Cl
F
CH₂[c-Pr(1-NH₂)]
O

A-0076
CH₂CF₃
H
Cl
F
CH₂[c-Pr(1-NHC(═O)O(t-Bu)]
O

A-0077
CH₂CF₃
H
Cl
F
CH₂{c-Pr[1-NHS(═O)₂CF₃]}
O

A-0078
CH₂CF₃
H
Cl
F
CH₂{c-Pr[1-Ph(4-CF₃)]}
O

A-0079
CH₂CF₃
H
Cl
F
CH₂{c-Pr[1-Ph(3,4,5-F₃)]}
O

A-0080
CH₂CF₃
H
Cl
F
CH₂{c-Hex[4-(t-Bu)]}
O

A-0081
CH₂CF₃
H
Cl
F
CH₂[c-Hex(4-CF₃)]
O

A-0082
CH₂CF₃
H
Cl
F
CH₂CH₂(c-Pr)
O

TABLE 3

Compound

Number
R¹
R²
R³
R⁴
R⁵
A

A-0083
CH₂CF₃
H
Cl
F
CH₂CH₂(c-Hex)
O

A-0084
CH₂CF₃
H
Cl
F
CH₂CH₂[c-Hex(4-CF₃)]
O

A-0085
CH₂CF₃
H
Cl
F
CH₂CH₂[c-Hex(4-SCF₃)]
O

A-0086
CH₂CF₃
H
Cl
F
CH₂CH₂CH₂(c-Pr)
O

A-0087
CH₂CF₃
H
Cl
F
CH₂CH₂CH₂(c-Hex)
O

A-0088
CH₂CF₃
H
Cl
F
CH₂CH₂CH₂{c-Hex[4-(t-Bu)]}
O

A-0089
CH₂CF₃
H
Cl
F
CH₂CH₂CH₂[c-Hex(4-CF₃)]
O

A-0090
CH₂CF₃
H
Cl
F
CH₂CH₂CH₂[c-Hex(4-SCF₃)]
O

A-0091
CH₂CF₃
H
Cl
F
CH₂CH₂CH₂CH₂(c-Pr)
O

A-0092
CH₂CF₃
H
Cl
F
CH₂CH₂CH₂CH₂(c-Hex)
O

A-0093
CH₂CF₃
H
Cl
F
CH₂CH₂CH₂CH₂[c-Hex(4-CF₃)]
O

A-0094
CH₂CF₃
H
Cl
F
CH₂[c-Pr(2,2-F2)]
O

A-0095
CH₂CF₃
H
Cl
F
CH₂[c-Hex(4,4-F₂)]
O

A-0096
CH₂CF₃
H
Cl
F
CH₂CH₂[c-Pr(2,2-F₂)]
O

A-0097
CH₂CF₃
H
Cl
F
CH₂CH₂[c-Hex(4,4-F₂)]
O

A-0098
CH₂CF₃
H
Cl
F
CH₂CH₂CH₂[c-Pr(2,2-F₂)]
O

A-0099
CH₂CF₃
H
Cl
F
CH₂CH₂CH₂CH₂[c-Pr(2,2-F₂)]
O

A-0100
CH₂CF₃
H
Cl
F
CH₂CH₂OH
O

A-0101
CH₂CF₃
H
Cl
F
CH₂CH₂CH₂OH
O

A-0102
CH₂CF₃
H
Cl
F
CH₂CH₂CH₂CH₂OH
O

A-0103
CH₂CF₃
H
Cl
F
CH₂CH₂CH₂CH₂CH₂OH
O

A-0104
CH₂CF₃
H
Cl
F
CH₂CH₂CH₂CH₂CH₂CH₂OH
O

A-0105
CH₂CF₃
H
Cl
F
CH₂C(═O)Me
O

A-0106
CH₂CF₃
H
Cl
F
CH₂CH(OH)Me
O

A-0107
CH₂CF₃
H
Cl
F
CH₂CH(OH)CF₃
O

A-0108
CH₂CF₃
H
Cl
F
CH₂C(OH)₂CF₃
O

A-0109
CH₂CF₃
H
Cl
F
CH₂C(CF₃)═NOH
O

A-0110
CH₂CF₃
H
Cl
F
CH₂C(CF₃)═NOMe
O

A-0111
CH₂CF₃
H
Cl
F
CH₂CH(CF₃)NH₂
O

A-0112
CH₂CF₃
H
Cl
F
CH₂CH₂OMe
O

A-0113
CH₂CF₃
H
Cl
F
CH₂CH₂CH₂OMe
O

A-0114
CH₂CF₃
H
Cl
F
CH₂CH₂CH₂CH₂OMe
O

A-0115
CH₂CF₃
H
Cl
F
CH₂CH₂CH₂CH₂CH₂OMe
O

A-0116
CH₂CF₃
H
Cl
F
CH₂CH₂CH₂CH₂CH₂CH₂OMe
O

A-0117
CH₂CF₃
H
Cl
F
CH₂CH₂OCHF₂
O

A-0118
CH₂CF₃
H
Cl
F
CH₂CH₂CH₂OCHF₂
O

A-0119
CH₂CF₃
H
Cl
F
CH₂CH₂CH₂CH₂OCHF₂
O

A-0120
CH₂CF₃
H
Cl
F
CH₂CH₂CH₂CH₂CH₂OCHF₂
O

A-0121
CH₂CF₃
H
Cl
F
CH₂CH₂CH₂CH₂CH₂CH₂OCHF₂
O

A-0122
CH₂CF₃
H
Cl
F
CH₂CH₂OCH₂CF₃
O

A-0123
CH₂CF₃
H
Cl
F
CH₂CH₂CH₂OCH₂CF₃
O

A-0124
CH₂CF₃
H
Cl
F
CH₂CH₂CH₂CH₂OCH₂CF₃
O

A-0125
CH₂CF₃
H
Cl
F
CH₂CH₂CH₂CH₂CH₂OCH₂CF₃
O

A-0126
CH₂CF₃
H
Cl
F
CH₂CH₂CH₂CH₂CH₂CH₂OCH₂CF₃
O

TABLE 4

Compound

Number
R¹
R²
R³
R⁴
R⁵
A

A-0127
CH₂CF₃
H
Cl
F
CH₂CH₂CH₂CH₂CH₂CH₂CH₂OCH₂CF₃
O

A-0128
CH₂CF₃
H
Cl
F
CH₂CH₂OC(CF₃)₃
O

A-0129
CH₂CF₃
H
Cl
F
CH₂CH₂CH₂OC(CF₃)₃
O

A-0130
CH₂CF₃
H
Cl
F
CH₂CH₂CH₂CH₂OC(CF₃)₃
O

A-0131
CH₂CF₃
H
Cl
F
CH₂CH₂CH₂CH₂CH₂OC(CF₃)₃
O

A-0132
CH₂CF₃
H
Cl
F
CF₂CHFOCF₂CF₂CF₃
O

A-0133
CH₂CF₃
H
Cl
F
CH₂CH₂O(c-Pr)
O

A-0134
CH₂CF₃
H
Cl
F
CH₂CH₂O(c-Pen)
O

A-0135
CH₂CF₃
H
Cl
F
CH₂CH₂O(c-Hex)
O

A-0136
CH₂CF₃
H
Cl
F
CH₂CH₂CH₂O(c-Pr)
O

A-0137
CH₂CF₃
H
Cl
F
CH₂CH₂CH₂O(c-Pen)
O

A-0138
CH₂CF₃
H
Cl
F
CH₂CH₂CH₂O(c-Hex)
O

A-0139
CH₂CF₃
H
Cl
F
CH₂CH₂CH₂CH₂O(c-Pr)
O

A-0140
CH₂CF₃
H
Cl
F
CH₂CH₂CH₂CH₂O(c-Pen)
O

A-0141
CH₂CF₃
H
Cl
F
CH₂CH₂CH₂CH₂O(c-Hex)
O

A-0142
CH₂CF₃
H
Cl
F
CH₂CH₂O[c-Pr(2,2-F₂)]
O

A-0143
CH₂CF₃
H
Cl
F
CH₂CH₂CH₂O[c-Pr(2,2-F₂)]
O

A-0144
CH₂CF₃
H
Cl
F
CH₂CH₂CH₂CH₂O[c-Pr(2,2-F₂)]
O

A-0145
CH₂CF₃
H
Cl
F
CH₂CH₂OCH₂CH₂OCH₃
O

A-0146
CH₂CF₃
H
Cl
F
CH₂CH₂OCH₂CH₂OCH₂CF₃
O

A-0147
CH₂CF₃
H
Cl
F
CH₂CF₂OCF₂CF₂OCF₃
O

A-0148
CH₂CF₃
H
Cl
F
CF₂CHFOCF₂CF₂OCF₃
O

A-0149
CH₂CF₃
H
Cl
F
CF₂CHFOCF₂CF(CF₃)OCF₂CF₂CF₃
O

A-0150
CH₂CF₃
H
Cl
F
CH₂CH₂SH
O

A-0151
CH₂CF₃
H
Cl
F
CH₂CH₂CH₂SH
O

A-0152
CH₂CF₃
H
Cl
F
CH₂CH₂CH₂CH₂SH
O

A-0153
CH₂CF₃
H
Cl
F
CH₂CH₂CH₂CH₂CH₂SH
O

A-0154
CH₂CF₃
H
Cl
F
CH₂CH₂CH₂CH₂CH₂CH₂SH
O

A-0155
CH₂CF₃
H
Cl
F
CH₂CH(SH)Me
O

A-0156
CH₂CF₃
H
Cl
F
CH₂CH[SC(═O)Me]Me
O

A-0157
CH₂CF₃
H
Cl
F
CH₂CH₂S(t-Bu)
O

A-0158
CH₂CF₃
H
Cl
F
CH₂CH₂CH₂S(t-Bu)
O

A-0159
CH₂CF₃
H
Cl
F
CH₂CH₂CH₂CH₂S(t-Bu)
O

A-0160
CH₂CF₃
H
Cl
F
CH₂CH₂CH₂CH₂CH₂SCH₃
O

A-0161
CH₂CF₃
H
Cl
F
CH₂CH₂CH₂CH₂CH₂SCH(CH₃)₂
O

A-0162
CH₂CF₃
H
Cl
F
CH₂CH₂CH₂CH₂CH₂S(t-Bu)
O

A-0163
CH₂CF₃
H
Cl
F
CH₂CH₂CH₂CH₂CH₂CH₂SCH(CH₃)₂
O

A-0164
CH₂CF₃
H
Cl
F
CH₂CH₂CH₂CH₂CH₂CH₂S(t-Bu)
O

A-0165
CH₂CF₃
H
Cl
F
CH₂CH₂CH₂CH₂CH₂CH₂CH₂S(t-Bu)
O

A-0166
CH₂CF₃
H
Cl
F
CH₂CH₂SCHF₂
O

A-0167
CH₂CF₃
H
Cl
F
CH₂CH₂CH₂SCHF₂
O

A-0168
CH₂CF₃
H
Cl
F
CH₂CH₂CH₂CH₂SCHF₂
O

A-0169
CH₂CF₃
H
Cl
H
CH₂CH₂CH₂CH₂CH₂SCHF₂
O

A-0170
CH₂CF₃
H
Cl
F
CH₂CH₂CH₂CH₂CH₂SCHF₂
O

TABLE 5

Compound

Number
R¹
R²
R³
R⁴
R⁵
A

A-0171
CH₂CF₃
H
Cl
F
CH₂CH₂CH₂CH₂CH₂CH₂SCHF₂
O

A-0172
CH₂CF₃
H
Cl
F
CH₂CH₂CH₂CH₂CH₂CH₂CH₂SCHF₂
O

A-0173
CH₂CF₃
H
Cl
F
CH₂CH₂SCH₂CF₃
O

A-0174
CH₂CF₃
H
Cl
F
CH₂CH₂CH₂SCH₂CF₃
O

A-0175
CH₂CF₃
H
Cl
F
CH₂CH₂CH₂CH₂SCH₂CF₃
O

A-0176
CH₂CF₃
H
Cl
F
CH₂CH₂CH₂CH₂CH₂SCH₂CF₃
O

A-0177
CH₂CF₃
H
Cl
F
CH₂CH₂CH₂CH₂CH₂CH₂SCH₂CF₃
O

A-0178
CH₂CF₃
H
Cl
F
CH₂CH₂CH₂CH₂CH₂CH₂CH₂SCH₂CF₃
O

A-0179
CH₂CF₃
H
Cl
F
CH₂CH(Me)SCH₂CF₃
O

A-0180
CH₂CF₃
H
Cl
F
CH₂CH₂SCH(CF₃)₂
O

A-0181
CH₂CF₃
H
Cl
F
CH₂CH₂CH₂SCH(CF₃)₂
O

A-0182
CH₂CF₃
H
Cl
F
CH₂CH₂CH₂CH₂SCH(CF₃)₂
O

A-0183
CH₂CF₃
H
Cl
F
CH₂CH₂CH₂CH₂CH₂SCH(CF₃)₂
O

A-0184
CH₂CF₃
H
Cl
F
CH₂CH₂CH₂CH₂CH₂CH₂SCH(CF₃)₂
O

A-0185
CH₂CF₃
H
Cl
F
CH₂CH₂CH₂CH₂CH₂SCF₂CF₃
O

A-0186
CH₂CF₃
H
Cl
F
CH₂CH₂CH₂CH₂CH₂CH₂SCF₂CF₃
O

A-0187
CH₂CF₃
H
Cl
F
CH₂CH₂CH₂CH₂CH₂CH₂SCF(CF₃)₂
O

A-0188
CH₂CF₃
H
Cl
F
CH₂CH₂CH₂CH₂CH₂CH₂CH₂SCF(CF₃)₂
O

A-0189
CH₂CF₃
H
Cl
F
CH₂CH₂CH₂CH₂CH₂SCCl₃
O

A-0190
CH₂CF₃
H
Cl
F
CH₂CH₂CH₂CH₂CH₂CH₂SCCl₃
O

A-0191
CH₂CF₃
H
Cl
F
CH₂CH₂SCH₂CH═CH₂
O

A-0192
CH₂CF₃
H
Cl
F
CH₂CH₂CH₂SCH₂CH═CH₂
O

A-0193
CH₂CF₃
H
Cl
F
CH₂CH₂CH₂CH₂SCH₂CH═CH₂
O

A-0194
CH₂CF₃
H
Cl
F
CH₂CH₂SCF═CFCF₃
O

A-0195
CH₂CF₃
H
Cl
F
CH₂CH₂CH₂SCF═CFCF₃
O

A-0196
CH₂CF₃
H
Cl
F
CH₂CH₂CH₂CH₂SCF═CFCF₃
O

A-0197
CH₂CF₃
H
Cl
F
CH₂CH₂CH₂S(c-Pr)
O

A-0198
CH₂CF₃
H
Cl
F
CH₂CH₂CH₂S(c-Hex)
O

A-0199
CH₂CF₃
H
Cl
F
CH₂CH₂CH₂CH₂S(c-Pr)
O

A-0200
CH₂CF₃
H
Cl
F
CH₂CH₂CH₂CH₂S(c-Hex)
O

A-0201
CH₂CF₃
H
Cl
F
CH₂CH₂CH₂CH₂CH₂S(c-Pr)
O

A-0202
CH₂CF₃
H
Cl
F
CH₂CH₂CH₂CH₂CH₂S(c-Hex)
O

A-0203
CH₂CF₃
H
Cl
F
CH₂CH₂CH₂S[c-Hex(4,4-F₂)]
O

A-0204
CH₂CF₃
H
Cl
F
CH₂CH₂CH₂CH₂S[c-Hex(4,4-F₂)]
O

A-0205
CH₂CF₃
H
Cl
F
CH₂CH₂CH₂CH₂CH₂S[c-Hex(4,4-F₂)]
O

A-0206
CH₂CF₃
H
Cl
F
CH₂CH₂CH₂SCH₂(c-Pr)
O

A-0207
CH₂CF₃
H
Cl
F
CH₂CH₂CH₂SCH₂(c-Hex)
O

A-0208
CH₂CF₃
H
Cl
F
CH₂CH₂CH₂CH₂SCH₂(c-Pr)
O

A-0209
CH₂CF₃
H
Cl
F
CH₂CH₂CH₂CH₂SCH₂(c-Hex)
O

A-0210
CH₂CF₃
H
Cl
F
CH₂CH₂CH₂CH₂CH₂SCH₂(c-Pr)
O

A-0211
CH₂CF₃
H
Cl
F
CH₂CH₂CH₂CH₂CH₂SCH₂(c-Hex)
O

A-0212
CH₂CF₃
H
Cl
F
CH₂CH₂CH₂SCH₂[c-Hex(4,4-F₂)]
O

A-0213
CH₂CF₃
H
Cl
F
CH₂CH₂CH₂CH₂SCH₂[C-Hex(4,4-F₂)]
O

A-0214
CH₂CF₃
H
Cl
F
CH₂CH₂CH₂CH₂CH₂SCH₂[C-Hex(4,4-F₂)]
O

TABLE 6

Compound

Number
R¹
R²
R³
R⁴
R⁵
A

A-0215
CH₂CF₃
H
Cl
F
CH₂CH₂CH₂SCH₂SiMe₃
O

A-0216
CH₂CF₃
H
Cl
F
CH₂CH₂CH₂CH₂SCH₂SiMe₃
O

A-0217
CH₂CF₃
H
Cl
F
CH₂CH₂CH₂CH₂CH₂SCH₂SiMe₃
O

A-0218
CH₂CF₃
H
Cl
F
CH₂CH₂OCH₂CH₂SCH₃
O

A-0219
CH₂CF₃
H
Cl
F
CH₂CH₂OCH₂CH₂SCHF₂
O

A-0220
CH₂CF₃
H
Cl
F
CH₂CH₂OCH₂CH₂SCF₃
O

A-0221
CH₂CF₃
H
Cl
F
CH₂CH₂OCH₂CH₂SCH₂CF₃
O

A-0222
CH₂CF₃
H
Cl
F
CH₂CH₂CH₂S(═O)(t-Bu)
O

A-0223
CH₂CF₃
H
Cl
F
CH₂CH₂CH₂CH₂S(═O)(t-Bu)
O

A-0224
CH₂CF₃
H
Cl
F
CH₂CH₂CH₂CH₂CH₂CH₂S(═O)(t-Bu)
O

A-0225
CH₂CF₃
H
Cl
F
CH₂CH₂S(═O)CHF₂
O

A-0226
CH₂CF₃
H
Cl
F
CH₂CH₂CH₂S(═O)CHF₂
O

A-0227
CH₂CF₃
H
Cl
F
CH₂CH₂CH₂CH₂S(═O)CHF₂
O

A-0228
CH₂CF₃
H
Cl
F
CH₂CH₂CH₂CH₂CH₂S(═O)CHF₂
O

A-0229
CH₂CF₃
H
Cl
F
CH₂CH₂CH₂CH₂CH₂CH₂S(═O)CHF₂
O

A-0230
CH₂CF₃
H
Cl
F
CH₂CH₂CH₂CH₂CH₂CH₂CH₂S(═O)CHF₂
O

A-0231
CH₂CF₃
H
Cl
F
CH₂CH₂S(═O)CF₃
O

A-0232
CH₂CF₃
H
Cl
F
CH₂CH₂CH₂S(═O)CF₃
O

A-0233
CH₂CF₃
H
Cl
F
CH₂CH₂CH₂CH₂S(═O)CF₃
O

A-0234
CH₂CF₃
H
Cl
F
CH₂CH₂CH₂CH₂CH₂S(═O)CF₃
O

A-0235
CH₂CF₃
H
Cl
F
CH₂CH₂CH₂CH₂CH₂CH₂S(═O)CF₃
O

A-0236
CH₂CF₃
H
Cl
F
CH₂CH₂CH₂CH₂CH₂CH₂CH₂S(═O)CF₃
O

A-0237
CH₂CF₃
H
Cl
F
CH₂CH₂S(═O)CH₂CF₃
O

A-0238
CH₂CF₃
H
Cl
F
CH₂CH₂CH₂S(═O)CH₂CF₃
O

A-0239
CH₂CF₃
H
Cl
F
CH₂CH₂CH₂CH₂S(═O)CH₂CF₃
O

A-0240
CH₂CF₃
H
Cl
F
CH₂CH₂CH₂CH₂CH₂S(═O)CH₂CF₃
O

A-0241
CH₂CF₃
H
Cl
F
CH₂CH₂CH₂CH₂CH₂CH₂S(═O)CH₂CF₃
O

A-0242
CH₂CF₃
H
Cl
F
CH₂CH₂CH₂CH₂CH₂CH₂CH₂S(═O)CH₂CF₃
O

A-0243
CH₂CF₃
H
Cl
F
CH₂CH(Me)S(═O)CH₂CF₃
O

A-0244
CH₂CF₃
H
Cl
F
CH₂CH₂CH₂S(═O)(c-Pr)
O

A-0245
CH₂CF₃
H
Cl
F
CH₂CH₂CH₂CH₂S(═O)(c-Pr)
O

A-0246
CH₂CF₃
H
Cl
F
CH₂CH₂CH₂CH₂S(═O)(c-Pen)
O

A-0247
CH₂CF₃
H
Cl
F
CH₂CH₂CH₂CH₂S(═O)(c-Hex)
O

A-0248
CH₂CF₃
H
Cl
F
CH₂CH₂CH₂CH₂CH₂S(═O)(c-Pr)
O

A-0249
CH₂CF₃
H
Cl
F
CH₂CH₂CH₂CH₂CH₂S(═O)(c-Hex)
O

A-0250
CH₂CF₃
H
Cl
F
CH₂CH₂CH₂S(═O)[c-Hex(4,4-F₂)]
O

A-0251
CH₂CF₃
H
Cl
F
CH₂CH₂CH₂CH₂S(═O)[c-Hex(4,4-F₂)]
O

A-0252
CH₂CF₃
H
Cl
F
CH₂CH₂CH₂CH₂CH₂S(═O)[c-Hex(4,4-F₂)]
O

A-0253
CH₂CF₃
H
Cl
F
CH₂CH₂CH₂CH₂S(═O)₂Me
O

A-0254
CH₂CF₃
H
Cl
F
CH₂CH₂CH₂CH₂CH₂S(═O)₂Me
O

A-0255
CH₂CF₃
H
Cl
F
CH₂CH₂CH₂CH₂CH₂S(═O)₂(t-Bu)
O

A-0256
CH₂CF₃
H
Cl
F
CH₂CH₂S(═O)₂CHF₂
O

A-0257
CH₂CF₃
H
Cl
F
CH₂CH₂CH₂S(═O)₂CHF₂
O

A-0258
CH₂CF₃
H
Cl
F
CH₂CH₂CH₂CH₂S(═O)₂CHF₂
O

TABLE 7

Compound

Number
R¹
R²
R³
R⁴
R⁵
A

A-0259
CH₂CF₃
H
Cl
F
CH₂CH₂CH₂CH₂CH₂S(═O)₂CHF₂
O

A-0260
CH₂CF₃
H
Cl
F
CH₂CH₂CH₂CH₂CH₂CH₂S(═O)₂CHF₂
O

A-0261
CH₂CF₃
H
Cl
F
CH₂CH₂S(═O)₂CF₃
O

A-0262
CH₂CF₃
H
Cl
F
CH₂CH₂CH₂S(═O)₂CF₃
O

A-0263
CH₂CF₃
H
Cl
F
CH₂CH₂CH₂CH₂S(═O)₂CF₃
O

A-0264
CH₂CF₃
H
Cl
F
CH₂CH₂CH₂CH₂CH₂S(═O)₂CF₃
O

A-0265
CH₂CF₃
H
Cl
F
CH₂CH₂CH₂CH₂CH₂CH₂S(═O)₂CF₃
O

A-0266
CH₂CF₃
H
Cl
F
CH₂CH₂CH₂CH₂CH₂CH₂CH₂S(═O)₂CF₃
O

A-0267
CH₂CF₃
H
Cl
F
CH₂CH₂CH₂CH₂CH₂CH₂CH₂CH₂S(═O)₂CF₃
O

A-0268
CH₂CF₃
H
Cl
F
CH₂CH₂S(═O)₂CH₂CF₃
O

A-0269
CH₂CF₃
H
Cl
F
CH₂CH₂CH₂S(═O)₂CH₂CF₃
O

A-0270
CH₂CF₃
H
Cl
F
CH₂CH₂CH₂CH₂S(═O)₂CH₂CF₃
O

A-0271
CH₂CF₃
H
Cl
F
CH₂CH₂CH₂CH₂CH₂S(═O)₂CH₂CF₃
O

A-0272
CH₂CF₃
H
Cl
F
CH₂CH₂CH₂CH₂CH₂CH₂S(═O)₂CH₂CF₃
O

A-0273
CH₂CF₃
H
Cl
F
CH₂CH(Me)S(═O)₂CH₂CF₃
O

A-0274
CH₂CF₃
H
Cl
F
CH₂CH₂CH₂S(═O)₂(c-Pr)
O

A-0275
CH₂CF₃
H
Cl
F
CH₂CH₂CH₂CH₂S(═O)₂(c-Pr)
O

A-0276
CH₂CF₃
H
Cl
F
CH₂CH₂CH₂CH₂CH₂S(═O)₂(c-Pr)
O

A-0277
CH₂CF₃
H
Cl
F
CH₂CH₂CH₂S(═O)₂[c-Hex(4,4-F₂)]
O

A-0278
CH₂CF₃
H
Cl
F
CH₂CH₂CH₂CH₂S(═O)₂[c-Hex(4,4-F₂)]
O

A-0279
CH₂CF₃
H
Cl
F
CH₂CH₂CH₂CH₂CH₂S(═O)₂[c-Hex(4,4-F₂)]
O

A-0280
CH₂CF₃
H
Cl
F
CH₂CH₂CH₂C(═O)H
O

A-0281
CH₂CF₃
H
Cl
F
CH₂CH₂CH₂CH₂C(═O)H
O

A-0282
CH₂CF₃
H
Cl
F
CH₂CH₂CH₂CH₂CH₂C(═O)H
O

A-0283
CH₂CF₃
H
Cl
F
CH₂CH₂CH₂C(═O)(t-Bu)
O

A-0284
CH₂CF₃
H
Cl
F
CH₂CH₂CH₂CH₂C(═O)(t-Bu)
O

A-0285
CH₂CF₃
H
Cl
F
CH₂CH₂CH₂CH₂CH₂C(═O)(t-Bu)
O

A-0286
CH₂CF₃
H
Cl
F
CH₂CH₂CH₂C(═O)CF₃
O

A-0287
CH₂CF₃
H
Cl
F
CH₂CH₂CH₂CH₂C(═O)CF₃
O

A-0288
CH₂CF₃
H
Cl
F
CH₂CH₂CH₂CH₂CH₂C(═O)CF₃
O

A-0289
CH₂CF₃
H
Cl
F
CH₂C(═O)Ph
O

A-0290
CH₂CF₃
H
Cl
F
CH₂C(═O)Ph(4-Cl)
O

A-0291
CH₂CF₃
H
Cl
F
CH₂C(═O)Ph(4-CF₃)
O

A-0292
CH₂CF₃
H
Cl
F
CH₂CH₂C(═O)Ph(4-CF₃)
O

A-0293
CH₂CF₃
H
Cl
F
CH₂CH₂CH₂C(═O)Ph(4-CF₃)
O

A-0294
CH₂CF₃
H
Cl
F
CH₂CH₂CH₂CH₂C(═O)Ph(4-CF₃)
O

A-0295
CH₂CF₃
H
Cl
F
CH₂CH₂CH₂CH₂CH₂C(═O)Ph(4-CF₃)
O

A-0296
CH₂CF₃
H
Cl
F
CH₂C(═O)OEt
O

A-0297
CH₂CF₃
H
Cl
F
CH₂CH₂C(═O)O(t-Bu)
O

A-0298
CH₂CF₃
H
Cl
F
CH₂CH₂CH₂C(═O)OEt
O

A-0299
CH₂CF₃
H
Cl
F
CH₂CH₂CH₂C(═O)O(t-Bu)
O

A-0300
CH₂CF₃
H
Cl
F
CH₂CH₂CH₂CH₂C(═O)O(t-Bu)
O

A-0301
CH₂CF₃
H
Cl
F
CH₂CH₂CH₂CH₂CH₂C(═O)O(t-Bu)
O

A-0302
CH₂CF₃
H
Cl
F
CH₂CH₂CH₂CH₂CH₂CH₂C(═O)O(t-Bu)
O

TABLE 8

Compound

Number
R¹
R²
R³
R⁴
R⁵
A

A-0303
CH₂CF₃
H
Cl
F
CH₂CH₂CH₂CH₂CH₂CH₂CH₂C(═O)OEt
O

A-0304
CH₂CF₃
H
Cl
F
CH₂CH₂C(═O)OCH₂CF₃
O

A-0305
CH₂CF₃
H
Cl
F
CH₂CH₂CH₂C(═O)OCH₂CF₃
O

A-0306
CH₂CF₃
H
Cl
F
CH₂CH₂CH₂CH₂C(═O)OCH₂CF₃
O

A-0307
CH₂CF₃
H
Cl
F
CH₂CH₂CH₂CH₂CH₂C(═O)OCH₂CF₃
O

A-0308
CH₂CF₃
H
Cl
F
CH₂CH₂C(═O)NH(t-Bu)
O

A-0309
CH₂CF₃
H
Cl
F
CH₂CH₂CH₂C(═O)NH(t-Bu)
O

A-0310
CH₂CF₃
H
Cl
F
CH₂CH₂CH₂C(═O)NH(t-Pen)
O

A-0311
CH₂CF₃
H
Cl
F
CH₂CH₂CH₂CH₂C(═O)NH(t-Bu)
O

A-0312
CH₂CF₃
H
Cl
F
CH₂CH₂C(═O)NHCH₂CF₃
O

A-0313
CH₂CF₃
H
Cl
F
CH₂CH₂CH₂C(═O)NHCH₂CF₃
O

A-0314
CH₂CF₃
H
Cl
F
CH₂CH₂CH₂CH₂C(═O)NHCH₂CF₃
O

A-0315
CH₂CF₃
H
Cl
F
CH₂CH₂SC(═O)N(Me)₂
O

A-0316
CH₂CF₃
H
Cl
F
CH₂CH₂CH₂SC(═O)N(Me)₂
O

A-0317
CH₂CF₃
H
Cl
F
CH₂CH₂CH₂SC(═O)NH(t-Bu)
O

A-0318
CH₂CF₃
H
Cl
F
CH₂CH₂CH₂CH₂CH₂SC(═O)NH(t-Bu)
O

A-0319
CH₂CF₃
H
Cl
F
CH₂CH₂SC(═O)NHCH₂CF₃
O

A-0320
CH₂CF₃
H
Cl
F
CH₂CH₂CH₂SC(═O)NHCH₂CF₃
O

A-0321
CH₂CF₃
H
Cl
F
CH₂CH₂CH₂CH₂SC(═O)NHCH₂CF₃
O

A-0322
CH₂CF₃
H
Cl
F
CH₂CH₂CH₂OC(═O)H
O

A-0323
CH₂CF₃
H
Cl
F
CH₂CH₂CH₂CH₂OC(═O)H
O

A-0324
CH₂CF₃
H
Cl
F
CH₂CH₂CH₂CH₂CH₂OC(═O)H
O

A-0325
CH₂CF₃
H
Cl
F
CH₂CH₂CH₂OC(═O)Me
O

A-0326
CH₂CF₃
H
Cl
F
CH₂CH₂CH₂CH₂OC(═O)Me
O

A-0327
CH₂CF₃
H
Cl
F
CH₂CH₂CH₂CH₂CH₂OC(═O)Me
O

A-0328
CH₂CF₃
H
Cl
F
CH₂CH₂OC(═O)CF₃
O

A-0329
CH₂CF₃
H
Cl
F
CH₂CH₂CH₂OC(═O)CF₃
O

A-0330
CH₂CF₃
H
Cl
F
CH₂CH₂CH₂CH₂OC(═O)CF₃
O

A-0331
CH₂CF₃
H
Cl
F
CH₂CH₂CH₂CH₂CH₂OC(═O)Ph(4-CF₃)
O

A-0332
CH₂CF₃
H
Cl
F
CH₂CH₂OC(═O)Ph
O

A-0333
CH₂CF₃
H
Cl
F
CH₂CH₂OC(═O)Ph(4-CF₃)
O

A-0334
CH₂CF₃
H
Cl
F
CH₂CH₂CH₂OC(═O)Ph(4-CF₃)
O

A-0335
CH₂CF₃
H
Cl
F
CH₂CH₂CH₂CH₂OC(═O)Ph(4-CF₃)
O

A-0336
CH₂CF₃
H
Cl
F
CH₂CH₂CH₂CH₂CH₂OC(═O)Ph(4-CF₃)
O

A-0337
CH₂CF₃
H
Cl
F
CH₂CH₂OS(═O)Me
O

A-0338
CH₂CF₃
H
Cl
F
CH₂CH₂CH₂OS(═O)Me
O

A-0339
CH₂CF₃
H
Cl
F
CH₂CH₂CH₂CH₂OS(═O)Me
O

A-0340
CH₂CF₃
H
Cl
F
CH₂CH₂CH₂CH₂CH₂OS(═O)Me
O

A-0341
CH₂CF₃
H
Cl
F
CH₂CH₂CH₂CH₂CH₂CH₂OS(═O)Me
O

A-0342
CH₂CF₃
H
Cl
F
CH₂CH₂OS(═O)CF₃
O

A-0343
CH₂CF₃
H
Cl
F
CH₂CH₂CH₂OS(═O)CF₃
O

A-0344
CH₂CF₃
H
Cl
F
CH₂CH₂CH₂CH₂OS(═O)CF₃
O

A-0345
CH₂CF₃
H
Cl
F
CH₂CH₂CH₂CH₂CH₂OS(═O)CF₃
O

A-0346
CH₂CF₃
H
Cl
F
CH₂CH₂CH₂CH₂CH₂CH₂OS(═O)CF₃
O

TABLE 9

Compound

Number
R¹
R²
R³
R⁴
R⁵
A

A-0347
CH₂CF₃
H
Cl
F
CH₂CH₂OS(═O)Ph
O

A-0348
CH₂CF₃
H
Cl
F
CH₂CH₂OS(═O)Ph(4-Me)
O

A-0349
CH₂CF₃
H
Cl
F
CH₂CH₂CH₂OS(═O)Ph
O

A-0350
CH₂CF₃
H
Cl
F
CH₂CH₂CH₂OS(═O)Ph(4-Me)
O

A-0351
CH₂CF₃
H
Cl
F
CH₂CH₂OS(═O)₂Me
O

A-0352
CH₂CF₃
H
Cl
F
CH₂CH₂CH₂OS(═O)₂Me
O

A-0353
CH₂CF₃
H
Cl
F
CH₂CH₂CH₂OS(═O)₂CF₃
O

A-0354
CH₂CF₃
H
Cl
F
CH₂CH₂CH₂CH₂OS(═O)₂CF₃
O

A-0355
CH₂CF₃
H
Cl
F
CH₂CH₂CH₂CH₂CH₂OS(═O)₂CF₃
O

A-0356
CH₂CF₃
H
Cl
F
CH₂CH₂CH₂CH₂CH₂OS(═O)₂CF₂CF₂CF₂CF₃
O

A-0357
CH₂CF₃
H
Cl
F
CH₂CH₂OS(═O)₂Ph
O

A-0358
CH₂CF₃
H
Cl
F
CH₂CH₂OS(═O)₂Ph(4-Me)
O

A-0359
CH₂CF₃
H
Cl
F
CH₂CH₂CH₂OS(═O)₂Ph
O

A-0360
CH₂CF₃
H
Cl
F
CH₂CH₂CH₂OS(═O)₂Ph(4-Me)
O

A-0361
CH₂CF₃
H
Cl
F
CH₂CH₂NH₂
O

A-0362
CH₂CF₃
H
Cl
F
CH₂CH₂CH₂NH₂
O

A-0363
CH₂CF₃
H
Cl
F
CH₂CH₂CH₂CH₂NH₂
O

A-0364
CH₂CF₃
H
Cl
F
CH₂CH₂CH₂CH₂CH₂NH₂
O

A-0365
CH₂CF₃
H
Cl
F
CH₂CH₂CH₂CH₂CH₂CH₂NH₂
O

A-0366
CH₂CF₃
H
Cl
F
CH₂CH₂CH₂CH₂CH₂CH₂CH₂NH₂
O

A-0367
CH₂CF₃
H
Cl
F
CH₂CH(Me)NH₂
O

A-0368
CH₂CF₃
H
Cl
F
CH₂C*H(Me)NH₂:(R)
O

A-0369
CH₂CF₃
H
Cl
F
CH₂C*H(Me)NH₂:(S)
O

A-0370
CH₂CF₃
H
Cl
F
CH₂CH(Et)NH₂
O

A-0371
CH₂CF₃
H
Cl
F
CH₂CH(i-Pr)NH₂
O

A-0372
CH₂CF₃
H
Cl
F
CH(Me)CH₂NH₂
O

A-0373
CH₂CF₃
H
Cl
F
CH(Et)CH₂NH₂
O

A-0374
CH₂CF₃
H
Cl
F
CH(i-Pr)CH₂NH₂
O

A-0375
CH₂CF₃
H
Cl
F
CH₂CH₂CH(Me)NH₂
O

A-0376
CH₂CF₃
H
Cl
F
CH₂CH(Me)CH₂NH₂
O

A-0377
CH₂CF₃
H
Cl
F
CH(Me)CH₂CH₂NH₂
O

A-0378
CH₂CF₃
H
Cl
F
CH₂CH(Me)NH(c-Pr)
O

A-0379
CH₂CF₃
H
Cl
F
CH₂CH(Me)NHOMe
O

A-0380
CH₂CF₃
H
Cl
F
CH₂CH(Me)N(OMe)S(═O)₂Ph(2-NO₂)
O

A-0381
CH₂CF₃
H
Cl
F
CH₂CH(Me)N(OMe)S(═O)₂Ph(4-NO₂)
O

A-0382
CH₂CF₃
H
Cl
F
CH₂CH₂N(Me)(t-Bu)
O

A-0383
CH₂CF₃
H
Cl
F
CH₂CH₂CH₂N(Me)(t-Bu)
O

A-0384
CH₂CF₃
H
Cl
F
CH₂CH₂CH₂CH₂N(Me)(t-Bu)
O

A-0385
CH₂CF₃
H
Cl
F
CH₂CH₂NHCH₂CF₃
O

A-0386
CH₂CF₃
H
Cl
F
CH₂CH₂CH₂NHCH₂CF₃
O

A-0387
CH₂CF₃
H
Cl
F
CH₂CH₂CH₂CH₂NHCH₂CF₃
O

A-0388
CH₂CF₃
H
Cl
F
CH₂CH₂NHC(═O)C(Me)(CF₃)₂
O

A-0389
CH₂CF₃
H
Cl
F
CH₂CH₂NHC(═O)Me
O

A-0390
CH₂CF₃
H
Cl
F
CH₂CH₂NHC(═O)(t-Bu)
O

TABLE 10

Compound

Number
R¹
R²
R³
R⁴
R⁵
A

A-0391
CH₂CF₃
H
Cl
F
CH₂CH₂CH₂CH₂NHC(═O)CH(CH₃)₂
O

A-0392
CH₂CF₃
H
Cl
F
CH₂CH₂CH₂CH₂NHC(═O)(t-Bu)
O

A-0393
CH₂CF₃
H
Cl
F
CH₂CH₂CH₂CH₂NHC(═O)CH₂(t-Bu)
O

A-0394
CH₂CF₃
H
Cl
F
CH₂CH₂NHC(═O)CF₃
O

A-0395
CH₂CF₃
H
Cl
F
CH₂CH₂NHC(═O)CH₂CF₃
O

A-0396
CH₂CF₃
H
Cl
F
CH₂CH₂NHC(═O)CF₂CF₃
O

A-0397
CH₂CF₃
H
Cl
F
CH₂CH₂CH₂NHC(═O)CF₃
O

A-0398
CH₂CF₃
H
Cl
F
CH₂CH₂CH₂NHC(═O)CH₂CF₃
O

A-0399
CH₂CF₃
H
Cl
F
CH₂CH₂CH₂NHC(═O)CF₂CF₃
O

A-0400
CH₂CF₃
H
Cl
F
CH₂CH₂CH₂CH₂NHC(═O)CF₃
O

A-0401
CH₂CF₃
H
Cl
F
CH₂CH₂CH₂CH₂NHC(═O)CH₂CF₃
O

A-0402
CH₂CF₃
H
Cl
F
CH₂CH₂CH₂CH₂NHC(═O)CF₂CF₃
O

A-0403
CH₂CF₃
H
Cl
F
CH₂CH₂CH₂CH₂NHC(═O)CF(CF₃)₂
O

A-0404
CH₂CF₃
H
Cl
F
CH₂CH₂CH₂CH₂NHC(═O)CCl₃
O

A-0405
CH₂CF₃
H
Cl
F
CH₂CH(Me)NHC(═O)CF₃
O

A-0406
CH₂CF₃
H
Cl
F
CH₂CH₂NHC(═O)Ph
O

A-0407
CH₂CF₃
H
Cl
F
CH₂CH₂NHC(═O)Ph(4-CF₃)
O

A-0408
CH₂CF₃
H
Cl
F
CH₂CH₂CH₂NHC(═O)Ph(4-CF₃)
O

A-0409
CH₂CF₃
H
Cl
F
CH₂CH₂CH₂CH₂NHC(═O)Ph(4-CF₃)
O

A-0410
CH₂CF₃
H
Cl
F
CH₂CH₂NHC(═O)O(t-Bu)
O

A-0411
CH₂CF₃
H
Cl
F
CH₂CH₂CH₂NHC(═O)O(t-Bu)
O

A-0412
CH₂CF₃
H
Cl
F
CH₂CH₂CH₂CH₂NHC(═O)O(t-Bu)
O

A-0413
CH₂CF₃
H
Cl
F
CH₂CH₂CH₂CH₂NHC(═O)OCH(CH₃)₂
O

A-0414
CH₂CF₃
H
Cl
F
CH₂CH(Me)NHC(═O)O(t-Bu)
O

A-0415
CH₂CF₃
H
Cl
F
CH₂C*H(Me)NHC(═O)O(t-Bu):(R)
O

A-0416
CH₂CF₃
H
Cl
F
CH₂C*H(Me)NHC(═O)O(t-Bu):(S)
O

A-0417
CH₂CF₃
H
Cl
F
CH₂CH(Et)NHC(═O)O(t-Bu)
O

A-0418
CH₂CF₃
H
Cl
F
CH₂CH(i-Pr)NHC(═O)O(t-Bu)
O

A-0419
CH₂CF₃
H
Cl
F
CH(Me)CH₂NHC(═O)O(t-Bu)
O

A-0420
CH₂CF₃
H
Cl
F
CH(Et)CH₂NHC(═O)O(t-Bu)
O

A-0421
CH₂CF₃
H
Cl
F
CH(i-Pr)CH₂NHC(═O)O(t-Bu)
O

A-0422
CH₂CF₃
H
Cl
F
CH₂CH(Me)CH₂NHC(═O)O(t-Bu)
O

A-0423
CH₂CF₃
H
Cl
F
CH₂CH₂NHC(═O)OC(Me)₂CF₃
O

A-0424
CH₂CF₃
H
Cl
F
CH₂CH₂CH₂NHC(═O)OCH₂CF₃
O

A-0425
CH₂CF₃
H
Cl
F
CH₂CH₂CH₂NHC(═O)OCH₂CH₂CF₃
O

A-0426
CH₂CF₃
H
Cl
F
CH₂CH₂CH₂CH₂NHC(═O)OCH₂CCl₃
O

A-0427
CH₂CF₃
H
Cl
F
CH₂CH₂CH₂CH₂NHC(═O)OCH₂CF₃
O

A-0428
CH₂CF₃
H
Cl
F
CH₂CH₂NHC(═O)NH(t-Bu)
O

A-0429
CH₂CF₃
H
Cl
F
CH₂CH₂CH₂NHC(═O)NH(t-Bu)
O

A-0430
CH₂CF₃
H
Cl
F
CH₂CH₂CH₂CH₂NHC(═O)NHEt
O

A-0431
CH₂CF₃
H
Cl
F
CH₂CH₂CH₂CH₂NHC(═O)NH(t-Bu)
O

A-0432
CH₂CF₃
H
Cl
F
CH₂CH₂CH₂NHC(═O)NHCH₂CCl₃
O

A-0433
CH₂CF₃
H
Cl
F
CH₂CH₂CH₂NHC(═O)NHCH₂CH₂F
O

A-0434
CH₂CF₃
H
Cl
F
CH₂CH₂CH₂NHC(═O)NHCH₂CF₃
O

TABLE 11

Compound

Number
R¹
R²
R³
R⁴
R⁵
A

A-0435
CH₂CF₃
H
Cl
F
CH₂CH₂CH₂CH₂NHC(═O)NHCH₂CCl₃
O

A-0436
CH₂CF₃
H
Cl
F
CH₂CH₂CH₂CH₂NHC(═O)NHCH₂CH₂F
O

A-0437
CH₂CF₃
H
Cl
F
CH₂CH₂CH₂CH₂NHC(═O)NHCH₂CF₃
O

A-0438
CH₂CF₃
H
Cl
F
CH₂CH₂NHS(═O)Me
O

A-0439
CH₂CF₃
H
Cl
F
CH₂CH₂CH₂NHS(═O)Me
O

A-0440
CH₂CF₃
H
Cl
F
CH₂CH₂CH₂CH₂NHS(═O)Me
O

A-0441
CH₂CF₃
H
Cl
F
CH₂CH₂CH₂CH₂NHS(═O)CH(CH₃)₂
O

A-0442
CH₂CF₃
H
Cl
F
CH₂CH₂CH₂CH₂CH₂NHS(═O)Me
O

A-0443
CH₂CF₃
H
Cl
F
CH₂CH₂NHS(═O)CHF₂
O

A-0444
CH₂CF₃
H
Cl
F
CH₂CH₂CH₂NHS(═O)CHF₂
O

A-0445
CH₂CF₃
H
Cl
F
CH₂CH₂CH₂CH₂NHS(═O)CHF₂
O

A-0446
CH₂CF₃
H
Cl
F
CH₂CH₂CH₂CH₂CH₂NHS(═O)CHF₂
O

A-0447
CH₂CF₃
H
Cl
F
CH₂CH(Me)NHS(═O)CHF₂
O

A-0448
CH₂CF₃
H
Cl
F
CH(Me)CH₂NHS(═O)CHF₂
O

A-0449
CH₂CF₃
H
Cl
F
CH₂CH₂CH(Me)NHS(═O)CHF₂
O

A-0450
CH₂CF₃
H
Cl
F
CH₂CH(Me)CH₂NHS(═O)CHF₂
O

A-0451
CH₂CF₃
H
Cl
F
CH(Me)CH₂CH₂NHS(═O)CHF₂
O

A-0452
CH₂CF₃
H
Cl
F
CH₂CH₂NHS(═O)CF₃
O

A-0453
CH₂CF₃
H
Cl
F
CH₂CH₂CH₂NHS(═O)CF₃
O

A-0454
CH₂CF₃
H
Cl
F
CH₂CH₂CH₂CH₂NHS(═O)CF₃
O

A-0455
CH₂CF₃
H
Cl
F
CH₂CH₂CH₂CH₂CH₂NHS(═O)CF₃
O

A-0456
CH₂CF₃
H
Cl
F
CH₂CH₂CH₂NHS(═O)Ph
O

A-0457
CH₂CF₃
H
Cl
F
CH₂CH₂CH₂CH₂NHS(═O)Ph
O

A-0458
CH₂CF₃
H
Cl
F
CH₂CH₂CH₂CH₂CH₂NHS(═O)Ph
O

A-0459
CH₂CF₃
H
Cl
F
CH₂CH₂CH₂CH₂CH₂NHS(═O)Ph(4-CF₃)
O

A-0460
CH₂CF₃
H
Cl
F
CH₂CH(Me)NHS(═O)Ph(4-CF₃)
O

A-0461
CH₂CF₃
H
Cl
F
CH₂CH(Et)NHS(═O)Ph(4-CF₃)
O

A-0462
CH₂CF₃
H
Cl
F
CH(Me)CH₂NHS(═O)Ph(4-CF₃)
O

A-0463
CH₂CF₃
H
Cl
F
CH(Et)CH₂NHS(═O)Ph(4-CF₃)
O

A-0464
CH₂CF₃
H
Cl
F
CH₂CH(Et)CH₂NHS(═O)Ph(4-CF₃)
O

A-0465
CH₂CF₃
H
Cl
F
CH₂CH₂NHS(═O)₂Me
O

A-0466
CH₂CF₃
H
Cl
F
CH₂CH₂CH₂NHS(═O)₂Me
O

A-0467
CH₂CF₃
H
Cl
F
CH₂CH₂CH₂CH₂NHS(═O)₂Me
O

A-0468
CH₂CF₃
H
Cl
F
CH₂CH₂CH₂CH₂NHS(═O)₂CH(CH₃)₂
O

A-0469
CH₂CF₃
H
Cl
F
CH₂CH₂CH₂CH₂CH₂NHS(═O)₂Me
O

A-0470
CH₂CF₃
H
Cl
F
CH₂CH₂NHS(═O)₂CHF₂
O

A-0471
CH₂CF₃
H
Cl
F
CH₂CH₂CH₂NHS(═O)₂CHF₂
O

A-0472
CH₂CF₃
H
Cl
F
CH₂CH₂CH₂CH₂NHS(═O)₂CHF₂
O

A-0473
CH₂CF₃
H
Cl
F
CH₂CH₂CH₂CH₂CH₂NHS(═O)₂CHF₂
O

A-0474
CH₂CF₃
H
Cl
F
CH₂CH(Me)NHS(═O)₂CHF₂
O

A-0475
CH₂CF₃
H
Cl
F
CH(Me)CH₂NHS(═O)₂CHF₂
O

A-0476
CH₂CF₃
H
Cl
F
CH₂CH₂CH(Me)NHS(═O)₂CHF₂
O

A-0477
CH₂CF₃
H
Cl
F
CH₂CH(Me)CH₂NHS(═O)₂CHF₂
O

A-0478
CH₂CF₃
H
Cl
F
CH(Me)CH₂CH₂NHS(═O)₂CHF₂
O

TABLE 12

Compound

Number
R¹
R²
R³
R⁴
R⁵
A

A-0479
CH₂CF₃
H
Cl
F
CH₂CH(Me)N(Me)S(═O)₂CHF₂
O

A-0480
CH₂CF₃
H
Cl
F
CH(Me)CH₂N(Me)S(═O)₂CHF₂
O

A-0481
CH₂CF₃
H
Cl
F
CH₂CH₂CH(Me)N(Me)S(═O)₂CHF₂
O

A-0482
CH₂CF₃
H
Cl
F
CH₂CH(Me)CH₂N(Me)S(═O)₂CHF₂
O

A-0483
CH₂CF₃
H
Cl
F
CH(Me)CH₂CH₂N(Me)S(═O)₂CHF₂
O

A-0484
CH₂CF₃
H
Cl
F
CH₂CH₂CH₂NHS(═O)₂Ph
O

A-0485
CH₂CF₃
H
Cl
F
CH₂CH₂CH₂CH₂NHS(═O)₂Ph
O

A-0486
CH₂CF₃
H
Cl
F
CH₂CH₂CH₂CH₂CH₂NHS(═O)₂Ph
O

A-0487
CH₂CF₃
H
Cl
F
CH₂CH₂CH₂CH₂CH₂NHS(═O)₂Ph(4-CF₃)
O

A-0488
CH₂CF₃
H
Cl
F
CH₂CH(Me)NHS(═O)₂Ph(4-CF₃)
O

A-0489
CH₂CF₃
H
Cl
F
CH₂CH(Et)NHS(═O)₂Ph(4-CF₃)
O

A-0490
CH₂CF₃
H
Cl
F
CH(Me)CH₂NHS(═O)₂Ph(4-CF₃)
O

A-0491
CH₂CF₃
H
Cl
F
CH(Et)CH₂NHS(═O)₂Ph(4-CF₃)
O

A-0492
CH₂CF₃
H
Cl
F
CH₂CH(Me)CH₂NHS(═O)₂Ph(4-CF₃)
O

A-0493
CH₂CF₃
H
Cl
F
CH₂CH₂SiMe₃
O

A-0494
CH₂CF₃
H
Cl
F
CH₂CH₂CH₂SiMe₃
O

A-0495
CH₂CF₃
H
Cl
F
CH₂CH₂CH₂CH₂SiMe₃
O

A-0496
CH₂CF₃
H
Cl
F
CH₂Ph
O

A-0497
CH₂CF₃
H
Cl
F
CH₂Ph(2-CF₃)
O

A-0498
CH₂CF₃
H
Cl
F
CH₂Ph(3-CF₃)
O

A-0499
CH₂CF₃
H
Cl
F
CH₂Ph(4-CF₃)
O

A-0500
CH₂CF₃
H
Cl
F
CH₂Ph(2-OCF₃)
O

A-0501
CH₂CF₃
H
Cl
F
CH₂Ph(3-OCF₃)
O

A-0502
CH₂CF₃
H
Cl
F
CH₂Ph(4-OCF₃)
O

A-0503
CH₂CF₃
H
Cl
F
CH₂Ph(2-SCF₃)
O

A-0504
CH₂CF₃
H
Cl
F
CH₂Ph(3-SCF₃)
O

A-0505
CH₂CF₃
H
Cl
F
CH₂Ph(4-SCF₃)
O

A-0506
CH₂CF₃
H
Cl
F
CH₂Ph(3-CH₂SCF₃)
O

A-0507
CH₂CF₃
H
Cl
F
CH₂Ph(4-F)
O

A-0508
CH₂CF₃
H
Cl
F
CH₂Ph(4-Cl)
O

A-0509
CH₂CF₃
H
Cl
F
CH₂Ph(4-Br)
O

A-0510
CH₂CF₃
H
Cl
F
CH₂Ph(4-Me)
O

A-0511
CH₂CF₃
H
Cl
F
CH₂Ph[4-(t-Bu)]
O

A-0512
CH₂CF₃
H
Cl
F
CH₂Ph(4-CN)
O

A-0513
CH₂CF₃
H
Cl
F
CH₂Ph(4-NO₂)
O

A-0514
CH₂CF₃
H
Cl
F
CH₂Ph(4-OCHF₂)
O

A-0515
CH₂CF₃
H
Cl
F
CH₂Ph(4-SCHF₂)
O

A-0516
CH₂CF₃
H
Cl
F
CH₂Ph(4-CH₂SCF₃)
O

A-0517
CH₂CF₃
H
Cl
F
CH₂Ph[4-CF(CF₃)₂]
O

A-0518
CH₂CF₃
H
Cl
F
CH₂Ph(4-CH₂SCF₃)
O

A-0519
CH₂CF₃
H
Cl
F
CH₂Ph[4-Ph(4-CF₃)]
O

A-0520
CH₂CF₃
H
Cl
F
CH₂Ph(2,4-Cl₂)
O

A-0521
CH₂CF₃
H
Cl
F
CH₂Ph[2,5-(CF₃)₂]
O

A-0522
CH₂CF₃
H
Cl
F
CH₂Ph(3,4-Cl₂)
O

TABLE 13

Com-

pound

Number
R¹
R²
R³
R⁴
R⁵
A

A-0523
CH₂CF₃
H
Cl
F
CH₂Ph(3-CF₃-4-F)
O

A-0524
CH₂CF₃
H
Cl
F
CH₂Ph(3-CF₃-4-Cl)
O

A-0525
CH₂CF₃
H
Cl
F
CH₂Ph(3-F-4-CF₃)
O

A-0526
CH₂CF₃
H
Cl
F
CH₂Ph(2,4,6-F₃)
O

A-0527
CH₂CF₃
H
Cl
F
CH₂Ph(3,4,5-F₃)
O

A-0528
CH₂CF₃
H
Cl
F
CH₂Ph(2,3,4-F₃)
O

A-0529
CH₂CF₃
H
Cl
F
CH₂Ph(3,4,5-Cl₃)
O

A-0530
CH₂CF₃
H
Cl
F
CH₂CH₂Ph
O

A-0531
CH₂CF₃
H
Cl
F
CH₂CH₂Ph(4-F)
O

A-0532
CH₂CF₃
H
Cl
F
CH₂CH₂Ph(4-Cl)
O

A-0533
CH₂CF₃
H
Cl
F
CH₂CH₂Ph(4-Br)
O

A-0534
CH₂CF₃
H
Cl
F
CH₂CH₂Ph[4-(t-Bu)]
O

A-0535
CH₂CF₃
H
Cl
F
CH₂CH₂Ph(2-CF₃)
O

A-0536
CH₂CF₃
H
Cl
F
CH₂CH₂Ph(3-CF₃)
O

A-0537
CH₂CF₃
H
Cl
H
CH₂CH₂Ph(4-CF₃)
O

A-0538
CH₂CF₃
H
Cl
F
CH₂CH₂Ph(4-CF₃)
O

A-0539
CH₂CF₃
H
Cl
F
CH₂CH₂Ph(4-CF(CF₃)₂)
O

A-0540
CH₂CF₃
H
Cl
F
CH₂CH₂Ph[4-(c-Pr)]
O

A-0541
CH₂CF₃
H
Cl
F
CH₂CH₂Ph{4-[c-Pr(2,2-F₂)]}
O

A-0542
CH₂CF₃
H
Cl
F
CH₂CH₂Ph(4-OMe)
O

A-0543
CH₂CF₃
H
Cl
F
CH₂CH₂Ph(3-OCF₃)
O

A-0544
CH₂CF₃
H
Cl
F
CH₂CH₂Ph(4-OCHF₂)
O

A-0545
CH₂CF₃
H
Cl
F
CH₂CH₂Ph(4-OCF₃)
O

A-0546
CH₂CF₃
H
Cl
F
CH₂CH₂Ph(4-SMe)
O

A-0547
CH₂CF₃
H
Cl
F
CH₂CH₂Ph(4-SCHF₂)
O

A-0548
CH₂CF₃
H
Cl
F
CH₂CH₂Ph(4-SCF₃)
O

A-0549
CH₂CF₃
H
Cl
F
CH₂CH₂Ph[4-S(═O)Me]
O

A-0550
CH₂CF₃
H
Cl
F
CH₂CH₂Ph[4-S(═O)CF₃]
O

A-0551
CH₂CF₃
H
Cl
F
CH₂CH₂Ph[4-S(═O)₂Me]
O

A-0552
CH₂CF₃
H
Cl
F
CH₂CH₂Ph[4-S(═O)₂CF₃]
O

A-0553
CH₂CF₃
H
Cl
F
CH₂CH₂Ph(4-CH₂SMe)
O

A-0554
CH₂CF₃
H
Cl
F
CH₂CH₂Ph(4-CH₂SCF₃)
O

A-0555
CH₂CF₃
H
Cl
F
CH₂CH₂Ph[4-OS(═O)₂Me]
O

A-0556
CH₂CF₃
H
Cl
F
CH₂CH₂Ph[4-OS(═O)₂CF₃]
O

A-0557
CH₂CF₃
H
Cl
F
CH₂CH₂Ph[4-Ph(4-CF₃)]
O

A-0558
CH₂CF₃
H
Cl
F
CH₂CH₂Ph(4-CH₂Ph)
O

A-0559
CH₂CF₃
H
Cl
F
CH₂CH₂Ph(4-OCH₂Ph)
O

A-0560
CH₂CF₃
H
Cl
F
CH₂CH₂Ph(4-CN)
O

A-0561
CH₂CF₃
H
Cl
F
CH₂CH₂Ph(4-NO₂)
O

A-0562
CH₂CF₃
H
Cl
F
CH₂CH₂Ph(2,4-Cl₂)
O

A-0563
CH₂CF₃
H
Cl
F
CH₂CH₂Ph(3,4-Cl₂)
O

A-0564
CH₂CF₃
H
Cl
F
CH₂CH₂Ph(3-CF₃-4-F)
O

A-0565
CH₂CF₃
H
Cl
F
CH₂CH₂Ph(2-CF₃-4-F)
O

A-0566
CH₂CF₃
H
Cl
F
CH₂CH₂Ph(3-F-4-CF₃)
O

TABLE 14

Com-

pound

Number
R¹
R²
R³
R⁴
R⁵
A

A-0567
CH₂CF₃
H
Cl
F
CH₂CH₂Ph(2-F-4-CF₃)
O

A-0568
CH₂CF₃
H
Cl
F
CH₂CH₂Ph(3-Cl-4-OCHF₂)
O

A-0569
CH₂CF₃
H
Cl
F
CH₂CH₂Ph(3,4,5-Cl₃)
O

A-0570
CH₂CF₃
H
Cl
F
CH₂CH₂Ph(2,3,4-F₃)
O

A-0571
CH₂CF₃
H
Cl
F
CH₂CH₂Ph(2,4,5-F₃)
O

A-0572
CH₂CF₃
H
Cl
F
CH₂CH₂Ph(3,4,5-F₃)
O

A-0573
CH₂CF₃
H
Cl
F
CH₂CH₂Ph(2,4,6-F₃)
O

A-0574
CH₂CF₃
H
Cl
F
CH₂CH₂CH₂Ph
O

A-0575
CH₂CF₃
H
Cl
F
CH₂CH₂CH₂Ph(3-CF₃)
O

A-0576
CH₂CF₃
H
Cl
F
CH₂CH₂CH₂Ph(4-CF₃)
O

A-0577
CH₂CF₃
H
Cl
F
CH₂CH₂CH₂Ph(4-F)
O

A-0578
CH₂CF₃
H
Cl
F
CH₂CH₂CH₂Ph[4-(t-Bu)]
O

A-0579
CH₂CF₃
H
Cl
F
CH₂CH₂CH₂Ph(4-CN)
O

A-0580
CH₂CF₃
H
Cl
F
CH₂CH₂CH₂Ph(4-CF₃)
O

A-0581
CH₂CF₃
H
Cl
F
CH₂CH₂CH₂Ph(4-OCHF₂)
O

A-0582
CH₂CF₃
H
Cl
F
CH₂CH₂CH₂Ph(4-OCF₃)
O

A-0583
CH₂CF₃
H
Cl
F
CH₂CH₂CH₂Ph(4-SCHF₂)
O

A-0584
CH₂CF₃
H
Cl
F
CH₂CH₂CH₂Ph(4-SCF₃)
O

A-0585
CH₂CF₃
H
Cl
F
CH₂CH₂CH₂Ph[4-CF(CF₃)₂]
O

A-0586
CH₂CF₃
H
Cl
F
CH₂CH₂CH₂Ph(3,4,5-F₃)
O

A-0587
CH₂CF₃
H
Cl
F
CH₂CH₂CH₂Ph(2,4,6-F₃)
O

A-0588
CH₂CF₃
H
Cl
F
CH₂CH₂CH₂CH₂Ph
O

A-0589
CH₂CF₃
H
Cl
F
CH₂CH₂CH₂CH₂Ph(4-F)
O

A-0590
CH₂CF₃
H
Cl
F
CH₂CH₂CH₂CH₂Ph(4-CF₃)
O

A-0591
CH₂CF₃
H
Cl
F
CH₂CH₂CH₂CH₂Ph(4-OCF₃)
O

A-0592
CH₂CF₃
H
Cl
F
CH₂CH₂CH₂CH₂Ph(4-SCF₃)
O

A-0593
CH₂CF₃
H
Cl
F
CH₂CH₂CH₂CH₂CH₂Ph
O

A-0594
CH₂CF₃
H
Cl
F
CH₂CH₂CH₂CH₂CH₂CH₂Ph
O

A-0595
CH₂CF₃
H
Cl
F
CH₂CF₂Ph(4-F)
O

A-0596
CH₂CF₃
H
Cl
F
CH₂CF₂Ph(4-CF₃)
O

A-0597
CH₂CF₃
H
Cl
H
CH₂CF₂Ph(3,4,5-F₃)
O

A-0598
CH₂CF₃
H
Cl
F
CH₂CF₂Ph(3,4,5-F₃)
O

A-0599
CH₂CF₃
H
Cl
F
CH₂CH₂OPh
O

A-0600
CH₂CF₃
H
Cl
F
CH₂CH₂OPh(4-F)
O

A-0601
CH₂CF₃
H
Cl
F
CH₂CH₂OPh(4-CF₃)
O

A-0602
CH₂CF₃
H
Cl
F
CH₂CH₂CH₂OPh
O

A-0603
CH₂CF₃
H
Cl
F
CH₂CH₂CH₂OPh(4-Cl)
O

A-0604
CH₂CF₃
H
Cl
F
CH₂CH₂CH₂OPh(4-CF₃)
O

A-0605
CH₂CF₃
H
Cl
F
CH₂CH₂CH₂CH₂OPh(4-CF₃)
O

A-0606
CH₂CF₃
H
Cl
F
CH₂CH₂CH₂CH₂OPh(4-OCF₃)
O

A-0607
CH₂CF₃
H
Cl
F
CH₂CH₂CH₂CH₂CH₂OPh(4-CF₃)
O

A-0608
CH₂CF₃
H
Cl
F
CH₂CH₂OCH₂Ph
O

A-0609
CH₂CF₃
H
Cl
F
CH₂CH₂CH₂OCH₂Ph
O

A-0610
CH₂CF₃
H
Cl
F
CH₂CH₂CH₂CH₂OCH₂Ph
O

TABLE 15

Com-

pound

Number
R¹
R²
R³
R⁴
R⁵
A

A-0611
CH₂CF₃
H
Cl
F
CH₂CH₂CH₂CH₂CH₂OCH₂Ph
O

A-0612
CH₂CF₃
H
Cl
F
CH₂CH₂SPh
O

A-0613
CH₂CF₃
H
Cl
F
CH₂CH₂CH₂SPh
O

A-0614
CH₂CF₃
H
Cl
F
CH₂CH₂CH₂SPh(4-F)
O

A-0615
CH₂CF₃
H
Cl
F
CH₂CH₂CH₂SPh(4-Cl)
O

A-0616
CH₂CF₃
H
Cl
F
CH₂CH₂CH₂SPh(4-Br)
O

A-0617
CH₂CF₃
H
Cl
F
CH₂CH₂CH₂SPh[4-(t-Bu)]
O

A-0618
CH₂CF₃
H
Cl
F
CH₂CH₂CH₂SPh(3-CF₃)
O

A-0619
CH₂CF₃
H
Cl
F
CH₂CH₂CH₂SPh(4-CF₃)
O

A-0620
CH₂CF₃
H
Cl
F
CH₂CH₂CH₂SPh(3-SCF₃)
O

A-0621
CH₂CF₃
H
Cl
F
CH₂CH₂CH₂SPh(4-SCF₃)
O

A-0622
CH₂CF₃
H
Cl
F
CH₂CH₂CH₂CH₂SPh
O

A-0623
CH₂CF₃
H
Cl
F
CH₂CH₂CH₂CH₂SPh(4-F)
O

A-0624
CH₂CF₃
H
Cl
F
CH₂CH₂CH₂CH₂SPh(4-Cl)
O

A-0625
CH₂CF₃
H
Cl
F
CH₂CH₂CH₂CH₂SPh[4-(t-Bu)]
O

A-0626
CH₂CF₃
H
Cl
F
CH₂CH₂CH₂CH₂SPh(4-CF₃)
O

A-0627
CH₂CF₃
H
Cl
F
CH₂CH₂CH₂CH₂CH₂SPh
O

A-0628
CH₂CF₃
H
Cl
F
CH₂CH₂CH₂CH₂CH₂SPh(4-F)
O

A-0629
CH₂CF₃
H
Cl
F
CH₂CH₂CH₂CH₂CH₂SPh(4-Cl)
O

A-0630
CH₂CF₃
H
Cl
F
CH₂CH₂CH₂CH₂CH₂SPh(4-CF₃)
O

A-0631
CH₂CF₃
H
Cl
F
CH₂CH₂S(═O)Ph
O

A-0632
CH₂CF₃
H
Cl
F
CH₂CH₂CH₂S(═O)Ph
O

A-0633
CH₂CF₃
H
Cl
F
CH₂CH₂CH₂S(═O)Ph(4-F)
O

A-0634
CH₂CF₃
H
Cl
F
CH₂CH₂CH₂S(═O)Ph[4-(t-Bu)]
O

A-0635
CH₂CF₃
H
Cl
F
CH₂CH₂CH₂S(═O)Ph(4-CF₃)
O

A-0636
CH₂CF₃
H
Cl
F
CH₂CH₂S(═O)₂Ph
O

A-0637
CH₂CF₃
H
Cl
F
CH₂CH₂S(═O)₂Ph(4-CF₃)
O

A-0638
CH₂CF₃
H
Cl
F
CH₂CH₂CH₂S(═O)₂Ph(4-F)
O

A-0639
CH₂CF₃
H
Cl
F
CH₂CH₂CH₂S(═O)₂Ph(4-Cl)
O

A-0640
CH₂CF₃
H
Cl
F
CH₂CH₂CH₂S(═O)₂Ph(4-CF₃)
O

A-0641
CH₂CF₃
H
Cl
F
CH₂CH₂CH₂CH₂S(═O)₂Ph
O

A-0642
CH₂CF₃
H
Cl
F
CH₂CH₂CH₂CH₂S(═O)₂Ph(4-Cl)
O

A-0643
CH₂CF₃
H
Cl
F
CH₂CH₂CH₂CH₂S(═O)₂Ph(4-CF₃)
O

A-0644
CH₂CF₃
H
Cl
F
CH₂CH₂SCH₂Ph
O

A-0645
CH₂CF₃
H
Cl
F
CH₂CH₂CH₂SCH₂Ph
O

A-0646
CH₂CF₃
H
Cl
F
CH₂CH₂CH₂SCH₂Ph(2-Cl)
O

A-0647
CH₂CF₃
H
Cl
F
CH₂CH₂CH₂SCH₂Ph(3-Cl)
O

A-0648
CH₂CF₃
H
Cl
F
CH₂CH₂CH₂SCH₂Ph(4-Cl)
O

A-0649
CH₂CF₃
H
Cl
F
CH₂CH₂CH₂SCH₂Ph(2-SCF₃)
O

A-0650
CH₂CF₃
H
Cl
F
CH₂CH₂CH₂SCH₂Ph(3-CF₃)
O

A-0651
CH₂CF₃
H
Cl
F
CH₂CH₂CH₂SCH₂Ph(4-CF₃)
O

A-0652
CH₂CF₃
H
Cl
F
CH₂CH₂CH₂SCH₂Ph(4-NO₂)
O

A-0653
CH₂CF₃
H
Cl
F
CH₂CH₂CH₂CH₂SCH₂Ph
O

A-0654
CH₂CF₃
H
Cl
F
CH₂CH₂CH₂CH₂SCH₂Ph(4-Cl)
O

TABLE 16

Compound

Number
R¹
R²
R³
R⁴
R⁵
A

A-0655
CH₂CF₃
H
Cl
F
CH₂CH₂CH₂CH₂SCH₂Ph(4-CF₃)
O

A-0656
CH₂CF₃
H
Cl
F
CH₂CH₂CH₂CH₂SCH₂Ph(4-CN)
O

A-0657
CH₂CF₃
H
Cl
F
CH₂CH₂CH₂CH₂CH₂SCH₂Ph
O

A-0658
CH₂CF₃
H
Cl
F
CH₂CH₂SCH₂CH₂Ph
O

A-0659
CH₂CF₃
H
Cl
F
CH₂CH₂CH₂SCH₂CH₂Ph
O

A-0660
CH₂CF₃
H
Cl
F
CH₂CH₂CH₂CH₂SCH₂CH₂Ph
O

A-0661
CH₂CF₃
H
Cl
F
CH₂CH₂SCH(Me)Ph
O

A-0662
CH₂CF₃
H
Cl
F
CH₂CH₂CH₂SCH(Me)Ph
O

A-0663
CH₂CF₃
H
Cl
F
CH₂CH₂CH₂CH₂SCH(Me)Ph
O

A-0664
CH₂CF₃
H
Cl
F
CH₂CH₂S(═O)CH₂Ph
O

A-0665
CH₂CF₃
H
Cl
F
CH₂CH₂S(═O)CH₂Ph(4-CF₃)
O

A-0666
CH₂CF₃
H
Cl
F
CH₂CH₂CH₂S(═O)CH₂Ph
O

A-0667
CH₂CF₃
H
Cl
F
CH₂CH₂CH₂S(═O)CH₂Ph(2-SCF₃)
O

A-0668
CH₂CF₃
H
Cl
F
CH₂CH₂CH₂S(═O)CH₂Ph(4-SCF₃)
O

A-0669
CH₂CF₃
H
Cl
F
CH₂CH₂CH₂S(═O)CH₂Ph(4-Cl)
O

A-0670
CH₂CF₃
H
Cl
F
CH₂CH₂CH₂S(═O)CH₂Ph(4-CF₃)
O

A-0671
CH₂CF₃
H
Cl
F
CH₂CH₂CH₂CH₂S(═O)CH₂Ph
O

A-0672
CH₂CF₃
H
Cl
F
CH₂CH₂CH₂CH₂S(═O)CH₂Ph(4-CF₃)
O

A-0673
CH₂CF₃
H
Cl
F
CH₂CH₂CH₂CH₂CH₂S(═O)CH₂Ph(4-CF₃)
O

A-0674
CH₂CF₃
H
Cl
F
CH₂CH₂S(═O)₂CH₂Ph
O

A-0675
CH₂CF₃
H
Cl
F
CH₂CH₂S(═O)₂CH₂Ph(4-CF₃)
O

A-0676
CH₂CF₃
H
Cl
F
CH₂CH₂CH₂S(═O)₂CH₂Ph
O

A-0677
CH₂CF₃
H
Cl
F
CH₂CH₂CH₂S(═O)₂CH₂Ph(4-Cl)
O

A-0678
CH₂CF₃
H
Cl
F
CH₂CH₂CH₂S(═O)₂CH₂Ph(4-CF₃)
O

A-0679
CH₂CF₃
H
Cl
F
CH₂CH₂CH₂CH₂S(═O)₂CH₂Ph
O

A-0680
CH₂CF₃
H
Cl
F
CH₂CH₂CH₂CH₂S(═O)₂CH₂Ph(4-CF₃)
O

A-0681
CH₂CF₃
H
Cl
F
CH₂CH₂CH₂CH₂CH₂S(═O)₂CH₂Ph
O

A-0682
CH₂CF₃
H
Cl
F
CH₂CH₂CH₂CH₂CH₂S(═O)₂CH₂Ph(4-CF₃)
O

A-0683
CH₂CF₃
H
Cl
F
CH₂CH₂ON═CH(t-Bu)
O

A-0684
CH₂CF₃
H
Cl
F
CH₂CH₂CH₂ON═CH(t-Bu)
O

A-0685
CH₂CF₃
H
Cl
F
CH₂CH₂CH₂CH₂ON═C(Me)(c-Pr)
O

A-0686
CH₂CF₃
H
Cl
F
CH₂CH₂ON═C(Me)CF₃
O

A-0687
CH₂CF₃
H
Cl
F
CH₂CH₂CH₂ON═CHCF₃
O

A-0688
CH₂CF₃
H
Cl
F
CH₂CH₂CH₂ON═C(Me)CF₃
O

A-0689
CH₂CF₃
H
Cl
F
CH₂CH₂CH₂ON═C(Me)CCl₃
O

A-0690
CH₂CF₃
H
Cl
F
CH₂CH₂CH₂CH₂ON═CHCF₃
O

A-0691
CH₂CF₃
H
Cl
F
CH₂CH₂CH₂CH₂ON═C(Me)CF₃
O

A-0692
CH₂CF₃
H
Cl
F
CH₂CH₂CH₂CH₂CH₂ON═C(Me)CF₃
O

A-0693
CH₂CF₃
H
Cl
F
CH₂CH₂ON═CHPh
O

A-0694
CH₂CF₃
H
Cl
F
CH₂CH₂ON═CHPh(4-CF₃)
O

A-0695
CH₂CF₃
H
Cl
F
CH₂CH₂ON═CHPh(4-SCF₃)
O

A-0696
CH₂CF₃
H
Cl
F
CH₂CH₂CH₂ON═CHPh(3-CF₃)
O

A-0697
CH₂CF₃
H
Cl
F
CH₂CH₂CH₂ON═CHPh(4-CF₃)
O

A-0698
CH₂CF₃
H
Cl
F
CH₂CH₂CH₂ON═CHPh(4-SCF₃)
O

TABLE 17

Compound

Number
R¹
R²
R³
R⁴
R⁵
A

A-0699
CH₂CF₃
H
Cl
F
CH₂CH₂CH₂ON═C(Me)Ph(4-CF₃)
O

A-0700
CH₂CF₃
H
Cl
F
CH₂CH₂CH₂CH₂ON═CHPh(4-SCF₃)
O

A-0701
CH₂CF₃
H
Cl
F
CH₂CH₂(adamant-1-yl)
O

A-0702
CH₂CF₃
H
Cl
F
CH₂CH₂CH₂(3-CF₃-pyrazol-1-yl)
O

A-0703
CH₂CF₃
H
Cl
F
CH₂CH₂CH₂CH₂(3-CF₃-pyrazol-1-yl)
O

A-0704
CH₂CF₃
H
Cl
F
CH₂CH₂CH₂CH₂CH₂(3-CF₃-pyrazol-1-yl)
O

A-0705
CH₂CF₃
H
Cl
F
CH₂(1-Me-4-CF₃-imidazol-5-yl)
O

A-0706
CH₂CF₃
H
Cl
F
CH₂CH₂(1-Me-4-CF 3-imidazol-5-yl)
O

A-0707
CH₂CF₃
H
Cl
F
CH₂CH₂CH₂(1-Me-4-CF₃-imidazol-5-yl)
O

A-0708
CH₂CF₃
H
Cl
F
CH₂CH₂CH₂(3-CF₃-1,2,4-triazol-1-yl)
O

A-0709
CH₂CF₃
H
Cl
F
CH₂CH₂CH₂CH₂(3-CF₃-1,2,4-triazol-1-yl)
O

A-0710
CH₂CF₃
H
Cl
F
CH₂CH₂CH₂CH₂CH₂(3-CF₃-1,2,4-triazol-1-yl)
O

A-0711
CH₂CF₃
H
Cl
F
CH₂CH₂CH₂(4-CF₃-thiazol-2-yl)
O

A-0712
CH₂CF₃
H
Cl
F
CH₂CH₂CH₂CH₂(4-CF₃-thiazol-2-yl)
O

A-0713
CH₂CF₃
H
Cl
F
CH₂CH₂CH₂CH₂CH₂(4-CF₃-thiazol-2-yl)
O

A-0714
CH₂CF₃
H
Cl
F
CH₂CH₂CH₂(2-CF₃-pyridin-5-yl)
O

A-0715
CH₂CF₃
H
Cl
F
CH₂CH₂CH₂CH₂(2-CF₃-pyridin-5-yl)
O

A-0716
CH₂CF₃
H
Cl
F
CH₂CH₂CH₂CH₂CH₂(2-CF₃-pyridin-5-yl)
O

A-0717
CH₂CF₃
H
Cl
F
CH₂(4-CF₃-pyrimidin-2-yl)
O

A-0718
CH₂CF₃
H
Cl
F
CH₂CH₂(4-CF₃-pyrimidin-2-yl)
O

A-0719
CH₂CF₃
H
Cl
F
CH₂CH₂CH₂(4-CF₃-pyrimidin-2-yl)
O

A-0720
CH₂CF₃
H
Cl
F
CH₂CH₂O(3-Cl-5-CF₃-pyridin-2-yl)
O

A-0721
CH₂CF₃
H
Cl
F
CH₂CH₂CH₂O(3-Cl-5-CF₃-pyridin-2-yl)
O

A-0722
CH₂CF₃
H
Cl
F
CH₂CH₂CH₂CH₂O(3-Cl-5-CF₃-pyridin-2-yl)
O

A-0723
CH₂CF₃
H
Cl
F
CH₂CH₂CH₂CH₂CH₂O(3-Cl-5-CF₃-pyridin-2-yl)
O

A-0724
CH₂CF₃
H
Cl
F
CH₂CH₂N(Phth)
O

A-0725
CH₂CF₃
H
Cl
F
CH₂CH₂CH₂N(Phth)
O

A-0726
CH₂CF₃
H
Cl
F
CH₂CH₂CH₂CH₂N(Phth)
O

A-0727
CH₂CF₃
H
Cl
F
CH₂CH₂CH₂CH₂CH₂N(Phth)
O

A-0728
CH₂CF₃
H
Cl
F
CH₂CH(Me)CH₂N(Phth)
O

A-0729
CH₂CF₃
H
Cl
F
CH₂[1,3-dioxolan(2-CF₃)-2-yl]
O

A-0730
CH₂CF₃
H
Cl
F
CH₂(azetidin-3-yl)
O

A-0731
CH₂CF₃
H
Cl
F
CH₂(pyrrolidin-3-yl)
O

A-0732
CH₂CF₃
H
Cl
F
CH₂(piperidin-3-yl)
O

A-0733
CH₂CF₃
H
Cl
F
CH₂{azetidin[1-C(═O)O(t-Bu)]-3-yl}
O

A-0734
CH₂CF₃
H
Cl
F
CH₂{pyrrolidin[1-C(═O)O(t-Bu)]-3-yl}
O

A-0735
CH₂CF₃
H
Cl
F
CH₂{piperidin[1-C(═O)O(t-Bu)]-3-yl}
O

A-0736
CH₂CF₃
H
Cl
F
CH₂{azetidin[1-C(═O)CF₃]-3-yl}
O

A-0737
CH₂CF₃
H
Cl
F
CH₂{azetidin[1-S(═O)₂CF₃]-3-yl}
O

A-0738
CH₂CF₃
H
Cl
F
CH₂{pyrrolidin[1-C(═O)CF₃]-3-yl}
O

A-0739
CH₂CF₃
H
Cl
F
CH₂{pyrrolidin[1-S(═O)₂CF₃]-3-yl}
O

A-0740
CH₂CF₃
H
Cl
F
CH₂{piperidin[1-C(═O)CF 3]-3-yl}
O

A-0741
CH₂CF₃
H
Cl
F
CH₂{piperidin[1-S(═O)₂CF₃]-3-yl}
O

A-0742
CH₂CF₃
H
Cl
F
CH₂CH₂CH₂CN
O

TABLE 18

Compound

Number
R¹
R²
R³
R⁴
R⁵
A

A-0743
CH₂CF₃
H
Cl
F
CH₂CH₂CH₂CH₂CN
O

A-0744
CH₂CF₃
H
Cl
F
CH₂CH₂CH₂CH₂CH₂CN
O

A-0745
CH₂CF₃
H
Cl
F
CH₂CH₂CH₂CH₂CH₂CH₂CN
O

A-0746
CH₂CF₃
H
Cl
F
CH₂CH₂CH₂C(═O)OH
O

A-0747
CH₂CF₃
H
Cl
F
CH₂CH₂CH₂CH₂C(═O)OH
O

A-0748
CH₂CF₃
H
Cl
F
CH₂CH₂CH₂CH₂CH₂C(═O)OH
O

A-0749
CH₂CF₃
H
Cl
F
CH₂CH₂SCN
O

A-0750
CH₂CF₃
H
Cl
F
CH₂CH₂CH₂SCN
O

A-0751
CH₂CF₃
H
Cl
F
CH₂CH₂CH₂CH₂SCN
O

A-0752
CH₂CF₃
H
Cl
F
CH₂CH₂CH₂CH₂CH₂SCN
O

A-0753
CH₂CF₃
H
Cl
Cl
CH₂CH₂CH₂CH₂CH₂SCN
O

A-0754
CH₂CF₃
H
Cl
F
CH₂CH₂CH₂CH₂CH₂CH₂SCN
O

A-0755
CH₂CF₃
H
Cl
F
CH₂CH₂CH₂CH₂CH₂CH₂CH₂SCN
O

A-0756
CH₂CF₃
H
Cl
F
CH₂CH₂CH₂CH₂CH₂CH₂CH₂CH₂SCN
O

A-0757
CH₂CF₃
H
Cl
F
CH₂CH₂CH(Me)SCN
O

A-0758
CH₂CF₃
H
Cl
F
CH₂CH(Me)CH₂SCN
O

A-0759
CH₂CF₃
H
Cl
F
CH(Me)CH₂CH₂SCN
O

A-0760
CH₂CF₃
H
Cl
F
CH₂CH₂CH₂CH(Me)SCN
O

A-0761
CH₂CF₃
H
Cl
F
CH₂CH₂CH(Me)CH₂SCN
O

A-0762
CH₂CF₃
H
Cl
F
CH₂CH(Me)CH₂CH₂SCN
O

A-0763
CH₂CF₃
H
Cl
F
CH(Me)CH₂CH₂CH₂SCN
O

A-0764
CH₂CF₃
H
Cl
F
CH₂CH₂CH₂CH₂CH(Me)SCN
O

A-0765
CH₂CF₃
H
Cl
F
CH₂CH₂CH₂CH(Me)CH₂SCN
O

A-0766
CH₂CF₃
H
Cl
F
CH₂CH₂CH(Me)CH₂CH₂SCN
O

A-0767
CH₂CF₃
H
Cl
F
CH₂CH(Me)CH₂CH₂CH₂SCN
O

A-0768
CH₂CF₃
H
Cl
F
CH(Me)CH₂CH₂CH₂CH₂SCN
O

A-0769
CH₂CF₃
H
Cl
F
CH₂CH₂ONH₂
O

A-0770
CH₂CF₃
H
Cl
F
CH₂CH₂CH₂ONH₂
O

A-0771
CH₂CF₃
H
Cl
F
CH₂CH₂CH₂CH₂ONH₂
O

A-0772
CH₂CF₃
H
Cl
F
CH₂CH₂CH₂CH₂CH₂ONH₂
O

A-0773
CH₂CF₃
H
Cl
F
CH₂CH₂CH₂CH₂CH₂CH₂ONH₂
O

A-0774
CH₂CF₃
H
Me
F
Me
O

A-0775
CH₂CF₃
H
Me
F
Et
O

A-0776
CH₂CF₃
H
Me
F
n-Pr
O

A-0777
CH₂CF₃
H
Me
F
i-Pr
O

A-0778
CH₂CF₃
H
Me
F
n-Bu
O

A-0779
CH₂CF₃
H
Me
F
n-Pen
O

A-0780
CH₂CF₃
H
Me
F
n-Hex
O

A-0781
CH₂CF₃
H
Me
F
n-Heptyl
O

A-0782
CH₂CF₃
H
Me
F
n-Octyl
O

A-0783
CH₂CF₃
H
Me
F
n-Nonyl
O

A-0784
CH₂CF₃
H
Me
F
n-Decyl
O

A-0785
CH₂CF₃
H
Me
F
c-Pr
O

A-0786
CH₂CF₃
H
Me
F
c-Pen
O

TABLE 19

Compound

Number
R¹
R²
R³
R⁴
R⁵
A

A-0787
CH₂CF₃
H
Me
F
c-Hex
O

A-0788
CH₂CF₃
H
Me
F
CH₂C(Me)═CH₂
O

A-0789
CH₂CF₃
H
Me
F
CH₂CH₂CH═CH₂
O

A-0790
CH₂CF₃
H
Me
F
CH₂CH₂CH═C(CH₃)₂
O

A-0791
CH₂CF₃
H
Me
F
CH₂CH₂CH₂CH═CH₂
O

A-0792
CH₂CF₃
H
Me
F
CH₂CH₂CH₂CH═C(CH₃)₂
O

A-0793
CH₂CF₃
H
Me
F
CH₂CH₂CH₂CH₂CH═CH₂
O

A-0794
CH₂CF₃
H
Me
F
CH₂CH₂CH₂CH₂CH═C(CH₃)₂
O

A-0795
CH₂CF₃
H
Me
F
CH₂CH₂CH [Image Omitted]

CH
O

A-0796
CH₂CF₃
H
Me
F
CH₂CH₂CH₂CH [Image Omitted]

CH
O

A-0797
CH₂CF₃
H
Me
F
CH₂CH₂CH₂CH₂CH [Image Omitted]

CH
O

A-0798
CH₂CF₃
H
Me
F
CH₂CH₂CH₂Cl
O

A-0799
CH₂CF₃
H
Me
F
CH₂CH₂CH₂Br
O

A-0800
CH₂CF₃
H
Me
F
CH₂CH₂CH₂CH₂Cl
O

A-0801
CH₂CF₃
H
Me
F
CH₂CH₂CH₂CH₂Br
O

A-0802
CH₂CF₃
H
Me
F
CH₂CH₂CH₂CH₂CH₂Cl
O

A-0803
CH₂CF₃
H
Me
F
CH₂CH₂CH₂CH₂CH₂Br
O

A-0804
CH₂CF₃
H
Me
Cl
CH₂CH₂CH₂CH₂CH₂Br
O

A-0805
CH₂CF₃
H
Me
F
CH₂CH₂CH₂CH₂CH₂CH₂Cl
O

A-0806
CH₂CF₃
H
Me
F
CH₂CH₂CH₂CH₂CH₂CH₂Br
O

A-0807
CH₂CF₃
H
Me
F
CH₂CH₂CH₂CH₂CH₂CH₂CH₂Cl
O

A-0808
CH₂CF₃
H
Me
F
CH₂CH₂CH₂CH₂CH₂CH₂CH₂Br
O

A-0809
CH₂CF₃
H
Me
F
CH₂CH₂CH₂CH₂CH₂CH₂CH₂CH₂Br
O

A-0810
CH₂CF₃
H
Me
F
CH₂CH(Me)CH₂Cl
O

A-0811
CH₂CF₃
H
Me
F
CH₂CH(Me)CH₂Br
O

A-0812
CH₂CF₃
H
Me
F
CH₂CH₂CH(Me)CH₂CH₂Cl
O

A-0813
CH₂CF₃
H
Me
F
CH₂CH₂CH(Me)CH₂CH₂Br
O

A-0814
CH₂CF₃
H
Me
F
CH₂CH₂CF═CF₂
O

A-0815
CH₂CF₃
H
Me
F
CH₂CH═C(Cl)CF₃
O

A-0816
CH₂CF₃
H
Me
F
CH₂CH₂CH₂CF═CF₂
O

A-0817
CH₂CF₃
H
Me
F
CH₂CH₂CH₂CH₂CF═CF₂
O

A-0818
CH₂CF₃
H
Me
F
CH₂CH₂CH₂CH₂CH₂CF═CF₂
O

A-0819
CH₂CF₃
H
Me
F
CH₂(t-Bu)
O

A-0820
CH₂CF₃
H
Me
F
CH₂CH2(t-Bu)
O

A-0821
CH₂CF₃
H
Me
F
CH₂CH₂CH₂(t-Bu)
O

A-0822
CH₂CF₃
H
Me
F
CH₂CH₂CH₂CH₂(t-Bu)
O

A-0823
CH₂CF₃
H
Me
F
CH₂CH₂CH₂CH₂CH₂(t-Bu)
O

A-0824
CH₂CF₃
H
Me
F
CH₂CH₂CH₂CH₂CH₂CH₂(t-Bu)
O

A-0825
CH₂CF₃
H
Me
F
CH₂CF₃
O

A-0826
CH₂CF₃
H
Me
F
CH₂CH₂CF₃
O

A-0827
CH₂CF₃
H
Me
F
CH₂CH₂CH₂CF₃
O

A-0828
CH₂CF₃
H
Me
F
CH₂CH₂CH₂CH₂CF₃
O

A-0829
CH₂CF₃
H
Me
F
CH₂CH₂CH₂CH₂CH₂CF₃
O

A-0830
CH₂CF₃
H
Me
F
CH₂CH₂CH₂CH₂CH₂CH₂CF₃
O

TABLE 20

Compound

Number
R¹
R²
R³
R⁴
R⁵
A

A-0831
CH₂CF₃
H
Me
F
CH₂CH₂CH₂CH₂CH₂CH₂CH₂CF₃
O

A-0832
CH₂CF₃
H
Me
F
CH₂CF₂CF₃
O

A-0833
CH₂CF₃
H
Me
F
CF₂CHFCF₃
O

A-0834
CH₂CF₃
H
Me
F
CF₂CF₂CF₃
O

A-0835
CH₂CF₃
H
Me
F
CH₂CF₂CF₂CF₃
O

A-0836
CH₂CF₃
H
Me
F
CH₂CF₂CF₂CF₂CF₃
O

A-0837
CH₂CF₃
H
Me
F
CH₂CF₂CF₂CF₂CHF₂
O

A-0838
CH₂CF₃
H
Me
F
CH(CF₃)CF₃
O

A-0839
CH₂CF₃
H
Me
F
CH₂CF(CF₃)CF₃
O

A-0840
CH₂CF₃
H
Me
F
CH₂CF₂CF(CF₃)CF₃
O

A-0841
CH₂CF₃
H
Me
F
CH₂CF(CF₃)CF₂CF₃
O

A-0842
CH₂CF₃
H
Me
F
CH₂CF₂CF₂CF(CF₃)CF₃
O

A-0843
CH₂CF₃
H
Me
F
CH₂CF₂CF(CF₃)CF₂CF₃
O

A-0844
CH₂CF₃
H
Me
F
CH₂CF(CF₃)CF₂CF₂CF₃
O

A-0845
CH₂CF₃
H
Me
F
CH₂(c-Pr)
O

A-0846
CH₂CF₃
H
Me
F
CH₂[c-Pr(1-Me)]
O

A-0847
CH₂CF₃
H
Me
F
CH₂[c-Pr(1-Ph)]
O

A-0848
CH₂CF₃
H
Me
F
CH₂[c-Pr(1-NH₂)]
O

A-0849
CH₂CF₃
H
Me
F
CH₂[c-Pr(1-NHC(═O)O(t-Bu)]
O

A-0850
CH₂CF₃
H
Me
F
CH₂{c-Pr[1-NHS(═O)₂CF₃]}
O

A-0851
CH₂CF₃
H
Me
F
CH₂{c-Pr[1-Ph(4-CF₃)]}
O

A-0852
CH₂CF₃
H
Me
F
CH₂{c-Pr[1-Ph(3,4,5-F₃)]}
O

A-0853
CH₂CF₃
H
Me
F
CH₂{c-Hex[4-(t-Bu)]}
O

A-0854
CH₂CF₃
H
Me
F
CH₂[c-Hex(4-CF₃)]
O

A-0855
CH₂CF₃
H
Me
F
CH₂CH₂(c-Pr)
O

A-0856
CH₂CF₃
H
Me
F
CH₂CH₂(c-Hex)
O

A-0857
CH₂CF₃
H
Me
F
CH₂CH₂[c-Hex(4-CF₃)]
O

A-0858
CH₂CF₃
H
Me
F
CH₂CH₂[c-Hex(4-SCF₃)]
O

A-0859
CH₂CF₃
H
Me
F
CH₂CH₂CH₂(c-Pr)
O

A-0860
CH₂CF₃
H
Me
F
CH₂CH₂CH₂(c-Hex)
O

A-0861
CH₂CF₃
H
Me
F
CH₂CH₂CH₂{c-Hex[4-(t-Bu)]}
O

A-0862
CH₂CF₃
H
Me
F
CH₂CH₂CH₂[c-Hex(4-CF₃)]
O

A-0863
CH₂CF₃
H
Me
F
CH₂CH₂CH₂[c-Hex(4-SCF₃)]
O

A-0864
CH₂CF₃
H
Me
F
CH₂CH₂CH₂CH₂(c-Pr)
O

A-0865
CH₂CF₃
H
Me
F
CH₂CH₂CH₂CH₂(c-Hex)
O

A-0866
CH₂CF₃
H
Me
F
CH₂CH₂CH₂CH₂[c-Hex(4-CF₃)]
O

A-0867
CH₂CF₃
H
Me
F
CH₂[c-Pr(2,2-F₂)]
O

A-0868
CH₂CF₃
H
Me
F
CH₂[c-Hex(4,4-F₂)]
O

A-0869
CH₂CF₃
H
Me
F
CH₂CH₂[c-Pr(2,2-F₂)]
O

A-0870
CH₂CF₃
H
Me
F
CH₂CH₂[c-Hex(4,4-F₂)]
O

A-0871
CH₂CF₃
H
Me
F
CH₂CH₂CH₂[c-Pr(2,2-F₂)]
O

A-0872
CH₂CF₃
H
Me
F
CH₂CH₂CH₂CH₂[c-Pr(2,2-F₂)]
O

A-0873
CH₂CF₃
H
Me
F
CH₂CH₂OH
O

A-0874
CH₂CF₃
H
Me
F
CH₂CH₂CH₂OH
O

TABLE 21

Compound

Number
R¹
R²
R³
R⁴
R⁵
A

A-0875
CH₂CF₃
H
Me
F
CH₂CH₂CH₂CH₂OH
O

A-0876
CH₂CF₃
H
Me
F
CH₂CH₂CH₂CH₂CH₂OH
O

A-0877
CH₂CF₃
H
Me
F
CH₂CH₂CH₂CH₂CH₂CH₂OH
O

A-0878
CH₂CF₃
H
Me
F
CH₂C(═O)Me
O

A-0879
CH₂CF₃
H
Me
F
CH₂CH(OH)Me
O

A-0880
CH₂CF₃
H
Me
F
CH₂CH(OH)CF₃
O

A-0881
CH₂CF₃
H
Me
F
CH₂C(OH)₂CF₃
O

A-0882
CH₂CF₃
H
Me
F
CH₂C(CF₃)═NOH
O

A-0883
CH₂CF₃
H
Me
F
CH₂C(CF₃)═NOMe
O

A-0884
CH₂CF₃
H
Me
F
CH₂CH(CF₃)NH₂
O

A-0885
CH₂CF₃
H
Me
F
CH₂CH₂OMe
O

A-0886
CH₂CF₃
H
Me
F
CH₂CH₂CH₂OMe
O

A-0887
CH₂CF₃
H
Me
F
CH₂CH₂CH₂CH₂OMe
O

A-0888
CH₂CF₃
H
Me
F
CH₂CH₂CH₂CH₂CH₂OMe
O

A-0889
CH₂CF₃
H
Me
F
CH₂CH₂CH₂CH₂CH₂CH₂OMe
O

A-0890
CH₂CF₃
H
Me
F
CH₂CH₂OCHF₂
O

A-0891
CH₂CF₃
H
Me
F
CH₂CH₂CH₂OCHF2
O

A-0892
CH₂CF₃
H
Me
F
CH₂CH₂CH₂CH₂OCHF₂
O

A-0893
CH₂CF₃
H
Me
F
CH₂CH₂CH₂CH₂CH₂OCHF₂
O

A-0894
CH₂CF₃
H
Me
F
CH₂CH₂CH₂CH₂CH₂CH₂OCHF₂
O

A-0895
CH₂CF₃
H
Me
F
CH₂CH₂OCH₂CF₃
O

A-0896
CH₂CF₃
H
Me
F
CH₂CH₂CH₂OCH₂CF₃
O

A-0897
CH₂CF₃
H
Me
F
CH₂CH₂CH₂CH₂OCH₂CF₃
O

A-0898
CH₂CF₃
H
Me
F
CH₂CH₂CH₂CH₂CH₂OCH₂CF₃
O

A-0899
CH₂CF₃
H
Me
F
CH₂CH₂CH₂CH₂CH₂CH₂OCH₂CF₃
O

A-0900
CH₂CF₃
H
Me
F
CH₂CH₂CH₂CH₂CH₂CH₂CH₂OCH₂CF₃
O

A-0901
CH₂CF₃
H
Me
F
CH₂CH₂OC(CF₃)₃
O

A-0902
CH₂CF₃
H
Me
F
CH₂CH₂CH₂OC(CF₃)₃
O

A-0903
CH₂CF₃
H
Me
F
CH₂CH₂CH₂CH₂OC(CF₃)₃
O

A-0904
CH₂CF₃
H
Me
F
CH₂CH₂CH₂CH₂CH₂OC(CF₃)₃
O

A-0905
CH₂CF₃
H
Me
F
CF₂CHFOCF₂CF₂CF₃
O

A-0906
CH₂CF₃
H
Me
F
CH₂CH₂O(c-Pr)
O

A-0907
CH₂CF₃
H
Me
F
CH₂CH₂O(c-Pen)
O

A-0908
CH₂CF₃
H
Me
F
CH₂CH₂O(c-Hex)
O

A-0909
CH₂CF₃
H
Me
F
CH₂CH₂CH₂O(c-Pr)
O

A-0910
CH₂CF₃
H
Me
F
CH₂CH₂CH₂O(c-Pen)
O

A-0911
CH₂CF₃
H
Me
F
CH₂CH₂CH₂O(c-Hex)
O

A-0912
CH₂CF₃
H
Me
F
CH₂CH₂CH₂CH₂O(c-Pr)
O

A-0913
CH₂CF₃
H
Me
F
CH₂CH₂CH₂CH₂O(c-Pen)
O

A-0914
CH₂CF₃
H
Me
F
CH₂CH₂CH₂CH₂O(c-Hex)
O

A-0915
CH₂CF₃
H
Me
F
CH₂CH₂O[c-Pr(2,2-F₂)]
O

A-0916
CH₂CF₃
H
Me
F
CH₂CH₂CH₂O[c-Pr(2,2-F₂)]
O

A-0917
CH₂CF₃
H
Me
F
CH₂CH₂CH₂CH₂O[c-Pr(2,2-F₂)]
O

A-0918
CH₂CF₃
H
Me
F
CH₂CH₂OCH₂CH₂OCH₃
O

TABLE 22

Compound

Number
R¹
R²
R³
R⁴
R⁵
A

A-0919
CH₂CF₃
H
Me
F
CH₂CH₂OCH₂CH₂OCH₂CF₃
O

A-0920
CH₂CF₃
H
Me
F
CH₂CF₂OCF₂CF₂OCF₃
O

A-0921
CH₂CF₃
H
Me
F
CF₂CHFOCF₂CF₂OCF₃
O

A-0922
CH₂CF₃
H
Me
F
CF₂CHFOCF₂CF(CF₃)OCF₂CF₂CF₃
O

A-0923
CH₂CF₃
H
Me
F
CH₂CH₂SH
O

A-0924
CH₂CF₃
H
Me
F
CH₂CH₂CH₂SH
O

A-0925
CH₂CF₃
H
Me
F
CH₂CH₂CH₂CH₂SH
O

A-0926
CH₂CF₃
H
Me
F
CH₂CH₂CH₂CH₂CH₂SH
O

A-0927
CH₂CF₃
H
Me
F
CH₂CH₂CH₂CH₂CH₂CH₂SH
O

A-0928
CH₂CF₃
H
Me
F
CH₂CH(SH)Me
O

A-0929
CH₂CF₃
H
Me
F
CH₂CH[SC(═O)Me]Me
O

A-0930
CH₂CF₃
H
Me
F
CH₂CH₂S(t-Bu)
O

A-0931
CH₂CF₃
H
Me
F
CH₂CH₂CH₂S(t-Bu)
O

A-0932
CH₂CF₃
H
Me
F
CH₂CH₂CH₂CH₂S(t-Bu)
O

A-0933
CH₂CF₃
H
Me
F
CH₂CH₂CH₂CH₂CH₂SCH₃
O

A-0934
CH₂CF₃
H
Me
F
CH₂CH₂CH₂CH₂CH₂SCH(CH₃)₂
O

A-0935
CH₂CF₃
H
Me
F
CH₂CH₂CH₂CH₂CH₂S(t-Bu)
O

A-0936
CH₂CF₃
H
Me
F
CH₂CH₂CH₂CH₂CH₂CH₂SCH(CH₃)₂
O

A-0937
CH₂CF₃
H
Me
F
CH₂CH₂CH₂CH₂CH₂CH₂S(t-Bu)
O

A-0938
CH₂CF₃
H
Me
F
CH₂CH₂CH₂CH₂CH₂CH₂CH₂S(t-Bu)
O

A-0939
CH₂CF₃
H
Me
F
CH₂CH₂SCHF₂
O

A-0940
CH₂CF₃
H
Me
F
CH₂CH₂CH₂SCHF₂
O

A-0941
CH₂CF₃
H
Me
F
CH₂CH₂CH₂CH₂SCHF₂
O

A-0942
CH₂CF₃
H
Me
H
CH₂CH₂CH₂CH₂CH₂SCHF₂
O

A-0943
CH₂CF₃
H
Me
F
CH₂CH₂CH₂CH₂CH₂SCHF₂
O

A-0944
CH₂CF₃
H
Me
F
CH₂CH₂CH₂CH₂CH₂CH₂SCHF₂
O

A-0945
CH₂CF₃
H
Me
F
CH₂CH₂CH₂CH₂CH₂CH₂CH₂SCHF₂
O

A-0946
CH₂CF₃
H
Me
F
CH₂CH₂SCH₂CF₃
O

A-0947
CH₂CF₃
H
Me
F
CH₂CH₂CH₂SCH₂CF₃
O

A-0948
CH₂CF₃
H
Me
F
CH₂CH₂CH₂CH₂SCH₂CF₃
O

A-0949
CH₂CF₃
H
Me
F
CH₂CH₂CH₂CH₂CH₂SCH₂CF₃
O

A-0950
CH₂CF₃
H
Me
F
CH₂CH₂CH₂CH₂CH₂CH₂SCH₂CF₃
O

A-0951
CH₂CF₃
H
Me
F
CH₂CH₂CH₂CH₂CH₂CH₂CH₂SCH₂CF₃
O

A-0952
CH₂CF₃
H
Me
F
CH₂CH(Me)SCH₂CF₃
O

A-0953
CH₂CF₃
H
Me
F
CH₂CH₂SCH(CF₃)₂
O

A-0954
CH₂CF₃
H
Me
F
CH₂CH₂CH₂SCH(CF₃)₂
O

A-0955
CH₂CF₃
H
Me
F
CH₂CH₂CH₂CH₂SCH(CF₃)₂
O

A-0956
CH₂CF₃
H
Me
F
CH₂CH₂CH₂CH₂CH₂SCH(CF₃)₂
O

A-0957
CH₂CF₃
H
Me
F
CH₂CH₂CH₂CH₂CH₂CH₂SCH(CF₃)₂
O

A-0958
CH₂CF₃
H
Me
F
CH₂CH₂CH₂CH₂CH₂SCF₂CF₃
O

A-0959
CH₂CF₃
H
Me
F
CH₂CH₂CH₂CH₂CH₂CH₂SCF₂CF₃
O

A-0960
CH₂CF₃
H
Me
F
CH₂CH₂CH₂CH₂CH₂CH₂SCF(CF3)₂
O

A-0961
CH₂CF₃
H
Me
F
CH₂CH₂CH₂CH₂CH₂CH₂CH₂SCF(CF₃)₂
O

A-0962
CH₂CF₃
H
Me
F
CH₂CH₂CH₂CH₂CH₂SCCl₃
O

TABLE 23

Compound

Number
R¹
R²
R³
R⁴
R⁵
A

A-0963
CH₂CF₃
H
Me
F
CH₂CH₂CH₂CH₂CH₂CH₂SCCl₃
O

A-0964
CH₂CF₃
H
Me
F
CH₂CH₂SCH₂CH═CH₂
O

A-0965
CH₂CF₃
H
Me
F
CH₂CH₂CH₂SCH₂CH═CH₂
O

A-0966
CH₂CF₃
H
Me
F
CH₂CH₂CH₂CH₂SCH₂CH═CH₂
O

A-0967
CH₂CF₃
H
Me
F
CH₂CH₂SCF═CFCF₃
O

A-0968
CH₂CF₃
H
Me
F
CH₂CH₂CH₂SCF═CFCF₃
O

A-0969
CH₂CF₃
H
Me
F
CH₂CH₂CH₂CH₂SCF═CFCF₃
O

A-0970
CH₂CF₃
H
Me
F
CH₂CH₂CH₂S(c-Pr)
O

A-0971
CH₂CF₃
H
Me
F
CH₂CH₂CH₂S(c-Hex)
O

A-0972
CH₂CF₃
H
Me
F
CH₂CH₂CH₂CH₂S(c-Pr)
O

A-0973
CH₂CF₃
H
Me
F
CH₂CH₂CH₂CH₂S(c-Hex)
O

A-0974
CH₂CF₃
H
Me
F
CH₂CH₂CH₂CH₂CH₂S(c-Pr)
O

A-0975
CH₂CF₃
H
Me
F
CH₂CH₂CH₂CH₂CH₂S(c-Hex)
O

A-0976
CH₂CF₃
H
Me
F
CH₂CH₂CH₂S[c-Hex(4,4-F₂)]
O

A-0977
CH₂CF₃
H
Me
F
CH₂CH₂CH₂CH₂S[c-Hex(4,4-F₂)]
O

A-0978
CH₂CF₃
H
Me
F
CH₂CH₂CH₂CH₂CH₂S[c-Hex(4,4-F₂)]
O

A-0979
CH₂CF₃
H
Me
F
CH₂CH₂CH₂SCH₂(c-Pr)
O

A-0980
CH₂CF₃
H
Me
F
CH₂CH₂CH₂SCH₂(c-Hex)
O

A-0981
CH₂CF₃
H
Me
F
CH₂CH₂CH₂CH₂SCH₂(c-Pr)
O

A-0982
CH₂CF₃
H
Me
F
CH₂CH₂CH₂CH₂SCH₂(c-Hex)
O

A-0983
CH₂CF₃
H
Me
F
CH₂CH₂CH₂CH₂CH₂SCH₂(c-Pr)
O

A-0984
CH₂CF₃
H
Me
F
CH₂CH₂CH₂CH₂CH₂SCH₂(c-Hex)
O

A-0985
CH₂CF₃
H
Me
F
CH₂CH₂CH₂SCH₂[c-Hex(4,4-F₂)]
O

A-0986
CH₂CF₃
H
Me
F
CH₂CH₂CH₂CH₂SCH₂[c-Hex(4,4-F₂)]
O

A-0987
CH₂CF₃
H
Me
F
CH₂CH₂CH₂CH₂CH₂SCH₂[c-Hex(4,4-F₂)]
O

A-0988
CH₂CF₃
H
Me
F
CH₂CH₂CH₂SCH₂SiMe₃
O

A-0989
CH₂CF₃
H
Me
F
CH₂CH₂CH₂CH₂SCH₂SiMe₃
O

A-0990
CH₂CF₃
H
Me
F
CH₂CH₂CH₂CH₂CH₂SCH₂SiMe₃
O

A-0991
CH₂CF₃
H
Me
F
CH₂CH₂OCH₂CH₂SCH₃
O

A-0992
CH₂CF₃
H
Me
F
CH₂CH₂OCH₂CH₂SCHF₂
O

A-0993
CH₂CF₃
H
Me
F
CH₂CH₂OCH₂CH₂SCF₃
O

A-0994
CH₂CF₃
H
Me
F
CH₂CH₂OCH₂CH₂SCH₂CF₃
O

A-0995
CH₂CF₃
H
Me
F
CH₂CH₂CH₂S(═O)(t-Bu)
O

A-0996
CH₂CF₃
H
Me
F
CH₂CH₂CH₂CH₂S(═O)(t-Bu)
O

A-0997
CH₂CF₃
H
Me
F
CH₂CH₂CH₂CH₂CH₂CH₂S(═O)(t-Bu)
O

A-0998
CH₂CF₃
H
Me
F
CH₂CH₂S(═O)CHF₂
O

A-0999
CH₂CF₃
H
Me
F
CH₂CH₂CH₂S(═O)CHF₂
O

A-1000
CH₂CF₃
H
Me
F
CH₂CH₂CH₂CH₂S(═O)CHF₂
O

A-1001
CH₂CF₃
H
Me
F
CH₂CH₂CH₂CH₂CH₂S(═O)CHF₂
O

A-1002
CH₂CF₃
H
Me
F
CH₂CH₂CH₂CH₂CH₂CH₂S(═O)CHF₂
O

A-1003
CH₂CF₃
H
Me
F
CH₂CH₂CH₂CH₂CH₂CH₂CH₂S(═O)CHF₂
O

A-1004
CH₂CF₃
H
Me
F
CH₂CH₂S(═O)CF₃
O

A-1005
CH₂CF₃
H
Me
F
CH₂CH₂CH₂S(═O)CF₃
O

A-1006
CH₂CF₃
H
Me
F
CH₂CH₂CH₂CH₂S(═O)CF₃
O

TABLE 24

Compound

Number
R¹
R²
R³
R⁴
R⁵
A

A-1007
CH₂CF₃
H
Me
F
CH₂CH₂CH₂CH₂CH₂S(═O)CF₃
O

A-1008
CH₂CF₃
H
Me
F
CH₂CH₂CH₂CH₂CH₂CH₂S(═O)CF₃
O

A-1009
CH₂CF₃
H
Me
F
CH₂CH₂CH₂CH₂CH₂CH₂CH₂S(═O)CF₃
O

A-1010
CH₂CF₃
H
Me
F
CH₂CH₂S(═O)CH₂CF₃
O

A-1011
CH₂CF₃
H
Me
F
CH₂CH₂CH₂S(═O)CH₂CF₃
O

A-1012
CH₂CF₃
H
Me
F
CH₂CH₂CH₂CH₂S(═O)CH₂CF₃
O

A-1013
CH₂CF₃
H
Me
F
CH₂CH₂CH₂CH₂CH₂S(═O)CH₂CF₃
O

A-1014
CH₂CF₃
H
Me
F
CH₂CH₂CH₂CH₂CH₂CH₂S(═O)CH₂CF₃
O

A-1015
CH₂CF₃
H
Me
F
CH₂CH₂CH₂CH₂CH₂CH₂CH₂S(═O)CH₂CF₃
O

A-1016
CH₂CF₃
H
Me
F
CH₂CH(Me)S(═O)CH₂CF₃
O

A-1017
CH₂CF₃
H
Me
F
CH₂CH₂CH₂S(═O)(c-Pr)
O

A-1018
CH₂CF₃
H
Me
F
CH₂CH₂CH₂CH₂S(═O)(c-Pr)
O

A-1019
CH₂CF₃
H
Me
F
CH₂CH₂CH₂CH₂S(═O)(c-Pen)
O

A-1020
CH₂CF₃
H
Me
F
CH₂CH₂CH₂CH₂S(═O)(c-Hex)
O

A-1021
CH₂CF₃
H
Me
F
CH₂CH₂CH₂CH₂CH₂S(═O)(c-Pr)
O

A-1022
CH₂CF₃
H
Me
F
CH₂CH₂CH₂CH₂CH₂S(═O)(c-Hex)
O

A-1023
CH₂CF₃
H
Me
F
CH₂CH₂CH₂S(═O)[c-Hex(4,4-F₂)]
O

A-1024
CH₂CF₃
H
Me
F
CH₂CH₂CH₂CH₂S(═O)[c-Hex(4,4-F₂)]
O

A-1025
CH₂CF₃
H
Me
F
CH₂CH₂CH₂CH₂CH₂S(═O)[c-Hex(4,4-F₂)]
O

A-1026
CH₂CF₃
H
Me
F
CH₂CH₂CH₂CH₂S(═O)₂Me
O

A-1027
CH₂CF₃
H
Me
F
CH₂CH₂CH₂CH₂CH₂S(═O)₂Me
O

A-1028
CH₂CF₃
H
Me
F
CH₂CH₂CH₂CH₂CH₂S(═O)₂(t-Bu)
O

A-1029
CH₂CF₃
H
Me
F
CH₂CH₂S(═O)₂CHF₂
O

A-1030
CH₂CF₃
H
Me
F
CH₂CH₂CH₂S(═O)₂CHF₂
O

A-1031
CH₂CF₃
H
Me
F
CH₂CH₂CH₂CH₂S(═O)₂CHF₂
O

A-1032
CH₂CF₃
H
Me
F
CH₂CH₂CH₂CH₂CH₂S(═O)₂CHF₂
O

A-1033
CH₂CF₃
H
Me
F
CH₂CH₂CH₂CH₂CH₂CH₂S(═O)₂CHF₂
O

A-1034
CH₂CF₃
H
Me
F
CH₂CH₂S(═O)₂CF₃
O

A-1035
CH₂CF₃
H
Me
F
CH₂CH₂CH₂S(═O)₂CF₃
O

A-1036
CH₂CF₃
H
Me
F
CH₂CH₂CH₂CH₂S(═O)₂CF₃
O

A-1037
CH₂CF₃
H
Me
F
CH₂CH₂CH₂CH₂CH₂S(═O)₂CF₃
O

A-1038
CH₂CF₃
H
Me
F
CH₂CH₂CH₂CH₂CH₂CH₂S(═O)₂CF₃
O

A-1039
CH₂CF₃
H
Me
F
CH₂CH₂CH₂CH₂CH₂CH₂CH₂S(═O)₂CF₃
O

A-1040
CH₂CF₃
H
Me
F
CH₂CH₂CH₂CH₂CH₂CH₂CH₂CH₂S(═O)₂CF₃
O

A-1041
CH₂CF₃
H
Me
F
CH₂CH₂S(═O)₂CH₂CF₃
O

A-1042
CH₂CF₃
H
Me
F
CH₂CH₂CH₂S(═O)₂CH₂CF₃
O

A-1043
CH₂CF₃
H
Me
F
CH₂CH₂CH₂CH₂S(═O)₂CH₂CF₃
O

A-1044
CH₂CF₃
H
Me
F
CH₂CH₂CH₂CH₂CH₂S(═O)₂CH₂CF₃
O

A-1045
CH₂CF₃
H
Me
F
CH₂CH₂CH₂CH₂CH₂CH₂S(═O)₂CH₂CF₃
O

A-1046
CH₂CF₃
H
Me
F
CH₂CH(Me)S(═O)₂CH₂CF₃
O

A-1047
CH₂CF₃
H
Me
F
CH₂CH₂CH₂S(═O)₂(c-Pr)
O

A-1048
CH₂CF₃
H
Me
F
CH₂CH₂CH₂CH₂S(═O)₂(c-Pr)
O

A-1049
CH₂CF₃
H
Me
F
CH₂CH₂CH₂CH₂CH₂S(═O)₂(c-Pr)
O

A-1050
CH₂CF₃
H
Me
F
CH₂CH₂CH₂S(═O)₂[c-Hex(4,4-F₂)]
O

TABLE 25

Compound

Number
R¹
R²
R³
R⁴
R⁵
A

A-1051
CH₂CF₃
H
Me
F
CH₂CH₂CH₂CH₂S(═O)₂[c-Hex(4,4-F₂)]
O

A-1052
CH₂CF₃
H
Me
F
CH₂CH₂CH₂CH₂CH₂S(═O)₂[c-Hex(4,4-F₂)]
O

A-1053
CH₂CF₃
H
Me
F
CH₂CH₂CH₂C(═O)H
O

A-1054
CH₂CF₃
H
Me
F
CH₂CH₂CH₂CH₂C(═O)H
O

A-1055
CH₂CF₃
H
Me
F
CH₂CH₂CH₂CH₂CH₂C(═O)H
O

A-1056
CH₂CF₃
H
Me
F
CH₂CH₂CH₂C(═O)(t-Bu)
O

A-1057
CH₂CF₃
H
Me
F
CH₂CH₂CH₂CH₂C(═O)(t-Bu)
O

A-1058
CH₂CF₃
H
Me
F
CH₂CH₂CH₂CH₂CH₂C(═O)(t-Bu)
O

A-1059
CH₂CF₃
H
Me
F
CH₂CH₂CH₂C(═O)CF₃
O

A-1060
CH₂CF₃
H
Me
F
CH₂CH₂CH₂CH₂C(═O)CF₃
O

A-1061
CH₂CF₃
H
Me
F
CH₂CH₂CH₂CH₂CH₂C(═O)CF₃
O

A-1062
CH₂CF₃
H
Me
F
CH₂C(═O)Ph
O

A-1063
CH₂CF₃
H
Me
F
CH₂C(═O)Ph(4-Cl)
O

A-1064
CH₂CF₃
H
Me
F
CH₂C(═O)Ph(4-CF₃)
O

A-1065
CH₂CF₃
H
Me
F
CH₂CH₂C(═O)Ph(4-CF₃)
O

A-1066
CH₂CF₃
H
Me
F
CH₂CH₂CH₂C(═O)Ph(4-CF₃)
O

A-1067
CH₂CF₃
H
Me
F
CH₂CH₂CH₂CH₂C(═O)Ph(4-CF₃)
O

A-1068
CH₂CF₃
H
Me
F
CH₂CH₂CH₂CH₂CH₂C(═O)Ph(4-CF₃)
O

A-1069
CH₂CF₃
H
Me
F
CH₂C(═O)OEt
O

A-1070
CH₂CF₃
H
Me
F
CH₂CH₂C(═O)O(t-Bu)
O

A-1071
CH₂CF₃
H
Me
F
CH₂CH₂CH₂C(═O)OEt
O

A-1072
CH₂CF₃
H
Me
F
CH₂CH₂CH₂C(═O)O(t-Bu)
O

A-1073
CH₂CF₃
H
Me
F
CH₂CH₂CH₂CH₂C(═O)O(t-Bu)
O

A-1074
CH₂CF₃
H
Me
F
CH₂CH₂CH₂CH₂CH₂C(═O)O(t-Bu)
O

A-1075
CH₂CF₃
H
Me
F
CH₂CH₂CH₂CH₂CH₂CH₂C(═O)O(t-Bu)
O

A-1076
CH₂CF₃
H
Me
F
CH₂CH₂CH₂CH₂CH₂CH₂CH₂C(═O)OEt
O

A-1077
CH₂CF₃
H
Me
F
CH₂CH₂C(═O)OCH₂CF₃
O

A-1078
CH₂CF₃
H
Me
F
CH₂CH₂CH₂C(═O)OCH₂CF₃
O

A-1079
CH₂CF₃
H
Me
F
CH₂CH₂CH₂CH₂C(═O)OCH₂CF₃
O

A-1080
CH₂CF₃
H
Me
F
CH₂CH₂CH₂CH₂CH₂C(═O)OCH₂CF₃
O

A-1081
CH₂CF₃
H
Me
F
CH₂CH₂C(═O)NH(t-Bu)
O

A-1082
CH₂CF₃
H
Me
F
CH₂CH₂CH₂C(═O)NH(t-Bu)
O

A-1083
CH₂CF₃
H
Me
F
CH₂CH₂CH₂C(═O)NH(t-Pen)
O

A-1084
CH₂CF₃
H
Me
F
CH₂CH₂CH₂CH₂C(═O)NH(t-Bu)
O

A-1085
CH₂CF₃
H
Me
F
CH₂CH₂C(═O)NHCH₂CF₃
O

A-1086
CH₂CF₃
H
Me
F
CH₂CH₂CH₂C(═O)NHCH₂CF₃
O

A-1087
CH₂CF₃
H
Me
F
CH₂CH₂CH₂CH₂C(═O)NHCH₂CF₃
O

A-1088
CH₂CF₃
H
Me
F
CH₂CH₂SC(═O)N(Me)₂
O

A-1089
CH₂CF₃
H
Me
F
CH₂CH₂CH₂SC(═O)N(Me)₂
O

A-1090
CH₂CF₃
H
Me
F
CH₂CH₂CH₂SC(═O)NH(t-Bu)
O

A-1091
CH₂CF₃
H
Me
F
CH₂CH₂CH₂CH₂CH₂SC(═O)NH(t-Bu)
O

A-1092
CH₂CF₃
H
Me
F
CH₂CH₂SC(═O)NHCH₂CF₃
O

A-1093
CH₂CF₃
H
Me
F
CH₂CH₂CH₂SC(═O)NHCH₂CF₃
O

A-1094
CH₂CF₃
H
Me
F
CH₂CH₂CH₂CH₂SC(═O)NHCH₂CF₃
O

TABLE 26

Compound

Number
R¹
R²
R³
R⁴
R⁵
A

A-1095
CH₂CF₃
H
Me
F
CH₂CH₂CH₂OC(═O)H
O

A-1096
CH₂CF₃
H
Me
F
CH₂CH₂CH₂CH₂OC(═O)H
O

A-1097
CH₂CF₃
H
Me
F
CH₂CH₂CH₂CH₂CH₂OC(═O)H
O

A-1098
CH₂CF₃
H
Me
F
CH₂CH₂CH₂OC(═O)Me
O

A-1099
CH₂CF₃
H
Me
F
CH₂CH₂CH₂CH₂OC(═O)Me
O

A-1100
CH₂CF₃
H
Me
F
CH₂CH₂CH₂CH₂CH₂OC(═O)Me
O

A-1101
CH₂CF₃
H
Me
F
CH₂CH₂OC(═O)CF₃
O

A-1102
CH₂CF₃
H
Me
F
CH₂CH₂CH₂OC(═O)CF₃
O

A-1103
CH₂CF₃
H
Me
F
CH₂CH₂CH₂CH₂OC(═O)CF₃
O

A-1104
CH₂CF₃
H
Me
F
CH₂CH₂CH₂CH₂CH₂OC(═O)Ph(4-CF₃)
O

A-1105
CH₂CF₃
H
Me
F
CH₂CH₂OC(═O)Ph
O

A-1106
CH₂CF₃
H
Me
F
CH₂CH₂OC(═O)Ph(4-CF₃)
O

A-1107
CH₂CF₃
H
Me
F
CH₂CH₂CH₂OC(═O)Ph(4-CF₃)
O

A-1108
CH₂CF₃
H
Me
F
CH₂CH₂CH₂CH₂OC(═O)Ph(4-CF₃)
O

A-1109
CH₂CF₃
H
Me
F
CH₂CH₂CH₂CH₂CH₂OC(═O)Ph(4-CF₃)
O

A-1110
CH₂CF₃
H
Me
F
CH₂CH₂OS(═O)Me
O

A-1111
CH₂CF₃
H
Me
F
CH₂CH₂CH₂OS(═O)Me
O

A-1112
CH₂CF₃
H
Me
F
CH₂CH₂CH₂CH₂OS(═O)Me
O

A-1113
CH₂CF₃
H
Me
F
CH₂CH₂CH₂CH₂CH₂OS(═O)Me
O

A-1114
CH₂CF₃
H
Me
F
CH₂CH₂CH₂CH₂CH₂CH₂OS(═O)Me
O

A-1115
CH₂CF₃
H
Me
F
CH₂CH₂OS(═O)CF₃
O

A-1116
CH₂CF₃
H
Me
F
CH₂CH₂CH₂OS(═O)CF₃
O

A-1117
CH₂CF₃
H
Me
F
CH₂CH₂CH₂CH₂OS(═O)CF₃
O

A-1118
CH₂CF₃
H
Me
F
CH₂CH₂CH₂CH₂CH₂OS(═O)CF₃
O

A-1119
CH₂CF₃
H
Me
F
CH₂CH₂CH₂CH₂CH₂CH₂OS(═O)CF₃
O

A-1120
CH₂CF₃
H
Me
F
CH₂CH₂OS(═O)Ph
O

A-1121
CH₂CF₃
H
Me
F
CH₂CH₂OS(═O)Ph(4-Me)
O

A-1122
CH₂CF₃
H
Me
F
CH₂CH₂CH₂OS(═O)Ph
O

A-1123
CH₂CF₃
H
Me
F
CH₂CH₂CH₂OS(═O)Ph(4-Me)
O

A-1124
CH₂CF₃
H
Me
F
CH₂CH₂OS(═O)₂Me
O

A-1125
CH₂CF₃
H
Me
F
CH₂CH₂CH₂OS(═O)₂Me
O

A-1126
CH₂CF₃
H
Me
F
CH₂CH₂CH₂OS(═O)₂CF₃
O

A-1127
CH₂CF₃
H
Me
F
CH₂CH₂CH₂CH₂OS(═O)₂CF₃
O

A-1128
CH₂CF₃
H
Me
F
CH₂CH₂CH₂CH₂CH₂OS(═O)₂CF₃
O

A-1129
CH₂CF₃
H
Me
F
CH₂CH₂CH₂CH₂CH₂OS(═O)₂CF₂CF₂CF₂CF₃
O

A-1130
CH₂CF₃
H
Me
F
CH₂CH₂OS(═O)₂Ph
O

A-1131
CH₂CF₃
H
Me
F
CH₂CH₂OS(═O)₂Ph(4-Me)
O

A-1132
CH₂CF₃
H
Me
F
CH₂CH₂CH₂OS(═O)₂Ph
O

A-1133
CH₂CF₃
H
Me
F
CH₂CH₂CH₂OS(═O)₂Ph(4-Me)
O

A-1134
CH₂CF₃
H
Me
F
CH₂CH₂NH₂
O

A-1135
CH₂CF₃
H
Me
F
CH₂CH₂CH₂NH₂
O

A-1136
CH₂CF₃
H
Me
F
CH₂CH₂CH₂CH₂NH₂
O

A-1137
CH₂CF₃
H
Me
F
CH₂CH₂CH₂CH₂CH₂NH₂
O

A-1138
CH₂CF₃
H
Me
F
CH₂CH₂CH₂CH₂CH₂CH₂NH₂
O

TABLE 27

Compound

Number
R¹
R²
R³
R⁴
R⁵
A

A-1139
CH₂CF₃
H
Me
F
CH₂CH₂CH₂CH₂CH₂CH₂CH₂NH₂
O

A-1140
CH₂CF₃
H
Me
F
CH₂CH(Me)NH₂
O

A-1141
CH₂CF₃
H
Me
F
CH₂C*H(Me)NH₂:(R)
O

A-1142
CH₂CF₃
H
Me
F
CH₂C*H(Me)NH₂:(S)
O

A-1143
CH₂CF₃
H
Me
F
CH₂CH(Et)NH₂
O

A-1144
CH₂CF₃
H
Me
F
CH₂CH(i-Pr)NH₂
O

A-1145
CH₂CF₃
H
Me
F
CH(Me)CH₂NH₂
O

A-1146
CH₂CF₃
H
Me
F
CH(Et)CH₂NH₂
O

A-1147
CH₂CF₃
H
Me
F
CH(i-Pr)CH₂NH₂
O

A-1148
CH₂CF₃
H
Me
F
CH₂CH₂CH(Me)NH₂
O

A-1149
CH₂CF₃
H
Me
F
CH₂CH(Me)CH₂NH₂
O

A-1150
CH₂CF₃
H
Me
F
CH(Me)CH₂CH₂NH₂
O

A-1151
CH₂CF₃
H
Me
F
CH₂CH(Me)NH(c-Pr)
O

A-1152
CH₂CF₃
H
Me
F
CH₂CH(Me)NHOMe
O

A-1153
CH₂CF₃
H
Me
F
CH₂CH(Me)N(OMe)S(═O)₂Ph(2-NO₂)
O

A-1154
CH₂CF₃
H
Me
F
CH₂CH(Me)N(OMe)S(═O)₂Ph(4-NO₂)
O

A-1155
CH₂CF₃
H
Me
F
CH₂CH₂N(Me)(t-Bu)
O

A-1156
CH₂CF₃
H
Me
F
CH₂CH₂CH₂N(Me)(t-Bu)
O

A-1157
CH₂CF₃
H
Me
F
CH₂CH₂CH₂CH₂N(Me)(t-Bu)
O

A-1158
CH₂CF₃
H
Me
F
CH₂CH₂NHCH₂CF₃
O

A-1159
CH₂CF₃
H
Me
F
CH₂CH₂CH₂NHCH₂CF₃
O

A-1160
CH₂CF₃
H
Me
F
CH₂CH₂CH₂CH₂NHCH₂CF₃
O

A-1161
CH₂CF₃
H
Me
F
CH₂CH₂NHC(═O)C(Me)(CF₃)₂
O

A-1162
CH₂CF₃
H
Me
F
CH₂CH₂NHC(═O)Me
O

A-1163
CH₂CF₃
H
Me
F
CH₂CH₂NHC(═O)(t-Bu)
O

A-1164
CH₂CF₃
H
Me
F
CH₂CH₂CH₂CH₂NHC(═O)CH(CH₃)₂
O

A-1165
CH₂CF₃
H
Me
F
CH₂CH₂CH₂CH₂NHC(═O)(t-Bu)
O

A-1166
CH₂CF₃
H
Me
F
CH₂CH₂CH₂CH₂NHC(═O)CH₂(t-Bu)
O

A-1167
CH₂CF₃
H
Me
F
CH₂CH₂NHC(═O)CF₃
O

A-1168
CH₂CF₃
H
Me
F
CH₂CH₂NHC(═O)CH₂CF₃
O

A-1169
CH₂CF₃
H
Me
F
CH₂CH₂NHC(═O)CF₂CF₃
O

A-1170
CH₂CF₃
H
Me
F
CH₂CH₂CH₂NHC(═O)CF₃
O

A-1171
CH₂CF₃
H
Me
F
CH₂CH₂CH₂NHC(═O)CH₂CF₃
O

A-1172
CH₂CF₃
H
Me
F
CH₂CH₂CH₂NHC(═O)CF₂CF₃
O

A-1173
CH₂CF₃
H
Me
F
CH₂CH₂CH₂CH₂NHC(═O)CF₃
O

A-1174
CH₂CF₃
H
Me
F
CH₂CH₂CH₂CH₂NHC(═O)CH₂CF₃
O

A-1175
CH₂CF₃
H
Me
F
CH₂CH₂CH₂CH₂NHC(═O)CF₂CF₃
O

A-1176
CH₂CF₃
H
Me
F
CH₂CH₂CH₂CH₂NHC(═O)CF(CF₃)₂
O

A-1177
CH₂CF₃
H
Me
F
CH₂CH₂CH₂CH₂NHC(═O)CCl₃
O

A-1178
CH₂CF₃
H
Me
F
CH₂CH(Me)NHC(═O)CF₃
O

A-1179
CH₂CF₃
H
Me
F
CH₂CH₂NHC(═O)Ph
O

A-1180
CH₂CF₃
H
Me
F
CH₂CH₂NHC(═O)Ph(4-CF₃)
O

A-1181
CH₂CF₃
H
Me
F
CH₂CH₂CH₂NHC(═O)Ph(4-CF₃)
O

A-1182
CH₂CF₃
H
Me
F
CH₂CH₂CH₂CH₂NHC(═O)Ph(4-CF₃)
O

TABLE 28

Compound

Number
R¹
R²
R³
R⁴
R⁵
A

A-1183
CH₂CF₃
H
Me
F
CH₂CH₂NHC(═O)O(t-Bu)
O

A-1184
CH₂CF₃
H
Me
F
CH₂CH₂CH₂NHC(═O)O(t-Bu)
O

A-1185
CH₂CF₃
H
Me
F
CH₂CH₂CH₂CH₂NHC(═O)O(t-Bu)
O

A-1186
CH₂CF₃
H
Me
F
CH₂CH₂CH₂CH₂NHC(═O)OCH(CH₃)₂
O

A-1187
CH₂CF₃
H
Me
F
CH₂CH(Me)NHC(═O)O(t-Bu)
O

A-1188
CH₂CF₃
H
Me
F
CH₂C*H(Me)NHC(═O)O(t-Bu):(R)
O

A-1189
CH₂CF₃
H
Me
F
CH₂C*H(Me)NHC(═O)O(t-Bu):(S)
O

A-1190
CH₂CF₃
H
Me
F
CH₂CH(Et)NHC(═O)O(t-Bu)
O

A-1191
CH₂CF₃
H
Me
F
CH₂CH(i-Pr)NHC(═O)O(t-Bu)
O

A-1192
CH₂CF₃
H
Me
F
CH(Me)CH₂NHC(═O)O(t-Bu)
O

A-1193
CH₂CF₃
H
Me
F
CH(Et)CH₂NHC(═O)O(t-Bu)
O

A-1194
CH₂CF₃
H
Me
F
CH(i-Pr)CH₂NHC(═O)O(t-Bu)
O

A-1195
CH₂CF₃
H
Me
F
CH₂CH(Me)CH₂NHC(═O)O(t-Bu)
O

A-1196
CH₂CF₃
H
Me
F
CH₂CH₂NHC(═O)OC(Me)₂CF₃
O

A-1197
CH₂CF₃
H
Me
F
CH₂CH₂CH₂NHC(═O)OCH₂CF₃
O

A-1198
CH₂CF₃
H
Me
F
CH₂CH₂CH₂NHC(═O)OCH₂CH₂CF₃
O

A-1199
CH₂CF₃
H
Me
F
CH₂CH₂CH₂CH₂NHC(═O)OCH₂CCl₃
O

A-1200
CH₂CF₃
H
Me
F
CH₂CH₂CH₂CH₂NHC(═O)OCH₂CF₃
O

A-1201
CH₂CF₃
H
Me
F
CH2CH₂NHC(═O)NH(t-Bu)
O

A-1202
CH₂CF₃
H
Me
F
CH₂CH₂CH₂NHC(═O)NH(t-Bu)
O

A-1203
CH₂CF₃
H
Me
F
CH₂CH₂CH₂CH₂NHC(═O)NHEt
O

A-1204
CH₂CF₃
H
Me
F
CH₂CH₂CH₂CH₂NHC(═O)NH(t-Bu)
O

A-1205
CH₂CF₃
H
Me
F
CH₂CH₂CH₂NHC(═O)NHCH₂CCl₃
O

A-1206
CH₂CF₃
H
Me
F
CH₂CH₂CH₂NHC(═O)NHCH₂CH₂F
O

A-1207
CH₂CF₃
H
Me
F
CH₂CH₂CH₂NHC(═O)NHCH₂CF₃
O

A-1208
CH₂CF₃
H
Me
F
CH₂CH₂CH₂CH₂NHC(═O)NHCH₂CCl₃
O

A-1209
CH₂CF₃
H
Me
F
CH₂CH₂CH₂CH₂NHC(═O)NHCH₂CH₂F
O

A-1210
CH₂CF₃
H
Me
F
CH₂CH₂CH₂CH₂NHC(═O)NHCH₂CF₃
O

A-1211
CH₂CF₃
H
Me
F
CH₂CH₂NHS(═O)Me
O

A-1212
CH₂CF₃
H
Me
F
CH₂CH₂CH₂NHS(═O)Me
O

A-1213
CH₂CF₃
H
Me
F
CH₂CH₂CH₂CH₂NHS(═O)Me
O

A-1214
CH₂CF₃
H
Me
F
CH₂CH₂CH₂CH₂NHS(═O)CH(CH₃)₂
O

A-1215
CH₂CF₃
H
Me
F
CH₂CH₂CH₂CH₂CH₂NHS(═O)Me
O

A-1216
CH₂CF₃
H
Me
F
CH₂CH₂NHS(═O)CHF₂
O

A-1217
CH₂CF₃
H
Me
F
CH₂CH₂CH₂NHS(═O)CHF₂
O

A-1218
CH₂CF₃
H
Me
F
CH₂CH₂CH₂CH₂NHS(═O)CHF₂
O

A-1219
CH₂CF₃
H
Me
F
CH₂CH₂CH₂CH₂CH₂NHS(═O)CHF₂
O

A-1220
CH₂CF₃
H
Me
F
CH₂CH(Me)NHS(═O)CHF₂
O

A-1221
CH₂CF₃
H
Me
F
CH(Me)CH₂NHS(═O)CHF₂
O

A-1222
CH₂CF₃
H
Me
F
CH₂CH₂CH(Me)NHS(═O)CHF₂
O

A-1223
CH₂CF₃
H
Me
F
CH₂CH(Me)CH₂NHS(═O)CHF₂
O

A-1224
CH₂CF₃
H
Me
F
CH(Me)CH₂CH₂NHS(═O)CHF₂
O

A-1225
CH₂CF₃
H
Me
F
CH₂CH₂NHS(═O)CF₃
O

A-1226
CH₂CF₃
H
Me
F
CH₂CH₂CH₂NHS(═O)CF₃
O

TABLE 29

Compound

Number
R¹
R²
R³
R⁴
R⁵
A

A-1227
CH₂CF₃
H
Me
F
CH₂CH₂CH₂CH₂NHS(═O)CF₃
O

A-1228
CH₂CF₃
H
Me
F
CH₂CH₂CH₂CH₂CH₂NHS(═O)CF₃
O

A-1229
CH₂CF₃
H
Me
F
CH₂CH₂CH₂NHS(═O)Ph
O

A-1230
CH₂CF₃
H
Me
F
CH₂CH₂CH₂CH₂NHS(═O)Ph
O

A-1231
CH₂CF₃
H
Me
F
CH₂CH₂CH₂CH₂CH₂NHS(═O)Ph
O

A-1232
CH₂CF₃
H
Me
F
CH₂CH₂CH₂CH₂CH₂NHS(═O)Ph(4-CF₃)
O

A-1233
CH₂CF₃
H
Me
F
CH₂CH(Me)NHS(═O)Ph(4-CF₃)
O

A-1234
CH₂CF₃
H
Me
F
CH₂CH(Et)NHS(═O)Ph(4-CF₃)
O

A-1235
CH₂CF₃
H
Me
F
CH(Me)CH₂NHS(═O)Ph(4-CF₃)
O

A-1236
CH₂CF₃
H
Me
F
CH(Et)CH₂NHS(═O)Ph(4-CF₃)
O

A-1237
CH₂CF₃
H
Me
F
CH₂CH(Et)CH₂NHS(═O)Ph(4-CF₃)
O

A-1238
CH₂CF₃
H
Me
F
CH₂CH₂NHS(═O)₂Me
O

A-1239
CH₂CF₃
H
Me
F
CH₂CH₂CH₂NHS(═O)₂Me
O

A-1240
CH₂CF₃
H
Me
F
CH₂CH₂CH₂CH₂NHS(═O)₂Me
O

A-1241
CH₂CF₃
H
Me
F
CH₂CH₂CH₂CH₂NHS(═O)₂CH(CH₃)₂
O

A-1242
CH₂CF₃
H
Me
F
CH₂CH₂CH₂CH₂CH₂NHS(═O)₂Me
O

A-1243
CH₂CF₃
H
Me
F
CH₂CH₂NHS(═O)₂CHF₂
O

A-1244
CH₂CF₃
H
Me
F
CH₂CH₂CH₂NHS(═O)₂CHF₂
O

A-1245
CH₂CF₃
H
Me
F
CH₂CH₂CH₂CH₂NHS(═O)₂CHF₂
O

A-1246
CH₂CF₃
H
Me
F
CH₂CH₂CH₂CH₂CH₂NHS(═O)₂CHF₂
O

A-1247
CH₂CF₃
H
Me
F
CH₂CH(Me)NHS(═O)₂CHF₂
O

A-1248
CH₂CF₃
H
Me
F
CH(Me)CH₂NHS(═O)₂CHF₂
O

A-1249
CH₂CF₃
H
Me
F
CH₂CH₂CH(Me)NHS(═O)₂CHF₂
O

A-1250
CH₂CF₃
H
Me
F
CH₂CH(Me)CH₂NHS(═O)₂CHF₂
O

A-1251
CH₂CF₃
H
Me
F
CH(Me)CH₂CH₂NHS(═O)₂CHF₂
O

A-1252
CH₂CF₃
H
Me
F
CH₂CH(Me)N(Me)S(═O)₂CHF₂
O

A-1253
CH₂CF₃
H
Me
F
CH(Me)CH₂N(Me)S(═O)₂CHF₂
O

A-1254
CH₂CF₃
H
Me
F
CH₂CH₂CH(Me)N(Me)S(═O)₂CHF₂
O

A-1255
CH₂CF₃
H
Me
F
CH₂CH(Me)CH₂N(Me)S(═O)₂CHF₂
O

A-1256
CH₂CF₃
H
Me
F
CH(Me)CH₂CH₂N(Me)S(═O)₂CHF₂
O

A-1257
CH₂CF₃
H
Me
F
CH₂CH₂CH₂NHS(═O)₂Ph
O

A-1258
CH₂CF₃
H
Me
F
CH₂CH₂CH₂CH₂NHS(═O)₂Ph
O

A-1259
CH₂CF₃
H
Me
F
CH₂CH₂CH₂CH₂CH₂NHS(═O)₂Ph
O

A-1260
CH₂CF₃
H
Me
F
CH₂CH₂CH₂CH₂CH₂NHS(═O)₂Ph(4-CF₃)
O

A-1261
CH₂CF₃
H
Me
F
CH₂CH(Me)NHS(═O)₂Ph(4-CF₃)
O

A-1262
CH₂CF₃
H
Me
F
CH₂CH(Et)NHS(═O)₂Ph(4-CF₃)
O

A-1263
CH₂CF₃
H
Me
F
CH(Me)CH₂NHS(═O)₂Ph(4-CF₃)
O

A-1264
CH₂CF₃
H
Me
F
CH(Et)CH₂NHS(═O)₂Ph(4-CF₃)
O

A-1265
CH₂CF₃
H
Me
F
CH₂CH(Me)CH₂NHS(═O)₂Ph(4-CF₃)
O

A-1266
CH₂CF₃
H
Me
F
CH₂CH₂SiMe₃
O

A-1267
CH₂CF₃
H
Me
F
CH₂CH₂CH₂SiMe₃
O

A-1268
CH₂CF₃
H
Me
F
CH₂CH₂CH₂CH₂SiMe₃
O

A-1269
CH₂CF₃
H
Me
F
CH₂Ph
O

A-1270
CH₂CF₃
H
Me
F
CH₂Ph(2-CF₃)
O

TABLE 30

Compound

Number
R¹
R²
R³
R⁴
R⁵
A

A-1271
CH₂CF₃
H
Me
F
CH₂Ph(3-CF₃)
O

A-1272
CH₂CF₃
H
Me
F
CH₂Ph(4-CF₃)
O

A-1273
CH₂CF₃
H
Me
F
CH₂Ph(2-OCF₃)
O

A-1274
CH₂CF₃
H
Me
F
CH₂Ph(3-OCF₃)
O

A-1275
CH₂CF₃
H
Me
F
CH₂Ph(4-OCF₃)
O

A-1276
CH₂CF₃
H
Me
F
CH₂Ph(2-SCF₃)
O

A-1277
CH₂CF₃
H
Me
F
CH₂Ph(3-SCF₃)
O

A-1278
CH₂CF₃
H
Me
F
CH₂Ph(4-SCF₃)
O

A-1279
CH₂CF₃
H
Me
F
CH₂Ph(3-CH₂SCF₃)
O

A-1280
CH₂CF₃
H
Me
F
CH₂Ph(4-F)
O

A-1281
CH₂CF₃
H
Me
F
CH₂Ph(4-Cl)
O

A-1282
CH₂CF₃
H
Me
F
CH₂Ph(4-Br)
O

A-1283
CH₂CF₃
H
Me
F
CH₂Ph(4-Me)
O

A-1284
CH₂CF₃
H
Me
F
CH₂Ph[4-(t-Bu)]
O

A-1285
CH₂CF₃
H
Me
F
CH₂Ph(4-CN)
O

A-1286
CH₂CF₃
H
Me
F
CH₂Ph(4-NO₂)
O

A-1287
CH₂CF₃
H
Me
F
CH₂Ph(4-OCHF₂)
O

A-1288
CH₂CF₃
H
Me
F
CH₂Ph(4-SCHF₂)
O

A-1289
CH₂CF₃
H
Me
F
CH₂Ph(4-CH₂SCF₃)
O

A-1290
CH₂CF₃
H
Me
F
CH₂Ph[4-CF(CF₃)₂]
O

A-1291
CH₂CF₃
H
Me
F
CH₂Ph(4-CH₂SCF₃)
O

A-1292
CH₂CF₃
H
Me
F
CH₂Ph[4-Ph(4-CF₃)]
O

A-1293
CH₂CF₃
H
Me
F
CH₂Ph(2,4-Cl₂)
O

A-1294
CH₂CF₃
H
Me
F
CH₂Ph[2,5-(CF₃)₂]
O

A-1295
CH₂CF₃
H
Me
F
CH₂Ph(3,4-Cl₂)
O

A-1296
CH₂CF₃
H
Me
F
CH₂Ph(3-CF₃-4-F)
O

A-1297
CH₂CF₃
H
Me
F
CH₂Ph(3-CF₃-4-Cl)
O

A-1298
CH₂CF₃
H
Me
F
CH₂Ph(3-F-4-CF₃)
O

A-1299
CH₂CF₃
H
Me
F
CH₂Ph(2,4,6-F₃)
O

A-1300
CH₂CF₃
H
Me
F
CH₂Ph(3,4,5-F₃)
O

A-1301
CH₂CF₃
H
Me
F
CH₂Ph(2,3,4-F₃)
O

A-1302
CH₂CF₃
H
Me
F
CH₂Ph(3,4,5-Cl₃)
O

A-1303
CH₂CF₃
H
Me
F
CH₂CH₂Ph
O

A-1304
CH₂CF₃
H
Me
F
CH₂CH₂Ph(4-F)
O

A-1305
CH₂CF₃
H
Me
F
CH₂CH₂Ph(4-Cl)
O

A-1306
CH₂CF₃
H
Me
F
CH₂CH₂Ph(4-Br)
O

A-1307
CH₂CF₃
H
Me
F
CH₂CH₂Ph[4-(t-Bu)]
O

A-1308
CH₂CF₃
H
Me
F
CH₂CH₂Ph(2-CF₃)
O

A-1309
CH₂CF₃
H
Me
F
CH₂CH₂Ph(3-CF₃)
O

A-1310
CH₂CF₃
H
Me
H
CH₂CH₂Ph(4-CF₃)
O

A-1311
CH₂CF₃
H
Me
F
CH₂CH₂Ph(4-CF₃)
O

A-1312
CH₂CF₃
H
Me
F
CH₂CH₂Ph(4-CF(CF₃)₂)
O

A-1313
CH₂CF₃
H
Me
F
CH₂CH₂Ph[4-(c-Pr)]
O

A-1314
CH₂CF₃
H
Me
F
CH₂CH₂Ph{4-[c-Pr(2,2-F₂)]}
O

TABLE 31

Compound

Number
R¹
R²
R³
R⁴
R⁵
A

A-1315
CH₂CF₃
H
Me
F
CH₂CH₂Ph(4-OMe)
O

A-1316
CH₂CF₃
H
Me
F
CH₂CH₂Ph(3-OCF₃)
O

A-1317
CH₂CF₃
H
Me
F
CH₂CH₂Ph(4-OCHF₂)
O

A-1318
CH₂CF₃
H
Me
F
CH₂CH₂Ph(4-OCF₃)
O

A-1319
CH₂CF₃
H
Me
F
CH₂CH₂Ph(4-SMe)
O

A-1320
CH₂CF₃
H
Me
F
CH₂CH₂Ph(4-SCHF₂)
O

A-1321
CH₂CF₃
H
Me
F
CH₂CH₂Ph(4-SCF₃)
O

A-1322
CH₂CF₃
H
Me
F
CH₂CH₂Ph[4-S(═O)Me]
O

A-1323
CH₂CF₃
H
Me
F
CH₂CH₂Ph[4-S(═O)CF₃]
O

A-1324
CH₂CF₃
H
Me
F
CH₂CH₂Ph[4-S(═O)₂Me]
O

A-1325
CH₂CF₃
H
Me
F
CH₂CH₂Ph[4-S(═O)₂CF₃]
O

A-1326
CH₂CF₃
H
Me
F
CH₂CH₂Ph(4-CH₂SMe)
O

A-1327
CH₂CF₃
H
Me
F
CH₂CH₂Ph(4-CH₂SCF₃)
O

A-1328
CH₂CF₃
H
Me
F
CH₂CH₂Ph[4-OS(═O)₂Me]
O

A-1329
CH₂CF₃
H
Me
F
CH₂CH₂Ph[4-OS(═O)₂CF₃]
O

A-1330
CH₂CF₃
H
Me
F
CH₂CH₂Ph[4-Ph(4-CF₃)]
O

A-1331
CH₂CF₃
H
Me
F
CH₂CH₂Ph(4-CH₂Ph)
O

A-1332
CH₂CF₃
H
Me
F
CH₂CH₂Ph(4-OCH₂Ph)
O

A-1333
CH₂CF₃
H
Me
F
CH₂CH₂Ph(4-CN)
O

A-1334
CH₂CF₃
H
Me
F
CH₂CH₂Ph(4-NO₂)
O

A-1335
CH₂CF₃
H
Me
F
CH₂CH₂Ph(2,4-Cl₂)
O

A-1336
CH₂CF₃
H
Me
F
CH₂CH₂Ph(3,4-Cl₂)
O

A-1337
CH₂CF₃
H
Me
F
CH₂CH₂Ph(3-CF₃-4-F)
O

A-1338
CH₂CF₃
H
Me
F
CH₂CH₂Ph(2-CF₃-4-F)
O

A-1339
CH₂CF₃
H
Me
F
CH₂CH₂Ph(3-F-4-CF₃)
O

A-1340
CH₂CF₃
H
Me
F
CH₂CH₂Ph(2-F-4-CF₃)
O

A-1341
CH₂CF₃
H
Me
F
CH₂CH₂Ph(3-Cl-4-OCHF₂)
O

A-1342
CH₂CF₃
H
Me
F
CH₂CH₂Ph(3,4,5-Cl₃)
O

A-1343
CH₂CF₃
H
Me
F
CH₂CH₂Ph(2,3,4-F₃)
O

A-1344
CH₂CF₃
H
Me
F
CH₂CH₂Ph(2,4,5-F₃)
O

A-1345
CH₂CF₃
H
Me
F
CH₂CH₂Ph(3,4,5-F₃)
O

A-1346
CH₂CF₃
H
Me
F
CH₂CH₂Ph(2,4,6-F₃)
O

A-1347
CH₂CF₃
H
Me
F
CH₂CH₂CH₂Ph
O

A-1348
CH₂CF₃
H
Me
F
CH₂CH₂CH₂Ph(3-CF₃)
O

A-1349
CH₂CF₃
H
Me
F
CH₂CH₂CH₂Ph(4-CF₃)
O

A-1350
CH₂CF₃
H
Me
F
CH₂CH₂CH₂Ph(4-F)
O

A-1351
CH₂CF₃
H
Me
F
CH₂CH₂CH₂Ph[4-(t-Bu)]
O

A-1352
CH₂CF₃
H
Me
F
CH₂CH₂CH₂Ph(4-CN)
O

A-1353
CH₂CF₃
H
Me
F
CH₂CH₂CH₂Ph(4-CF₃)
O

A-1354
CH₂CF₃
H
Me
F
CH₂CH₂CH₂Ph(4-OCHF₂)
O

A-1355
CH₂CF₃
H
Me
F
CH₂CH₂CH₂Ph(4-OCF₃)
O

A-1356
CH₂CF₃
H
Me
F
CH₂CH₂CH₂Ph(4-SCHF₂)
O

A-1357
CH₂CF₃
H
Me
F
CH₂CH₂CH₂Ph(4-SCF₃)
O

A-1358
CH₂CF₃
H
Me
F
CH₂CH₂CH₂Ph[4-CF(CF₃)₂]
O

TABLE 32

Compound

Number
R¹
R²
R³
R⁴
R⁵
A

A-1359
CH₂CF₃
H
Me
F
CH₂CH₂CH₂Ph(3,4,5-F₃)
O

A-1360
CH₂CF₃
H
Me
F
CH₂CH₂CH₂Ph(2,4,6-F₃)
O

A-1361
CH₂CF₃
H
Me
F
CH₂CH₂CH₂CH₂Ph
O

A-1362
CH₂CF₃
H
Me
F
CH₂CH₂CH₂CH₂Ph(4-F)
O

A-1363
CH₂CF₃
H
Me
F
CH₂CH₂CH₂CH₂Ph(4-CF₃)
O

A-1364
CH₂CF₃
H
Me
F
CH₂CH₂CH₂CH₂Ph(4-OCF₃)
O

A-1365
CH₂CF₃
H
Me
F
CH₂CH₂CH₂CH₂Ph(4-SCF₃)
O

A-1366
CH₂CF₃
H
Me
F
CH₂CH₂CH₂CH₂CH₂Ph
O

A-1367
CH₂CF₃
H
Me
F
CH₂CH₂CH₂CH₂CH₂CH₂Ph
O

A-1368
CH₂CF₃
H
Me
F
CH₂CF₂Ph(4-F)
O

A-1369
CH₂CF₃
H
Me
F
CH₂CF₂Ph(4-CF₃)
O

A-1370
CH₂CF₃
H
Me
H
CH₂CF₂Ph(3,4,5-F₃)
O

A-1371
CH₂CF₃
H
Me
F
CH₂CF₂Ph(3,4,5-F₃)
O

A-1372
CH₂CF₃
H
Me
F
CH₂CH₂OPh
O

A-1373
CH₂CF₃
H
Me
F
CH₂CH₂OPh(4-F)
O

A-1374
CH₂CF₃
H
Me
F
CH₂CH₂OPh(4-CF₃)
O

A-1375
CH₂CF₃
H
Me
F
CH₂CH₂CH₂OPh
O

A-1376
CH₂CF₃
H
Me
F
CH₂CH₂CH₂OPh(4-Cl)
O

A-1377
CH₂CF₃
H
Me
F
CH₂CH₂CH₂OPh(4-CF₃)
O

A-1378
CH₂CF₃
H
Me
F
CH₂CH₂CH₂CH₂OPh(4-CF₃)
O

A-1379
CH₂CF₃
H
Me
F
CH₂CH₂CH₂CH₂OPh(4-OCF₃)
O

A-1380
CH₂CF₃
H
Me
F
CH₂CH₂CH₂CH₂CH₂OPh(4-CF₃)
O

A-1381
CH₂CF₃
H
Me
F
CH₂CH₂OCH₂Ph
O

A-1382
CH₂CF₃
H
Me
F
CH₂CH₂CH₂OCH₂Ph
O

A-1383
CH₂CF₃
H
Me
F
CH₂CH₂CH₂CH₂OCH₂Ph
O

A-1384
CH₂CF₃
H
Me
F
CH₂CH₂CH₂CH₂CH₂OCH₂Ph
O

A-1385
CH₂CF₃
H
Me
F
CH₂CH₂SPh
O

A-1386
CH₂CF₃
H
Me
F
CH₂CH₂CH₂SPh
O

A-1387
CH₂CF₃
H
Me
F
CH₂CH₂CH₂SPh(4-F)
O

A-1388
CH₂CF₃
H
Me
F
CH₂CH₂CH₂SPh(4-Cl)
O

A-1389
CH₂CF₃
H
Me
F
CH₂CH₂CH₂SPh(4-Br)
O

A-1390
CH₂CF₃
H
Me
F
CH₂CH₂CH₂SPh[4-(t-Bu)]
O

A-1391
CH₂CF₃
H
Me
F
CH₂CH₂CH₂SPh(3-CF₃)
O

A-1392
CH₂CF₃
H
Me
F
CH₂CH₂CH₂SPh(4-CF₃)
O

A-1393
CH₂CF₃
H
Me
F
CH₂CH₂CH₂SPh(3-SCF₃)
O

A-1394
CH₂CF₃
H
Me
F
CH₂CH₂CH₂SPh(4-SCF₃)
O

A-1395
CH₂CF₃
H
Me
F
CH₂CH₂CH₂CH₂SPh
O

A-1396
CH₂CF₃
H
Me
F
CH₂CH₂CH₂CH₂SPh(4-F)
O

A-1397
CH₂CF₃
H
Me
F
CH₂CH₂CH₂CH₂SPh(4-Cl)
O

A-1398
CH₂CF₃
H
Me
F
CH₂CH₂CH₂CH₂SPh[4-(t-Bu)]
O

A-1399
CH₂CF₃
H
Me
F
CH₂CH₂CH₂CH₂SPh(4-CF₃)
O

A-1400
CH₂CF₃
H
Me
F
CH₂CH₂CH₂CH₂CH₂SPh
O

A-1401
CH₂CF₃
H
Me
F
CH₂CH₂CH₂CH₂CH₂SPh(4-F)
O

A-1402
CH₂CF₃
H
Me
F
CH₂CH₂CH₂CH₂CH₂SPh(4-Cl)
O

TABLE 33

Compound

Number
R¹
R²
R³
R⁴
R⁵
A

A-1403
CH₂CF₃
H
Me
F
CH₂CH₂CH₂CH₂CH₂SPh(4-CF₃)
O

A-1404
CH₂CF₃
H
Me
F
CH₂CH₂S(═O)Ph
O

A-1405
CH₂CF₃
H
Me
F
CH₂CH₂CH₂S(═O)Ph
O

A-1406
CH₂CF₃
H
Me
F
CH₂CH₂CH₂S(═O)Ph(4-F)
O

A-1407
CH₂CF₃
H
Me
F
CH₂CH₂CH₂S(═O)Ph[4-(t-Bu)]
O

A-1408
CH₂CF₃
H
Me
F
CH₂CH₂CH₂S(═O)Ph(4-CF₃)
O

A-1409
CH₂CF₃
H
Me
F
CH₂CH₂S(═O)₂Ph
O

A-1410
CH₂CF₃
H
Me
F
CH₂CH₂S(═O)₂Ph(4-CF₃)
O

A-1411
CH₂CF₃
H
Me
F
CH₂CH₂CH₂S(═O)₂Ph(4-F)
O

A-1412
CH₂CF₃
H
Me
F
CH₂CH₂CH₂S(═O)₂Ph(4-Cl)
O

A-1413
CH₂CF₃
H
Me
F
CH₂CH₂CH₂S(═O)₂Ph(4-CF₃)
O

A-1414
CH₂CF₃
H
Me
F
CH₂CH₂CH₂CH₂S(═O)₂Ph
O

A-1415
CH₂CF₃
H
Me
F
CH₂CH₂CH₂CH₂S(═O)₂Ph(4-Cl)
O

A-1416
CH₂CF₃
H
Me
F
CH₂CH₂CH₂CH₂S(═O)₂Ph(4-CF₃)
O

A-1417
CH₂CF₃
H
Me
F
CH₂CH₂SCH₂Ph
O

A-1418
CH₂CF₃
H
Me
F
CH₂CH₂CH₂SCH₂Ph
O

A-1419
CH₂CF₃
H
Me
F
CH₂CH₂CH₂SCH₂Ph(2-Cl)
O

A-1420
CH₂CF₃
H
Me
F
CH₂CH₂CH₂SCH₂Ph(3-Cl)
O

A-1421
CH₂CF₃
H
Me
F
CH₂CH₂CH₂SCH₂Ph(4-Cl)
O

A-1422
CH₂CF₃
H
Me
F
CH₂CH₂CH₂SCH₂Ph(2-SCF₃)
O

A-1423
CH₂CF₃
H
Me
F
CH₂CH₂CH₂SCH₂Ph(3-CF₃)
O

A-1424
CH₂CF₃
H
Me
F
CH₂CH₂CH₂SCH₂Ph(4-CF₃)
O

A-1425
CH₂CF₃
H
Me
F
CH₂CH₂CH₂SCH₂Ph(4-NO₂)
O

A-1426
CH₂CF₃
H
Me
F
CH₂CH₂CH₂CH₂SCH₂Ph
O

A-1427
CH₂CF₃
H
Me
F
CH₂CH₂CH₂CH₂SCH₂Ph(4-Cl)
O

A-1428
CH₂CF₃
H
Me
F
CH₂CH₂CH₂CH₂SCH₂Ph(4-CF₃)
O

A-1429
CH₂CF₃
H
Me
F
CH₂CH₂CH₂CH₂SCH₂Ph(4-CN)
O

A-1430
CH₂CF₃
H
Me
F
CH₂CH₂CH₂CH₂CH₂SCH₂Ph
O

A-1431
CH₂CF₃
H
Me
F
CH₂CH₂SCH₂CH₂Ph
O

A-1432
CH₂CF₃
H
Me
F
CH₂CH₂CH₂SCH₂CH₂Ph
O

A-1433
CH₂CF₃
H
Me
F
CH₂CH₂CH₂CH₂SCH₂CH₂Ph
O

A-1434
CH₂CF₃
H
Me
F
CH₂CH₂SCH(Me)Ph
O

A-1435
CH₂CF₃
H
Me
F
CH₂CH₂CH₂SCH(Me)Ph
O

A-1436
CH₂CF₃
H
Me
F
CH₂CH₂CH₂CH₂SCH(Me)Ph
O

A-1437
CH₂CF₃
H
Me
F
CH₂CH₂S(═O)CH₂Ph
O

A-1438
CH₂CF₃
H
Me
F
CH₂CH₂S(═O)CH₂Ph(4-CF₃)
O

A-1439
CH₂CF₃
H
Me
F
CH₂CH₂CH2S(═O)CH₂Ph
O

A-1440
CH₂CF₃
H
Me
F
CH₂CH₂CH₂S(═O)CH₂Ph(2-SCF₃)
O

A-1441
CH₂CF₃
H
Me
F
CH₂CH₂CH₂S(═O)CH₂Ph(4-SCF₃)
O

A-1442
CH₂CF₃
H
Me
F
CH₂CH₂CH₂S(═O)CH₂Ph(4-Cl)
O

A-1443
CH₂CF₃
H
Me
F
CH₂CH₂CH₂S(═O)CH₂Ph(4-CF₃)
O

A-1444
CH₂CF₃
H
Me
F
CH₂CH₂CH₂CH₂S(═O)CH₂Ph
O

A-1445
CH₂CF₃
H
Me
F
CH₂CH₂CH₂CH₂S(═O)CH₂Ph(4-CF₃)
O

A-1446
CH₂CF₃
H
Me
F
CH₂CH₂CH₂CH₂CH₂S(═O)CH₂Ph(4-CF₃)
O

TABLE 34

Compound

Number
R¹
R²
R³
R⁴
R⁵
A

A-1447
CH₂CF₃
H
Me
F
CH₂CH₂S(═O)₂CH₂Ph
O

A-1448
CH₂CF₃
H
Me
F
CH₂CH₂S(═O)₂CH₂Ph(4-CF₃)
O

A-1449
CH₂CF₃
H
Me
F
CH₂CH₂CH₂S(═O)₂CH₂Ph
O

A-1450
CH₂CF₃
H
Me
F
CH₂CH₂CH₂S(═O)₂CH₂Ph(4-Cl)
O

A-1451
CH₂CF₃
H
Me
F
CH₂CH₂CH₂S(═O)₂CH₂Ph(4-CF₃)
O

A-1452
CH₂CF₃
H
Me
F
CH₂CH₂CH₂CH₂S(═O)₂CH₂Ph
O

A-1453
CH₂CF₃
H
Me
F
CH₂CH₂CH₂CH₂S(═O)₂CH₂Ph(4-CF₃)
O

A-1454
CH₂CF₃
H
Me
F
CH₂CH₂CH₂CH₂CH₂S(═O)₂CH₂Ph
O

A-1455
CH₂CF₃
H
Me
F
CH₂CH₂CH₂CH₂CH₂S(═O)₂CH₂Ph(4-CF₃)
O

A-1456
CH₂CF₃
H
Me
F
CH₂CH₂ON═CH(t-Bu)
O

A-1457
CH₂CF₃
H
Me
F
CH₂CH₂CH₂ON═CH(t-Bu)
O

A-1458
CH₂CF₃
H
Me
F
CH₂CH₂CH₂CH₂ON═C(Me)(c-Pr)
O

A-1459
CH₂CF₃
H
Me
F
CH₂CH₂ON═C(Me)CF₃
O

A-1460
CH₂CF₃
H
Me
F
CH₂CH₂CH₂ON═CHCF₃
O

A-1461
CH₂CF₃
H
Me
F
CH₂CH₂CH₂ON═C(Me)CF₃
O

A-1462
CH₂CF₃
H
Me
F
CH₂CH₂CH₂ON═C(Me)CCl₃
O

A-1463
CH₂CF₃
H
Me
F
CH₂CH₂CH₂CH₂ON═CHCF₃
O

A-1464
CH₂CF₃
H
Me
F
CH₂CH₂CH₂CH₂ON═C(Me)CF₃
O

A-1465
CH₂CF₃
H
Me
F
CH₂CH₂CH₂CH₂CH₂ON═C(Me)CF₃
O

A-1466
CH₂CF₃
H
Me
F
CH₂CH₂ON═CHPh
O

A-1467
CH₂CF₃
H
Me
F
CH₂CH₂ON═CHPh(4-CF₃)
O

A-1468
CH₂CF₃
H
Me
F
CH₂CH₂ON═CHPh(4-SCF₃)
O

A-1469
CH₂CF₃
H
Me
F
CH₂CH₂CH₂ON═CHPh(3-CF₃)
O

A-1470
CH₂CF₃
H
Me
F
CH₂CH₂CH₂ON═CHPh(4-CF₃)
O

A-1471
CH₂CF₃
H
Me
F
CH₂CH₂CH₂ON═CHPh(4-SCF₃)
O

A-1472
CH₂CF₃
H
Me
F
CH₂CH₂CH₂ON═C(Me)Ph(4-CF₃)
O

A-1473
CH₂CF₃
H
Me
F
CH₂CH₂CH₂CH₂ON═CHPh(4-SCF₃)
O

A-1474
CH₂CF₃
H
Me
F
CH₂CH₂(adamant-1-yl)
O

A-1475
CH₂CF₃
H
Me
F
CH₂CH₂CH₂(3-CF₃-pyrazol-1-yl)
O

A-1476
CH₂CF₃
H
Me
F
CH₂CH₂CH₂CH₂(3-CF₃-pyrazol-1-yl)
O

A-1477
CH₂CF₃
H
Me
F
CH₂CH₂CH₂CH₂CH₂(3-CF₃-pyrazol-1-yl)
O

A-1478
CH₂CF₃
H
Me
F
CH₂(1-Me-4-CF₃-imidazol-5-yl)
O

A-1479
CH₂CF₃
H
Me
F
CH₂CH₂(1-Me-4-CF₃-imidazol-5-yl)
O

A-1480
CH₂CF₃
H
Me
F
CH₂CH₂CH₂(1-Me-4-CF₃-imidazol-5-yl)
O

A-1481
CH₂CF₃
H
Me
F
CH₂CH₂CH₂(3-CF₃-1,2,4-triazol-1-yl)
O

A-1482
CH₂CF₃
H
Me
F
CH₂CH₂CH₂CH₂(3-CF₃-1,2,4-triazol-1-yl)
O

A-1483
CH₂CF₃
H
Me
F
CH₂CH₂CH₂CH₂CH₂(3-CF₃-1,2,4-triazol-1-yl)
O

A-1484
CH₂CF₃
H
Me
F
CH₂CH₂CH₂(4-CF₃-thiazol-2-yl)
O

A-1485
CH₂CF₃
H
Me
F
CH₂CH₂CH₂CH₂(4-CF₃-thiazol-2-yl)
O

A-1486
CH₂CF₃
H
Me
F
CH₂CH₂CH₂CH₂CH₂(4-CF₃-thiazol-2-yl)
O

A-1487
CH₂CF₃
H
Me
F
CH₂CH₂CH₂(2-CF₃-pyridin-5-yl)
O

A-1488
CH₂CF₃
H
Me
F
CH₂CH₂CH₂CH₂(2-CF₃-pyridin-5-yl)
O

A-1489
CH₂CF₃
H
Me
F
CH₂CH₂CH₂CH₂CH₂(2-CF₃-pyridin-5-yl)
O

A-1490
CH₂CF₃
H
Me
F
CH₂(4-CF₃-pyrimidin-2-yl)
O

TABLE 35

Compound

Number
R¹
R²
R³
R⁴
R⁵
A

A-1491
CH₂CF₃
H
Me
F
CH₂CH₂(4-CF₃-pyrimidin-2-yl)
O

A-1492
CH₂CF₃
H
Me
F
CH₂CH₂CH₂(4-CF₃-pyrimidin-2-yl)
O

A-1493
CH₂CF₃
H
Me
F
CH₂CH₂O(3-Cl-5-CF₃-pyridin-2-yl)
O

A-1494
CH₂CF₃
H
Me
F
CH₂CH₂CH₂O(3-Cl-5-CF₃-pyridin-2-yl)
O

A-1495
CH₂CF₃
H
Me
F
CH₂CH₂CH₂CH₂O(3-Cl-5-CF₃-pyridin-2-yl)
O

A-1496
CH₂CF₃
H
Me
F
CH₂CH₂CH₂CH₂CH₂O(3-Cl-5-CF₃-pyridin-2-yl)
O

A-1497
CH₂CF₃
H
Me
F
CH₂CH₂N(Phth)
O

A-1498
CH₂CF₃
H
Me
F
CH₂CH₂CH₂N(Phth)
O

A-1499
CH₂CF₃
H
Me
F
CH₂CH₂CH₂CH₂N(Phth)
O

A-1500
CH₂CF₃
H
Me
F
CH₂CH₂CH₂CH₂CH₂N(Phth)
O

A-1501
CH₂CF₃
H
Me
F
CH₂CH(Me)CH₂N(Phth)
O

A-1502
CH₂CF₃
H
Me
F
CH₂[1,3-dioxolan(2-CF₃)-2-yl]
O

A-1503
CH₂CF₃
H
Me
F
CH₂(azetidin-3-yl)
O

A-1504
CH₂CF₃
H
Me
F
CH₂(pyrrolidin-3-yl)
O

A-1505
CH₂CF₃
H
Me
F
CH₂(piperidin-3-yl)
O

A-1506
CH₂CF₃
H
Me
F
CH₂{azetidin[1-C(═O)O(t-Bu)]-3-yl}
O

A-1507
CH₂CF₃
H
Me
F
CH₂{pyrrolidin[1-C(═O)O(t-Bu)]-3-yl}
O

A-1508
CH₂CF₃
H
Me
F
CH₂{piperidin[1-C(═O)O(t-Bu)]-3-yl}
O

A-1509
CH₂CF₃
H
Me
F
CH₂{azetidin[1-C(═O)CF₃]-3-yl}
O

A-1510
CH₂CF₃
H
Me
F
CH₂{azetidin[1-S(═O)₂CF₃]-3-yl}
O

A-1511
CH₂CF₃
H
Me
F
CH₂{pyrrolidin[1-C(═O)CF₃]-3-yl}
O

A-1512
CH₂CF₃
H
Me
F
CH₂{pyrrolidin[1-S(═O)₂CF₃]-3-yl}
O

A-1513
CH₂CF₃
H
Me
F
CH₂{piperidin[1-C(═O)CF₃]-3-yl}
O

A-1514
CH₂CF₃
H
Me
F
CH₂{piperidin[1-S(═O)₂CF₃]-3-yl}
O

A-1515
CH₂CF₃
H
Me
F
CH₂CH₂CH₂CN
O

A-1516
CH₂CF₃
H
Me
F
CH₂CH₂CH₂CH₂CN
O

A-1517
CH₂CF₃
H
Me
F
CH₂CH₂CH₂CH₂CH₂CN
O

A-1518
CH₂CF₃
H
Me
F
CH₂CH₂CH₂CH₂CH₂CH₂CN
O

A-1519
CH₂CF₃
H
Me
F
CH₂CH₂CH₂C(═O)OH
O

A-1520
CH₂CF₃
H
Me
F
CH₂CH₂CH₂CH₂C(═O)OH
O

A-1521
CH₂CF₃
H
Me
F
CH₂CH₂CH₂CH₂CH₂C(═O)OH
O

A-1522
CH₂CF₃
H
Me
F
CH₂CH₂SCN
O

A-1523
CH₂CF₃
H
Me
F
CH₂CH₂CH₂SCN
O

A-1524
CH₂CF₃
H
Me
F
CH₂CH₂CH₂CH₂SCN
O

A-1525
CH₂CF₃
H
Me
F
CH₂CH₂CH₂CH₂CH₂SCN
O

A-1526
CH₂CF₃
H
Me
Cl
CH₂CH₂CH₂CH₂CH₂SCN
O

A-1527
CH₂CF₃
H
Me
F
CH₂CH₂CH₂CH₂CH₂CH₂SCN
O

A-1528
CH₂CF₃
H
Me
F
CH₂CH₂CH₂CH₂CH₂CH₂CH₂SCN
O

A-1529
CH₂CF₃
H
Me
F
CH₂CH₂CH₂CH₂CH₂CH₂CH₂CH₂SCN
O

A-1530
CH₂CF₃
H
Me
F
CH₂CH₂CH(Me)SCN
O

A-1531
CH₂CF₃
H
Me
F
CH₂CH(Me)CH₂SCN
O

A-1532
CH₂CF₃
H
Me
F
CH(Me)CH₂CH₂SCN
O

A-1533
CH₂CF₃
H
Me
F
CH₂CH₂CH₂CH(Me)SCN
O

A-1534
CH₂CF₃
H
Me
F
CH₂CH₂CH(Me)CH₂SCN
O

TABLE 36

Compound

Number
R¹
R²
R³
R⁴
R⁵
A

A-1535
CH₂CF₃
H
Me
F
CH₂CH(Me)CH₂CH₂SCN
O

A-1536
CH₂CF₃
H
Me
F
CH(Me)CH₂CH₂CH₂SCN
O

A-1537
CH₂CF₃
H
Me
F
CH₂CH₂CH₂CH₂CH(Me)SCN
O

A-1538
CH₂CF₃
H
Me
F
CH₂CH₂CH₂CH(Me)CH₂SCN
O

A-1539
CH₂CF₃
H
Me
F
CH₂CH₂CH(Me)CH₂CH₂SCN
O

A-1540
CH₂CF₃
H
Me
F
CH₂CH(Me)CH₂CH₂CH₂SCN
O

A-1541
CH₂CF₃
H
Me
F
CH(Me)CH₂CH₂CH₂CH₂SCN
O

A-1542
CH₂CF₃
H
Me
F
CH₂CH₂ONH₂
O

A-1543
CH₂CF₃
H
Me
F
CH₂CH₂CH₂ONH₂
O

A-1544
CH₂CF₃
H
Me
F
CH₂CH₂CH₂CH₂ONH₂
O

A-1545
CH₂CF₃
H
Me
F
CH₂CH₂CH₂CH₂CH₂ONH₂
O

A-1546
CH₂CF₃
H
Me
F
CH₂CH₂CH₂CH₂CH₂CH₂ONH₂
O

A-1547
Et
H
Cl
F
Me
O

A-1548
Et
H
Cl
F
Et
O

A-1549
Et
H
Cl
F
n-Pr
O

A-1550
Et
H
Cl
F
i-Pr
O

A-1551
Et
H
Cl
F
n-Bu
O

A-1552
Et
H
Cl
F
n-Pen
O

A-1553
Et
H
Cl
F
n-Hex
O

A-1554
Et
H
Cl
F
n-Heptyl
O

A-1555
Et
H
Cl
F
n-Octyl
O

A-1556
Et
H
Cl
F
n-Nonyl
O

A-1557
Et
H
Cl
F
n-Decyl
O

A-1558
Et
H
Cl
F
c-Pr
O

A-1559
Et
H
Cl
F
c-Pen
O

A-1560
Et
H
Cl
F
c-Hex
O

A-1561
Et
H
Cl
F
CH₂C(Me)═CH₂
O

A-1562
Et
H
Cl
F
CH₂CH₂CH═CH₂
O

A-1563
Et
H
Cl
F
CH₂CH₂CH═C(CH₃)₂
O

A-1564
Et
H
Cl
F
CH₂CH₂CH₂CH═CH₂
O

A-1565
Et
H
Cl
F
CH₂CH₂CH₂CH═C(CH₃)₂
O

A-1566
Et
H
Cl
F
CH₂CH₂CH₂CH₂CH═CH₂
O

A-1567
Et
H
Cl
F
CH₂CH₂CH₂CH₂CH═C(CH₃)₂
O

A-1568
Et
H
Cl
F
CH₂CH₂CH [Image Omitted]

CH
O

A-1569
Et
H
Cl
F
CH₂CH₂CH₂CH [Image Omitted]

CH
O

A-1570
Et
H
Cl
F
CH₂CH₂CH₂CH₂CH [Image Omitted]

CH
O

A-1571
Et
H
Cl
F
CH₂CH₂CH₂Cl
O

A-1572
Et
H
Cl
F
CH₂CH₂CH₂Br
O

A-1573
Et
H
Cl
F
CH₂CH₂CH₂CH₂Cl
O

A-1574
Et
H
Cl
F
CH₂CH₂CH₂CH₂Br
O

A-1575
Et
H
Cl
F
CH₂CH₂CH₂CH₂CH₂Cl
O

A-1576
Et
H
Cl
F
CH₂CH₂CH₂CH₂CH₂Br
O

A-1577
Et
H
Cl
Cl
CH₂CH₂CH₂CH₂CH₂Br
O

A-1578
Et
H
Cl
F
CH₂CH₂CH₂CH₂CH₂CH₂Cl
O

TABLE 37

Compound

Number
R¹
R²
R³
R⁴
R⁵
A

A-1579
Et
H
Cl
F
CH₂CH₂CH₂CH₂CH₂CH₂Br
O

A-1580
Et
H
Cl
F
CH₂CH₂CH₂CH₂CH₂CH₂CH₂Cl
O

A-1581
Et
H
Cl
F
CH₂CH₂CH₂CH₂CH₂CH₂CH₂Br
O

A-1582
Et
H
Cl
F
CH₂CH₂CH₂CH₂CH₂CH₂CH₂CH₂Br
O

A-1583
Et
H
Cl
F
CH₂CH(Me)CH₂Cl
O

A-1584
Et
H
Cl
F
CH₂CH(Me)CH₂Br
O

A-1585
Et
H
Cl
F
CH₂CH₂CH(Me)CH₂CH₂Cl
O

A-1586
Et
H
Cl
F
CH₂CH₂CH(Me)CH₂CH₂Br
O

A-1587
Et
H
Cl
F
CH₂CH₂CF═CF₂
O

A-1588
Et
H
Cl
F
CH₂CH═C(Cl)CF₃
O

A-1589
Et
H
Cl
F
CH₂CH₂CH₂CF═CF₂
O

A-1590
Et
H
Cl
F
CH₂CH₂CH₂CH₂CF═CF₂
O

A-1591
Et
H
Cl
F
CH₂CH₂CH₂CH₂CH₂CF═CF₂
O

A-1592
Et
H
Cl
F
CH₂(t-Bu)
O

A-1593
Et
H
Cl
F
CH₂CH₂(t-Bu)
O

A-1594
Et
H
Cl
F
CH₂CH₂CH₂(t-Bu)
O

A-1595
Et
H
Cl
F
CH₂CH₂CH₂CH₂(t-Bu)
O

A-1596
Et
H
Cl
F
CH₂CH₂CH₂CH₂CH₂(t-Bu)
O

A-1597
Et
H
Cl
F
CH₂CH₂CH₂CH₂CH₂CH₂(t-Bu)
O

A-1598
Et
H
Cl
F
CH₂CF₃
O

A-1599
Et
H
Cl
F
CH₂CH₂CF₃
O

A-1600
Et
H
Cl
F
CH₂CH₂CH₂CF₃
O

A-1601
Et
H
Cl
F
CH₂CH₂CH₂CH₂CF₃
O

A-1602
Et
H
Cl
F
CH₂CH₂CH₂CH₂CH₂CF₃
O

A-1603
Et
H
Cl
F
CH₂CH₂CH₂CH₂CH₂CH₂CF₃
O

A-1604
Et
H
Cl
F
CH₂CH₂CH₂CH₂CH₂CH₂CH₂CF₃
O

A-1605
Et
H
Cl
F
CH₂CF₂CF₃
O

A-1606
Et
H
Cl
F
CF₂CHFCF₃
O

A-1607
Et
H
Cl
F
CF₂CF₂CF₃
O

A-1608
Et
H
Cl
F
CH₂CF₂CF₂CF₃
O

A-1609
Et
H
Cl
F
CH₂CF₂CF₂CF₂CF₃
O

A-1610
Et
H
Cl
F
CH₂CF₂CF₂CF₂CHF₂
O

A-1611
Et
H
Cl
F
CH(CF₃)CF₃
O

A-1612
Et
H
Cl
F
CH₂CF(CF₃)CF₃
O

A-1613
Et
H
Cl
F
CH₂CF₂CF(CF₃)CF₃
O

A-1614
Et
H
Cl
F
CH₂CF(CF₃)CF₂CF₃
O

A-1615
Et
H
Cl
F
CH₂CF₂CF₂CF(CF₃)CF₃
O

A-1616
Et
H
Cl
F
CH₂CF₂CF(CF₃)CF₂CF₃
O

A-1617
Et
H
Cl
F
CH₂CF(CF₃)CF₂CF₂CF₃
O

A-1618
Et
H
Cl
F
CH₂(c-Pr)
O

A-1619
Et
H
Cl
F
CH₂[c-Pr(1-Me)]
O

A-1620
Et
H
Cl
F
CH₂[c-Pr(1-Ph)]
O

A-1621
Et
H
Cl
F
CH₂[c-Pr(1-NH₂)]
O

A-1622
Et
H
Cl
F
CH₂[c-Pr(1-NHC(═O)O(t-Bu)]
O

TABLE 38

Compound

Number
R¹
R²
R³
R⁴
R⁵
A

A-1623
Et
H
Cl
F
CH₂{c-Pr[1-NHS(═O)₂CF₃]}
O

A-1624
Et
H
Cl
F
CH₂{c-Pr[1-Ph(4-CF₃)]}
O

A-1625
Et
H
Cl
F
CH₂{c-Pr[1-Ph(3,4,5-F₃)]}
O

A-1626
Et
H
Cl
F
CH₂{c-Hex[4-(t-Bu)]}
O

A-1627
Et
H
Cl
F
CH₂[c-Hex(4-CF₃)]
O

A-1628
Et
H
Cl
F
CH₂CH₂(c-Pr)
O

A-1629
Et
H
Cl
F
CH₂CH₂(c-Hex)
O

A-1630
Et
H
Cl
F
CH₂CH₂[c-Hex(4-CF₃)]
O

A-1631
Et
H
Cl
F
CH₂CH₂[c-Hex(4-SCF₃)]
O

A-1632
Et
H
Cl
F
CH₂CH₂CH₂(c-Pr)
O

A-1633
Et
H
Cl
F
CH₂CH₂CH₂(c-Hex)
O

A-1634
Et
H
Cl
F
CH₂CH₂CH₂{c-Hex[4-(t-Bu)]}
O

A-1635
Et
H
Cl
F
CH₂CH₂CH₂[c-Hex(4-CF₃)]
O

A-1636
Et
H
Cl
F
CH₂CH₂CH₂[c-Hex(4-SCF₃)]
O

A-1637
Et
H
Cl
F
CH₂CH₂CH₂CH₂(c-Pr)
O

A-1638
Et
H
Cl
F
CH₂CH₂CH₂CH₂(c-Hex)
O

A-1639
Et
H
Cl
F
CH₂CH₂CH₂CH₂[c-Hex(4-CF₃)]
O

A-1640
Et
H
Cl
F
CH₂[c-Pr(2,2-F₂)]
O

A-1641
Et
H
Cl
F
CH₂[c-Hex(4,4-F₂)]
O

A-1642
Et
H
Cl
F
CH₂CH₂[c-Pr(2,2-F₂)]
O

A-1643
Et
H
Cl
F
CH₂CH₂[c-Hex(4,4-F₂)]
O

A-1644
Et
H
Cl
F
CH₂CH₂CH₂[c-Pr(2,2-F₂)]
O

A-1645
Et
H
Cl
F
CH₂CH₂CH₂CH₂[c-Pr(2,2-F₂)]
O

A-1646
Et
H
Cl
F
CH₂CH₂OH
O

A-1647
Et
H
Cl
F
CH₂CH₂CH₂OH
O

A-1648
Et
H
Cl
F
CH₂CH₂CH₂CH₂OH
O

A-1649
Et
H
Cl
F
CH₂CH₂CH₂CH₂CH₂OH
O

A-1650
Et
H
Cl
F
CH₂CH₂CH₂CH₂CH₂CH₂OH
O

A-1651
Et
H
Cl
F
CH₂C(═O)Me
O

A-1652
Et
H
Cl
F
CH₂CH(OH)Me
O

A-1653
Et
H
Cl
F
CH₂CH(OH)CF₃
O

A-1654
Et
H
Cl
F
CH₂C(OH)₂CF₃
O

A-1655
Et
H
Cl
F
CH₂C(CF₃)═NOH
O

A-1656
Et
H
Cl
F
CH₂C(CF₃)═NOMe
O

A-1657
Et
H
Cl
F
CH₂CH(CF₃)NH₂
O

A-1658
Et
H
Cl
F
CH₂CH₂OMe
O

A-1659
Et
H
Cl
F
CH₂CH₂CH₂OMe
O

A-1660
Et
H
Cl
F
CH₂CH₂CH₂CH₂OMe
O

A-1661
Et
H
Cl
F
CH₂CH₂CH₂CH₂CH₂OMe
O

A-1662
Et
H
Cl
F
CH₂CH₂CH₂CH₂CH₂CH₂OMe
O

A-1663
Et
H
Cl
F
CH₂CH₂OCHF₂
O

A-1664
Et
H
Cl
F
CH₂CH₂CH₂OCHF₂
O

A-1665
Et
H
Cl
F
CH₂CH₂CH₂CH₂OCHF₂
O

A-1666
Et
H
Cl
F
CH₂CH₂CH₂CH₂CH₂OCHF₂
O

TABLE 39

Compound

Number
R¹
R²
R³
R⁴
R⁵
A

A-1667
Et
H
Cl
F
CH₂CH₂CH₂CH₂CH₂CH₂OCHF₂
O

A-1668
Et
H
Cl
F
CH₂CH₂OCH₂CF₃
O

A-1669
Et
H
Cl
F
CH₂CH₂CH₂OCH₂CF₃
O

A-1670
Et
H
Cl
F
CH₂CH₂CH₂CH₂OCH₂CF₃
O

A-1671
Et
H
Cl
F
CH₂CH₂CH₂CH₂CH₂OCH₂CF₃
O

A-1672
Et
H
Cl
F
CH₂CH₂CH₂CH₂CH₂CH₂OCH₂CF₃
O

A-1673
Et
H
Cl
F
CH₂CH₂CH₂CH₂CH₂CH₂CH₂OCH₂CF₃
O

A-1674
Et
H
Cl
F
CH₂CH₂OC(CF₃)₃
O

A-1675
Et
H
Cl
F
CH₂CH₂CH₂OC(CF₃)₃
O

A-1676
Et
H
Cl
F
CH₂CH₂CH₂CH₂OC(CF₃)₃
O

A-1677
Et
H
Cl
F
CH₂CH₂CH₂CH₂CH₂OC(CF₃)₃
O

A-1678
Et
H
Cl
F
CF₂CHFOCF₂CF₂CF₃
O

A-1679
Et
H
Cl
F
CH₂CH₂O(c-Pr)
O

A-1680
Et
H
Cl
F
CH₂CH₂O(c-Pen)
O

A-1681
Et
H
Cl
F
CH₂CH₂O(c-Hex)
O

A-1682
Et
H
Cl
F
CH₂CH₂CH₂O(c-Pr)
O

A-1683
Et
H
Cl
F
CH₂CH₂CH₂O(c-Pen)
O

A-1684
Et
H
Cl
F
CH₂CH₂CH₂O(c-Hex)
O

A-1685
Et
H
Cl
F
CH₂CH₂CH₂CH₂O(c-Pr)
O

A-1686
Et
H
Cl
F
CH₂CH₂CH₂CH₂O(c-Pen)
O

A-1687
Et
H
Cl
F
CH₂CH₂CH₂CH₂O(c-Hex)
O

A-1688
Et
H
Cl
F
CH₂CH₂O[c-Pr(2,2-F₂)]
O

A-1689
Et
H
Cl
F
CH₂CH₂CH₂O[c-Pr(2,2-F₂)]
O

A-1690
Et
H
Cl
F
CH₂CH₂CH₂CH₂O[c-Pr(2,2-F₂)]
O

A-1691
Et
H
Cl
F
CH₂CH₂OCH₂CH₂OCH₃
O

A-1692
Et
H
Cl
F
CH₂CH₂OCH₂CH₂OCH₂CF₃
O

A-1693
Et
H
Cl
F
CH₂CF₂OCF₂CF₂OCF₃
O

A-1694
Et
H
Cl
F
CF₂CHFOCF₂CF₂OCF₃
O

A-1695
Et
H
Cl
F
CF₂CHFOCF₂CF(CF₃)OCF₂CF₂CF₃
O

A-1696
Et
H
Cl
F
CH₂CH₂SH
O

A-1697
Et
H
Cl
F
CH₂CH₂CH₂SH
O

A-1698
Et
H
Cl
F
CH₂CH₂CH₂CH₂SH
O

A-1699
Et
H
Cl
F
CH₂CH₂CH₂CH₂CH₂SH
O

A-1700
Et
H
Cl
F
CH₂CH₂CH₂CH₂CH₂CH₂SH
O

A-1701
Et
H
Cl
F
CH₂CH(SH)Me
O

A-1702
Et
H
Cl
F
CH₂CH[SC(═O)Me]Me
O

A-1703
Et
H
Cl
F
CH₂CH₂S(t-Bu)
O

A-1704
Et
H
Cl
F
CH₂CH₂CH₂S(t-Bu)
O

A-1705
Et
H
Cl
F
CH₂CH₂CH₂CH₂S(t-Bu)
O

A-1706
Et
H
Cl
F
CH₂CH₂CH₂CH₂CH₂SCH₃
O

A-1707
Et
H
Cl
F
CH₂CH₂CH₂CH₂CH₂SCH(CH₃)₂
O

A-1708
Et
H
Cl
F
CH₂CH₂CH₂CH₂CH₂S(t-Bu)
O

A-1709
Et
H
Cl
F
CH₂CH₂CH₂CH₂CH₂CH₂SCH(CH₃)₂
O

A-1710
Et
H
Cl
F
CH₂CH₂CH₂CH₂CH₂CH₂S(t-Bu)
O

TABLE 40

Com-

pound

Number
R¹
R²
R³
R⁴
R⁵
A

A-1711
Et
H
Cl
F
CH₂CH₂CH₂CH₂CH₂CH₂CH₂S(t-Bu)
O

A-1712
Et
H
Cl
F
CH₂CH₂SCHF₂
O

A-1713
Et
H
Cl
F
CH₂CH₂CH₂SCHF₂
O

A-1714
Et
H
Cl
F
CH₂CH₂CH₂CH₂SCHF₂
O

A-1715
Et
H
Cl
H
CH₂CH₂CH₂CH₂CH₂SCHF₂
O

A-1716
Et
H
Cl
F
CH₂CH₂CH₂CH₂CH₂SCHF₂
O

A-1717
Et
H
Cl
F
CH₂CH₂CH₂CH₂CH₂CH₂SCHF₂
O

A-1718
Et
H
Cl
F
CH₂CH₂CH₂CH₂CH₂CH₂CH₂SCHF₂
O

A-1719
Et
H
Cl
F
CH₂CH₂SCH₂CF₃
O

A-1720
Et
H
Cl
F
CH₂CH₂CH₂SCH₂CF₃
O

A-1721
Et
H
Cl
F
CH₂CH₂CH₂CH₂SCH₂CF₃
O

A-1722
Et
H
Cl
F
CH₂CH₂CH₂CH₂CH₂SCH₂CF₃
O

A-1723
Et
H
Cl
F
CH₂CH₂CH₂CH₂CH₂CH₂SCH₂CF₃
O

A-1724
Et
H
Cl
F
CH₂CH₂CH₂CH₂CH₂CH₂CH₂SCH₂CF₃
O

A-1725
Et
H
Cl
F
CH₂CH(Me)SCH₂CF₃
O

A-1726
Et
H
Cl
F
CH₂CH₂SCH(CF₃)₂
O

A-1727
Et
H
Cl
F
CH₂CH₂CH₂SCH(CF₃)₂
O

A-1728
Et
H
Cl
F
CH₂CH₂CH₂CH₂SCH(CF₃)₂
O

A-1729
Et
H
Cl
F
CH₂CH₂CH₂CH₂CH₂SCH(CF₃)₂
O

A-1730
Et
H
Cl
F
CH₂CH₂CH₂CH₂CH₂CH₂SCH(CF₃)₂
O

A-1731
Et
H
Cl
F
CH₂CH₂CH₂CH₂CH₂SCF₂CF₃
O

A-1732
Et
H
Cl
F
CH₂CH₂CH₂CH₂CH₂CH₂SCF₂CF₃
O

A-1733
Et
H
Cl
F
CH₂CH₂CH₂CH₂CH₂CH₂SCF(CF₃)₂
O

A-1734
Et
H
Cl
F
CH₂CH₂CH₂CH₂CH₂CH₂CH₂SCF(CF₃)₂
O

A-1735
Et
H
Cl
F
CH₂CH₂CH₂CH₂CH₂SCCl₃
O

A-1736
Et
H
Cl
F
CH₂CH₂CH₂CH₂CH₂CH₂SCCl₃
O

A-1737
Et
H
Cl
F
CH₂CH₂SCH₂CH═CH₂
O

A-1738
Et
H
Cl
F
CH₂CH₂CH₂SCH₂CH═CH₂
O

A-1739
Et
H
Cl
F
CH₂CH₂CH₂CH₂SCH₂CH═CH₂
O

A-1740
Et
H
Cl
F
CH₂CH₂SCF═CFCF₃
O

A-1741
Et
H
Cl
F
CH₂CH₂CH₂SCF═CFCF₃
O

A-1742
Et
H
Cl
F
CH₂CH₂CH₂CH₂SCF═CFCF₃
O

A-1743
Et
H
Cl
F
CH₂CH₂CH₂S(c-Pr)
O

A-1744
Et
H
Cl
F
CH₂CH₂CH₂S(c-Hex)
O

A-1745
Et
H
Cl
F
CH₂CH₂CH₂CH₂S(c-Pr)
O

A-1746
Et
H
Cl
F
CH₂CH₂CH₂CH₂S(c-Hex)
O

A-1747
Et
H
Cl
F
CH₂CH₂CH₂CH₂CH₂S(c-Pr)
O

A-1748
Et
H
Cl
F
CH₂CH₂CH₂CH₂CH₂S(c-Hex)
O

A-1749
Et
H
Cl
F
CH₂CH₂CH₂S[c-Hex(4,4-F₂)]
O

A-1750
Et
H
Cl
F
CH₂CH₂CH₂CH₂S[c-Hex(4,4-F₂)]
O

A-1751
Et
H
Cl
F
CH₂CH₂CH₂CH₂CH₂S[c-Hex(4,4-F₂)]
O

A-1752
Et
H
Cl
F
CH₂CH₂CH₂SCH₂(c-Pr)
O

A-1753
Et
H
Cl
F
CH₂CH₂CH₂SCH₂(c-Hex)
O

A-1754
Et
H
Cl
F
CH₂CH₂CH₂CH₂SCH₂(c-Pr)
O

TABLE 41

Compound

Number
R¹
R²
R³
R⁴
R⁵
A

A-1755
Et
H
Cl
F
CH₂CH₂CH₂CH₂SCH₂(c-Hex)
O

A-1756
Et
H
Cl
F
CH₂CH₂CH₂CH₂CH₂SCH₂(c-Pr)
O

A-1757
Et
H
Cl
F
CH₂CH₂CH₂CH₂CH₂SCH₂(c-Hex)
O

A-1758
Et
H
Cl
F
CH₂CH₂CH₂SCH₂[c-Hex(4,4-F₂)]
O

A-1759
Et
H
Cl
F
CH₂CH₂CH₂CH₂SCH₂[c-Hex(4,4-F₂)]
O

A-1760
Et
H
Cl
F
CH₂CH₂CH₂CH₂CH₂SCH₂[c-Hex(4,4-F₂)]
O

A-1761
Et
H
Cl
F
CH₂CH₂CH₂SCH₂SiMe₃
O

A-1762
Et
H
Cl
F
CH₂CH₂CH₂CH₂SCH₂SiMe₃
O

A-1763
Et
H
Cl
F
CH₂CH₂CH₂CH₂CH₂SCH₂SiMe₃
O

A-1764
Et
H
Cl
F
CH₂CH₂OCH₂CH₂SCH₃
O

A-1765
Et
H
Cl
F
CH₂CH₂OCH₂CH₂SCHF₂
O

A-1766
Et
H
Cl
F
CH₂CH₂OCH₂CH₂SCF₃
O

A-1767
Et
H
Cl
F
CH₂CH₂OCH₂CH₂SCH₂CF₃
O

A-1768
Et
H
Cl
F
CH₂CH₂CH₂S(═O)(t-Bu)
O

A-1769
Et
H
Cl
F
CH₂CH₂CH₂CH₂S(═O)(t-Bu)
O

A-1770
Et
H
Cl
F
CH₂CH₂CH₂CH₂CH₂CH₂S(═O)(t-Bu)
O

A-1771
Et
H
Cl
F
CH₂CH₂S(═O)CHF₂
O

A-1772
Et
H
Cl
F
CH₂CH₂CH₂S(═O)CHF₂
O

A-1773
Et
H
Cl
F
CH₂CH₂CH₂CH₂S(═O)CHF₂
O

A-1774
Et
H
Cl
F
CH₂CH₂CH₂CH₂CH₂S(═O)CHF₂
O

A-1775
Et
H
Cl
F
CH₂CH₂CH₂CH₂CH₂CH₂S(═O)CHF₂
O

A-1776
Et
H
Cl
F
CH₂CH₂CH₂CH₂CH₂CH₂CH₂S(═O)CHF₂
O

A-1777
Et
H
Cl
F
CH₂CH₂S(═O)CF₃
O

A-1778
Et
H
Cl
F
CH₂CH₂CH₂S(═O)CF₃
O

A-1779
Et
H
Cl
F
CH₂CH₂CH₂CH₂S(═O)CF₃
O

A-1780
Et
H
Cl
F
CH₂CH₂CH₂CH₂CH₂S(═O)CF₃
O

A-1781
Et
H
Cl
F
CH₂CH₂CH₂CH₂CH₂CH₂S(═O)CF₃
O

A-1782
Et
H
Cl
F
CH₂CH₂CH₂CH₂CH₂CH₂CH₂S(═O)CF₃
O

A-1783
Et
H
Cl
F
CH₂CH₂S(═O)CH₂CF₃
O

A-1784
Et
H
Cl
F
CH₂CH₂CH₂S(═O)CH₂CF₃
O

A-1785
Et
H
Cl
F
CH₂CH₂CH₂CH₂S(═O)CH₂CF₃
O

A-1786
Et
H
Cl
F
CH₂CH₂CH₂CH₂CH₂S(═O)CH₂CF₃
O

A-1787
Et
H
Cl
F
CH₂CH₂CH₂CH₂CH₂CH₂S(═O)CH₂CF₃
O

A-1788
Et
H
Cl
F
CH₂CH₂CH₂CH₂CH₂CH₂CH₂S(═O)CH₂CF₃
O

A-1789
Et
H
Cl
F
CH₂CH(Me)S(═O)CH₂CF₃
O

A-1790
Et
H
Cl
F
CH₂CH₂CH₂S(═O)(c-Pr)
O

A-1791
Et
H
Cl
F
CH₂CH₂CH₂CH₂S(═O)(c-Pr)
O

A-1792
Et
H
Cl
F
CH₂CH₂CH₂CH₂S(═O)(c-Pen)
O

A-1793
Et
H
Cl
F
CH₂CH₂CH₂CH₂S(═O)(c-Hex)
O

A-1794
Et
H
Cl
F
CH₂CH₂CH₂CH₂CH₂S(═O)(c-Pr)
O

A-1795
Et
H
Cl
F
CH₂CH₂CH₂CH₂CH₂S(═O)(c-Hex)
O

A-1796
Et
H
Cl
F
CH₂CH₂CH₂S(═O)[c-Hex(4,4-F₂)]
O

A-1797
Et
H
Cl
F
CH₂CH₂CH₂CH₂S(═O)[c-Hex(4,4-F₂)]
O

A-1798
Et
H
Cl
F
CH₂CH₂CH₂CH₂CH₂S(═O)[c-Hex(4,4-F₂)]
O

TABLE 42

Compound

Number
R¹
R²
R³
R⁴
R⁵
A

A-1799
Et
H
Cl
F
CH₂CH₂CH₂CH₂S(═O)₂Me
O

A-1800
Et
H
Cl
F
CH₂CH₂CH₂CH₂CH₂S(═O)₂Me
O

A-1801
Et
H
Cl
F
CH₂CH₂CH₂CH₂CH₂S(═O)₂(t-Bu)
O

A-1802
Et
H
Cl
F
CH₂CH₂S(═O)₂CHF₂
O

A-1803
Et
H
Cl
F
CH₂CH₂CH₂S(═O)₂CHF₂
O

A-1804
Et
H
Cl
F
CH₂CH₂CH₂CH₂S(═O)₂CHF₂
O

A-1805
Et
H
Cl
F
CH₂CH₂CH₂CH₂CH₂S(═O)₂CHF₂
O

A-1806
Et
H
Cl
F
CH₂CH₂CH₂CH₂CH₂CH₂S(═O)₂CHF₂
O

A-1807
Et
H
Cl
F
CH₂CH₂S(═O)₂CF₃
O

A-1808
Et
H
Cl
F
CH₂CH₂CH₂S(═O)₂CF₃
O

A-1809
Et
H
Cl
F
CH₂CH₂CH₂CH₂S(═O)₂CF₃
O

A-1810
Et
H
Cl
F
CH₂CH₂CH₂CH₂CH₂S(═O)₂CF₃
O

A-1811
Et
H
Cl
F
CH₂CH₂CH₂CH₂CH₂CH₂S(═O)₂CF₃
O

A-1812
Et
H
Cl
F
CH₂CH₂CH₂CH₂CH₂CH₂CH₂S(═O)₂CF₃
O

A-1813
Et
H
Cl
F
CH₂CH₂CH₂CH₂CH₂CH₂CH₂CH₂S(═O)₂CF₃
O

A-1814
Et
H
Cl
F
CH₂CH₂S(═O)₂CH₂CF₃
O

A-1815
Et
H
Cl
F
CH₂CH₂CH₂S(═O)₂CH₂CF₃
O

A-1816
Et
H
Cl
F
CH₂CH₂CH₂CH₂S(═O)₂CH₂CF₃
O

A-1817
Et
H
Cl
F
CH₂CH₂CH₂CH₂CH₂S(═O)₂CH₂CF₃
O

A-1818
Et
H
Cl
F
CH₂CH₂CH₂CH₂CH₂CH₂S(═O)₂CH₂CF₃
O

A-1819
Et
H
Cl
F
CH₂CH(Me)S(═O)₂CH₂CF₃
O

A-1820
Et
H
Cl
F
CH₂CH₂CH₂S(═O)₂(c-Pr)
O

A-1821
Et
H
Cl
F
CH₂CH₂CH₂CH₂S(═O)₂(c-Pr)
O

A-1822
Et
H
Cl
F
CH₂CH₂CH₂CH₂CH₂S(═O)₂(c-Pr)
O

A-1823
Et
H
Cl
F
CH₂CH₂CH₂S(═O)₂[c-Hex(4,4-F₂)]
O

A-1824
Et
H
Cl
F
CH₂CH₂CH₂CH₂S(═O)₂[c-Hex(4,4-F₂)]
O

A-1825
Et
H
Cl
F
CH₂CH₂CH₂CH₂CH₂S(═O)₂[c-Hex(4,4-F₂)]
O

A-1826
Et
H
Cl
F
CH₂CH₂CH₂C(═O)H
O

A-1827
Et
H
Cl
F
CH₂CH₂CH₂CH₂C(═O)H
O

A-1828
Et
H
Cl
F
CH₂CH₂CH₂CH₂CH₂C(═O)H
O

A-1829
Et
H
Cl
F
CH₂CH₂CH₂C(═O)(t-Bu)
O

A-1830
Et
H
Cl
F
CH₂CH₂CH₂CH₂C(═O)(t-Bu)
O

A-1831
Et
H
Cl
F
CH₂CH₂CH₂CH₂CH₂C(═O)(t-Bu)
O

A-1832
Et
H
Cl
F
CH₂CH₂CH₂C(═O)CF₃
O

A-1833
Et
H
Cl
F
CH₂CH₂CH₂CH₂C(═O)CF₃
O

A-1834
Et
H
Cl
F
CH₂CH₂CH₂CH₂CH₂C(═O)CF₃
O

A-1835
Et
H
Cl
F
CH₂C(═O)Ph
O

A-1836
Et
H
Cl
F
CH₂C(═O)Ph(4-Cl)
O

A-1837
Et
H
Cl
F
CH₂C(═O)Ph(4-CF₃)
O

A-1838
Et
H
Cl
F
CH₂CH₂C(═O)Ph(4-CF₃)
O

A-1839
Et
H
Cl
F
CH₂CH₂CH₂C(═O)Ph(4-CF₃)
O

A-1840
Et
H
Cl
F
CH₂CH₂CH₂CH₂C(═O)Ph(4-CF₃)
O

A-1841
Et
H
Cl
F
CH₂CH₂CH₂CH₂CH₂C(═O)Ph(4-CF₃)
O

A-1842
Et
H
Cl
F
CH₂C(═O)OEt
O

TABLE 437

Compound

Number
R¹
R²
R³
R⁴
R⁵
A

A-1843
Et
H
Cl
F
CH₂CH₂C(═O)O(t-Bu)
O

A-1844
Et
H
Cl
F
CH₂CH₂CH₂C(═O)OEt
O

A-1845
Et
H
Cl
F
CH₂CH₂CH₂C(═O)O(t-Bu)
O

A-1846
Et
H
Cl
F
CH₂CH₂CH₂CH₂C(═O)O(t-Bu)
O

A-1847
Et
H
Cl
F
CH₂CH₂CH₂CH₂CH₂C(═O)O(t-Bu)
O

A-1848
Et
H
Cl
F
CH₂CH₂CH₂CH₂CH₂CH₂C(═O)O(t-Bu)
O

A-1849
Et
H
Cl
F
CH₂CH₂CH₂CH₂CH₂CH₂CH₂C(═O)OEt
O

A-1850
Et
H
Cl
F
CH₂CH₂C(═O)OCH₂CF₃
O

A-1851
Et
H
Cl
F
CH₂CH₂CH₂C(═O)OCH₂CF₃
O

A-1852
Et
H
Cl
F
CH₂CH₂CH₂CH₂C(═O)OCH₂CF₃
O

A-1853
Et
H
Cl
F
CH₂CH₂CH₂CH₂CH₂C(═O)OCH₂CF₃
O

A-1854
Et
H
Cl
F
CH₂CH₂C(═O)NH(t-Bu)
O

A-1855
Et
H
Cl
F
CH₂CH₂CH₂C(═O)NH(t-Bu)
O

A-1856
Et
H
Cl
F
CH₂CH₂CH₂C(═O)NH(t-Pen)
O

A-1857
Et
H
Cl
F
CH₂CH₂CH₂CH₂C(═O)NH(t-Bu)
O

A-1858
Et
H
Cl
F
CH₂CH₂C(═O)NHCH₂CF₃
O

A-1859
Et
H
Cl
F
CH₂CH₂CH₂C(═O)NHCH₂CF₃
O

A-1860
Et
H
Cl
F
CH₂CH₂CH₂CH₂C(═O)NHCH₂CF₃
O

A-1861
Et
H
Cl
F
CH₂CH₂SC(═O)N(Me)₂
O

A-1862
Et
H
Cl
F
CH₂CH₂CH₂SC(═O)N(Me)₂
O

A-1863
Et
H
Cl
F
CH₂CH₂CH₂SC(═O)NH(t-Bu)
O

A-1864
Et
H
Cl
F
CH₂CH₂CH₂CH₂CH₂SC(═O)NH(t-Bu)
O

A-1865
Et
H
Cl
F
CH₂CH₂SC(═O)NHCH₂CF₃
O

A-1866
Et
H
Cl
F
CH₂CH₂CH₂SC(═O)NHCH₂CF₃
O

A-1867
Et
H
Cl
F
CH₂CH₂CH₂CH₂SC(═O)NHCH₂CF₃
O

A-1868
Et
H
Cl
F
CH₂CH₂CH₂OC(═O)H
O

A-1869
Et
H
Cl
F
CH₂CH₂CH₂CH₂OC(═O)H
O

A-1870
Et
H
Cl
F
CH₂CH₂CH₂CH₂CH₂OC(═O)H
O

A-1871
Et
H
Cl
F
CH₂CH₂CH₂OC(═O)Me
O

A-1872
Et
H
Cl
F
CH₂CH₂CH₂CH₂OC(═O)Me
O

A-1873
Et
H
Cl
F
CH₂CH₂CH₂CH₂CH₂OC(═O)Me
O

A-1874
Et
H
Cl
F
CH₂CH₂OC(═O)CF₃
O

A-1875
Et
H
Cl
F
CH₂CH₂CH₂OC(═O)CF₃
O

A-1876
Et
H
Cl
F
CH₂CH₂CH₂CH₂OC(═O)CF₃
O

A-1877
Et
H
Cl
F
CH₂CH₂CH₂CH₂CH₂OC(═O)Ph(4-CF₃)
O

A-1878
Et
H
Cl
F
CH₂CH₂OC(═O)Ph
O

A-1879
Et
H
Cl
F
CH₂CH₂OC(═O)Ph(4-CF₃)
O

A-1880
Et
H
Cl
F
CH₂CH₂CH₂OC(═O)Ph(4-CF₃)
O

A-1881
Et
H
Cl
F
CH₂CH₂CH₂CH₂OC(═O)Ph(4-CF₃)
O

A-1882
Et
H
Cl
F
CH₂CH₂CH₂CH₂CH₂OC(═O)Ph(4-CF₃)
O

A-1883
Et
H
Cl
F
CH₂CH₂OS(═O)Me
O

A-1884
Et
H
Cl
F
CH₂CH₂CH₂OS(═O)Me
O

A-1885
Et
H
Cl
F
CH₂CH₂CH₂CH₂OS(═O)Me
O

A-1886
Et
H
Cl
F
CH₂CH₂CH₂CH₂CH₂OS(═O)Me
O

TABLE 44

Compound

Number
R¹
R²
R³
R⁴
R⁵
A

A-1887
Et
H
Cl
F
CH₂CH₂CH₂CH₂CH₂CH₂OS(═O)Me
O

A-1888
Et
H
Cl
F
CH₂CH₂OS(═O)CF₃
O

A-1889
Et
H
Cl
F
CH₂CH₂CH₂OS(═O)CF₃
O

A-1890
Et
H
Cl
F
CH₂CH₂CH₂CH₂OS(═O)CF₃
O

A-1891
Et
H
Cl
F
CH₂CH₂CH₂CH₂CH₂OS(═O)CF₃
O

A-1892
Et
H
Cl
F
CH₂CH₂CH₂CH₂CH₂CH₂OS(═O)CF₃
O

A-1893
Et
H
Cl
F
CH₂CH₂OS(═O)Ph
O

A-1894
Et
H
Cl
F
CH₂CH₂OS(═O)Ph(4-Me)
O

A-1895
Et
H
Cl
F
CH₂CH₂CH₂OS(═O)Ph
O

A-1896
Et
H
Cl
F
CH₂CH₂CH₂OS(═O)Ph(4-Me)
O

A-1897
Et
H
Cl
F
CH₂CH₂OS(═O)₂Me
O

A-1898
Et
H
Cl
F
CH₂CH₂CH₂OS(═O)₂Me
O

A-1899
Et
H
Cl
F
CH₂CH₂CH₂OS(═O)₂CF₃
O

A-1900
Et
H
Cl
F
CH₂CH₂CH₂CH₂OS(═O)₂CF₃
O

A-1901
Et
H
Cl
F
CH₂CH₂CH₂CH₂CH₂OS(═O)₂CF₃
O

A-1902
Et
H
Cl
F
CH₂CH₂CH₂CH₂CH₂OS(═O)₂CF₂CF₂CF₂CF₃
O

A-1903
Et
H
Cl
F
CH₂CH₂OS(═O)₂Ph
O

A-1904
Et
H
Cl
F
CH₂CH₂OS(═O)₂Ph(4-Me)
O

A-1905
Et
H
Cl
F
CH₂CH₂CH₂OS(═O)₂Ph
O

A-1906
Et
H
Cl
F
CH₂CH₂CH₂OS(═O)₂Ph(4-Me)
O

A-1907
Et
H
Cl
F
CH₂CH₂NH₂
O

A-1908
Et
H
Cl
F
CH₂CH₂CH₂NH₂
O

A-1909
Et
H
Cl
F
CH₂CH₂CH₂CH₂NH₂
O

A-1910
Et
H
Cl
F
CH₂CH₂CH₂CH₂CH₂NH₂
O

A-1911
Et
H
Cl
F
CH₂CH₂CH₂CH₂CH₂CH₂NH₂
O

A-1912
Et
H
Cl
F
CH₂CH₂CH₂CH₂CH₂CH₂CH₂NH₂
O

A-1913
Et
H
Cl
F
CH₂CH(Me)NH₂
O

A-1914
Et
H
Cl
F
CH₂C*H(Me)NH₂:(R)
O

A-1915
Et
H
Cl
F
CH₂C*H(Me)NH₂:(S)
O

A-1916
Et
H
Cl
F
CH₂CH(Et)NH₂
O

A-1917
Et
H
Cl
F
CH₂CH(i-Pr)NH₂
O

A-1918
Et
H
Cl
F
CH(Me)CH₂NH₂
O

A-1919
Et
H
Cl
F
CH(Et)CH₂NH₂
O

A-1920
Et
H
Cl
F
CH(i-Pr)CH₂NH₂
O

A-1921
Et
H
Cl
F
CH₂CH₂CH(Me)NH₂
O

A-1922
Et
H
Cl
F
CH₂CH(Me)CH₂NH₂
O

A-1923
Et
H
Cl
F
CH(Me)CH₂CH₂NH₂
O

A-1924
Et
H
Cl
F
CH₂CH(Me)NH(c-Pr)
O

A-1925
Et
H
Cl
F
CH₂CH(Me)NHOMe
O

A-1926
Et
H
Cl
F
CH₂CH(Me)N(OMe)S(═O)₂Ph(2-NO₂)
O

A-1927
Et
H
Cl
F
CH₂CH(Me)N(OMe)S(═O)₂Ph(4-NO₂)
O

A-1928
Et
H
Cl
F
CH₂CH₂N(Me)(t-Bu)
O

A-1929
Et
H
Cl
F
CH₂CH₂CH₂N(Me)(t-Bu)
O

A-1930
Et
H
Cl
F
CH₂CH₂CH₂CH₂N(Me)(t-Bu)
O

TABLE 45

Compound

Number
R¹
R²
R³
R⁴
R⁵
A

A-1931
Et
H
Cl
F
CH₂CH₂NHCH₂CF₃
O

A-1932
Et
H
Cl
F
CH₂CH₂CH₂NHCH₂CF₃
O

A-1933
Et
H
Cl
F
CH₂CH₂CH₂CH₂NHCH₂CF₃
O

A-1934
Et
H
Cl
F
CH₂CH₂NHC(═O)C(Me)(CF₃)₂
O

A-1935
Et
H
Cl
F
CH₂CH₂NHC(═O)Me
O

A-1936
Et
H
Cl
F
CH₂CH₂NHC(═O)(t-Bu)
O

A-1937
Et
H
Cl
F
CH₂CH₂CH₂CH₂NHC(═O)CH(CH₃)₂
O

A-1938
Et
H
Cl
F
CH₂CH₂CH₂CH₂NHC(═O)(t-Bu)
O

A-1939
Et
H
Cl
F
CH₂CH₂CH₂CH₂NHC(═O)CH₂(t-Bu)
O

A-1940
Et
H
Cl
F
CH₂CH₂NHC(═O)CF₃
O

A-1941
Et
H
Cl
F
CH₂CH₂NHC(═O)CH₂CF₃
O

A-1942
Et
H
Cl
F
CH₂CH₂NHC(═O)CF₂CF₃
O

A-1943
Et
H
Cl
F
CH₂CH₂CH₂NHC(═O)CF₃
O

A-1944
Et
H
Cl
F
CH₂CH₂CH₂NHC(═O)CH₂CF₃
O

A-1945
Et
H
Cl
F
CH₂CH₂CH₂NHC(═O)CF₂CF₃
O

A-1946
Et
H
Cl
F
CH₂CH₂CH₂CH₂NHC(═O)CF₃
O

A-1947
Et
H
Cl
F
CH₂CH₂CH₂CH₂NHC(═O)CH₂CF₃
O

A-1948
Et
H
Cl
F
CH₂CH₂CH₂CH₂NHC(═O)CF₂CF₃
O

A-1949
Et
H
Cl
F
CH₂CH₂CH₂CH₂NHC(═O)CF(CF₃)₂
O

A-1950
Et
H
Cl
F
CH₂CH₂CH₂CH₂NHC(═O)CCl₃
O

A-1951
Et
H
Cl
F
CH₂CH(Me)NHC(═O)CF₃
O

A-1952
Et
H
Cl
F
CH₂CH₂NHC(═O)Ph
O

A-1953
Et
H
Cl
F
CH₂CH₂NHC(═O)Ph(4-CF₃)
O

A-1954
Et
H
Cl
F
CH₂CH₂CH₂NHC(═O)Ph(4-CF₃)
O

A-1955
Et
H
Cl
F
CH₂CH₂CH₂CH₂NHC(═O)Ph(4-CF₃)
O

A-1956
Et
H
Cl
F
CH₂CH₂NHC(═O)O(t-Bu)
O

A-1957
Et
H
Cl
F
CH₂CH₂CH₂NHC(═O)O(t-Bu)
O

A-1958
Et
H
Cl
F
CH₂CH₂CH₂CH₂NHC(═O)O(t-Bu)
O

A-1959
Et
H
Cl
F
CH₂CH₂CH₂CH₂NHC(═O)OCH(CH₃)₂
O

A-1960
Et
H
Cl
F
CH₂CH(Me)NHC(═O)O(t-Bu)
O

A-1961
Et
H
Cl
F
CH₂C*H(Me)NHC(═O)O(t-Bu):(R)
O

A-1962
Et
H
Cl
F
CH₂C*H(Me)NHC(═O)O(t-Bu):(S)
O

A-1963
Et
H
Cl
F
CH₂CH(Et)NHC(═O)O(t-Bu)
O

A-1964
Et
H
Cl
F
CH₂CH(i-Pr)NHC(═O)O(t-Bu)
O

A-1965
Et
H
Cl
F
CH(Me)CH₂NHC(═O)O(t-Bu)
O

A-1966
Et
H
Cl
F
CH(Et)CH₂NHC(═O)O(t-Bu)
O

A-1967
Et
H
Cl
F
CH(i-Pr)CH₂NHC(═O)O(t-Bu)
O

A-1968
Et
H
Cl
F
CH₂CH(Me)CH₂NHC(═O)O(t-Bu)
O

A-1969
Et
H
Cl
F
CH₂CH₂NHC(═O)OC(Me)₂CF₃
O

A-1970
Et
H
Cl
F
CH₂CH₂CH₂NHC(═O)OCH₂CF₃
O

A-1971
Et
H
Cl
F
CH₂CH₂CH₂NHC(═O)OCH₂CH₂CF₃
O

A-1972
Et
H
Cl
F
CH₂CH₂CH₂CH₂NHC(═O)OCH₂CCl₃
O

A-1973
Et
H
Cl
F
CH₂CH₂CH₂CH₂NHC(═O)OCH₂CF₃
O

A-1974
Et
H
Cl
F
CH₂CH₂NHC(═O)NH(t-Bu)
O

TABLE 46

Compound

Number
R¹
R²
R³
R⁴
R⁵
A

A-1975
Et
H
Cl
F
CH₂CH₂CH₂NHC(═O)NH(t-Bu)
O

A-1976
Et
H
Cl
F
CH₂CH₂CH₂CH₂NHC(═O)NHEt
O

A-1977
Et
H
Cl
F
CH₂CH₂CH₂CH₂NHC(═O)NH(t-Bu)
O

A-1978
Et
H
Cl
F
CH₂CH₂CH₂NHC(═O)NHCH₂CCl₃
O

A-1979
Et
H
Cl
F
CH₂CH₂CH₂NHC(═O)NHCH₂CH₂F
O

A-1980
Et
H
Cl
F
CH₂CH₂CH₂NHC(═O)NHCH₂CF₃
O

A-1981
Et
H
Cl
F
CH₂CH₂CH₂CH₂NHC(═O)NHCH₂CCl₃
O

A-1982
Et
H
Cl
F
CH₂CH₂CH₂CH₂NHC(═O)NHCH₂CH₂F
O

A-1983
Et
H
Cl
F
CH₂CH₂CH₂CH₂NHC(═O)NHCH₂CF₃
O

A-1984
Et
H
Cl
F
CH₂CH₂NHS(═O)Me
O

A-1985
Et
H
Cl
F
CH₂CH₂CH₂NHS(═O)Me
O

A-1986
Et
H
Cl
F
CH₂CH₂CH₂CH₂NHS(═O)Me
O

A-1987
Et
H
Cl
F
CH₂CH₂CH₂CH₂NHS(═O)CH(CH₃)₂
O

A-1988
Et
H
Cl
F
CH₂CH₂CH₂CH₂CH₂NHS(═O)Me
O

A-1989
Et
H
Cl
F
CH₂CH₂NHS(═O)CHF₂
O

A-1990
Et
H
Cl
F
CH₂CH₂CH₂NHS(═O)CHF₂
O

A-1991
Et
H
Cl
F
CH₂CH₂CH₂CH₂NHS(═O)CHF₂
O

A-1992
Et
H
Cl
F
CH₂CH₂CH₂CH₂CH₂NHS(═O)CHF₂
O

A-1993
Et
H
Cl
F
CH₂CH(Me)NHS(═O)CHF₂
O

A-1994
Et
H
Cl
F
CH(Me)CH₂NHS(═O)CHF₂
O

A-1995
Et
H
Cl
F
CH₂CH₂CH(Me)NHS(═O)CHF₂
O

A-1996
Et
H
Cl
F
CH₂CH(Me)CH₂NHS(═O)CHF₂
O

A-1997
Et
H
Cl
F
CH(Me)CH₂CH₂NHS(═O)CHF₂
O

A-1998
Et
H
Cl
F
CH₂CH₂NHS(═O)CF₃
O

A-1999
Et
H
Cl
F
CH₂CH₂CH₂NHS(═O)CF₃
O

A-2000
Et
H
Cl
F
CH₂CH₂CH₂CH₂NHS(═O)CF₃
O

A-2001
Et
H
Cl
F
CH₂CH₂CH₂CH₂CH₂NHS(═O)CF₃
O

A-2002
Et
H
Cl
F
CH₂CH₂CH₂NHS(═O)Ph
O

A-2003
Et
H
Cl
F
CH₂CH₂CH₂CH₂NHS(═O)Ph
O

A-2004
Et
H
Cl
F
CH₂CH₂CH₂CH₂CH₂NHS(═O)Ph
O

A-2005
Et
H
Cl
F
CH₂CH₂CH₂CH₂CH₂NHS(═O)Ph(4-CF₃)
O

A-2006
Et
H
Cl
F
CH₂CH(Me)NHS(═O)Ph(4-CF₃)
O

A-2007
Et
H
Cl
F
CH₂CH(Et)NHS(═O)Ph(4-CF₃)
O

A-2008
Et
H
Cl
F
CH(Me)CH₂NHS(═O)Ph(4-CF₃)
O

A-2009
Et
H
Cl
F
CH(Et)CH₂NHS(═O)Ph(4-CF₃)
O

A-2010
Et
H
Cl
F
CH₂CH(Et)CH₂NHS(═O)Ph(4-CF₃)
O

A-2011
Et
H
Cl
F
CH₂CH₂NHS(═O)₂Me
O

A-2012
Et
H
Cl
F
CH₂CH₂CH₂NHS(═O)₂Me
O

A-2013
Et
H
Cl
F
CH₂CH₂CH₂CH₂NHS(═O)₂Me
O

A-2014
Et
H
Cl
F
CH₂CH₂CH₂CH₂NHS(═O)₂CH(CH₃)₂
O

A-2015
Et
H
Cl
F
CH₂CH₂CH₂CH₂CH₂NHS(═O)₂Me
O

A-2016
Et
H
Cl
F
CH₂CH₂NHS(═O)₂CHF₂
O

A-2017
Et
H
Cl
F
CH₂CH₂CH₂NHS(═O)₂CHF₂
O

A-2018
Et
H
Cl
F
CH₂CH₂CH₂CH₂NHS(═O)₂CHF₂
O

TABLE 47

Compound

Number
R¹
R²
R³
R⁴
R⁵
A

A-2019
Et
H
Cl
F
CH₂CH₂CH₂CH₂CH₂NHS(═O)₂CHF₂
O

A-2020
Et
H
Cl
F
CH₂CH(Me)NHS(═O)₂CHF₂
O

A-2021
Et
H
Cl
F
CH(Me)CH₂NHS(═O)₂CHF₂
O

A-2022
Et
H
Cl
F
CH₂CH₂CH(Me)NHS(═O)₂CHF₂
O

A-2023
Et
H
Cl
F
CH₂CH(Me)CH₂NHS(═O)₂CHF₂
O

A-2024
Et
H
Cl
F
CH(Me)CH₂CH₂NHS(═O)₂CHF₂
O

A-2025
Et
H
Cl
F
CH₂CH(Me)N(Me)S(═O)₂CHF₂
O

A-2026
Et
H
Cl
F
CH(Me)CH₂N(Me)S(═O)₂CHF₂
O

A-2027
Et
H
Cl
F
CH₂CH₂CH(Me)N(Me)S(═O)₂CHF₂
O

A-2028
Et
H
Cl
F
CH₂CH(Me)CH₂N(Me)S(═O)₂CHF₂
O

A-2029
Et
H
Cl
F
CH(Me)CH₂CH₂N(Me)S(═O)₂CHF₂
O

A-2030
Et
H
Cl
F
CH₂CH₂CH₂NHS(═O)₂Ph
O

A-2031
Et
H
Cl
F
CH₂CH₂CH₂CH₂NHS(═O)₂Ph
O

A-2032
Et
H
Cl
F
CH₂CH₂CH₂CH₂CH₂NHS(═O)₂Ph
O

A-2033
Et
H
Cl
F
CH₂CH₂CH₂CH₂CH₂NHS(═O)₂Ph(4-CF₃)
O

A-2034
Et
H
Cl
F
CH₂CH(Me)NHS(═O)₂Ph(4-CF₃)
O

A-2035
Et
H
Cl
F
CH₂CH(Et)NHS(═O)₂Ph(4-CF₃)
O

A-2036
Et
H
Cl
F
CH(Me)CH₂NHS(═O)₂Ph(4-CF₃)
O

A-2037
Et
H
Cl
F
CH(Et)CH₂NHS(═O)₂Ph(4-CF₃)
O

A-2038
Et
H
Cl
F
CH₂CH(Me)CH₂NHS(═O)₂Ph(4-CF₃)
O

A-2039
Et
H
Cl
F
CH₂CH₂SiMe₃
O

A-2040
Et
H
Cl
F
CH₂CH₂CH₂SiMe₃
O

A-2041
Et
H
Cl
F
CH₂CH₂CH₂CH₂SiMe₃
O

A-2042
Et
H
Cl
F
CH₂Ph
O

A-2043
Et
H
Cl
F
CH₂Ph(2-CF₃)
O

A-2044
Et
H
Cl
F
CH₂Ph(3-CF₃)
O

A-2045
Et
H
Cl
F
CH₂Ph(4-CF₃)
O

A-2046
Et
H
Cl
F
CH₂Ph(2-OCF₃)
O

A-2047
Et
H
Cl
F
CH₂Ph(3-OCF₃)
O

A-2048
Et
H
Cl
F
CH₂Ph(4-OCF₃)
O

A-2049
Et
H
Cl
F
CH₂Ph(2-SCF₃)
O

A-2050
Et
H
Cl
F
CH₂Ph(3-SCF₃)
O

A-2051
Et
H
Cl
F
CH₂Ph(4-SCF₃)
O

A-2052
Et
H
Cl
F
CH₂Ph(3-CH₂SCF₃)
O

A-2053
Et
H
Cl
F
CH₂Ph(4-F)
O

A-2054
Et
H
Cl
F
CH₂Ph(4-Cl)
O

A-2055
Et
H
Cl
F
CH₂Ph(4-Br)
O

A-2056
Et
H
Cl
F
CH₂Ph(4-Me)
O

A-2057
Et
H
Cl
F
CH₂Ph[4-(t-Bu)]
O

A-2058
Et
H
Cl
F
CH₂Ph(4-CN)
O

A-2059
Et
H
Cl
F
CH₂Ph(4-NO₂)
O

A-2060
Et
H
Cl
F
CH₂Ph(4-OCHF₂)
O

A-2061
Et
H
Cl
F
CH₂Ph(4-SCHF₂)
O

A-2062
Et
H
Cl
F
CH₂Ph(4-CH₂SCF₃)
O

TABLE 48

Compound

Number
R¹
R²
R³
R⁴
R⁵
A

A-2063
Et
H
Cl
F
CH₂Ph[4-CF(CF₃)₂]
O

A-2064
Et
H
Cl
F
CH₂Ph(4-CH₂SCF₃)
O

A-2065
Et
H
Cl
F
CH₂Ph[4-Ph(4-CF₃)]
O

A-2066
Et
H
Cl
F
CH₂Ph(2,4-Cl₂)
O

A-2067
Et
H
Cl
F
CH₂Ph[2,5-(CF₃)₂]
O

A-2068
Et
H
Cl
F
CH₂Ph(3,4-Cl₂)
O

A-2069
Et
H
Cl
F
CH₂Ph(3-CF₃-4-F)
O

A-2070
Et
H
Cl
F
CH₂Ph(3-CF₃-4-Cl)
O

A-2071
Et
H
Cl
F
CH₂Ph(3-F-4-CF₃)
O

A-2072
Et
H
Cl
F
CH₂Ph(2,4,6-F₃)
O

A-2073
Et
H
Cl
F
CH₂Ph(3,4,5-F₃)
O

A-2074
Et
H
Cl
F
CH₂Ph(2,3,4-F₃)
O

A-2075
Et
H
Cl
F
CH₂Ph(3,4,5-Cl₃)
O

A-2076
Et
H
Cl
F
CH₂CH₂Ph
O

A-2077
Et
H
Cl
F
CH₂CH₂Ph(4-F)
O

A-2078
Et
H
Cl
F
CH₂CH₂Ph(4-Cl)
O

A-2079
Et
H
Cl
F
CH₂CH₂Ph(4-Br)
O

A-2080
Et
H
Cl
F
CH₂CH₂Ph[4-(t-Bu)]
O

A-2081
Et
H
Cl
F
CH₂CH₂Ph(2-CF₃)
O

A-2082
Et
H
Cl
F
CH₂CH₂Ph(3-CF₃)
O

A-2083
Et
H
Cl
H
CH₂CH₂Ph(4-CF₃)
O

A-2084
Et
H
Cl
F
CH₂CH₂Ph(4-CF₃)
O

A-2085
Et
H
Cl
F
CH₂CH₂Ph(4-CF(CF₃)₂)
O

A-2086
Et
H
Cl
F
CH₂CH₂Ph[4-(c-Pr)]
O

A-2087
Et
H
Cl
F
CH₂CH₂Ph{4-[c-Pr(2,2-F₂)]}
O

A-2088
Et
H
Cl
F
CH₂CH₂Ph(4-OMe)
O

A-2089
Et
H
Cl
F
CH₂CH₂Ph(3-OCF₃)
O

A-2090
Et
H
Cl
F
CH₂CH₂Ph(4-OCHF₂)
O

A-2091
Et
H
Cl
F
CH₂CH₂Ph(4-OCF₃)
O

A-2092
Et
H
Cl
F
CH₂CH₂Ph(4-SMe)
O

A-2093
Et
H
Cl
F
CH₂CH₂Ph(4-SCHF₂)
O

A-2094
Et
H
Cl
F
CH₂CH₂Ph(4-SCF₃)
O

A-2095
Et
H
Cl
F
CH₂CH₂Ph[4-S(═O)Me]
O

A-2096
Et
H
Cl
F
CH₂CH₂Ph[4-S(═O)CF₃]
O

A-2097
Et
H
Cl
F
CH₂CH₂Ph[4-S(═O)₂Me]
O

A-2098
Et
H
Cl
F
CH₂CH₂Ph[4-S(═O)₂CF₃]
O

A-2099
Et
H
Cl
F
CH₂CH₂Ph(4-CH₂SMe)
O

A-2100
Et
H
Cl
F
CH₂CH₂Ph(4-CH₂SCF₃)
O

A-2101
Et
H
Cl
F
CH₂CH₂Ph[4-OS(═O)₂Me]
O

A-2102
Et
H
Cl
F
CH₂CH₂Ph[4-OS(═O)₂CF₃]
O

A-2103
Et
H
Cl
F
CH₂CH₂Ph[4-Ph(4-CF₃)]
O

A-2104
Et
H
Cl
F
CH₂CH₂Ph(4-CH₂Ph)
O

A-2105
Et
H
Cl
F
CH₂CH₂Ph(4-OCH₂Ph)
O

A-2106
Et
H
Cl
F
CH₂CH₂Ph(4-CN)
O

TABLE 49

Compound

Number
R¹
R²
R³
R⁴
R⁵
A

A-2107
Et
H
Cl
F
CH₂CH₂Ph(4-NO₂)
O

A-2108
Et
H
Cl
F
CH₂CH₂Ph(2,4-Cl₂)
O

A-2109
Et
H
Cl
F
CH₂CH₂Ph(3,4-Cl₂)
O

A-2110
Et
H
Cl
F
CH₂CH₂Ph(3-CF3-4-F)
O

A-2111
Et
H
Cl
F
CH₂CH₂Ph(2-CF3-4-F)
O

A-2112
Et
H
Cl
F
CH₂CH₂Ph(3-F-4-CF₃)
O

A-2113
Et
H
Cl
F
CH₂CH₂Ph(2-F-4-CF₃)
O

A-2114
Et
H
Cl
F
CH₂CH₂Ph(3-Cl-4-OCHF₂)
O

A-2115
Et
H
Cl
F
CH₂CH₂Ph(3,4,5-Cl₃)
O

A-2116
Et
H
Cl
F
CH₂CH₂Ph(2,3,4-F₃)
O

A-2117
Et
H
Cl
F
CH₂CH₂Ph(2,4,5-F₃)
O

A-2118
Et
H
Cl
F
CH₂CH₂Ph(3,4,5-F₃)
O

A-2119
Et
H
Cl
F
CH₂CH₂Ph(2,4,6-F₃)
O

A-2120
Et
H
Cl
F
CH₂CH₂CH₂Ph
O

A-2121
Et
H
Cl
F
CH₂CH₂CH₂Ph(3-CF₃)
O

A-2122
Et
H
Cl
F
CH₂CH₂CH₂Ph(4-CF₃)
O

A-2123
Et
H
Cl
F
CH₂CH₂CH₂Ph(4-F)
O

A-2124
Et
H
Cl
F
CH₂CH₂CH₂Ph[4-(t-Bu)]
O

A-2125
Et
H
Cl
F
CH₂CH₂CH₂Ph(4-CN)
O

A-2126
Et
H
Cl
F
CH₂CH₂CH₂Ph(4-CF₃)
O

A-2127
Et
H
Cl
F
CH₂CH₂CH₂Ph(4-OCHF₂)
O

A-2128
Et
H
Cl
F
CH₂CH₂CH₂Ph(4-OCF₃)
O

A-2129
Et
H
Cl
F
CH₂CH₂CH₂Ph(4-SCHF₂)
O

A-2130
Et
H
Cl
F
CH₂CH₂CH₂Ph(4-SCF₃)
O

A-2131
Et
H
Cl
F
CH₂CH₂CH₂Ph[4-CF(CF₃)₂]
O

A-2132
Et
H
Cl
F
CH₂CH₂CH₂Ph(3,4,5-F₃)
O

A-2133
Et
H
Cl
F
CH₂CH₂CH₂Ph(2,4,6-F₃)
O

A-2134
Et
H
Cl
F
CH₂CH₂CH₂CH₂Ph
O

A-2135
Et
H
Cl
F
CH₂CH₂CH₂CH₂Ph(4-F)
O

A-2136
Et
H
Cl
F
CH₂CH₂CH₂CH₂Ph(4-CF₃)
O

A-2137
Et
H
Cl
F
CH₂CH₂CH₂CH₂Ph(4-OCF₃)
O

A-2138
Et
H
Cl
F
CH₂CH₂CH₂CH₂Ph(4-SCF₃)
O

A-2139
Et
H
Cl
F
CH₂CH₂CH₂CH₂CH₂Ph
O

A-2140
Et
H
Cl
F
CH₂CH₂CH₂CH₂CH₂CH₂Ph
O

A-2141
Et
H
Cl
F
CH₂CF₂Ph(4-F)
O

A-2142
Et
H
Cl
F
CH₂CF₂Ph(4-CF₃)
O

A-2143
Et
H
Cl
F
CH₂CF₂Ph(3,4,5-F₃)
O

A-2144
Et
H
Cl
F
CH₂CF₂Ph(3,4,5-F₃)
O

A-2145
Et
H
Cl
F
CH₂CH₂OPh
O

A-2146
Et
H
Cl
F
CH₂CH₂OPh(4-F)
O

A-2147
Et
H
Cl
F
CH₂CH₂OPh(4-CF₃)
O

A-2148
Et
H
Cl
F
CH₂CH₂CH₂OPh
O

A-2149
Et
H
Cl
F
CH₂CH₂CH₂OPh(4-Cl)
O

A-2150
Et
H
Cl
F
CH₂CH₂CH₂OPh(4-CF₃)
O

TABLE 50

Compound

Number
R¹
R²
R³
R⁴
R⁵
A

A-2151
Et
H
Cl
F
CH₂CH₂CH₂CH₂OPh(4-CF₃)
O

A-2152
Et
H
Cl
F
CH₂CH₂CH₂CH₂OPh(4-OCF₃)
O

A-2153
Et
H
Cl
F
CH₂CH₂CH₂CH₂CH₂OPh(4-CF₃)
O

A-2154
Et
H
Cl
F
CH₂CH₂OCH₂Ph
O

A-2155
Et
H
Cl
F
CH₂CH₂CH₂OCH₂Ph
O

A-2156
Et
H
Cl
F
CH₂CH₂CH₂CH₂OCH₂Ph
O

A-2157
Et
H
Cl
F
CH₂CH₂CH₂CH₂CH₂OCH₂Ph
O

A-2158
Et
H
Cl
F
CH₂CH₂SPh
O

A-2159
Et
H
Cl
F
CH₂CH₂CH₂SPh
O

A-2160
Et
H
Cl
F
CH₂CH₂CH₂SPh(4-F)
O

A-2161
Et
H
Cl
F
CH₂CH₂CH₂SPh(4-Cl)
O

A-2162
Et
H
Cl
F
CH₂CH₂CH₂SPh(4-Br)
O

A-2163
Et
H
Cl
F
CH₂CH₂CH₂SPh[4-(t-Bu)]
O

A-2164
Et
H
Cl
F
CH₂CH₂CH₂SPh(3-CF₃)
O

A-2165
Et
H
Cl
F
CH₂CH₂CH₂SPh(4-CF₃)
O

A-2166
Et
H
Cl
F
CH₂CH₂CH₂SPh(3-SCF₃)
O

A-2167
Et
H
Cl
F
CH₂CH₂CH₂SPh(4-SCF₃)
O

A-2168
Et
H
Cl
F
CH₂CH₂CH₂CH₂SPh
O

A-2169
Et
H
Cl
F
CH₂CH₂CH₂CH₂SPh(4-F)
O

A-2170
Et
H
Cl
F
CH₂CH₂CH₂CH₂SPh(4-Cl)
O

A-2171
Et
H
Cl
F
CH₂CH₂CH₂CH₂SPh[4-(t-Bu)]
O

A-2172
Et
H
Cl
F
CH₂CH₂CH₂CH₂SPh(4-CF₃)
O

A-2173
Et
H
Cl
F
CH₂CH₂CH₂CH₂CH₂SPh
O

A-2174
Et
H
Cl
F
CH₂CH₂CH₂CH₂CH₂SPh(4-F)
O

A-2175
Et
H
Cl
F
CH₂CH₂CH₂CH₂CH₂SPh(4-Cl)
O

A-2176
Et
H
Cl
F
CH₂CH₂CH₂CH₂CH₂SPh(4-CF₃)
O

A-2177
Et
H
Cl
F
CH₂CH₂S(═O)Ph
O

A-2178
Et
H
Cl
F
CH₂CH₂CH₂S(═O)Ph
O

A-2179
Et
H
Cl
F
CH₂CH₂CH₂S(═O)Ph(4-F)
O

A-2180
Et
H
Cl
F
CH₂CH₂CH₂S(═O)Ph[4-(t-Bu)]
O

A-2181
Et
H
Cl
F
CH₂CH₂CH₂S(═O)Ph(4-CF₃)
O

A-2182
Et
H
Cl
F
CH₂CH₂S(═O)₂Ph
O

A-2183
Et
H
Cl
F
CH₂CH₂S(═O)₂Ph(4-CF₃)
O

A-2184
Et
H
Cl
F
CH₂CH₂CH₂S(═O)₂Ph(4-F)
O

A-2185
Et
H
Cl
F
CH₂CH₂CH₂S(═O)₂Ph(4-Cl)
O

A-2186
Et
H
Cl
F
CH₂CH₂CH₂S(═O)₂Ph(4-CF₃)
O

A-2187
Et
H
Cl
F
CH₂CH₂CH₂CH₂S(═O)₂Ph
O

A-2188
Et
H
Cl
F
CH₂CH₂CH₂CH₂S(═O)₂Ph(4-Cl)
O

A-2189
Et
H
Cl
F
CH₂CH₂CH₂CH₂S(═O)₂Ph(4-CF₃)
O

A-2190
Et
H
Cl
F
CH₂CH₂SCH₂Ph
O

A-2191
Et
H
Cl
F
CH₂CH₂CH₂SCH₂Ph
O

A-2192
Et
H
Cl
F
CH₂CH₂CH₂SCH₂Ph(2-Cl)
O

A-2193
Et
H
Cl
F
CH₂CH₂CH₂SCH₂Ph(3-Cl)
O

A-2194
Et
H
Cl
F
CH₂CH₂CH₂SCH₂Ph(4-Cl)
O

TABLE 51

Compound

Number
R¹
R²
R³
R⁴
R⁵
A

A-2195
Et
H
Cl
F
CH₂CH₂CH₂SCH₂Ph(2-SCF₃)
O

A-2196
Et
H
Cl
F
CH₂CH₂CH₂SCH₂Ph(3-CF₃)
O

A-2197
Et
H
Cl
F
CH₂CH₂CH₂SCH₂Ph(4-CF₃)
O

A-2198
Et
H
Cl
F
CH₂CH₂CH₂SCH₂Ph(4-NO₂)
O

A-2199
Et
H
Cl
F
CH₂CH₂CH₂CH₂SCH₂Ph
O

A-2200
Et
H
Cl
F
CH₂CH₂CH₂CH₂SCH₂Ph(4-Cl)
O

A-2201
Et
H
Cl
F
CH₂CH₂CH₂CH₂SCH₂Ph(4-CF₃)
O

A-2202
Et
H
Cl
F
CH₂CH₂CH₂CH₂SCH₂Ph(4-CN)
O

A-2203
Et
H
Cl
F
CH₂CH₂CH₂CH₂CH₂SCH₂Ph
O

A-2204
Et
H
Cl
F
CH₂CH₂SCH₂CH₂Ph
O

A-2205
Et
H
Cl
F
CH₂CH₂CH₂SCH₂CH₂Ph
O

A-2206
Et
H
Cl
F
CH₂CH₂CH₂CH₂SCH₂CH₂Ph
O

A-2207
Et
H
Cl
F
CH₂CH₂SCH(Me)Ph
O

A-2208
Et
H
Cl
F
CH₂CH₂CH₂SCH(Me)Ph
O

A-2209
Et
H
Cl
F
CH₂CH₂CH₂CH₂SCH(Me)Ph
O

A-2210
Et
H
Cl
F
CH₂CH₂S(═O)CH₂Ph
O

A-2211
Et
H
Cl
F
CH₂CH₂S(═O)CH₂Ph(4-CF₃)
O

A-2212
Et
H
Cl
F
CH₂CH₂CH₂S(═O)CH₂Ph
O

A-2213
Et
H
Cl
F
CH₂CH₂CH₂S(═O)CH₂Ph(2-SCF₃)
O

A-2214
Et
H
Cl
F
CH₂CH₂CH₂S(═O)CH₂Ph(4-SCF₃)
O

A-2215
Et
H
Cl
F
CH₂CH₂CH₂S(═O)CH₂Ph(4-Cl)
O

A-2216
Et
H
Cl
F
CH₂CH₂CH₂S(═O)CH₂Ph(4-CF₃)
O

A-2217
Et
H
Cl
F
CH₂CH₂CH₂CH₂S(═O)CH₂Ph
O

A-2218
Et
H
Cl
F
CH₂CH₂CH₂CH₂S(═O)CH₂Ph(4-CF₃)
O

A-2219
Et
H
Cl
F
CH₂CH₂CH₂CH₂CH₂S(═O)CH₂Ph(4-CF₃)
O

A-2220
Et
H
Cl
F
CH₂CH₂S(═O)₂CH₂Ph
O

A-2221
Et
H
Cl
F
CH₂CH₂S(═O)₂CH₂Ph(4-CF₃)
O

A-2222
Et
H
Cl
F
CH₂CH₂CH₂S(═O)₂CH₂Ph
O

A-2223
Et
H
Cl
F
CH₂CH₂CH₂S(═O)₂CH₂Ph(4-Cl)
O

A-2224
Et
H
Cl
F
CH₂CH₂CH₂S(═O)₂CH₂Ph(4-CF₃)
O

A-2225
Et
H
Cl
F
CH₂CH₂CH₂CH₂S(═O)₂CH₂Ph
O

A-2226
Et
H
Cl
F
CH₂CH₂CH₂CH₂S(═O)₂CH₂Ph(4-CF₃)
O

A-2227
Et
H
Cl
F
CH₂CH₂CH₂CH₂CH₂S(═O)₂CH₂Ph
O

A-2228
Et
H
Cl
F
CH₂CH₂CH₂CH₂CH₂S(═O)₂CH₂Ph(4-CF₃)
O

A-2229
Et
H
Cl
F
CH₂CH₂ON═CH(t-Bu)
O

A-2230
Et
H
Cl
F
CH₂CH₂CH₂ON═CH(t-Bu)
O

A-2231
Et
H
Cl
F
CH₂CH₂CH₂CH₂ON═C(Me)(c-Pr)
O

A-2232
Et
H
Cl
F
CH₂CH₂ON═C(Me)CF₃
O

A-2233
Et
H
Cl
F
CH₂CH₂CH₂ON═CHCF₃
O

A-2234
Et
H
Cl
F
CH₂CH₂CH₂ON═C(Me)CF₃
O

A-2235
Et
H
Cl
F
CH₂CH₂CH₂ON═C(Me)CCl₃
O

A-2236
Et
H
Cl
F
CH₂CH₂CH₂CH₂ON═CHCF₃
O

A-2237
Et
H
Cl
F
CH₂CH₂CH₂CH₂ON═C(Me)CF₃
O

A-2238
Et
H
Cl
F
CH₂CH₂CH₂CH₂CH₂ON═C(Me)CF₃
O

TABLE 52

Compound

Number
R¹
R²
R³
R⁴
R⁵
A

A-2239
Et
H
Cl
F
CH₂CH₂ON═CHPh
O

A-2240
Et
H
Cl
F
CH₂CH₂ON═CHPh(4-CF₃)
O

A-2241
Et
H
Cl
F
CH₂CH₂ON═CHPh(4-SCF₃)
O

A-2242
Et
H
Cl
F
CH₂CH₂CH₂ON═CHPh(3-CF₃)
O

A-2243
Et
H
Cl
F
CH₂CH₂CH₂ON═CHPh(4-CF₃)
O

A-2244
Et
H
Cl
F
CH₂CH₂CH₂ON═CHPh(4-SCF₃)
O

A-2245
Et
H
Cl
F
CH₂CH₂CH₂ON═C(Me)Ph(4-CF₃)
O

A-2246
Et
H
Cl
F
CH₂CH₂CH₂CH₂ON═CHPh(4-SCF₃)
O

A-2247
Et
H
Cl
F
CH₂CH₂(adamant-1-yl)
O

A-2248
Et
H
Cl
F
CH₂CH₂CH₂(3-CF₃-pyrazol-1-yl)
O

A-2249
Et
H
Cl
F
CH2CH2CH2CH2(3-CF₃-pyrazol-1-yl)
O

A-2250
Et
H
Cl
F
CH₂CH₂CH₂CH₂CH₂(3-CF₃-pyrazol-1-yl)
O

A-2251
Et
H
Cl
F
CH₂(1-Me-4-CF₃-imidazol-5-yl)
O

A-2252
Et
H
Cl
F
CH₂CH₂(1-Me-4-CF₃-imidazol-5-yl)
O

A-2253
Et
H
Cl
F
CH₂CH₂CH₂(1-Me-4-CF₃-imidazol-5-yl)
O

A-2254
Et
H
Cl
F
CH₂CH₂CH₂(3-CF₃-1,2,4-triazol-1-yl)
O

A-2255
Et
H
Cl
F
CH₂CH₂CH₂CH₂(3-CF₃-1,2,4-triazol-1-yl)
O

A-2256
Et
H
Cl
F
CH2CH2CH2CH2CH2(3-CF₃-1,2,4-triazol-1-yl)
O

A-2257
Et
H
Cl
F
CH₂CH₂CH₂(4-CF₃-thiazol-2-yl)
O

A-2258
Et
H
Cl
F
CH₂CH₂CH₂CH₂(4-CF₃-thiazol-2-yl)
O

A-2259
Et
H
Cl
F
CH₂CH₂CH₂CH₂CH₂(4-CF₃-thiazol-2-yl)
O

A-2260
Et
H
Cl
F
CH₂CH₂CH₂(2-CF₃-pyridin-5-yl)
O

A-2261
Et
H
Cl
F
CH₂CH₂CH₂CH₂(2-CF₃-pyridin-5-yl)
O

A-2262
Et
H
Cl
F
CH₂CH₂CH₂CH₂CH₂(2-CF₃-pyridin-5-yl)
O

A-2263
Et
H
Cl
F
CH₂(4-CF₃-pyrimidin-2-yl)
O

A-2264
Et
H
Cl
F
CH₂CH₂(4-CF₃-pyrimidin-2-yl)
O

A-2265
Et
H
Cl
F
CH₂CH₂CH₂(4-CF₃-pyrimidin-2-yl)
O

A-2266
Et
H
Cl
F
CH₂CH₂O(3-Cl-5-CF₃-pyridin-2-yl)
O

A-2267
Et
H
Cl
F
CH₂CH₂CH₂O(3-Cl-5-CF₃-pyridin-2-yl)
O

A-2268
Et
H
Cl
F
CH₂CH₂CH₂CH₂O(3-Cl-5-CF₃-pyridin-2-yl)
O

A-2269
Et
H
Cl
F
CH₂CH₂CH₂CH₂CH₂O(3-Cl-5-CF₃-pyridin-2-yl)
O

A-2270
Et
H
Cl
F
CH₂CH₂N(Phth)
O

A-2271
Et
H
Cl
F
CH₂CH₂CH₂N(Phth)
O

A-2272
Et
H
Cl
F
CH₂CH₂CH₂CH₂N(Phth)
O

A-2273
Et
H
Cl
F
CH₂CH₂CH₂CH₂CH₂N(Phth)
O

A-2274
Et
H
Cl
F
CH₂CH(Me)CH₂N(Phth)
O

A-2275
Et
H
Cl
F
CH₂[1,3-dioxolan(2-CF₃)-2-yl]
O

A-2276
Et
H
Cl
F
CH₂(azetidin-3-yl)
O

A-2277
Et
H
Cl
F
CH₂(pyrrolidin-3-yl)
O

A-2278
Et
H
Cl
F
CH₂(piperidin-3-yl)
O

A-2279
Et
H
Cl
F
CH₂{azetidin[1-C(═O)O(t-Bu)]-3-yl}
O

A-2280
Et
H
Cl
F
CH₂{pyrrolidin[1-C(═O)O(t-Bu)]-3-yl}
O

A-2281
Et
H
Cl
F
CH₂{piperidin[1-C(═O)O(t-Bu)]-3-yl}
O

A-2282
Et
H
Cl
F
CH₂{azetidin[1-C(═O)CF3]-3-yl}
O

TABLE 53

Compound

Number
R¹
R²
R³
R⁴
R⁵
A

A-2283
Et
H
Cl
F
CH₂{azetidin[1-S(═O)₂CF₃]-3-yl}
O

A-2284
Et
H
Cl
F
CH₂{pyrrolidin[1-C(═O)CF₃]-3-yl}
O

A-2285
Et
H
Cl
F
CH₂{pyrrolidin[1-S(═O)₂CF₃]-3-yl}
O

A-2286
Et
H
Cl
F
CH₂{piperidin[1-C(═O)CF₃]-3-yl}
O

A-2287
Et
H
Cl
F
CH₂{piperidin[1-S(═O)₂CF₃]-3-yl}
O

A-2288
Et
H
Cl
F
CH₂CH₂CH₂CN
O

A-2289
Et
H
Cl
F
CH₂CH₂CH₂CH₂CN
O

A-2290
Et
H
Cl
F
CH₂CH₂CH₂CH₂CH₂CN
O

A-2291
Et
H
Cl
F
CH₂CH₂CH₂CH₂CH₂CH₂CN
O

A-2292
Et
H
Cl
F
CH₂CH₂CH₂C(═O)OH
O

A-2293
Et
H
Cl
F
CH₂CH₂CH₂CH₂C(═O)OH
O

A-2294
Et
H
Cl
F
CH₂CH₂CH₂CH₂CH₂C(═O)OH
O

A-2295
Et
H
Cl
F
CH₂CH₂SCN
O

A-2296
Et
H
Cl
F
CH₂CH₂CH₂SCN
O

A-2297
Et
H
Cl
F
CH₂CH₂CH₂CH₂SCN
O

A-2298
Et
H
Cl
F
CH₂CH₂CH₂CH₂CH₂SCN
O

A-2299
Et
H
Cl
Cl
CH₂CH₂CH₂CH₂CH₂SCN
O

A-2300
Et
H
Cl
F
CH₂CH₂CH₂CH₂CH₂CH₂SCN
O

A-2301
Et
H
Cl
F
CH₂CH₂CH₂CH₂CH₂CH₂CH₂SCN
O

A-2302
Et
H
Cl
F
CH₂CH₂CH₂CH₂CH₂CH₂CH₂CH₂SCN
O

A-2303
Et
H
Cl
F
CH₂CH₂CH(Me)SCN
O

A-2304
Et
H
Cl
F
CH₂CH(Me)CH₂SCN
O

A-2305
Et
H
Cl
F
CH(Me)CH₂CH₂SCN
O

A-2306
Et
H
Cl
F
CH₂CH₂CH₂CH(Me)SCN
O

A-2307
Et
H
Cl
F
CH₂CH₂CH(Me)CH₂SCN
O

A-2308
Et
H
Cl
F
CH₂CH(Me)CH₂CH₂SCN
O

A-2309
Et
H
Cl
F
CH(Me)CH₂CH₂CH₂SCN
O

A-2310
Et
H
Cl
F
CH₂CH₂CH₂CH₂CH(Me)SCN
O

A-2311
Et
H
Cl
F
CH₂CH₂CH₂CH(Me)CH₂SCN
O

A-2312
Et
H
Cl
F
CH₂CH₂CH(Me)CH₂CH₂SCN
O

A-2313
Et
H
Cl
F
CH₂CH(Me)CH₂CH₂CH₂SCN
O

A-2314
Et
H
Cl
F
CH(Me)CH₂CH₂CH₂CH₂SCN
O

A-2315
Et
H
Cl
F
CH₂CH₂ONH₂
O

A-2316
Et
H
Cl
F
CH₂CH₂CH₂ONH₂
O

A-2317
Et
H
Cl
F
CH₂CH₂CH₂CH₂ONH₂
O

A-2318
Et
H
Cl
F
CH₂CH₂CH₂CH₂CH₂ONH₂
O

A-2319
Et
H
Cl
F
CH₂CH₂CH₂CH₂CH₂CH₂ONH₂
O

A-2320
Et
H
Me
F
Me
O

A-2321
Et
H
Me
F
Et
O

A-2322
Et
H
Me
F
n-Pr
O

A-2323
Et
H
Me
F
i-Pr
O

A-2324
Et
H
Me
F
n-Bu
O

A-2325
Et
H
Me
F
n-Pen
O

A-2326
Et
H
Me
F
n-Hex
O

TABLE 54

Compound

Number
R¹
R²
R³
R⁴
R⁵
A

A-2327
Et
H
Me
F
n-Heptyl
O

A-2328
Et
H
Me
F
n-Octyl
O

A-2329
Et
H
Me
F
n-Nonyl
O

A-2330
Et
H
Me
F
n-Decyl
O

A-2331
Et
H
Me
F
c-Pr
O

A-2332
Et
H
Me
F
c-Pen
O

A-2333
Et
H
Me
F
c-Hex
O

A-2334
Et
H
Me
F
CH₂C(Me)═CH₂
O

A-2335
Et
H
Me
F
CH₂CH₂CH═CH₂
O

A-2336
Et
H
Me
F
CH₂CH₂CH═C(CH₃)₂
O

A-2337
Et
H
Me
F
CH₂CH₂CH₂CH═CH₂
O

A-2338
Et
H
Me
F
CH₂CH₂CH₂CH═C(CH₃)₂
O

A-2339
Et
H
Me
F
CH₂CH₂CH₂CH₂CH═CH₂
O

A-2340
Et
H
Me
F
CH₂CH₂CH₂CH₂CH═C(CH₃)₂
O

A-2341
Et
H
Me
F
CH₂CH₂CH [Image Omitted]

CH
O

A-2342
Et
H
Me
F
CH₂CH₂CH₂C [Image Omitted]

CH
O

A-2343
Et
H
Me
F
CH₂CH₂CH₂CH₂CH [Image Omitted]

CH
O

A-2344
Et
H
Me
F
CH₂CH₂CH₂Cl
O

A-2345
Et
H
Me
F
CH₂CH₂CH₂Br
O

A-2346
Et
H
Me
F
CH₂CH₂CH₂CH₂Cl
O

A-2347
Et
H
Me
F
CH₂CH₂CH₂CH₂Br
O

A-2348
Et
H
Me
F
CH₂CH₂CH₂CH₂CH₂Cl
O

A-2349
Et
H
Me
F
CH₂CH₂CH₂CH₂CH₂Br
O

A-2350
Et
H
Me
Cl
CH₂CH₂CH₂CH₂CH₂Br
O

A-2351
Et
H
Me
F
CH₂CH₂CH₂CH₂CH₂CH₂Cl
O

A-2352
Et
H
Me
F
CH2CH2CH2CH2CH2CH2Br
O

A-2353
Et
H
Me
F
CH₂CH₂CH₂CH₂CH₂CH₂CH₂Cl
O

A-2354
Et
H
Me
F
CH₂CH₂CH₂CH₂CH₂CH₂CH₂Br
O

A-2355
Et
H
Me
F
CH₂CH₂CH₂CH₂CH₂CH₂CH₂CH₂Br
O

A-2356
Et
H
Me
F
CH₂CH(Me)CH₂Cl
O

A-2357
Et
H
Me
F
CH₂CH(Me)CH₂Br
O

A-2358
Et
H
Me
F
CH₂CH₂CH(Me)CH₂CH₂Cl
O

A-2359
Et
H
Me
F
CH₂CH₂CH(Me)CH₂CH₂Br
O

A-2360
Et
H
Me
F
CH₂CH₂CF═CF₂
O

A-2361
Et
H
Me
F
CH₂CH═C(Cl)CF₃
O

A-2362
Et
H
Me
F
CH₂CH₂CH₂CF═CF₂
O

A-2363
Et
H
Me
F
CH₂CH₂CH₂CH₂CF═CF₂
O

A-2364
Et
H
Me
F
CH₂CH₂CH₂CH₂CH₂CF═CF₂
O

A-2365
Et
H
Me
F
CH₂(t-Bu)
O

A-2366
Et
H
Me
F
CH₂CH₂(t-Bu)
O

A-2367
Et
H
Me
F
CH₂CH₂CH₂(t-Bu)
O

A-2368
Et
H
Me
F
CH₂CH₂CH₂CH₂(t-Bu)
O

A-2369
Et
H
Me
F
CH₂CH₂CH₂CH₂CH₂(t-Bu)
O

A-2370
Et
H
Me
F
CH₂CH₂CH₂CH₂CH₂CH₂(t-Bu)
O

TABLE 55

Compound

Number
R¹
R²
R³
R⁴
R⁵
A

A-2371
Et
H
Me
F
CH₂CF₃
O

A-2372
Et
H
Me
F
CH₂CH₂CF₃
O

A-2373
Et
H
Me
F
CH₂CH₂CH₂CF₃
O

A-2374
Et
H
Me
F
CH₂CH₂CH₂CH₂CF₃
O

A-2375
Et
H
Me
F
CH₂CH₂CH₂CH₂CH₂CF₃
O

A-2376
Et
H
Me
F
CH₂CH₂CH₂CH₂CH₂CH₂₂CF₃
O

A-2377
Et
H
Me
F
CH₂CH₂CH₂CH₂CH₂CH₂CH₂CF₃
O

A-2378
Et
H
Me
F
CH₂CH₂CF₃
O

A-2379
Et
H
Me
F
CF₂CHFCF₃
O

A-2380
Et
H
Me
F
CF₂CF₂CF₃
O

A-2381
Et
H
Me
F
CH₂CF₂CF₂CF₃
O

A-2382
Et
H
Me
F
CH₂CF₂CF₂CF₂CF₃
O

A-2383
Et
H
Me
F
CH₂CF₂CF₂CF₂CF₂
O

A-2384
Et
H
Me
F
CH(CF₃)CF₃
O

A-2385
Et
H
Me
F
CH₂CF(CF₃)CF₃
O

A-2386
Et
H
Me
F
CH₂CF₂CF(CF₃)CF₃
O

A-2387
Et
H
Me
F
CH₂CF(CF₃)CF2CF₃
O

A-2388
Et
H
Me
F
CH₂CF₂CF₂CF(CF₃)CF₃
O

A-2389
Et
H
Me
F
CH₂CF₂CF(CF₃)CF₂CF₃
O

A-2390
Et
H
Me
F
CH₂CF(CF3)CF₂CF₂CF₃
O

A-2391
Et
H
Me
F
CH₂(c-Pr)
O

A-2392
Et
H
Me
F
CH₂[c-Pr(1-Me)]
O

A-2393
Et
H
Me
F
CH₂[c-Pr(1-Ph)]
O

A-2394
Et
H
Me
F
CH₂[C-Pr(1-NH₂)]
O

A-2395
Et
H
Me
F
CH₂[c-Pr(1-NHC(═O)O(t-Bu)]
O

A-2396
Et
H
Me
F
CH₂{c-Pr[1-NHS(═O)₂CF₃]}
O

A-2397
Et
H
Me
F
CH₂{C-Pr[1-Ph(4-CCF₃)]}
O

A-2398
Et
H
Me
F
CH₂{C-Pr[1-Ph(3,4,5-F₃)]}
O

A-2399
Et
H
Me
F
CH₂{C-Hex[4-(t-Bu)]}
O

A-2400
Et
H
Me
F
CH₂[c-Hex(4-CF₃)]
O

A-2401
Et
H
Me
F
CH₂CH₂(c-Pr)
O

A-2402
Et
H
Me
F
CH₂CH₂(c-Hex)
O

A-2403
Et
H
Me
F
CH₂CH₂[c-Hex(4-CF₃)]
O

A-2404
Et
H
Me
F
CH₂CH₂[C-Hex(4-SCF₃)]
O

A-2405
Et
H
Me
F
CH₂CH₂CH₂(c-Pr)
O

A-2406
Et
H
Me
F
CH₂CH₂CH₂(c-Hex)
O

A-2407
Et
H
Me
F
CH₂CH₂CH₂{C-Hex[4-(t-Bu)]}
O

A-2408
Et
H
Me
F
CH₂CH₂CH₂[c-Hex(4-CF₃)]
O

A-2409
Et
H
Me
F
CH₂CH₂CH₂[C-Hex(4-SCF₃)]
O

A-2410
Et
H
Me
F
CH₂CH₂CH₂CH₂(c-Pr)
O

A-2411
Et
H
Me
F
CH₂CH₂CH₂CH₂(c-Hex)
O

A-2412
Et
H
Me
F
CH₂CH₂CH₂CH₂[C-Hex(4-CF₃)]
O

A-2413
Et
H
Me
F
CH₂[C-Pr(2,2-F₂)]
O

A-2414
Et
H
Me
F
CH₂[c-Hex(4,4-F₂)]
O

TABLE 56

Compound

Number
R¹
R²
R³
R⁴
R⁵
A

A-2415
Et
H
Me
F
CH₂CH₂[C-Pr(2,2-F₂)]
O

A-2416
Et
H
Me
F
CH₂CH₂[c-Hex(4,4-F₂)]
O

A-2417
Et
H
Me
F
CH₂CH₂CH₂[C-Pr(2,2-F₂)]
O

A-2418
Et
H
Me
F
CH₂CH₂CH₂CH₂[C-Pr(2,2-F₂)]
O

A-2419
Et
H
Me
F
CH₂CH₂OH
O

A-2420
Et
H
Me
F
CH₂CH₂CH₂OH
O

A-2421
Et
H
Me
F
CH₂CH₂CH₂CH₂OH
O

A-2422
Et
H
Me
F
CH₂CH₂CH₂CH₂CH₂OH
O

A-2423
Et
H
Me
F
CH₂CH₂CH₂CH₂CH₂CH₂OH
O

A-2424
Et
H
Me
F
CH₂C(═O)Me
O

A-2425
Et
H
Me
F
CH₂CH(OH)Me
O

A-2426
Et
H
Me
F
CH₂CH(OH)CF₃
O

A-2427
Et
H
Me
F
CH₂C(OH)2CF₃
O

A-2428
Et
H
Me
F
CH₂C(CF₃)═NOH
O

A-2429
Et
H
Me
F
CH₂C(CF₃)═NOMe
O

A-2430
Et
H
Me
F
CH₂CH(CF₃)NH₂
O

A-2431
Et
H
Me
F
CH₂CH₂OMe
O

A-2432
Et
H
Me
F
CH₂CH₂CH₂OMe
O

A-2433
Et
H
Me
F
CH₂CH₂CH₂CH₂OMe
O

A-2434
Et
H
Me
F
CH₂CH₂CH₂CH₂CH₂OMe
O

A-2435
Et
H
Me
F
CH₂CH₂CH₂CH₂CH₂CH₂OMe
O

A-2436
Et
H
Me
F
CH₂CH₂OCHF₂
O

A-2437
Et
H
Me
F
CH₂CH₂CH₂OCHF₂
O

A-2438
Et
H
Me
F
CH₂CH₂CH₂CH₂OCHF₂
O

A-2439
Et
H
Me
F
CH₂CH₂CH₂CH₂CH₂OCHF₂
O

A-2440
Et
H
Me
F
CH₂CH₂CH₂CH₂CH₂CH₂OCHF₂
O

A-2441
Et
H
Me
F
CH₂CH₂OCH₂CF₃
O

A-2442
Et
H
Me
F
CH₂CH₂CH₂OCH₂CF₃
O

A-2443
Et
H
Me
F
CH₂CH₂CH₂CH₂OCH₂CF₃
O

A-2444
Et
H
Me
F
CH₂CH₂CH₂CH₂CH₂OCH₂CF₃
O

A-2445
Et
H
Me
F
CH₂CH₂CH₂CH₂CH₂CH₂OCH₂CF₃
O

A-2446
Et
H
Me
F
CH₂CH₂CH₂CH₂CH₂CH₂CH₂OCH₂CF₃
O

A-2447
Et
H
Me
F
CH₂CH₂OC(CF₃)₃
O

A-2448
Et
H
Me
F
CH₂CH₂CH₂OC(CF₃)₃
O

A-2449
Et
H
Me
F
CH₂CH₂CH₂CH₂OC(CF₃)₃
O

A-2450
Et
H
Me
F
CH₂CH₂CH₂CH₂CH₂OC(CF₃)₃
O

A-2451
Et
H
Me
F
CF₂CHFOCF₂CF₂CF₃
O

A-2452
Et
H
Me
F
CH₂CH₂O(c-Pr)
O

A-2453
Et
H
Me
F
CH₂CH₂O(c-Pen)
O

A-2454
Et
H
Me
F
CH₂CH₂O(c-Hex)
O

A-2455
Et
H
Me
F
CH₂CH₂CH₂O(c-Pr)
O

A-2456
Et
H
Me
F
CH₂CH₂CH₂O(c-Pen)
O

A-2457
Et
H
Me
F
CH₂CH₂CH₂O(c-Hex)
O

A-2458
Et
H
Me
F
CH₂CH₂CH₂CH₂O(c-Pr)
O

TABLE 57

Compound

Number
R¹
R²
R³
R⁴
R⁵
A

A-2459
Et
H
Me
F
CH₂CH₂CH₂CH₂O(c-Pen)
O

A-2460
Et
H
Me
F
CH₂CH₂CH₂CH₂O(c-Hex)
O

A-2461
Et
H
Me
F
CH₂CH₂O[c-Pr(2,2-F₂)]
O

A-2462
Et
H
Me
F
CH₂CH₂CH₂O[c-Pr(2,2-F₂)]
O

A-2463
Et
H
Me
F
CH₂CH₂CH₂CH₂O[c-Pr(2,2-F₂)]
O

A-2464
Et
H
Me
F
CH₂CH₂OCH₂CH₂OCH₃
O

A-2465
Et
H
Me
F
CH₂CH₂OCH₂CH₂OCH₂CF₃
O

A-2466
Et
H
Me
F
CH₂CF₂OCF₂CF₂OCF₃
O

A-2467
Et
H
Me
F
CF₂CHFOCF₂CF₂OCF₃
O

A-2468
Et
H
Me
F
CF₂CHFOCF₂CF(CF3)OCF₂CF₂CF₃
O

A-2469
Et
H
Me
F
CH₂CH₂SH
O

A-2470
Et
H
Me
F
CH₂CH₂CH₂SH
O

A-2471
Et
H
Me
F
CH₂CH₂CH₂CH₂SH
O

A-2472
Et
H
Me
F
CH₂CH₂CH₂CH₂CH₂SH
O

A-2473
Et
H
Me
F
CH₂CH₂CH₂CH₂CH₂CH₂SH
O

A-2474
Et
H
Me
F
CH₂CH(SH)Me
O

A-2475
Et
H
Me
F
CH₂CH[SC(═O)Me]Me
O

A-2476
Et
H
Me
F
CH₂CH₂S(t-Bu)
O

A-2477
Et
H
Me
F
CH₂CH₂CH₂S(t-Bu)
O

A-2478
Et
H
Me
F
CH₂CH₂CH₂CH₂S(t-Bu)
O

A-2479
Et
H
Me
F
CH₂CH₂CH₂CH₂CH₂SCH₃
O

A-2480
Et
H
Me
F
CH₂CH₂CH₂CH₂CH₂SCH(CH₃)₂
O

A-2481
Et
H
Me
F
CH₂CH₂CH₂CH₂CH₂S(t-Bu)
O

A-2482
Et
H
Me
F
CH₂CH₂CH₂CH₂CH₂CH₂SCH(CH₃)₂
O

A-2483
Et
H
Me
F
CH₂CH₂CH₂CH₂CH₂CH₂S(t-Bu)
O

A-2484
Et
H
Me
F
CH₂CH₂CH₂CH₂CH₂CH₂CH₂S(t-Bu)
O

A-2485
Et
H
Me
F
CH₂CH₂SCHF₂
O

A-2486
Et
H
Me
F
CH₂CH₂CH₂SCHF₂
O

A-2487
Et
H
Me
F
CH₂CH₂CH₂CH₂SCHF₂
O

A-2488
Et
H
Me
F
CH₂CH₂CH₂CH₂CH₂SCHF₂
O

A-2489
Et
H
Me
F
CH₂CH₂CH₂CH₂CH₂SCHF₂
O

A-2490
Et
H
Me
F
CH₂CH₂CH₂CH₂CH₂CH₂SCHF₂
O

A-2491
Et
H
Me
F
CH₂CH₂CH₂CH₂CH₂CH₂CH₂SCHF₂
O

A-2492
Et
H
Me
F
CH₂CH₂SCH₂CF₃
O

A-2493
Et
H
Me
F
CH₂CH₂CH₂CH₂CF₃
O

A-2494
Et
H
Me
F
CH₂CH₂CH₂CH₂SCH₂CF₃
O

A-2495
Et
H
Me
F
CH₂CH₂CH₂CH₂CH₂SCH₂CF₃
O

A-2496
Et
H
Me
F
CH₂CH₂CH₂CH₂CH₂CH₂SCH₂CF₃
O

A-2497
Et
H
Me
F
CH₂CH₂CH₂CH₂CH₂CH₂CH₂SCH₂CF₃
O

A-2498
Et
H
Me
F
CH₂CH(Me)SCH₂CF₃
O

A-2499
Et
H
Me
F
CH₂CH₂SCH(CF₃)₂
O

A-2500
Et
H
Me
F
CH₂CH₂CH₂SCH(CF₃)₂
O

A-2501
Et
H
Me
F
CH₂CH₂CH₂CH₂SCH(CF₃)₂
O

A-2502
Et
H
Me
F
CH₂CH₂CH₂CH₂CH₂SCH(CF₃)₂
O

TABLE 58

Compound

Number
R¹
R²
R³
R⁴
R⁵
A

A-2503
Et
H
Me
F
CH₂CH₂CH₂CH₂CH₂CH₂SCH(CF₃)₂
O

A-2504
Et
H
Me
F
CH₂CH₂CH₂CH₂CH₂SCF₂CF₃
O

A-2505
Et
H
Me
F
CH₂CH₂CH₂CH₂CH₂CH₂SCF₂CF₃
O

A-2506
Et
H
Me
F
CH₂CH₂CH₂CH₂CH₂CH₂SCF(CF₃)₂
O

A-2507
Et
H
Me
F
CH₂CH₂CH₂CH₂CH₂CH₂CH₂SCF(CF₃)₂
O

A-2508
Et
H
Me
F
CH₂CH₂CH₂CH₂CH₂SCCl₃
O

A-2509
Et
H
Me
F
CH₂CH₂CH₂CH₂CH₂CH₂SCCl₃
O

A-2510
Et
H
Me
F
CH₂CH₂SCH₂CH═CH₂
O

A-2511
Et
H
Me
F
CH₂CH₂CH₂SCH₂CH═CH₂
O

A-2512
Et
H
Me
F
CH₂CH₂CH₂CH₂SCH₂CH═CH₂
O

A-2513
Et
H
Me
F
CH₂CH₂SCF═CFCF₃
O

A-2514
Et
H
Me
F
CH₂CH₂CH₂SCF═CFCF₃
O

A-2515
Et
H
Me
F
CH₂CH₂CH₂CH₂SCF═CFCF₃
O

A-2516
Et
H
Me
F
CH₂CH₂CH₂S(c-Pr)
O

A-2517
Et
H
Me
F
CH₂CH₂CH₂S(c-Hex)
O

A-2518
Et
H
Me
F
CH₂CH₂CH₂CH₂S(c-Pr)
O

A-2519
Et
H
Me
F
CH₂CH₂CH₂CH₂S(c-Hex)
O

A-2520
Et
H
Me
F
CH₂CH₂CH₂CH₂CH₂S(c-Pr)
O

A-2521
Et
H
Me
F
CH₂CH₂CH₂CH₂CH₂S(c-Hex)
O

A-2522
Et
H
Me
F
CH₂CH₂CH₂S[c-Hex(4,4-F₂)]
O

A-2523
Et
H
Me
F
CH₂CH₂CH₂CH₂S[c-Hex(4,4-F₂)]
O

A-2524
Et
H
Me
F
CH₂CH₂CH₂CH₂CH₂S[c-Hex(4,4-F₂)]
O

A-2525
Et
H
Me
F
CH₂CH₂CH₂SCH₂(c-Pr)
O

A-2526
Et
H
Me
F
CH₂CH₂CH₂SCH₂(c-Hex)
O

A-2527
Et
H
Me
F
CH₂CH₂CH₂CH₂SCH₂(c-Pr)
O

A-2528
Et
H
Me
F
CH₂CH₂CH₂CH₂SCH₂(C-Hex)
O

A-2529
Et
H
Me
F
CH₂CH₂CH₂CH₂CH₂SCH₂(c-Pr)
O

A-2530
Et
H
Me
F
CH₂CH₂CH₂CH₂CH₂SCH₂(c-Hex)
O

A-2531
Et
H
Me
F
CH₂CH₂CH₂SCH₂[c-Hex(4,4-F₂)]
O

A-2532
Et
H
Me
F
CH₂CH₂CH₂CH₂SCH₂[c-Hex(4,4-F₂)]
O

A-2533
Et
H
Me
F
CH₂CH₂CH₂CH₂CH₂SCH₂[c-Hex(4,4-F₂)]
O

A-2534
Et
H
Me
F
CH₂CH₂CH₂SCH₂SiMe₃
O

A-2535
Et
H
Me
F
CH₂CH₂CH₂CH₂SCH₂SiMe₃
O

A-2536
Et
H
Me
F
CH₂CH₂CH₂CH₂CH₂SCH₂SiMe₃
O

A-2537
Et
H
Me
F
CH₂CH₂OCH₂CH₂SCH₃
O

A-2538
Et
H
Me
F
CH₂CH₂OCH₂CH₂SCHF₂
O

A-2539
Et
H
Me
F
CH₂CH₂OCH₂CH₂SCF₃
O

A-2540
Et
H
Me
F
CH₂CH₂OCH₂CH₂SCH₂CF₃
O

A-2541
Et
H
Me
F
CH₂CH₂CH₂S(═O)(t-Bu)
O

A-2542
Et
H
Me
F
CH₂CH₂CH₂CH₂S(═O)(t-Bu)
O

A-2543
Et
H
Me
F
CH₂CH₂CH₂CH₂CH₂CH₂S(═O)(t-Bu)
O

A-2544
Et
H
Me
F
CH₂CH₂S(═O)CHF₂
O

A-2545
Et
H
Me
F
CH₂CH₂CH₂S(═O)CHF₂
O

A-2546
Et
H
Me
F
CH₂CH₂CH₂CH₂S(═O)CHF₂
O

TABLE 59

Compound

Number
R¹
R²
R³
R⁴
R⁵
A

A-2547
Et
H
Me
F
CH₂CH₂CH₂CH₂CH₂S(═O)CHF₂
O

A-2548
Et
H
Me
F
CH₂CH₂CH₂CH₂CH₂CH₂S(═O)CHF₂
O

A-2549
Et
H
Me
F
CH₂CH₂CH₂CH₂CH₂CH₂CH₂S(═O)CHF₂
O

A-2550
Et
H
Me
F
CH₂CH₂S(═O)CF₃
O

A-2551
Et
H
Me
F
CH₂CH₂CH₂S(═O)CF₃
O

A-2552
Et
H
Me
F
CH₂CH₂CH₂CH₂S(═O)CF₃
O

A-2553
Et
H
Me
F
CH₂CH₂CH₂CH₂CH₂S(═O)CF₃
O

A-2554
Et
H
Me
F
CH₂CH₂CH₂CH₂CH₂CH₂S(═O)CF₃
O

A-2555
Et
H
Me
F
CH₂CH₂CH₂CH₂CH₂CH₂CH₂S(═O)CF₃
O

A-2556
Et
H
Me
F
CH₂CH₂S(═O)CH₂CF₃
O

A-2557
Et
H
Me
F
CH₂CH₂CH₂S(═O)CH₂CF₃
O

A-2558
Et
H
Me
F
CH₂CH₂CH₂CH₂S(═O)CH₂CF₃
O

A-2559
Et
H
Me
F
CH₂CH₂CH₂CH₂CH₂S(═O)CH₂CF₃
O

A-2560
Et
H
Me
F
CH₂CH₂CH₂CH₂CH₂CH₂S(═O)CH₂CF₃
O

A-2561
Et
H
Me
F
CH₂CH₂CH₂CH₂CH₂CH₂CH₂S(═O)CH₂CF₃
O

A-2562
Et
H
Me
F
CH₂CH(Me)S(═O)CH₂CF₃
O

A-2563
Et
H
Me
F
CH₂CH₂CH₂S(═O)(c-Pr)
O

A-2564
Et
H
Me
F
CH₂CH₂CH₂CH₂S(═O)(c-Pr)
O

A-2565
Et
H
Me
F
CH₂CH₂CH₂CH₂S(═O)(c-Pen)
O

A-2566
Et
H
Me
F
CH₂CH₂CH₂CH₂S(═O)(c-Hex)
O

A-2567
Et
H
Me
F
CH₂CH₂CH₂CH₂CH₂S(═O)(c-Pr)
O

A-2568
Et
H
Me
F
CH₂CH₂CH₂CH₂CH₂S(═O)(c-Hex)
O

A-2569
Et
H
Me
F
CH₂CH₂CH₂S(═O)[c-Hex(4,4-F₂)]
O

A-2570
Et
H
Me
F
CH₂CH₂CH₂CH₂S(═O)[c-Hex(4,4-F₂)]
O

A-2571
Et
H
Me
F
CH₂CH₂CH₂CH₂CH2S(═O)[c-Hex(4,4-F₂)]
O

A-2572
Et
H
Me
F
CH₂CH₂CH₂CH₂S(═O)₂Me
O

A-2573
Et
H
Me
F
CH₂CH₂CH₂CH₂CH₂S(═O)₂Me
O

A-2574
Et
H
Me
F
CH₂CH₂CH₂CH₂CH₂S(═O)₂(t-Bu)
O

A-2575
Et
H
Me
F
CH₂CH₂S(═O)₂CHF₂
O

A-2576
Et
H
Me
F
CH₂CH₂CH₂S(═O)₂CHF₂
O

A-2577
Et
H
Me
F
CH₂CH₂CH₂CH₂S(═O)₂CHF₂
O

A-2578
Et
H
Me
F
CH₂CH₂CH₂CH₂CH₂S(═O)₂CHF₂
O

A-2579
Et
H
Me
F
CH₂CH₂CH₂CH₂CH₂CH₂S(═O)₂CHF₂
O

A-2580
Et
H
Me
F
CH₂CH₂S(═O)₂CF₃
O

A-2581
Et
H
Me
F
CH₂CH₂CH₂S(═O)₂CF₃
O

A-2582
Et
H
Me
F
CH₂CH₂CH₂CH₂S(═O)₂CF₃
O

A-2583
Et
H
Me
F
CH₂CH₂CH₂CH₂CH₂S(═O)₂CF₃
O

A-2584
Et
H
Me
F
CH₂CH₂CH₂CH₂CH₂CH₂S(═O)₂CF₃
O

A-2585
Et
H
Me
F
CH₂CH₂CH₂CH₂CH₂CH₂CH₂S(═O)₂CF₃
O

A-2586
Et
H
Me
F
CH₂CH₂CH₂CH₂CH₂CH₂CH₂CH₂S(═O)₂CF₃
O

A-2587
Et
H
Me
F
CH₂CH₂S(═O)₂CH2CF₃
O

A-2588
Et
H
Me
F
CH₂CH₂CH₂S(═O)₂CH2CF₃
O

A-2589
Et
H
Me
F
CH₂CH₂CH₂CH₂S(═O)₂CH2CF₃
O

A-2590
Et
H
Me
F
CH₂CH₂CH₂CH₂CH₂S(═O)₂CH2CF₃
O

TABLE 60

Compound

Number
R¹
R²
R³
R⁴
R⁵
A

A-2591
Et
H
Me
F
CH₂CH₂CH₂CH₂CH₂CH₂S(═O)₂CH₂CF₃
O

A-2592
Et
H
Me
F
CH₂CH(Me)S(═O)₂CH2CF₃
O

A-2593
Et
H
Me
F
CH₂CH₂CH₂S(═O)₂(c-Pr)
O

A-2594
Et
H
Me
F
CH₂CH₂CH₂CH₂S(═O)₂(c-Pr)
O

A-2595
Et
H
Me
F
CH₂CH₂CH₂CH₂CH₂S(═O)₂(c-Pr)
O

A-2596
Et
H
Me
F
CH₂CH₂CH2S(═O)₂[c-Hex(4,4-F₂)]
O

A-2597
Et
H
Me
F
CH₂CH₂CH₂CH₂S(═O)₂[c-Hex(4,4-F₂)]
O

A-2598
Et
H
Me
F
CH₂CH₂CH₂CH₂CH₂S(═O)₂[c-Hex(4,4-F₂)]
O

A-2599
Et
H
Me
F
CH₂CH₂CH₂C(═O)H
O

A-2600
Et
H
Me
F
CH₂CH₂CH₂CH₂C(═O)H
O

A-2601
Et
H
Me
F
CH₂CH₂CH₂CH₂CH₂C(═O)H
O

A-2602
Et
H
Me
F
CH₂CH₂CH₂C(═O)(t-Bu)
O

A-2603
Et
H
Me
F
CH₂CH₂CH₂CH₂C(═O)(t-Bu)
O

A-2604
Et
H
Me
F
CH₂CH₂CH₂CH₂CH₂C(═O)(t-Bu)
O

A-2605
Et
H
Me
F
CH₂CH₂CH₂C(═O)CF₃
O

A-2606
Et
H
Me
F
CH₂CH₂CH₂CH₂C(═O)CF₃
O

A-2607
Et
H
Me
F
CH₂CH₂CH₂CH₂CH₂C(═O)CF₃
O

A-2608
Et
H
Me
F
CH₂C(═O)Ph
O

A-2609
Et
H
Me
F
CH₂C(═O)Ph(4-Cl)
O

A-2610
Et
H
Me
F
CH₂C(═O)Ph(4-CF₃)
O

A-2611
Et
H
Me
F
CH₂CH₂C(═O)Ph(4-CF₃)
O

A-2612
Et
H
Me
F
CH₂CH₂CH₂C(═O)Ph(4-CF₃)
O

A-2613
Et
H
Me
F
CH₂CH₂CH₂CH₂C(═O)Ph(4-CF₃)
O

A-2614
Et
H
Me
F
CH₂CH₂CH₂CH₂CH₂C(═O)Ph(4-CF₃)
O

A-2615
Et
H
Me
F
CH₂C(═O)OEt
O

A-2616
Et
H
Me
F
CH₂CH₂C(═O)O(t-Bu)
O

A-2617
Et
H
Me
F
CH₂CH₂CH₂C(═O)OEt
O

A-2618
Et
H
Me
F
CH₂CH₂CH₂C(═O)O(t-Bu)
O

A-2619
Et
H
Me
F
CH₂CH₂CH₂CH₂C(═O)O(t-Bu)
O

A-2620
Et
H
Me
F
CH₂CH₂CH₂CH₂CH₂C(═O)O(t-Bu)
O

A-2621
Et
H
Me
F
CH₂CH₂CH₂CH₂CH₂CH₂C(═O)O(t-Bu)
O

A-2622
Et
H
Me
F
CH₂CH₂CH₂CH₂CH₂CH₂CH₂C(═O)OEt
O

A-2623
Et
H
Me
F
CH₂CH₂C(═O)OCH₂CF₃
O

A-2624
Et
H
Me
F
CH₂CH₂CH₂C(═O)OCH₂CF₃
O

A-2625
Et
H
Me
F
CH₂CH₂CH₂CH₂C(═O)OCH₂CF₃
O

A-2626
Et
H
Me
F
CH₂CH₂CH₂CH₂CH₂C(═O)OCH₂CF₃
O

A-2627
Et
H
Me
F
CH₂CH₂C(═O)NH(t-Bu)
O

A-2628
Et
H
Me
F
CH₂CH₂CH₂C(═O)NH(t-Bu)
O

A-2629
Et
H
Me
F
CH₂CH₂CH₂C(═O)NH(t-Pen)
O

A-2630
Et
H
Me
F
CH₂CH₂CH₂CH₂C(═O)NH(t-Bu)
O

A-2631
Et
H
Me
F
CH₂CH₂C(═O)NHCH₂CF₃
O

A-2632
Et
H
Me
F
CH₂CH₂CH₂C(═O)NHCH₂CF₃
O

A-2633
Et
H
Me
F
CH₂CH₂CH₂CH₂C(═O)NHCH₂CF₃
O

A-2634
Et
H
Me
F
CH₂CH₂SC(═O)N(Me)₂
O

TABLE 61

Compound

Number
R¹
R²
R³
R⁴
R⁵
A

A-2635
Et
H
Me
F
CH₂CH₂CH₂SC(═O)N(Me)₂
O

A-2636
Et
H
Me
F
CH₂CH₂CH₂SC(═O)NH(t-Bu)
O

A-2637
Et
H
Me
F
CH₂CH₂CH₂CH₂CH₂SC(═O)NH(t-Bu)
O

A-2638
Et
H
Me
F
CH₂CH₂SC(═O)NHCH₂CF₃
O

A-2639
Et
H
Me
F
CH₂CH₂CH₂SC(═O)NHCH₂CF₃
O

A-2640
Et
H
Me
F
CH₂CH₂CH₂CH₂SC(═O)NHCH₂CF₃
O

A-2641
Et
H
Me
F
CH₂CH₂CH₂OC(═O)H
O

A-2642
Et
H
Me
F
CH₂CH₂CH₂CH₂OC(═O)H
O

A-2643
Et
H
Me
F
CH₂CH₂CH₂CH₂CH₂OC(═O)H
O

A-2644
Et
H
Me
F
CH₂CH₂CH₂OC(═O)Me
O

A-2645
Et
H
Me
F
CH₂CH₂CH₂CH₂OC(═O)Me
O

A-2646
Et
H
Me
F
CH₂CH₂CH₂CH₂CH₂OC(═O)Me
O

A-2647
Et
H
Me
F
CH₂CH₂OC(═O)CF₃
O

A-2648
Et
H
Me
F
CH₂CH₂CH₂OC(═O)CF₃
O

A-2649
Et
H
Me
F
CH₂CH₂CH₂CH₂OC(═O)CF₃
O

A-2650
Et
H
Me
F
CH₂CH₂CH₂CH₂CH₂OC(═O)Ph(4-CF₃)
O

A-2651
Et
H
Me
F
CH₂CH₂OC(═O)Ph
O

A-2652
Et
H
Me
F
CH₂CH₂OC(═O)Ph(4-CF₃)
O

A-2653
Et
H
Me
F
CH₂CH₂CH₂OC(═O)Ph(4-CF₃)
O

A-2654
Et
H
Me
F
CH₂CH₂CH₂CH₂OC(═O)Ph(4-CF₃)
O

A-2655
Et
H
Me
F
CH₂CH₂CH₂CH₂CH₂OC(═O)Ph(4-CF₃)
O

A-2656
Et
H
Me
F
CH₂CH₂OS(═O)Me
O

A-2657
Et
H
Me
F
CH₂CH₂CH₂OS(═O)Me
O

A-2658
Et
H
Me
F
CH₂CH₂CH₂CH₂OS(═O)Me
O

A-2659
Et
H
Me
F
CH₂CH₂CH₂CH₂CH₂OS(═O)Me
O

A-2660
Et
H
Me
F
CH₂CH₂CH₂CH₂CH₂CH₂OS(═O)Me
O

A-2661
Et
H
Me
F
CH₂CH₂OS(═O)CF₃
O

A-2662
Et
H
Me
F
CH₂CH₂CH₂OS(═O)CF₃
O

A-2663
Et
H
Me
F
CH₂CH₂CH₂CH₂OS(═O)CF₃
O

A-2664
Et
H
Me
F
CH₂CH₂CH₂CH₂CH₂OS(═O)CF₃
O

A-2665
Et
H
Me
F
CH₂CH₂CH₂CH₂CH₂CH₂OS(═O)CF₃
O

A-2666
Et
H
Me
F
CH₂CH₂OS(═O)Ph
O

A-2667
Et
H
Me
F
CH₂CH₂OS(═O)Ph(4-Me)
O

A-2668
Et
H
Me
F
CH₂CH₂CH₂OS(═O)Ph
O

A-2669
Et
H
Me
F
CH₂CH₂CH₂OS(═O)Ph(4-Me)
O

A-2670
Et
H
Me
F
CH₂CH₂OS(═O)₂Me
O

A-2671
Et
H
Me
F
CH₂CH₂CH₂OS(═O)₂Me
O

A-2672
Et
H
Me
F
CH₂CH₂CH₂OS(═O)₂CF₃
O

A-2673
Et
H
Me
F
CH₂CH₂CH₂CH₂OS(═O)₂CF₃
O

A-2674
Et
H
Me
F
CH₂CH₂CH₂CH₂CH₂OS(═O)₂CF₃
O

A-2675
Et
H
Me
F
CH₂CH₂CH₂CH₂CH₂OS(═O)₂CF₂CF₂CF₂CF₃
O

A-2676
Et
H
Me
F
CH₂CH₂OS(═O)₂Ph
O

A-2677
Et
H
Me
F
CH₂CH₂OS(═O)₂Ph(4-Me)
O

A-2678
Et
H
Me
F
CH₂CH₂CH₂OS(═O)₂Ph
O